fasudil has been researched along with Adult Spinal Muscular Atrophy in 2 studies
fasudil: intracellular calcium antagonist; structure in first source
fasudil : An isoquinoline substituted by a (1,4-diazepan-1-yl)sulfonyl group at position 5. It is a Rho-kinase inhibitor and its hydrochloride hydrate form is approved for the treatment of cerebral vasospasm and cerebral ischemia.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Fasudil was administered by oral gavage from post-natal day 3 to 21 at a concentration of 30 mg/kg twice daily." | 1.38 | Fasudil improves survival and promotes skeletal muscle development in a mouse model of spinal muscular atrophy. ( Anderson, CL; Bowerman, M; Boyer, JG; Kothary, R; Murray, LM, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hensel, N | 1 |
| Baskal, S | 1 |
| Walter, LM | 1 |
| Brinkmann, H | 1 |
| Gernert, M | 1 |
| Claus, P | 1 |
| Bowerman, M | 1 |
| Murray, LM | 1 |
| Boyer, JG | 1 |
| Anderson, CL | 1 |
| Kothary, R | 1 |
2 other studies available for fasudil and Adult Spinal Muscular Atrophy
| Article | Year |
|---|---|
ERK and ROCK functionally interact in a signaling network that is compensationally upregulated in Spinal Muscular Atrophy.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Benzimidazoles; Cell Death; Cell Line; Cytop | 2017 |
Fasudil improves survival and promotes skeletal muscle development in a mouse model of spinal muscular atrophy.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Anterior Horn Cells; Disease Models, Animal; | 2012 |