fasudil has been researched along with Biliary Cirrhosis in 1 studies
fasudil: intracellular calcium antagonist; structure in first source
fasudil : An isoquinoline substituted by a (1,4-diazepan-1-yl)sulfonyl group at position 5. It is a Rho-kinase inhibitor and its hydrochloride hydrate form is approved for the treatment of cerebral vasospasm and cerebral ischemia.
| Excerpt | Relevance | Reference |
|---|---|---|
| "These results show in secondary biliary cirrhosis that (1) Rho-kinase activation with resultant eNOS down-regulation is substantially involved in the pathogenesis of portal hypertension and (2) Rho-kinase might interact with Akt and subsequently inhibit the binding of Akt to eNOS." | 1.35 | Defective endothelial nitric oxide synthase signaling is mediated by rho-kinase activation in rats with secondary biliary cirrhosis. ( Anegawa, G; Hashizume, M; Kawanaka, H; Kinjo, N; Konishi, K; Maehara, Y; Shimokawa, H; Taketomi, A; Yamaguchi, S; Yoshida, D, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Anegawa, G | 1 |
| Kawanaka, H | 1 |
| Yoshida, D | 1 |
| Konishi, K | 1 |
| Yamaguchi, S | 1 |
| Kinjo, N | 1 |
| Taketomi, A | 1 |
| Hashizume, M | 1 |
| Shimokawa, H | 1 |
| Maehara, Y | 1 |
1 other study available for fasudil and Biliary Cirrhosis
| Article | Year |
|---|---|
Defective endothelial nitric oxide synthase signaling is mediated by rho-kinase activation in rats with secondary biliary cirrhosis.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Actins; Animals; Aorta; Disease Models, Animal; Hemod | 2008 |