fasudil has been researched along with Brain Injuries in 4 studies
fasudil: intracellular calcium antagonist; structure in first source
fasudil : An isoquinoline substituted by a (1,4-diazepan-1-yl)sulfonyl group at position 5. It is a Rho-kinase inhibitor and its hydrochloride hydrate form is approved for the treatment of cerebral vasospasm and cerebral ischemia.
Brain Injuries: Acute and chronic (see also BRAIN INJURIES, CHRONIC) injuries to the brain, including the cerebral hemispheres, CEREBELLUM, and BRAIN STEM. Clinical manifestations depend on the nature of injury. Diffuse trauma to the brain is frequently associated with DIFFUSE AXONAL INJURY or COMA, POST-TRAUMATIC. Localized injuries may be associated with NEUROBEHAVIORAL MANIFESTATIONS; HEMIPARESIS, or other focal neurologic deficits.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Here, we used the model of hypoxia/reoxygenation (H/R) injury to explore the possibility whether Fasudil, a ROCK inhibitor in clinical application for subarachnoid hemorrhage and stroke, mobilizes adult neural stem cells in vivo." | 7.76 | Fasudil, a Rho kinase inhibitor, drives mobilization of adult neural stem cells after hypoxia/reoxygenation injury in mice. ( Ding, J; Li, QY; Lu, CZ; Sun, CH; Wang, X; Xiao, BG; Yu, JZ, 2010) |
| " Here, we used the model of hypoxia/reoxygenation (H/R) injury to explore the possibility whether Fasudil, a ROCK inhibitor in clinical application for subarachnoid hemorrhage and stroke, mobilizes adult neural stem cells in vivo." | 3.76 | Fasudil, a Rho kinase inhibitor, drives mobilization of adult neural stem cells after hypoxia/reoxygenation injury in mice. ( Ding, J; Li, QY; Lu, CZ; Sun, CH; Wang, X; Xiao, BG; Yu, JZ, 2010) |
| "Ischemic stroke is a deleterious cerebrovascular disease with few therapeutic options, and its functional recovery is highly associated with the integrity of the blood-brain barrier and neuroinflammation." | 1.91 | FDCA Attenuates Neuroinflammation and Brain Injury after Cerebral Ischemic Stroke. ( Guan, X; Huang, Z; Liang, Z; Pang, T; Wang, Y; Wei, D; Wu, J; Xie, L, 2023) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 3 (75.00) | 24.3611 |
| 2020's | 1 (25.00) | 2.80 |
| Authors | Studies |
|---|---|
| Guan, X | 1 |
| Wei, D | 1 |
| Liang, Z | 1 |
| Xie, L | 1 |
| Wang, Y | 1 |
| Huang, Z | 1 |
| Wu, J | 1 |
| Pang, T | 1 |
| Fan, R | 1 |
| Enkhjargal, B | 1 |
| Camara, R | 1 |
| Yan, F | 1 |
| Gong, L | 1 |
| Tang, J | 1 |
| Chen, Y | 1 |
| Zhang, JH | 1 |
| Ding, J | 1 |
| Li, QY | 1 |
| Yu, JZ | 1 |
| Wang, X | 1 |
| Sun, CH | 1 |
| Lu, CZ | 1 |
| Xiao, BG | 1 |
| Alford, PW | 1 |
| Dabiri, BE | 1 |
| Goss, JA | 1 |
| Hemphill, MA | 1 |
| Brigham, MD | 1 |
| Parker, KK | 1 |
4 other studies available for fasudil and Brain Injuries
| Article | Year |
|---|---|
FDCA Attenuates Neuroinflammation and Brain Injury after Cerebral Ischemic Stroke.
Topics: Animals; Blood-Brain Barrier; Brain Injuries; Brain Ischemia; Humans; Infarction, Middle Cerebral Ar | 2023 |
Critical role of EphA4 in early brain injury after subarachnoid hemorrhage in rat.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Blood-Brain Barrier; Brain; Brain Edema; Bra | 2017 |
Fasudil, a Rho kinase inhibitor, drives mobilization of adult neural stem cells after hypoxia/reoxygenation injury in mice.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adult Stem Cells; Animals; Antibodies; Astrocytes; Br | 2010 |
Blast-induced phenotypic switching in cerebral vasospasm.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Algorithms; Arteries; Blast Injuries; Blotting, Weste | 2011 |