farnesol and Neoplasms

farnesol has been researched along with Neoplasms in 20 studies

Research

Studies (20)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (5.00)18.2507
2000's5 (25.00)29.6817
2010's14 (70.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Arellano, ML; Boggon, TJ; Brat, DJ; Chen, GZ; Chen, J; Chen, PR; DeBerardinis, RJ; Elf, S; Fan, J; Gu, TL; He, C; Hitosugi, T; Hurwitz, SJ; Ji, Q; Jiang, L; Kang, HB; Kang, S; Khoury, HJ; Khuri, FR; Lee, BH; Lei, Q; Li, Y; Lin, R; Lonial, S; Mao, H; Mitsche, M; Seo, JH; Shan, C; Sudderth, J; Tucker, M; Wang, D; Wu, S; Xie, J; Ye, K; Zhang, L; Zhang, S; Zhou, L1
Fujisaka, Y; Furuse, J; Iwasa, T; Kitamura, H; Kurata, T; Nagashima, F; Nakagawa, K; Naruge, D; Okano, N; Shimizu, T1
Ahn, KS; Arfuso, F; Fan, L; Hwang, ST; Jung, YY; Sethi, G1
Arora, N; Gupta, P; Poluri, KM; Pruthi, V; Sharma, M1
Morris, AJ; Onono, F; Spielmann, HP; Subramanian, KL; Subramanian, T; Sunkara, M1
Efferth, T; Kuete, V1
Chen, L; Huang, Z; Ling, Y; Wang, X; Wang, Z; Zhang, W; Zhang, Y; Zhu, H1
Elad-Sfadia, G; Haklai, R; Kloog, Y; Mor, A1
Chen, L; Dai, H; Li, X; Ling, Y; Wang, X; Wang, Z; Zhang, W; Zhang, Y1
Kloog, Y; Pinkas-Kramarski, R; Schmukler, E; Schokoroy, ST; Wolfson, E1
Bauer, V; Goldberg, L; Haklai, R; Heiss, A; Kloog, Y1
Blair, J; Goldsweig, H; Hong, D; Kurzrock, R; Ng, CS; Rudek, MA; Tsimberidou, AM1
Jetten, AM; Joo, JH1
Bustinza-Linares, E; Kurzrock, R; Tsimberidou, AM1
Alperstein, D; Kloog, Y; Kraitzer, A; Zilberman, M1
Fairn, GD; MacDonald, K; McMaster, CR1
Blum, R; Elkon, R; Jacob-Hirsch, J; Kloog, Y; Rechavi, G; Shamir, R; Yaari, S; Zundelevich, A1
Ehrlich, M; Haklai, R; Kloog, Y; Rotblat, B1
kato, J; Kogo, Y1
Cox, AD; Kloog, Y1

Reviews

9 review(s) available for farnesol and Neoplasms

ArticleYear
6-Phosphogluconate dehydrogenase links oxidative PPP, lipogenesis and tumour growth by inhibiting LKB1-AMPK signalling.
    Nature cell biology, 2015, Volume: 17, Issue:11

    Topics: AMP-Activated Protein Kinase Kinases; AMP-Activated Protein Kinases; Humans; Lipogenesis; Neoplasms; Oxidative Stress; Pentose Phosphate Pathway; Phosphogluconate Dehydrogenase; Protein Serine-Threonine Kinases; Ribulosephosphates; Signal Transduction

2015
Potential Anti-Inflammatory and Anti-Cancer Properties of Farnesol.
    Molecules (Basel, Switzerland), 2018, Oct-31, Volume: 23, Issue:11

    Topics: Apoptosis; Cyclooxygenase 2; Farnesol; Gene Expression Regulation, Neoplastic; Humans; Inflammation; Neoplasms; Nitric Oxide Synthase Type II; ras Proteins; Tumor Necrosis Factor-alpha

2018
Chemistry and Biology of Farnesol and its Derivatives: Quorum Sensing Molecules with Immense Therapeutic Potential.
    Current topics in medicinal chemistry, 2018, Volume: 18, Issue:22

    Topics: Antifungal Agents; Antineoplastic Agents; Biofilms; Drug Screening Assays, Antitumor; Farnesol; Fungi; Humans; Microbial Sensitivity Tests; Neoplasms; Quorum Sensing

2018
Ras chaperones: new targets for cancer and immunotherapy.
    The Enzymes, 2013, Volume: 33 Pt A

    Topics: Animals; Antineoplastic Agents; Farnesol; Humans; Immunotherapy; Molecular Chaperones; Neoplasms; ras Proteins; Salicylates; Signal Transduction

2013
Enhancing FTS (Salirasib) efficiency via combinatorial treatment.
    Biology of the cell, 2015, Volume: 107, Issue:5

    Topics: Animals; Anti-Inflammatory Agents; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Farnesol; Humans; Neoplasms; Salicylates; Signal Transduction

2015
Molecular mechanisms involved in farnesol-induced apoptosis.
    Cancer letters, 2010, Jan-28, Volume: 287, Issue:2

    Topics: Animals; Antineoplastic Agents; Apoptosis; Apoptosomes; Cell Proliferation; Cytidine Diphosphate Choline; Endoplasmic Reticulum; Farnesol; Humans; Hydroxymethylglutaryl CoA Reductases; Mitogen-Activated Protein Kinases; Neoplasms; NF-kappa B; Oxidative Stress; PPAR gamma; Receptors, Cytoplasmic and Nuclear; Signal Transduction; Thyroid Hormone Receptors beta; Unfolded Protein Response

2010
Salirasib in the treatment of pancreatic cancer.
    Future oncology (London, England), 2010, Volume: 6, Issue:6

    Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Cell Membrane; Clinical Trials, Phase I as Topic; Deoxycytidine; Disease-Free Survival; Drug Screening Assays, Antitumor; Farnesol; Farnesyltranstransferase; Galectins; Gemcitabine; Gene Expression Regulation, Neoplastic; Humans; Mice; Mice, Nude; Middle Aged; Neoplasm Proteins; Neoplasms; Pancreatic Neoplasms; Protein Binding; Protein Kinase Inhibitors; Proto-Oncogene Proteins p21(ras); Salicylates; Signal Transduction

2010
[Malignant tumor and apoptosis].
    Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine, 1997, Sep-10, Volume: 86, Issue:9

    Topics: Alkyl and Aryl Transferases; Animals; Antineoplastic Agents; Apoptosis; Farnesol; Farnesyltranstransferase; Humans; Neoplasms; ras Proteins; Tumor Suppressor Protein p53

1997
RAS inhibitors: potential for cancer therapeutics.
    Molecular medicine today, 2000, Volume: 6, Issue:10

    Topics: Alkyl and Aryl Transferases; Antineoplastic Agents; Drug Design; Enzyme Inhibitors; Farnesol; Farnesyltranstransferase; Humans; Neoplasms; ras Proteins; Salicylates

2000

Trials

2 trial(s) available for farnesol and Neoplasms

ArticleYear
An early clinical trial of Salirasib, an oral RAS inhibitor, in Japanese patients with relapsed/refractory solid tumors.
    Cancer chemotherapy and pharmacology, 2018, Volume: 82, Issue:3

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Dose-Response Relationship, Drug; Enzyme Inhibitors; Farnesol; Female; Humans; Male; Middle Aged; Neoplasm Staging; Neoplasms; ras Proteins; Salicylates

2018
Phase 1 first-in-human clinical study of S-trans,trans-farnesylthiosalicylic acid (salirasib) in patients with solid tumors.
    Cancer chemotherapy and pharmacology, 2010, Volume: 65, Issue:2

    Topics: Adult; Aged; Antineoplastic Agents; Farnesol; Female; Humans; Lymphoma; Male; Middle Aged; Neoplasms; Salicylates; Stereoisomerism

2010

Other Studies

9 other study(ies) available for farnesol and Neoplasms

ArticleYear
Efficient use of exogenous isoprenols for protein isoprenylation by MDA-MB-231 cells is regulated independently of the mevalonate pathway.
    The Journal of biological chemistry, 2013, Sep-20, Volume: 288, Issue:38

    Topics: Antineoplastic Agents; Cell Line, Tumor; Diterpenes; Farnesol; Humans; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Mevalonic Acid; Mutation; Neoplasms; Polyisoprenyl Phosphates; Protein Prenylation; Tumor Suppressor Protein p53

2013
Molecular determinants of cancer cell sensitivity and resistance towards the sesquiterpene farnesol.
    Die Pharmazie, 2013, Volume: 68, Issue:7

    Topics: Antibiotics, Antineoplastic; ATP-Binding Cassette Transporters; Cell Division; Cell Line, Tumor; Cluster Analysis; Doxorubicin; Drug Resistance, Neoplasm; Farnesol; Genes, erbB-1; Genes, p53; HL-60 Cells; Humans; Microarray Analysis; Neoplasms; Oxazines; RNA, Messenger; Transfection; Xanthenes

2013
Synthesis and biological evaluation of farnesylthiosalicylamides as potential anti-tumor agents.
    Bioorganic & medicinal chemistry, 2014, Jan-01, Volume: 22, Issue:1

    Topics: Antineoplastic Agents; Apoptosis; Farnesol; Humans; Neoplasms; Salicylates; Signal Transduction

2014
Hybrid molecule from Farnesylthiosalicylic acid-diamine and phenylpropenoic acid as Ras-related signaling inhibitor with potent antitumor activities.
    Chemical biology & drug design, 2015, Volume: 85, Issue:2

    Topics: Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Proliferation; Diamines; Farnesol; Humans; Neoplasms; NF-kappa B; Phenylpropionates; Phosphorylation; ras Proteins; Salicylates; Signal Transduction

2015
New derivatives of farnesylthiosalicylic acid (salirasib) for cancer treatment: farnesylthiosalicylamide inhibits tumor growth in nude mice models.
    Journal of medicinal chemistry, 2009, Jan-08, Volume: 52, Issue:1

    Topics: Amides; Animals; Antineoplastic Agents; Cell Line, Tumor; Cyclic AMP-Dependent Protein Kinases; Disease Models, Animal; Disease Progression; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Farnesol; Humans; MAP Kinase Signaling System; Mice; Mice, Nude; Molecular Structure; Neoplasms; Oncogene Protein p21(ras); Salicylates; Xenograft Model Antitumor Assays

2009
Mechanisms of antiproliferative drug release from bioresorbable porous structures.
    Journal of biomedical materials research. Part A, 2013, Volume: 101, Issue:5

    Topics: Antineoplastic Agents; Biocompatible Materials; Drug-Eluting Stents; Farnesol; Humans; Models, Molecular; Neoplasms; Paclitaxel; Polyglactin 910; Porosity; Salicylates; Sirolimus; Solubility

2013
A chemogenomic screen in Saccharomyces cerevisiae uncovers a primary role for the mitochondria in farnesol toxicity and its regulation by the Pkc1 pathway.
    The Journal of biological chemistry, 2007, Feb-16, Volume: 282, Issue:7

    Topics: Animals; Cell Death; DNA, Mitochondrial; Drug Resistance, Fungal; Electron Transport; Electron Transport Complex III; Farnesol; Genome, Fungal; Humans; Iron-Sulfur Proteins; MAP Kinase Kinase 1; Mitochondria; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Neoplasms; Protein Kinase C; Protein Transport; Reactive Oxygen Species; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Signal Transduction

2007
Gene expression signature of human cancer cell lines treated with the ras inhibitor salirasib (S-farnesylthiosalicylic acid).
    Cancer research, 2007, Apr-01, Volume: 67, Issue:7

    Topics: Antineoplastic Agents; Cell Cycle; Cell Line, Tumor; Cluster Analysis; Down-Regulation; Farnesol; Gene Expression; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Humans; Neoplasms; Promoter Regions, Genetic; ras Proteins; Salicylates; Transcription, Genetic; Up-Regulation

2007
The Ras inhibitor farnesylthiosalicylic acid (Salirasib) disrupts the spatiotemporal localization of active Ras: a potential treatment for cancer.
    Methods in enzymology, 2008, Volume: 439

    Topics: Animals; Antineoplastic Agents; Cell Proliferation; Cells, Cultured; Farnesol; Humans; Mice; Neoplasms; ras Proteins; Salicylates; Signal Transduction

2008