Page last updated: 2024-10-28

fasudil and Brain Infarction

fasudil has been researched along with Brain Infarction in 4 studies

fasudil: intracellular calcium antagonist; structure in first source
fasudil : An isoquinoline substituted by a (1,4-diazepan-1-yl)sulfonyl group at position 5. It is a Rho-kinase inhibitor and its hydrochloride hydrate form is approved for the treatment of cerebral vasospasm and cerebral ischemia.

Brain Infarction: Tissue NECROSIS in any area of the brain, including the CEREBRAL HEMISPHERES, the CEREBELLUM, and the BRAIN STEM. Brain infarction is the result of a cascade of events initiated by inadequate blood flow through the brain that is followed by HYPOXIA and HYPOGLYCEMIA in brain tissue. Damage may be temporary, permanent, selective or pan-necrosis.

Research Excerpts

ExcerptRelevanceReference
"Early CIMT promotes motor recovery after acute ischemic stroke when it is administered with fasudil pharmacotherapy, but not without it."7.83Combination of early constraint-induced movement therapy and fasudil enhances motor recovery after ischemic stroke in rats. ( Bonney, E; Chen, YH; Huang, FZ; Liu, BQ; Liu, YH; Wang, HX; Zhao, Y, 2016)
" To determine if a ROCK mechanism is involved in simvastatin-induced neuroprotection following embolic strokes, we used pharmacological intervention with the ROCK inhibitor, fasudil."7.76Simvastatin improves clinical scores in a rabbit multiple infarct ischemic stroke model: synergism with a ROCK inhibitor but not the thrombolytic tissue plasminogen activator. ( Han, MK; Lapchak, PA, 2010)
"Early CIMT promotes motor recovery after acute ischemic stroke when it is administered with fasudil pharmacotherapy, but not without it."3.83Combination of early constraint-induced movement therapy and fasudil enhances motor recovery after ischemic stroke in rats. ( Bonney, E; Chen, YH; Huang, FZ; Liu, BQ; Liu, YH; Wang, HX; Zhao, Y, 2016)
" To determine if a ROCK mechanism is involved in simvastatin-induced neuroprotection following embolic strokes, we used pharmacological intervention with the ROCK inhibitor, fasudil."3.76Simvastatin improves clinical scores in a rabbit multiple infarct ischemic stroke model: synergism with a ROCK inhibitor but not the thrombolytic tissue plasminogen activator. ( Han, MK; Lapchak, PA, 2010)
" In this study, we assessed the temporal and spatial profiles of Rho-kianse activity and the effect of the Rho-kinase inhibitor fasudil on microcirculatory disturbances in the focal brain ischemia."3.74Rho-kinase activation in endothelial cells contributes to expansion of infarction after focal cerebral ischemia. ( Hori, M; Kaibuchi, K; Kitagawa, K; Omura-Matsuoka, E; Sasaki, T; Terasaki, Y; Todo, K; Yagita, Y, 2007)
"Treatment with fasudil (1 and 10 mg/kg, n=15 each) resulted in a significant improvement in neurological deficits."1.31A new model of cerebral microthrombosis in rats and the neuroprotective effect of a Rho-kinase inhibitor. ( Asano, T; Ikegaki, I; Satoh, S; Toshima, Y, 2000)

Research

Studies (4)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's2 (50.00)29.6817
2010's2 (50.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Liu, YH1
Zhao, Y1
Huang, FZ1
Chen, YH1
Wang, HX1
Bonney, E1
Liu, BQ1
Lapchak, PA1
Han, MK1
Yagita, Y1
Kitagawa, K1
Sasaki, T1
Terasaki, Y1
Todo, K1
Omura-Matsuoka, E1
Kaibuchi, K1
Hori, M1
Toshima, Y1
Satoh, S1
Ikegaki, I1
Asano, T1

Other Studies

4 other studies available for fasudil and Brain Infarction

ArticleYear
Combination of early constraint-induced movement therapy and fasudil enhances motor recovery after ischemic stroke in rats.
    The International journal of neuroscience, 2016, Volume: 126, Issue:2

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Analysis of Variance; Animals; Brain Infarction; Brai

2016
Simvastatin improves clinical scores in a rabbit multiple infarct ischemic stroke model: synergism with a ROCK inhibitor but not the thrombolytic tissue plasminogen activator.
    Brain research, 2010, Jul-16, Volume: 1344

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Anticholesteremic Agents; Brain Infarction;

2010
Rho-kinase activation in endothelial cells contributes to expansion of infarction after focal cerebral ischemia.
    Journal of neuroscience research, 2007, Aug-15, Volume: 85, Issue:11

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Brain; Brain Infarction; Brain Ischemia; Cal

2007
A new model of cerebral microthrombosis in rats and the neuroprotective effect of a Rho-kinase inhibitor.
    Stroke, 2000, Volume: 31, Issue:9

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Brain Infarction; Carotid Artery, Internal;

2000