fasudil has been researched along with Alveolitis, Fibrosing in 6 studies
fasudil: intracellular calcium antagonist; structure in first source
fasudil : An isoquinoline substituted by a (1,4-diazepan-1-yl)sulfonyl group at position 5. It is a Rho-kinase inhibitor and its hydrochloride hydrate form is approved for the treatment of cerebral vasospasm and cerebral ischemia.
| Excerpt | Relevance | Reference |
|---|---|---|
| " This study was performed to determine the efficacy of ROCK inhibitor fasudil in blocking the development of hyperoxia-induced lung injury and fibrosis in neonatal rats." | 7.81 | Fasudil, an inhibitor of Rho-associated coiled-coil kinase, attenuates hyperoxia-induced pulmonary fibrosis in neonatal rats. ( Dang, HX; Fang, F; Li, J; Ning, W; Qi, XJ; Xu, F, 2015) |
| "To determine the beneficial effects and mechanisms of fasudil, a selective ROCK inhibitor, on bleomycin-induced pulmonary fibrosis in mice and to determine the effects and mechanisms of fasudil on the biological behaviors in NIH3T3 mouse fibroblast cell line." | 7.80 | [Effects of fasudil on bleomycin-induced pulmonary fibrosis in mice and on the biological behaviors in NIH3T3 mouse fibroblast cell line]. ( Huang, H; Jiang, C; Liu, J; Wang, Y; Xu, Z; Zhao, Y, 2014) |
| "Treatment with fasudil (30 mg kg(-1) day(-1)) was given intraperitoneally for 7, 14 or 21 days until mice underwent hemodynamic measurements." | 5.39 | Long-term treatment with fasudil improves bleomycin-induced pulmonary fibrosis and pulmonary hypertension via inhibition of Smad2/3 phosphorylation. ( Batteux, F; Bei, Y; Chen, W; Dinh-Xuan, AT; Duong-Quy, S; Hua-Huy, T; Nguyen, VH; Nicco, C, 2013) |
| " This study was performed to determine the efficacy of ROCK inhibitor fasudil in blocking the development of hyperoxia-induced lung injury and fibrosis in neonatal rats." | 3.81 | Fasudil, an inhibitor of Rho-associated coiled-coil kinase, attenuates hyperoxia-induced pulmonary fibrosis in neonatal rats. ( Dang, HX; Fang, F; Li, J; Ning, W; Qi, XJ; Xu, F, 2015) |
| "To determine the beneficial effects and mechanisms of fasudil, a selective ROCK inhibitor, on bleomycin-induced pulmonary fibrosis in mice and to determine the effects and mechanisms of fasudil on the biological behaviors in NIH3T3 mouse fibroblast cell line." | 3.80 | [Effects of fasudil on bleomycin-induced pulmonary fibrosis in mice and on the biological behaviors in NIH3T3 mouse fibroblast cell line]. ( Huang, H; Jiang, C; Liu, J; Wang, Y; Xu, Z; Zhao, Y, 2014) |
| "Our study aimed firstly to describe pulmonary inflammation and fibrosis induced by HOCl in mice, and secondly to determine whether fasudil, a selective inhibitor of ROCK, could prevent lung and skin fibroses in HOCl-injected mice." | 1.43 | RhoA/Rho-kinase activation promotes lung fibrosis in an animal model of systemic sclerosis. ( Batteux, F; Bei, Y; Chéreau, C; Dinh-Xuan, AT; Duong-Quy, S; Hua-Huy, T; Le-Dong, NN; Nicco, C; Tiev, KP, 2016) |
| "Treatment with fasudil during the postinflammatory fibrotic phase of lung injury or genetic ablation of Mkl1 protected mice from experimental lung fibrosis." | 1.39 | Inhibition of mechanosensitive signaling in myofibroblasts ameliorates experimental pulmonary fibrosis. ( Bernard, K; Desai, L; Hecker, L; Huang, X; Jin, TH; Kurundkar, A; Kurundkar, D; Liu, H; Thannickal, VJ; Zhou, Y, 2013) |
| "Treatment with fasudil (30 mg kg(-1) day(-1)) was given intraperitoneally for 7, 14 or 21 days until mice underwent hemodynamic measurements." | 1.39 | Long-term treatment with fasudil improves bleomycin-induced pulmonary fibrosis and pulmonary hypertension via inhibition of Smad2/3 phosphorylation. ( Batteux, F; Bei, Y; Chen, W; Dinh-Xuan, AT; Duong-Quy, S; Hua-Huy, T; Nguyen, VH; Nicco, C, 2013) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 6 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Zhou, Y | 1 |
| Huang, X | 1 |
| Hecker, L | 1 |
| Kurundkar, D | 1 |
| Kurundkar, A | 1 |
| Liu, H | 1 |
| Jin, TH | 1 |
| Desai, L | 1 |
| Bernard, K | 1 |
| Thannickal, VJ | 1 |
| Bei, Y | 2 |
| Hua-Huy, T | 2 |
| Duong-Quy, S | 2 |
| Nguyen, VH | 1 |
| Chen, W | 1 |
| Nicco, C | 2 |
| Batteux, F | 2 |
| Dinh-Xuan, AT | 2 |
| Jiang, C | 2 |
| Huang, H | 2 |
| Liu, J | 2 |
| Wang, Y | 2 |
| Zhao, Y | 1 |
| Xu, Z | 2 |
| Qi, XJ | 1 |
| Ning, W | 1 |
| Xu, F | 1 |
| Dang, HX | 1 |
| Fang, F | 1 |
| Li, J | 1 |
| Le-Dong, NN | 1 |
| Tiev, KP | 1 |
| Chéreau, C | 1 |
| Lu, Z | 1 |
6 other studies available for fasudil and Alveolitis, Fibrosing
| Article | Year |
|---|---|
Inhibition of mechanosensitive signaling in myofibroblasts ameliorates experimental pulmonary fibrosis.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Actin Cytoskeleton; Active Transport, Cell Nucleus; A | 2013 |
Long-term treatment with fasudil improves bleomycin-induced pulmonary fibrosis and pulmonary hypertension via inhibition of Smad2/3 phosphorylation.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Bleomycin; Disease Models, Animal; Humans; H | 2013 |
[Effects of fasudil on bleomycin-induced pulmonary fibrosis in mice and on the biological behaviors in NIH3T3 mouse fibroblast cell line].
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Bleomycin; Cyclin D1; Fibroblasts; Lung; Mat | 2014 |
Fasudil, an inhibitor of Rho-associated coiled-coil kinase, attenuates hyperoxia-induced pulmonary fibrosis in neonatal rats.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Animals, Newborn; Blotting, Western; Disease | 2015 |
RhoA/Rho-kinase activation promotes lung fibrosis in an animal model of systemic sclerosis.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Actins; Animals; Disease Models, Animal; Female; Hypo | 2016 |
Fasudil, a Rho-kinase inhibitor, attenuates bleomycin-induced pulmonary fibrosis in mice.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Bleomycin; Cytokines; Drug Evaluation, Precl | 2012 |