fasudil has been researched along with Bronchial Hyperreactivity in 2 studies
fasudil: intracellular calcium antagonist; structure in first source
fasudil : An isoquinoline substituted by a (1,4-diazepan-1-yl)sulfonyl group at position 5. It is a Rho-kinase inhibitor and its hydrochloride hydrate form is approved for the treatment of cerebral vasospasm and cerebral ischemia.
Bronchial Hyperreactivity: Tendency of the smooth muscle of the tracheobronchial tree to contract more intensely in response to a given stimulus than it does in the response seen in normal individuals. This condition is present in virtually all symptomatic patients with asthma. The most prominent manifestation of this smooth muscle contraction is a decrease in airway caliber that can be readily measured in the pulmonary function laboratory.
| Excerpt | Relevance | Reference |
|---|---|---|
| "When fasudil was administrated to OVA-challenged mice, increased cell numbers of total cells and eosinophils were significantly attenuated in a dose-dependent manner." | 1.34 | Effects of Rho-kinase inactivation on eosinophilia and hyper-reactivity in murine airways by allergen challenges. ( Aratake, H; Kobayashi, T; Kume, H; Ohta, H; Shimokata, K; Taki, F, 2007) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (50.00) | 29.6817 |
| 2010's | 1 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Zychowski, KE | 1 |
| Lucas, SN | 1 |
| Sanchez, B | 1 |
| Herbert, G | 1 |
| Campen, MJ | 1 |
| Taki, F | 1 |
| Kume, H | 1 |
| Kobayashi, T | 1 |
| Ohta, H | 1 |
| Aratake, H | 1 |
| Shimokata, K | 1 |
2 other studies available for fasudil and Bronchial Hyperreactivity
| Article | Year |
|---|---|
Hypoxia-induced pulmonary arterial hypertension augments lung injury and airway reactivity caused by ozone exposure.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Air Pollutants; Animals; Bronchial Hyperreactivity; B | 2016 |
Effects of Rho-kinase inactivation on eosinophilia and hyper-reactivity in murine airways by allergen challenges.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Allergens; Animals; Bronchial Hyperreactivity; Bronch | 2007 |