fasudil has been researched along with Acute Kidney Injury in 6 studies
fasudil: intracellular calcium antagonist; structure in first source
fasudil : An isoquinoline substituted by a (1,4-diazepan-1-yl)sulfonyl group at position 5. It is a Rho-kinase inhibitor and its hydrochloride hydrate form is approved for the treatment of cerebral vasospasm and cerebral ischemia.
Acute Kidney Injury: Abrupt reduction in kidney function. Acute kidney injury encompasses the entire spectrum of the syndrome including acute kidney failure; ACUTE KIDNEY TUBULAR NECROSIS; and other less severe conditions.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In this study, we tested the hypothesis that fasudil, a Rho kinase inhibitor, would protect against contrast-induced acute kidney injury (CI-AKI) in a mouse model and attempted to elucidate the mechanism involved." | 7.88 | Rho Kinase Inhibitor, Fasudil, Attenuates Contrast-induced Acute Kidney Injury. ( Miao, D; Wang, Y; Yang, Z; Zhang, D; Zhang, H, 2018) |
| " We have previously demonstrated that fasudil, a Rho/ROCK inhibitor, has antioxidant, anti-inflammatory and anti-apoptotic effects in contrast-induced acute kidney injury model." | 4.02 | Alleviation of the doxorubicin-induced nephrotoxicity by fasudil in vivo and in vitro. ( Xiang, C; Yan, Y; Zhang, D, 2021) |
| "In this study, we tested the hypothesis that fasudil, a Rho kinase inhibitor, would protect against contrast-induced acute kidney injury (CI-AKI) in a mouse model and attempted to elucidate the mechanism involved." | 3.88 | Rho Kinase Inhibitor, Fasudil, Attenuates Contrast-induced Acute Kidney Injury. ( Miao, D; Wang, Y; Yang, Z; Zhang, D; Zhang, H, 2018) |
| "Fasudil is a derivative of 5-isoquinoline sulfonamide, which is a Rho kinase inhibitor, a wide range of pharmacological effects." | 1.51 | Metabolomics study of fasudil on cisplatin-induced kidney injury. ( Guo, Z; Lai, X; Li, L; Wu, K; Xia, D; Xu, S; Zhou, P, 2019) |
| "It was picked a model of acute renal injury by an intraperitoneal organization of fasudil." | 1.48 | Fabrication of fasudil hydrochloride modified graphene oxide biocomposites and its defensive effect acute renal injury in septicopyemia rats. ( Chang, L; Fu, J, 2018) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 5 (83.33) | 24.3611 |
| 2020's | 1 (16.67) | 2.80 |
| Authors | Studies |
|---|---|
| Xia, D | 1 |
| Lai, X | 1 |
| Wu, K | 1 |
| Zhou, P | 1 |
| Li, L | 1 |
| Guo, Z | 1 |
| Xu, S | 1 |
| Xiang, C | 1 |
| Yan, Y | 1 |
| Zhang, D | 2 |
| Wang, Y | 1 |
| Zhang, H | 1 |
| Yang, Z | 1 |
| Miao, D | 1 |
| Fu, J | 1 |
| Chang, L | 1 |
| Nozaki, Y | 1 |
| Kinoshita, K | 1 |
| Hino, S | 1 |
| Yano, T | 1 |
| Niki, K | 1 |
| Hirooka, Y | 1 |
| Kishimoto, K | 1 |
| Funauchi, M | 1 |
| Matsumura, I | 1 |
| Wang, YD | 1 |
| Zhang, L | 1 |
| Cai, GY | 1 |
| Zhang, XG | 1 |
| Lv, Y | 1 |
| Hong, Q | 1 |
| Shi, SZ | 1 |
| Yin, Z | 1 |
| Liu, XF | 1 |
| Chen, XM | 1 |
6 other studies available for fasudil and Acute Kidney Injury
| Article | Year |
|---|---|
Metabolomics study of fasudil on cisplatin-induced kidney injury.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acute Kidney Injury; Animals; Cisplatin; Kidney; Male | 2019 |
Alleviation of the doxorubicin-induced nephrotoxicity by fasudil in vivo and in vitro.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acute Kidney Injury; Animals; Apoptosis; Cells, Cultu | 2021 |
Rho Kinase Inhibitor, Fasudil, Attenuates Contrast-induced Acute Kidney Injury.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acute Kidney Injury; Animals; Apoptosis; Biomarkers; | 2018 |
Fabrication of fasudil hydrochloride modified graphene oxide biocomposites and its defensive effect acute renal injury in septicopyemia rats.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acute Kidney Injury; Animals; Biocompatible Materials | 2018 |
Signaling Rho-kinase mediates inflammation and apoptosis in T cells and renal tubules in cisplatin nephrotoxicity.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acute Kidney Injury; Amides; Animals; Anti-Inflammato | 2015 |
Fasudil ameliorates rhabdomyolysis-induced acute kidney injury via inhibition of apoptosis.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acute Kidney Injury; Animals; Apoptosis; Male; Protei | 2011 |