Page last updated: 2024-10-26

famotidine and Peptic Ulcer

famotidine has been researched along with Peptic Ulcer in 96 studies

Famotidine: A competitive histamine H2-receptor antagonist. Its main pharmacodynamic effect is the inhibition of gastric secretion.

Peptic Ulcer: Ulcer that occurs in the regions of the GASTROINTESTINAL TRACT which come into contact with GASTRIC JUICE containing PEPSIN and GASTRIC ACID. It occurs when there are defects in the MUCOSA barrier. The common forms of peptic ulcers are associated with HELICOBACTER PYLORI and the consumption of nonsteroidal anti-inflammatory drugs (NSAIDS).

Research Excerpts

ExcerptRelevanceReference
" Patients without ulcers or erosive oesophagitis on endoscopy at baseline were randomly assigned by computer-generated randomisation sequence to receive famotidine 20 mg twice daily (n=204) or placebo twice daily (n=200)."9.14Famotidine for the prevention of peptic ulcers and oesophagitis in patients taking low-dose aspirin (FAMOUS): a phase III, randomised, double-blind, placebo-controlled trial. ( Bezlyak, V; McCloskey, C; Prasad, R; Taha, AS, 2009)
"Little is known about the efficacy of H(2)-receptor antagonists in preventing recurrence of aspirin-related peptic ulcers."9.14Famotidine is inferior to pantoprazole in preventing recurrence of aspirin-related peptic ulcers or erosions. ( Chan, P; Chu, WM; Kng, C; Kwan, A; Lam, KF; Lau, YK; Ling, YH; Ng, FH; Wong, BC; Wong, SY; Yuen, WC, 2010)
"The aim of this study was to evaluate the effect of famotidine, a histamine receptor antagonist on corpus gastritis in patients with peptic ulcer disease."9.11Effect of long-term half-dose famotidine therapy on corpus gastritis in peptic ulcer disease. ( Chayama, K; Haruma, K; Hata, J; Ito, M; Kamada, T; Kawamura, Y; Kusunoki, H; Sugiu, K; Tanaka, S, 2005)
"We studied the effects of lansoprazole on ulcer healing and Helicobacter pylori infection in elderly patients with peptic ulcers."9.08Therapeutic effects of lansoprazole on peptic ulcers in elderly patients. ( Asagoe, K; Dekigai, H; Kusaka, S; Maeda, S; Matsumoto, M; Mizuno, M; Murakami, M; Saita, H; Seki, M; Takahashi, Y, 1995)
"One hundred four patients with rheumatoid or osteoarthritis who had gastroduodenal ulceration received famotidine, 40 mg twice daily."9.08Famotidine for healing and maintenance in nonsteroidal anti-inflammatory drug-associated gastroduodenal ulceration. ( Cottrell, J; Hawkey, CJ; Hudson, N; Mann, SG; Russell, RI; Sturrock, RD; Swanell, AJ; Taha, AS; Trye, P, 1997)
" We conducted a cross-sectional study to compare the prevalence of gastroduodenal ulcers or erosions in patients taking LDA with either 40 mg/day of famotidine or 15 mg/day of lansoprazole for at least three months."7.79Prevalence of gastroduodenal ulcers/erosions in patients taking low-dose aspirin with either 15 mg/day of lansoprazole or 40 mg/day of famotidine: the OITA-GF study 2. ( Kadota, J; Murakami, K; Tamura, A, 2013)
"The purpose of this study was to assess the incidence and clinical significance of famotidine-associated thrombocytopenia in the trauma patient population."7.77Famotidine use and thrombocytopenia in the trauma patient. ( Compoginis, JM; Gaspard, D; Obaid, A, 2011)
"A total of 30 patients (29 with peptic ulcer and 2 with erosive gastroduodenitis) received lecedil, a new famotidine blocker of histamine H2-receptors."7.68[Effectiveness of lecedil (famotidine) in the therapy of patients with peptic ulcer]. ( Grebenev, AL; Kornienko, AA; Sheptulin, AA; Smakov, GM; Trukhmanov, AS, 1993)
"The acute effects of histamine H2 receptor antagonist, famotidine, on hepatic hemodynamics were studied in six normal volunteers and eight patients with chronic liver disease, and its chronic effects on peptic ulcer, portal hemodynamics, and hepatic function were studied in 20 patients with chronic liver disease and peptic ulcer (16 with gastric ulcer, four with duodenal ulcer)."7.67Effect of famotidine on hepatic hemodynamics and peptic ulcer. ( Goto, N; Nomura, F; Ohnishi, K; Ohtsuki, T; Okuda, K; Saito, M; Suzuki, N; Takashi, M, 1987)
" Pharmacokinetic parameters were calculated assuming a one-compartment model."6.67Pharmacokinetics and pharmacodynamics of famotidine in children with gastroduodenal ulcers. ( Aoki, S; Ashida, K; Manago, M; Mino, M; Nagita, A; Suzuki, K, 1994)
"In the treatment of gastroduodenal ulceration both the reduction of gastric acidity and the defence of mucosal membrane have an important role."6.39[Famotidine in the treatment of gastroduodenal ulcer]. ( Fehér, J; Lengyel, G, 1994)
"Famotidine is a highly selective histamine H2-receptor antagonist."6.38Famotidine. An updated review of its pharmacodynamic and pharmacokinetic properties, and therapeutic use in peptic ulcer disease and other allied diseases. ( Goa, KL; Grant, SM; Langtry, HD, 1989)
"Famotidine is a new histamine H2-receptor antagonist."6.37Famotidine. Pharmacodynamic and pharmacokinetic properties and a preliminary review of its therapeutic use in peptic ulcer disease and Zollinger-Ellison syndrome. ( Campoli-Richards, DM; Clissold, SP, 1986)
"The aim of this work was to prepare a combined drug dosage form of famotidine (FAM) and quercetin (QRT) to augment treatment of gastric ulcer."5.42Evaluation of combined famotidine with quercetin for the treatment of peptic ulcer: in vivo animal study. ( Abourehab, MA; Ahmed, OA; Khaled, KA; Sarhan, HA, 2015)
"Omeprazole was superior to famotidine with less gastrointestinal symptoms and recurrent ulcers/erosions in patients using 24-week low-dose aspirin."5.40Comparison of proton pump inhibitor and histamine-2 receptor antagonist in the prevention of recurrent peptic ulcers/erosions in long-term low-dose aspirin users: a retrospective cohort study. ( Chan, HH; Chen, WC; Cheng, JS; Chiang, PH; Lai, KH; Li, YD; Tsai, TJ; Tsai, WL; Tsay, FW; Wang, EM, 2014)
"It was found that patients with gastroduodenal ulcer have metabolic, less frequently hypercapnic acidosis with suppressed gastric secretion of HCO3-."5.31[Relations of acid-base balance and gastric secretion of hydrogen carbonate ions in patients with peptic ulcer]. ( Ivashkina, TG; Kulikov, AN; Malov, IuS, 2001)
"Famotidine clearance was reduced only in patients with decompensated cirrhosis, probably because of concomitant renal impairment."5.28Effects of hepatic disease on the pharmacokinetics of famotidine and effects of famotidine on hepatic hemodynamics and peptic ulcer. ( Ohnishi, K, 1990)
"From January 2012 to 2016, long-termed thienopyridine users with a peptic ulcer history who did not have peptic ulcers at initial endoscopy were randomly assigned to receive either famotidine (40 mg, before bedtime) or placebo (before bedtime) for 6 months."5.24Histamine-2 Receptor Antagonist Cannot Prevent Recurrent Peptic Ulcers in Patients With Atherosclerotic Diseases Who Receive Platelet ADP Receptor Antagonist Monotherapy: A Randomized-Controlled, Double-Blind, and Double-Dummy Trial. ( Chen, WC; Cheng, JS; Hsu, PI; Kao, SS; Lai, KH; Liu, CP; Tsai, KW; Tsai, TJ; Tsay, FW; Wang, HM; Wu, DC, 2017)
" Patients without ulcers or erosive oesophagitis on endoscopy at baseline were randomly assigned by computer-generated randomisation sequence to receive famotidine 20 mg twice daily (n=204) or placebo twice daily (n=200)."5.14Famotidine for the prevention of peptic ulcers and oesophagitis in patients taking low-dose aspirin (FAMOUS): a phase III, randomised, double-blind, placebo-controlled trial. ( Bezlyak, V; McCloskey, C; Prasad, R; Taha, AS, 2009)
"Little is known about the efficacy of H(2)-receptor antagonists in preventing recurrence of aspirin-related peptic ulcers."5.14Famotidine is inferior to pantoprazole in preventing recurrence of aspirin-related peptic ulcers or erosions. ( Chan, P; Chu, WM; Kng, C; Kwan, A; Lam, KF; Lau, YK; Ling, YH; Ng, FH; Wong, BC; Wong, SY; Yuen, WC, 2010)
"The healing rate of gastroduodenal ulcers during continuous use of low-dose aspirin was greater than 80% in both the PPI group and the H2RA group, with no significant difference between the two groups."5.14Comparative study of therapeutic effects of PPI and H2RA on ulcers during continuous aspirin therapy. ( Kato, M; Nema, H, 2010)
"The aim of this study was to evaluate the effect of famotidine, a histamine receptor antagonist on corpus gastritis in patients with peptic ulcer disease."5.11Effect of long-term half-dose famotidine therapy on corpus gastritis in peptic ulcer disease. ( Chayama, K; Haruma, K; Hata, J; Ito, M; Kamada, T; Kawamura, Y; Kusunoki, H; Sugiu, K; Tanaka, S, 2005)
"A total of 120 patients with peptic ulcer and non-ulcer dyspepsia were randomly assigned to a 2-week course of either: famotidine 40 mg twice a day, amoxycillin 1 g twice a day and tinidazole 500 mg twice a day (FAT group; n = 60); or omeprazole 20 mg twice a day, amoxycillin 1 g twice a day and tinidazole 500 mg twice a day (OAT group; n = 60)."5.09Famotidine versus omeprazole, in combination with amoxycillin and tinidazole, for eradication of Helicobacter pylori infection. ( Changchien, CS; Chen, JJ; Hsu, CC; Hu, TH; Lu, SN, 2001)
" pylori-positive patients who had peptic ulcers or reflux oesophagitis were treated for 3 years with either omeprazole (20 mg/day) alone (n=7) or with omeprazole for primary therapy (8 weeks), followed by famotidine (40 mg/day) for maintenance therapy (n=134)."5.09Changes in Helicobacter pylori-induced gastritis in the antrum and corpus during long-term acid-suppressive treatment in Japan. ( Mashiba, H; Matsumura, N; Okamoto, S; Sasaki, N; Taniyama, K; Uemura, N; Yamaguchi, S; Yamamoto, S, 2000)
"We studied the effects of lansoprazole on ulcer healing and Helicobacter pylori infection in elderly patients with peptic ulcers."5.08Therapeutic effects of lansoprazole on peptic ulcers in elderly patients. ( Asagoe, K; Dekigai, H; Kusaka, S; Maeda, S; Matsumoto, M; Mizuno, M; Murakami, M; Saita, H; Seki, M; Takahashi, Y, 1995)
"One hundred four patients with rheumatoid or osteoarthritis who had gastroduodenal ulceration received famotidine, 40 mg twice daily."5.08Famotidine for healing and maintenance in nonsteroidal anti-inflammatory drug-associated gastroduodenal ulceration. ( Cottrell, J; Hawkey, CJ; Hudson, N; Mann, SG; Russell, RI; Sturrock, RD; Swanell, AJ; Taha, AS; Trye, P, 1997)
" Early indications that acid suppression was effective in the management of NSAID-related peptic ulcers came from studies showing that gastric ulcers could be healed by omeprazole in patients who continued to take NSAIDs."4.80Management of nonsteroidal anti-inflammatory drug-induced gastroduodenal disease by acid suppression. ( Armstrong, D; Lad, R, 1999)
" The purpose of the present work was to characterize the interaction and investigate the protective effect of H2 blocker famotidine and gallic acid in combination against experimentally induced peptic ulcer."3.80Synergistic effect of the combination of gallic acid and famotidine in protection of rat gastric mucosa. ( Asokkumar, K; Sen, S; Sivashanmugam, AT; Subhadradevi, V; Umamaheswari, M, 2014)
" We conducted a cross-sectional study to compare the prevalence of gastroduodenal ulcers or erosions in patients taking LDA with either 40 mg/day of famotidine or 15 mg/day of lansoprazole for at least three months."3.79Prevalence of gastroduodenal ulcers/erosions in patients taking low-dose aspirin with either 15 mg/day of lansoprazole or 40 mg/day of famotidine: the OITA-GF study 2. ( Kadota, J; Murakami, K; Tamura, A, 2013)
"The purpose of this study was to assess the incidence and clinical significance of famotidine-associated thrombocytopenia in the trauma patient population."3.77Famotidine use and thrombocytopenia in the trauma patient. ( Compoginis, JM; Gaspard, D; Obaid, A, 2011)
"In an open clinical endoscopically controlled study in 30 consecutive patients with rheumatic diseases complicated by the ulcerative and erosive form of gastroduodenopathy induced by non-steroidal antiinflammatory drugs and oesophagitis, after four weeks treatment with oral famotidine (one dose of 40 mg/day) confirmed a significant improvement of the mean oesophageal (0."3.69[Famotidine in the treatment of gastropathy induced by non-steroidal antirheumatic agents]. ( Hyrdel, R; Rovenský, J; Rybár, I, 1997)
"4 mg/kg as an intravenous infusion over 5 min (a dosage previously used to test drug interactions with cimetidine and ranitidine) were evaluated in 7 patients with chronic obstructive pulmonary disease (COPD) and peptic ulcer disease before and after 8 days' treatment with famotidine 40mg at night."3.68Famotidine and theophylline pharmacokinetics. An unexpected cimetidine-like interaction in patients with chronic obstructive pulmonary disease. ( Dal Negro, R; Pomari, C; Turco, P, 1993)
"A total of 30 patients (29 with peptic ulcer and 2 with erosive gastroduodenitis) received lecedil, a new famotidine blocker of histamine H2-receptors."3.68[Effectiveness of lecedil (famotidine) in the therapy of patients with peptic ulcer]. ( Grebenev, AL; Kornienko, AA; Sheptulin, AA; Smakov, GM; Trukhmanov, AS, 1993)
"The effect of ranitidine 300 mg po given at 1800 h (famotidine 40 mg/cimetidine 800 mg) on the night time gastric pH was tested using longterm intragastric pH monitoring in 27 patients with and 32 patients without liver cirrhosis."3.67Frequent non-response to histamine H2-receptor antagonists in cirrhotics. ( Bode, JC; Klotz, U; Krishna, DR; Walker, S, 1989)
"The acute effects of histamine H2 receptor antagonist, famotidine, on hepatic hemodynamics were studied in six normal volunteers and eight patients with chronic liver disease, and its chronic effects on peptic ulcer, portal hemodynamics, and hepatic function were studied in 20 patients with chronic liver disease and peptic ulcer (16 with gastric ulcer, four with duodenal ulcer)."3.67Effect of famotidine on hepatic hemodynamics and peptic ulcer. ( Goto, N; Nomura, F; Ohnishi, K; Ohtsuki, T; Okuda, K; Saito, M; Suzuki, N; Takashi, M, 1987)
" During the late period (7-9 h post-dose), when the subjects were dosed with placebo, mean gastric acid output was 41."2.68Early and late effects of low-dose famotidine, ranitidine or placebo on pentagastrin-stimulated gastric acid secretion in man. ( Cottrell, J; Grimley, CE; Loft, DE; Mann, SG; Nwokolo, CU; Stauffer, L; West, JM, 1996)
"Cimetidine-treated group consisted of 15, famotidine-treated group of 18, ranitidine-treated group of 19, and antacid-treated group of 5 patients."2.67Comparative efficacy of cimetidine, famotidine, ranitidine, and mylanta in postoperative stress ulcers. Gastric pH control and ulcer prevention in patients undergoing coronary artery bypass graft surgery. ( Castellano, J; Lamothe, PH; Lemole, GM; McNicholas, KW; Rao, E; Serra, AJ; Woronick, CL, 1991)
" Pharmacokinetic parameters were calculated assuming a one-compartment model."2.67Pharmacokinetics and pharmacodynamics of famotidine in children with gastroduodenal ulcers. ( Aoki, S; Ashida, K; Manago, M; Mino, M; Nagita, A; Suzuki, K, 1994)
" Dosage requirements vary according to age and clinical condition, and children require a relatively higher drug dosage (mg/kg) than adults."2.39Do H2 receptor antagonists have a therapeutic role in childhood? ( Kelly, DA, 1994)
"In the treatment of gastroduodenal ulceration both the reduction of gastric acidity and the defence of mucosal membrane have an important role."2.39[Famotidine in the treatment of gastroduodenal ulcer]. ( Fehér, J; Lengyel, G, 1994)
" While very safe, clinicians need to know correct dosing guidelines, drug interactions, and side effect profiles."2.38The clinical use of histamine-2 receptor antagonists. ( Michocki, RJ; Richardson, JP, 1992)
"Famotidine is a highly selective histamine H2-receptor antagonist."2.38Famotidine. An updated review of its pharmacodynamic and pharmacokinetic properties, and therapeutic use in peptic ulcer disease and other allied diseases. ( Goa, KL; Grant, SM; Langtry, HD, 1989)
"Famotidine is a new histamine H2-receptor antagonist."2.37Famotidine. Pharmacodynamic and pharmacokinetic properties and a preliminary review of its therapeutic use in peptic ulcer disease and Zollinger-Ellison syndrome. ( Campoli-Richards, DM; Clissold, SP, 1986)
"Famotidine is an even more potent H2 receptor antagonist, and initial clinical studies are promising."2.37Pharmacological management of patients with peptic ulcer disease: prospects for the late 1980's. ( Mahachai, V; Thomson, AB, 1987)
" This single evening dosage regimen produces effective healing of gastric and duodenal ulceration; maintenance of healing can then be achieved satisfactorily with 20 mg in the evening."2.37The place of famotidine in anti-ulcer therapy. ( Mann, SG, 1987)
"The aim of this work was to prepare a combined drug dosage form of famotidine (FAM) and quercetin (QRT) to augment treatment of gastric ulcer."1.42Evaluation of combined famotidine with quercetin for the treatment of peptic ulcer: in vivo animal study. ( Abourehab, MA; Ahmed, OA; Khaled, KA; Sarhan, HA, 2015)
"Omeprazole was superior to famotidine with less gastrointestinal symptoms and recurrent ulcers/erosions in patients using 24-week low-dose aspirin."1.40Comparison of proton pump inhibitor and histamine-2 receptor antagonist in the prevention of recurrent peptic ulcers/erosions in long-term low-dose aspirin users: a retrospective cohort study. ( Chan, HH; Chen, WC; Cheng, JS; Chiang, PH; Lai, KH; Li, YD; Tsai, TJ; Tsai, WL; Tsay, FW; Wang, EM, 2014)
" History of uncomplicated peptic ulcer and frequent dosing were additional factors associated with non-adherence to NSAIDs."1.38Prescription of and adherence to non-steroidal anti-inflammatory drugs and gastroprotective agents in at-risk gastrointestinal patients. ( Gonzalez, MA; Lanas, A; Polo-Tomás, M; Roncales, P; Zapardiel, J, 2012)
"Ampicillin (800 mg/kg) was given p."1.36Protective effect of lafutidine, a histamine H2 receptor antagonist, against loxoprofen-induced small intestinal lesions in rats. ( Amagase, K; Kato, S; Ochi, A; Sugihara, T; Takeuchi, K, 2010)
"Diclofenac can cause gastric mucosal lesions, including ulcers, more easily than other NSAIDs."1.34Up-to-date information on gastric mucosal lesions from long-term NSAID therapy in orthopedic outpatients: a study using logistic regression analysis. ( Fukui, H; Takakura, Y; Yajima, H; Yamao, J, 2007)
"It was found that patients with gastroduodenal ulcer have metabolic, less frequently hypercapnic acidosis with suppressed gastric secretion of HCO3-."1.31[Relations of acid-base balance and gastric secretion of hydrogen carbonate ions in patients with peptic ulcer]. ( Ivashkina, TG; Kulikov, AN; Malov, IuS, 2001)
" The authors' five cases and the other seven previously reported emphasize the need for dosage adjustment of famotidine in elderly patients and in those with renal failure, and that these patients should be carefully monitored for development of central nervous system reactions, which sometimes could be very serious."1.30Central nervous system reactions associated with famotidine: report of five cases. ( Odeh, M; Oliven, A, 1998)
" cimetidine or famotidine for stress ulcer prophylaxis were reviewed during a two-month period in 1997, and information on demographics, dosage and duration of H2RA therapy, admission date, laboratory test values, and adverse drug reactions was collected."1.30Using multiple pharmacoeconomic methods to conduct a cost-effectiveness analysis of histamine H2-receptor antagonists. ( Blayney-Chandramouli, J; McCoy, S; Mutnick, A, 1998)
"Hyperemesis gravidarum is the most severe spectrum of gastrointestinal complaints in pregnant women."1.30Helicobacter pylori infection and persistent hyperemesis gravidarum. ( Jacoby, EB; Porter, KB, 1999)
" However, there are possibilities that long term administration of H2-RA might cause changes in intragastric environment."1.28[Problems in ulcer surgery after the introduction of H2-receptor antagonists]. ( Akimoto, H; Aoki, T; Fukuchi, Y; Ito, A; Kashiwagi, H; Kashiwagi, T; Kimura, K, 1992)
"Famotidine clearance was reduced only in patients with decompensated cirrhosis, probably because of concomitant renal impairment."1.28Effects of hepatic disease on the pharmacokinetics of famotidine and effects of famotidine on hepatic hemodynamics and peptic ulcer. ( Ohnishi, K, 1990)

Research

Studies (96)

TimeframeStudies, this research(%)All Research%
pre-199022 (22.92)18.7374
1990's39 (40.63)18.2507
2000's15 (15.63)29.6817
2010's19 (19.79)24.3611
2020's1 (1.04)2.80

Authors

AuthorsStudies
El-Dakroury, WA1
Zewail, MB1
Elsabahy, M1
Shabana, ME1
Asaad, GF1
Tamura, A1
Murakami, K1
Kadota, J1
Asokkumar, K1
Sen, S1
Umamaheswari, M1
Sivashanmugam, AT1
Subhadradevi, V1
He, Y1
Chan, EW1
Man, KK1
Lau, WC1
Leung, WK1
Ho, LM1
Wong, IC1
Nichitaĭlo, ME1
Chen, WC2
Li, YD1
Chiang, PH1
Tsay, FW2
Chan, HH1
Tsai, WL1
Tsai, TJ2
Wang, EM1
Cheng, JS2
Lai, KH2
Takeuchi, T2
Ota, K1
Harada, S1
Kojima, Y1
Inoue, T1
Iwakiri, R1
Sakata, Y2
Fujimoto, K2
Fujita, T1
Azuma, T1
Higuchi, K3
Abourehab, MA1
Khaled, KA1
Sarhan, HA1
Ahmed, OA1
Chan, FK1
Kyaw, M1
Tanigawa, T1
Cheong, PK1
Lee, V1
Kinoshita, Y2
Naito, Y1
Watanabe, T1
Ching, JY1
Lam, K1
Lo, A1
Chan, H1
Lui, R1
Tang, RS1
Tse, YK1
Handa, O1
Nebiki, H1
Wu, JC1
Abe, T1
Mishiro, T1
Ng, SC1
Arakawa, T1
Hsu, PI1
Wu, DC1
Liu, CP1
Wang, HM1
Tsai, KW1
Kao, SS1
Hawkey, CJ3
Taha, AS3
McCloskey, C1
Prasad, R1
Bezlyak, V1
Ng, FH1
Wong, SY1
Lam, KF1
Chu, WM1
Chan, P1
Ling, YH1
Kng, C1
Yuen, WC1
Lau, YK1
Kwan, A1
Wong, BC1
Amagase, K1
Ochi, A1
Sugihara, T1
Kato, S1
Takeuchi, K1
Umegaki, E1
Yoda, Y1
Tokioka, S1
Murano, M1
Nema, H1
Kato, M1
Hiraishi, H1
Maeda, M1
Sasai, T1
Kanke, K1
Shimada, T1
Drozdov, VN1
Kim, VA1
Lazebnik, LB1
Compoginis, JM1
Gaspard, D1
Obaid, A1
Lanas, A1
Polo-Tomás, M1
Roncales, P1
Gonzalez, MA1
Zapardiel, J1
Wu, CS1
Sung, SF1
Tong, SH1
Ong, CT1
Szabó, IL1
Czimmer, J1
Szolcsányi, J1
Mózsik, G1
Mak, SK1
Loo, CK1
Wong, AM1
Wong, PN1
Lo, KY1
Tong, GM1
Lam, EK1
Wong, AK1
Coursol, CJ1
Sanzari, SE1
Miyake, K1
Ueki, N1
Suzuki, K2
Shinji, Y1
Kusunoki, M1
Hiratsuka, T1
Nishigaki, H1
Tatsuguchi, A1
Futagami, S1
Wada, K1
Tsukui, T1
Nakajima, A1
Yoshino, S1
Sakamoto, C1
Kamada, T1
Hata, J1
Kusunoki, H1
Sugiu, K1
Ito, M1
Tanaka, S1
Kawamura, Y1
Chayama, K1
Haruma, K1
Adachi, K1
Komazawa, Y1
Mihara, T1
Azumi, T1
Fujisawa, T1
Katsube, T1
Furuta, K1
Gostishchev, VK1
Evseev, MA1
Belousov, IuB1
Karpov, OI1
Belousov, DIu1
Beketov, AS1
Yajima, H1
Yamao, J1
Fukui, H1
Takakura, Y1
Dammann, HG1
Walter, TA1
Müller, P1
Simon, B1
Mori, H1
Murakami, M1
Saita, H1
Takahashi, Y1
Kusaka, S1
Asagoe, K1
Dekigai, H1
Matsumoto, M1
Seki, M1
Mizuno, M1
Maeda, S1
Okhlobystin, AV1
Baghaie, AA1
Mojtahedzadeh, M1
Levine, RL1
Fromm, RE1
Guntupalli, KK1
Opekun, AR1
Kelly, DA1
Nagita, A1
Manago, M1
Aoki, S1
Mino, M1
Ashida, K1
Lengyel, G1
Fehér, J1
Grebenev, AL2
Sheptulin, AA1
Smakov, GM1
Kornienko, AA1
Trukhmanov, AS1
Wilson, P1
Clark, GW1
Anselmino, M1
Welch, NT1
Singh, S1
Perdikis, G1
Hinder, RA1
Vargas, V1
Castro, J1
del Solar, F1
Sanhueza, H1
Aguila, R1
Luppi, M1
Fernández, D1
Rojas, M1
Dal Negro, R1
Pomari, C1
Turco, P1
Golochevskaia, VS1
Shonová, O1
Petr, P1
Lawless, C1
Force, RW1
Grimley, CE1
West, JM1
Loft, DE1
Cottrell, J2
Mann, SG3
Stauffer, L1
Nwokolo, CU1
Singh, G1
Fries, JF1
Nogaller, AM1
Butov, MA1
Luniakov, AS1
Hudson, N2
Russell, RI2
Trye, P1
Swanell, AJ1
Sturrock, RD2
Graham, DY1
Palop, D1
Romero, A1
Villamayor, F1
Conejo, L1
Sacristán, A1
Ortiz, JA1
Moayyedi, P1
Haga, Y1
Nakatsura, T1
Shibata, Y1
Sameshima, H1
Nakamura, Y1
Tanimura, M1
Ogawa, M1
Rybár, I1
Rovenský, J1
Hyrdel, R1
Odeh, M1
Oliven, A1
McCoy, S1
Blayney-Chandramouli, J1
Mutnick, A1
Dahill, S1
Morran, C1
Lee, FD1
Lad, R1
Armstrong, D1
Jacoby, EB1
Porter, KB1
Uemura, N1
Okamoto, S1
Yamamoto, S1
Matsumura, N1
Yamaguchi, S1
Mashiba, H1
Sasaki, N1
Taniyama, K1
Malov, IuS1
Kulikov, AN1
Ivashkina, TG1
Hsu, CC1
Chen, JJ1
Hu, TH1
Lu, SN1
Changchien, CS1
Maev, IV1
Samsonov, A1
Val'tova, ED1
Ismailova, MZ1
Ovchinnikova, NI1
Wade, EE1
Rebuck, JA1
Healey, MA1
Rogers, FB1
Akimoto, H1
Kashiwagi, H1
Ito, A1
Fukuchi, Y1
Kimura, K1
Kashiwagi, T1
Aoki, T2
Stuart, RC1
Hehir, D1
Michocki, RJ1
Richardson, JP1
Miagkova, LP1
Kkhorshed, AM1
Grigor'ev, PIa1
Isakov, VA1
Iakovenko, EP1
Davydov, SM1
Vasil'eva, ZI1
Hoshino, R1
Kagoshima, M1
Shimada, H1
Inatomi, N1
Nagaya, H1
Takami, K1
Shino, A1
Satoh, H1
Kaminsky, R1
Moriarty, TM1
Bodine, J1
Wolf, DE1
Davidson, M1
Lamothe, PH1
Rao, E1
Serra, AJ1
Castellano, J1
Woronick, CL1
McNicholas, KW1
Lemole, GM1
Ahmad, S1
Ohnishi, K2
Walt, RP1
De Natale, G1
De Natale, F1
Marino, A1
Walker, S1
Krishna, DR1
Klotz, U1
Bode, JC1
Langtry, HD1
Grant, SM1
Goa, KL1
Campoli-Richards, DM1
Clissold, SP1
Saito, M1
Nomura, F1
Okuda, K1
Suzuki, N1
Ohtsuki, T1
Goto, N1
Takashi, M1
Thomson, AB1
Mahachai, V1
Saigenji, K1
Fukutomi, H1
Nakazawa, S1
Weir, DG1
Blanco, M1
Pajares, JM1
Jimenez, ML1
Lopez-Brea, M1
Berta, L1
Dusio, P1
Fortunati, N1
Fazzari, A1
Crua, MR1
Frairia, R1
Gaidano, G1
Gugler, R2
Polloni, A1
Marchi, S1
Greco, A1
Cipparrone, G1
Costa, F1
Bellini, M1
Maltinti, G1
Lewis, JH1

Clinical Trials (3)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Histamine-2 Receptor Antagonist Versus Proton-Pump Inhibitor for the Prevention of Recurrent Upper Gastrointestinal Bleeding (UGI) in High-risk Users of Low-dose Aspirin (ASA)[NCT01408186]Phase 3264 participants (Actual)Interventional2011-01-31Completed
Efficacy of H2 Receptor Antagonist in Prevention of Thienopyridine-related Peptic Ulcer[NCT02418312]228 participants (Actual)Interventional2012-01-31Completed
Pantoprazole Versus Famotidine for the Prevention of Recurrent Peptic Ulcers in Thienopyridine Users - a Double-blind Randomized Controlled Trial[NCT02551744]101 participants (Actual)Interventional2012-07-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Number of Participants With Healed Peptic Ulcer

Follow-up endoscopy was performed at the end of the 6th month (NCT02418312)
Timeframe: 6 months

Interventionparticipants (Number)
Histamine-2 Receptor Antagonist Group106
Placebo Group101

Number of Participants With Ulcer Recurrence

Follow-up endoscopy was performed at the end of the 6th month (NCT02551744)
Timeframe: six month

Interventionparticipants (Number)
Proton Pump Inhibitor Group1
Histamine-2 Receptor Antagonist Group7

Reviews

17 reviews available for famotidine and Peptic Ulcer

ArticleYear
[Strategy to manage low dose aspirin-induced gastrointestinal injury].
    Nihon rinsho. Japanese journal of clinical medicine, 2011, Volume: 69, Issue:2

    Topics: Anti-Ulcer Agents; Aspirin; Cardiovascular Diseases; Cerebrovascular Disorders; Clopidogrel; Famotid

2011
Molecular pharmacological approaches to effects of capsaicinoids and of classical antisecretory drugs on gastric basal acid secretion and on indomethacin-induced gastric mucosal damage in human healthy subjects (mini review).
    Current pharmaceutical design, 2013, Volume: 19, Issue:1

    Topics: Adult; Afferent Pathways; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Atrop

2013
Do H2 receptor antagonists have a therapeutic role in childhood?
    Journal of pediatric gastroenterology and nutrition, 1994, Volume: 19, Issue:3

    Topics: Adolescent; Child; Child, Preschool; Cimetidine; Cystic Fibrosis; Drug Interactions; Famotidine; Gas

1994
[Famotidine in the treatment of gastroduodenal ulcer].
    Orvosi hetilap, 1994, Oct-16, Volume: 135, Issue:42

    Topics: Famotidine; Humans; Peptic Ulcer

1994
[Clinical aspects of Kvamatel (famotidine) administration].
    Klinicheskaia meditsina, 1996, Volume: 74, Issue:1

    Topics: Anti-Ulcer Agents; Famotidine; Gastroesophageal Reflux; Histamine H2 Antagonists; Humans; Peptic Ulc

1996
Management of nonsteroidal anti-inflammatory drug-induced gastroduodenal disease by acid suppression.
    Canadian journal of gastroenterology = Journal canadien de gastroenterologie, 1999, Volume: 13, Issue:2

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Duodenal Ulcer; Famotidine; Gastric Juic

1999
H(2) antagonist-induced thrombocytopenia: is this a real phenomenon?
    Intensive care medicine, 2002, Volume: 28, Issue:4

    Topics: Cimetidine; Critical Care; Famotidine; Histamine H2 Antagonists; Humans; Peptic Ulcer; Ranitidine; R

2002
The clinical use of histamine-2 receptor antagonists.
    Maryland medical journal (Baltimore, Md. : 1985), 1992, Volume: 41, Issue:5

    Topics: Cimetidine; Drug Evaluation; Famotidine; Gastroesophageal Reflux; Humans; Nizatidine; Peptic Ulcer;

1992
[Histamine H2 receptor blockaders: possibilities and prognosis in the use of stage III-IV preparations in the therapy of internal diseases].
    Klinicheskaia meditsina, 1991, Volume: 69, Issue:3

    Topics: Cimetidine; Famotidine; Gastric Acid; Histamine H2 Antagonists; Humans; Peptic Ulcer; Ranitidine

1991
[Famotidine--a new histamine H2 receptor blockader].
    Klinicheskaia meditsina, 1991, Volume: 69, Issue:4

    Topics: Cimetidine; Famotidine; Gastric Acid; Gastric Mucosa; Humans; Peptic Ulcer; Receptors, Histamine H2

1991
Clinical importance of the new H2-antagonists.
    Methods and findings in experimental and clinical pharmacology, 1989, Volume: 11 Suppl 1

    Topics: Animals; Famotidine; Histamine H2 Antagonists; Humans; Nizatidine; Peptic Ulcer; Piperidines; Thiazo

1989
[Drugs used in the therapy of peptic ulcer with special reference to H2 receptor blockaders].
    La Clinica terapeutica, 1989, Apr-15, Volume: 129, Issue:1

    Topics: Antacids; Anti-Ulcer Agents; Cimetidine; Famotidine; Female; Histamine H2 Antagonists; Humans; Male;

1989
Famotidine. An updated review of its pharmacodynamic and pharmacokinetic properties, and therapeutic use in peptic ulcer disease and other allied diseases.
    Drugs, 1989, Volume: 38, Issue:4

    Topics: Famotidine; Histamine H2 Antagonists; Humans; Peptic Ulcer

1989
Famotidine. Pharmacodynamic and pharmacokinetic properties and a preliminary review of its therapeutic use in peptic ulcer disease and Zollinger-Ellison syndrome.
    Drugs, 1986, Volume: 32, Issue:3

    Topics: Animals; Famotidine; Histamine H2 Antagonists; Humans; Kinetics; Peptic Ulcer; Thiazoles; Zollinger-

1986
Pharmacological management of patients with peptic ulcer disease: prospects for the late 1980's.
    Clinical and investigative medicine. Medecine clinique et experimentale, 1987, Volume: 10, Issue:3

    Topics: Alprostadil; Antacids; Anti-Ulcer Agents; Cimetidine; Drug Resistance; Enprostil; Famotidine; Histam

1987
Peptic ulceration.
    British medical journal (Clinical research ed.), 1988, Jan-16, Volume: 296, Issue:6616

    Topics: Adenosine Triphosphatases; Anti-Ulcer Agents; Famotidine; H(+)-K(+)-Exchanging ATPase; Histamine H2

1988
The place of famotidine in anti-ulcer therapy.
    Alimentary pharmacology & therapeutics, 1987, Volume: 1 Suppl 1

    Topics: Famotidine; Humans; Peptic Ulcer

1987

Trials

30 trials available for famotidine and Peptic Ulcer

ArticleYear
Comparison of teprenone and famotidine against gastroduodenal mucosal damage in patients taking low-dose aspirin.
    Journal of gastroenterology and hepatology, 2014, Volume: 29 Suppl 4

    Topics: Aged; Anti-Ulcer Agents; Aspirin; Diterpenes; Famotidine; Female; Histamine H2 Antagonists; Humans;

2014
Similar Efficacy of Proton-Pump Inhibitors vs H2-Receptor Antagonists in Reducing Risk of Upper Gastrointestinal Bleeding or Ulcers in High-Risk Users of Low-Dose Aspirin.
    Gastroenterology, 2017, Volume: 152, Issue:1

    Topics: Aged; Aged, 80 and over; Aspirin; Double-Blind Method; Famotidine; Female; Hemoglobins; Histamine H2

2017
Histamine-2 Receptor Antagonist Cannot Prevent Recurrent Peptic Ulcers in Patients With Atherosclerotic Diseases Who Receive Platelet ADP Receptor Antagonist Monotherapy: A Randomized-Controlled, Double-Blind, and Double-Dummy Trial.
    The American journal of gastroenterology, 2017, Volume: 112, Issue:2

    Topics: Aged; Aged, 80 and over; Anti-Bacterial Agents; Atherosclerosis; Clopidogrel; Double-Blind Method; F

2017
Famotidine for the prevention of peptic ulcers and oesophagitis in patients taking low-dose aspirin (FAMOUS): a phase III, randomised, double-blind, placebo-controlled trial.
    Lancet (London, England), 2009, Jul-11, Volume: 374, Issue:9684

    Topics: Adult; Aged; Aged, 80 and over; Anti-Ulcer Agents; Aspirin; Cardiovascular Diseases; Double-Blind Me

2009
Famotidine is inferior to pantoprazole in preventing recurrence of aspirin-related peptic ulcers or erosions.
    Gastroenterology, 2010, Volume: 138, Issue:1

    Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Aged; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-

2010
Famotidine is inferior to pantoprazole in preventing recurrence of aspirin-related peptic ulcers or erosions.
    Gastroenterology, 2010, Volume: 138, Issue:1

    Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Aged; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-

2010
Famotidine is inferior to pantoprazole in preventing recurrence of aspirin-related peptic ulcers or erosions.
    Gastroenterology, 2010, Volume: 138, Issue:1

    Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Aged; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-

2010
Famotidine is inferior to pantoprazole in preventing recurrence of aspirin-related peptic ulcers or erosions.
    Gastroenterology, 2010, Volume: 138, Issue:1

    Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Aged; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-

2010
Comparative study of therapeutic effects of PPI and H2RA on ulcers during continuous aspirin therapy.
    World journal of gastroenterology, 2010, Nov-14, Volume: 16, Issue:42

    Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Aged; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer A

2010
[Modern approach to the prevention and treatment of NSAID-gastropathy].
    Eksperimental'naia i klinicheskaia gastroenterologiia = Experimental & clinical gastroenterology, 2011, Issue:2

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Diclofenac; Famotidine; Gastric Mucosa;

2011
Molecular pharmacological approaches to effects of capsaicinoids and of classical antisecretory drugs on gastric basal acid secretion and on indomethacin-induced gastric mucosal damage in human healthy subjects (mini review).
    Current pharmaceutical design, 2013, Volume: 19, Issue:1

    Topics: Adult; Afferent Pathways; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Atrop

2013
Impact of stress ulcer prophylaxis algorithm study.
    The Annals of pharmacotherapy, 2005, Volume: 39, Issue:5

    Topics: Adult; Aged; Aged, 80 and over; Algorithms; Anti-Ulcer Agents; Drug Administration Schedule; Famotid

2005
Preventive therapy for non-steroidal anti-inflammatory drug-induced ulcers in Japanese patients with rheumatoid arthritis: the current situation and a prospective controlled-study of the preventive effects of lansoprazole or famotidine.
    Alimentary pharmacology & therapeutics, 2005, Volume: 21 Suppl 2

    Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Aged; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer A

2005
Effect of long-term half-dose famotidine therapy on corpus gastritis in peptic ulcer disease.
    Alimentary pharmacology & therapeutics, 2005, Volume: 21 Suppl 2

    Topics: Adolescent; Adult; Aged; Antacids; Anti-Ulcer Agents; Famotidine; Female; Gastric Acid; Gastritis; H

2005
Comparative study of the speed of acid-suppressing effects of oral administration of cimetidine and famotidine.
    Journal of gastroenterology and hepatology, 2005, Volume: 20, Issue:7

    Topics: Adult; Chromatography, High Pressure Liquid; Cimetidine; Cross-Over Studies; Famotidine; Follow-Up S

2005
Therapeutic effects of lansoprazole on peptic ulcers in elderly patients.
    Journal of clinical gastroenterology, 1995, Volume: 20 Suppl 2

    Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Aged; Aged, 80 and over; Amoxicillin; Ampicillin; Anti-Ulce

1995
Comparison of the effect of intermittent administration and continuous infusion of famotidine on gastric pH in critically ill patients: results of a prospective, randomized, crossover study.
    Critical care medicine, 1995, Volume: 23, Issue:4

    Topics: Adult; Aged; Critical Illness; Cross-Over Studies; Famotidine; Female; Gastric Acid; Humans; Hydroge

1995
Pharmacokinetics and pharmacodynamics of famotidine in children with gastroduodenal ulcers.
    Therapeutic drug monitoring, 1994, Volume: 16, Issue:5

    Topics: Administration, Oral; Adolescent; Biological Availability; Child; Famotidine; Gastric Acid; Gastric

1994
Comparison of an intravenous bolus of famotidine and Mylanta II for the control of gastric pH in critically ill patients.
    American journal of surgery, 1993, Volume: 166, Issue:6

    Topics: Adult; Aluminum Hydroxide; Antacids; Critical Illness; Drug Combinations; Famotidine; Female; Gastri

1993
[Comparative study of famotidine vs ranitidine in critically ill patients in mechanical ventilation].
    Revista medica de Chile, 1993, Volume: 121, Issue:7

    Topics: Acute Disease; Adult; Aged; Aged, 80 and over; Critical Care; Double-Blind Method; Famotidine; Femal

1993
Early and late effects of low-dose famotidine, ranitidine or placebo on pentagastrin-stimulated gastric acid secretion in man.
    Alimentary pharmacology & therapeutics, 1996, Volume: 10, Issue:5

    Topics: Administration, Oral; Adult; Analysis of Variance; Anti-Ulcer Agents; Cross-Over Studies; Famotidine

1996
Famotidine for healing and maintenance in nonsteroidal anti-inflammatory drug-associated gastroduodenal ulceration.
    Gastroenterology, 1997, Volume: 112, Issue:6

    Topics: Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Duodenal Ulcer; Famotidine;

1997
Quadruple therapy: the golden bullet or a drug too far?
    Helicobacter, 1996, Volume: 1, Issue:2

    Topics: Antacids; Drug Therapy, Combination; Enzyme Inhibitors; Famotidine; Helicobacter Infections; Helicob

1996
Neutrophils, Helicobacter pylori, and nonsteroidal anti-inflammatory drug ulcers.
    Gastroenterology, 1999, Volume: 116, Issue:2

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Arthritis, Rheumatoid; Double-Blind Meth

1999
Changes in Helicobacter pylori-induced gastritis in the antrum and corpus during long-term acid-suppressive treatment in Japan.
    Alimentary pharmacology & therapeutics, 2000, Volume: 14, Issue:10

    Topics: Anti-Ulcer Agents; Enzyme Inhibitors; Famotidine; Gastric Mucosa; Gastritis; Gastroscopy; Helicobact

2000
Famotidine versus omeprazole, in combination with amoxycillin and tinidazole, for eradication of Helicobacter pylori infection.
    European journal of gastroenterology & hepatology, 2001, Volume: 13, Issue:8

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Amoxicillin; Anti-Bacterial Agents; Drug Therapy, Combin

2001
[Efficiency of quamatel in combination with device sound stimulation of the gastroduodenal zone in ulcer patients].
    Klinicheskaia meditsina, 2001, Volume: 79, Issue:8

    Topics: Acoustic Stimulation; Adolescent; Adult; Amoxicillin; Anti-Ulcer Agents; Antifungal Agents; Combined

2001
[Famotidine--a new histamine H2 receptor blockader].
    Klinicheskaia meditsina, 1991, Volume: 69, Issue:4

    Topics: Cimetidine; Famotidine; Gastric Acid; Gastric Mucosa; Humans; Peptic Ulcer; Receptors, Histamine H2

1991
Comparative efficacy of cimetidine, famotidine, ranitidine, and mylanta in postoperative stress ulcers. Gastric pH control and ulcer prevention in patients undergoing coronary artery bypass graft surgery.
    Gastroenterology, 1991, Volume: 100, Issue:6

    Topics: Aged; Aluminum Hydroxide; Antacids; Cimetidine; Coronary Artery Bypass; Drug Combinations; Famotidin

1991
Treatment of upper gastro-intestinal bleeding with the H2-receptor antagonist famotidine.
    The Journal of international medical research, 1989, Volume: 17 Suppl 1

    Topics: Anti-Ulcer Agents; Clinical Trials as Topic; Famotidine; Histamine H2 Antagonists; Humans; Multicent

1989
Effect of acid inhibition on Campylobacter pylori.
    Scandinavian journal of gastroenterology. Supplement, 1988, Volume: 142

    Topics: Adult; Campylobacter; Campylobacter Infections; Duodenitis; Famotidine; Female; Gastric Acid; Gastri

1988
Famotidine in the short-term treatment of duodenal ulcer and of concomitant peptic lesions: comparison with cimetidine.
    International journal of clinical pharmacology research, 1988, Volume: 8, Issue:2

    Topics: Cimetidine; Duodenal Ulcer; Famotidine; Female; Humans; Male; Middle Aged; Peptic Ulcer; Thiazoles

1988
Summary of the 30th meeting of the Food and Drug Administration Gastrointestinal Drugs Advisory Committee January 16-17, 1986.
    The American journal of gastroenterology, 1986, Volume: 81, Issue:6

    Topics: Aluminum; Cimetidine; Clinical Trials as Topic; Duodenal Ulcer; Famotidine; Humans; Peptic Ulcer; Su

1986

Other Studies

51 other studies available for famotidine and Peptic Ulcer

ArticleYear
Famotidine-loaded solid self-nanoemulsifying drug delivery system demonstrates exceptional efficiency in amelioration of peptic ulcer.
    International journal of pharmaceutics, 2022, Jan-05, Volume: 611

    Topics: Animals; Drug Delivery Systems; Famotidine; Microscopy, Electron, Scanning; Peptic Ulcer; Rats

2022
Prevalence of gastroduodenal ulcers/erosions in patients taking low-dose aspirin with either 15 mg/day of lansoprazole or 40 mg/day of famotidine: the OITA-GF study 2.
    BMC research notes, 2013, Mar-26, Volume: 6

    Topics: Aged; Anti-Ulcer Agents; Aspirin; Cohort Studies; Cross-Sectional Studies; Drug Administration Sched

2013
Synergistic effect of the combination of gallic acid and famotidine in protection of rat gastric mucosa.
    Pharmacological reports : PR, 2014, Volume: 66, Issue:4

    Topics: Animals; Anti-Ulcer Agents; Antioxidants; Disease Models, Animal; Drug Synergism; Drug Therapy, Comb

2014
Dosage effects of histamine-2 receptor antagonist on the primary prophylaxis of non-steroidal anti-inflammatory drug (NSAID)-associated peptic ulcers: a retrospective cohort study.
    Drug safety, 2014, Volume: 37, Issue:9

    Topics: Administration, Oral; Adverse Drug Reaction Reporting Systems; Age Factors; Aged; Anti-Inflammatory

2014
[Prophylaxis of an acute postoperative pancreatitis and the stress ulcers occurrence after operations, performed on organs of hepatopancreatoduodenal zone, using miniinvasive and open access].
    Klinichna khirurhiia, 2014, Issue:4

    Topics: Acute Disease; Drug Administration Schedule; Drug Dosage Calculations; Duodenal Ulcer; Endoscopy, Ga

2014
Comparison of proton pump inhibitor and histamine-2 receptor antagonist in the prevention of recurrent peptic ulcers/erosions in long-term low-dose aspirin users: a retrospective cohort study.
    BioMed research international, 2014, Volume: 2014

    Topics: Aged; Aged, 80 and over; Aspirin; Cohort Studies; Drug-Related Side Effects and Adverse Reactions; F

2014
Evaluation of combined famotidine with quercetin for the treatment of peptic ulcer: in vivo animal study.
    Drug design, development and therapy, 2015, Volume: 9

    Topics: Alginates; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Antioxidants; Chemis

2015
NSAIDs and aspirin: notorious or FAMOUS?
    Lancet (London, England), 2009, Jul-11, Volume: 374, Issue:9684

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Aspirin; Cyclooxygenase Inhibitors; Esop

2009
Protective effect of lafutidine, a histamine H2 receptor antagonist, against loxoprofen-induced small intestinal lesions in rats.
    Journal of gastroenterology and hepatology, 2010, Volume: 25 Suppl 1

    Topics: 16,16-Dimethylprostaglandin E2; Acetamides; Ampicillin; Animals; Anti-Bacterial Agents; Anti-Ulcer A

2010
Protective effect of roxatidine against indomethacin-induced small intestinal mucosal injury in rats.
    Journal of gastroenterology and hepatology, 2010, Volume: 25 Suppl 1

    Topics: Animals; Anti-Ulcer Agents; Cimetidine; Disease Models, Animal; Famotidine; Histamine H2 Antagonists

2010
Famotidine use and thrombocytopenia in the trauma patient.
    The American surgeon, 2011, Volume: 77, Issue:12

    Topics: California; Dose-Response Relationship, Drug; Famotidine; Female; Follow-Up Studies; Histamine H2 An

2011
Prescription of and adherence to non-steroidal anti-inflammatory drugs and gastroprotective agents in at-risk gastrointestinal patients.
    The American journal of gastroenterology, 2012, Volume: 107, Issue:5

    Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Famotidine; Female; Humans; Male;

2012
Multiple cerebral infarctions related to famotidine-induced eosinophilia.
    Journal of neurology, 2012, Volume: 259, Issue:10

    Topics: Acarbose; Adrenergic alpha-1 Receptor Antagonists; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulc

2012
Efficacy of a 1-week course of proton-pump inhibitor-based triple therapy for eradicating Helicobacter pylori in patients with and without chronic renal failure.
    American journal of kidney diseases : the official journal of the National Kidney Foundation, 2002, Volume: 40, Issue:3

    Topics: Amoxicillin; Anti-Ulcer Agents; Clarithromycin; Drug Administration Schedule; Drug Therapy, Combinat

2002
[Antisecretory therapy as a component of hemostasis in acute gastroduodenal ulcer bleedings].
    Khirurgiia, 2005, Issue:8

    Topics: Acute Disease; Anti-Ulcer Agents; Famotidine; Gastrointestinal Agents; Histamine H2 Antagonists; Hum

2005
[Pharmacological efficacy of bismuth tripotassium dicitrate in peptic ulcer].
    Terapevticheskii arkhiv, 2007, Volume: 79, Issue:2

    Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Antacids; Anti-Ulcer Agents; Cost-Benefit Analysis; Drug Th

2007
Up-to-date information on gastric mucosal lesions from long-term NSAID therapy in orthopedic outpatients: a study using logistic regression analysis.
    Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association, 2007, Volume: 12, Issue:4

    Topics: Adult; Aged; Alanine; Anti-Ulcer Agents; Bone Diseases; Cyclooxygenase 2 Inhibitors; Diclofenac; End

2007
[H2 receptor antagonists and intragastric acidity].
    Deutsche medizinische Wochenschrift (1946), 1984, Nov-16, Volume: 109, Issue:46

    Topics: Cimetidine; Drug Administration Schedule; Famotidine; Histamine Antagonists; Histamine H2 Antagonist

1984
[Effects of protective agents on ulcer formation].
    Nihon rinsho. Japanese journal of clinical medicine, 1984, Volume: 42, Issue:1

    Topics: Adult; Animals; Cimetidine; Dogs; Duodenal Ulcer; Famotidine; Gastric Juice; Gastric Mucosa; Humans;

1984
[Properties of a new drug famocid: indications and contraindications of its use?].
    Klinicheskaia meditsina, 1995, Volume: 73, Issue:2

    Topics: Contraindications; Duodenitis; Famotidine; Gastritis; Humans; Kidney; Liver; Peptic Ulcer

1995
[Effectiveness of lecedil (famotidine) in the therapy of patients with peptic ulcer].
    Klinicheskaia meditsina, 1993, Volume: 71, Issue:6

    Topics: Adult; Famotidine; Female; Humans; Male; Middle Aged; Peptic Ulcer; Treatment Outcome

1993
Famotidine and theophylline pharmacokinetics. An unexpected cimetidine-like interaction in patients with chronic obstructive pulmonary disease.
    Clinical pharmacokinetics, 1993, Volume: 24, Issue:3

    Topics: Cimetidine; Drug Interactions; Famotidine; Humans; Infusions, Intravenous; Lung Diseases, Obstructiv

1993
[Ulfamid Krka (famotidine) in monotherapy of peptic ulcer].
    Vnitrni lekarstvi, 1996, Volume: 42, Issue:2

    Topics: Adult; Anti-Ulcer Agents; Famotidine; Female; Humans; Male; Peptic Ulcer; Prospective Studies

1996
Prevention of NSAID-induced ulcers.
    The Journal of family practice, 1996, Volume: 43, Issue:3

    Topics: Adolescent; Adult; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Double-Blind Method;

1996
Famotidine to prevent peptic ulcer caused by NSAIDs.
    The New England journal of medicine, 1996, Oct-24, Volume: 335, Issue:17

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Arthritis, Rheumatoid; Famotidine; Gastr

1996
[Quamatel efficacy against ulcer].
    Klinicheskaia meditsina, 1996, Volume: 74, Issue:9

    Topics: Administration, Oral; Adolescent; Adult; Biopsy; Endoscopy, Digestive System; Famotidine; Follow-Up

1996
High-dose famotidine for prevention of NSAID ulcers?
    Gastroenterology, 1997, Volume: 112, Issue:6

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Famotidine; Humans; Peptic Ulcer

1997
Effect of ebrotidine on ethanol-induced gastric mucosal damage in the rat. Comparative study with other H2-receptor antagonists.
    Arzneimittel-Forschung, 1997, Volume: 47, Issue:4A

    Topics: Animals; Benzenesulfonates; Cimetidine; Dose-Response Relationship, Drug; Ethanol; Famotidine; Femal

1997
Human gastric carcinoid detected during long-term antiulcer therapy of H2 receptor antagonist and proton pump inhibitor.
    Digestive diseases and sciences, 1998, Volume: 43, Issue:2

    Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Adult; Anti-Ulcer Agents; Carcinoid Tumor; Famotidine; Hist

1998
[Famotidine in the treatment of gastropathy induced by non-steroidal antirheumatic agents].
    Vnitrni lekarstvi, 1997, Volume: 43, Issue:4

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Esophagitis; Famotidine; Female; Histamine H2 Antagonists;

1997
Central nervous system reactions associated with famotidine: report of five cases.
    Journal of clinical gastroenterology, 1998, Volume: 27, Issue:3

    Topics: Aged; Aged, 80 and over; Anti-Ulcer Agents; Brain Diseases; Famotidine; Female; Histamine H2 Antagon

1998
Using multiple pharmacoeconomic methods to conduct a cost-effectiveness analysis of histamine H2-receptor antagonists.
    American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists, 1998, Dec-15, Volume: 55, Issue:24 Suppl 4

    Topics: Cimetidine; Cost-Benefit Analysis; Decision Trees; Famotidine; Female; Histamine H2 Antagonists; Hum

1998
Helicobacter pylori infection and persistent hyperemesis gravidarum.
    American journal of perinatology, 1999, Volume: 16, Issue:2

    Topics: Adolescent; Adult; Amoxicillin; Anti-Bacterial Agents; Anti-Ulcer Agents; Clarithromycin; Famotidine

1999
[Relations of acid-base balance and gastric secretion of hydrogen carbonate ions in patients with peptic ulcer].
    Terapevticheskii arkhiv, 2001, Volume: 73, Issue:2

    Topics: Acid-Base Equilibrium; Acidosis; Adult; Anti-Ulcer Agents; Bicarbonates; Famotidine; Female; Gastric

2001
[Problems in ulcer surgery after the introduction of H2-receptor antagonists].
    Nihon Geka Gakkai zasshi, 1992, Volume: 93, Issue:9

    Topics: Animals; Cell Count; Famotidine; Gastric Acid; Gastrins; Histamine H2 Antagonists; Humans; Hyperplas

1992
Comparative efficacy of cimetidine, famotidine, ranitidine, and mylanta in postoperative stress ulcers.
    Gastroenterology, 1992, Volume: 102, Issue:3

    Topics: Aluminum Hydroxide; Antacids; Cimetidine; Drug Combinations; Famotidine; Humans; Magnesium Hydroxide

1992
[Effects of 3-hydroxymethyl-2-methylimidazo [2, 1-b] benzothiazole (NIK-228) on gastric acid secretion and various experimental peptic ulcers in rats].
    Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 1991, Volume: 97, Issue:5

    Topics: Administration, Oral; Animals; Anti-Ulcer Agents; Benzothiazoles; Depression, Chemical; Dose-Respons

1991
Effects of a proton pump inhibitor, AG-1749 (lansoprazole), on reflux esophagitis and experimental ulcers in rats.
    Japanese journal of pharmacology, 1991, Volume: 55, Issue:4

    Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Animals; Anti-Ulcer Agents; Duodenal Ulcer; Duodenum; Esoph

1991
Effect of famotidine on deficit symptoms of schizophrenia.
    Lancet (London, England), 1990, Jun-02, Volume: 335, Issue:8701

    Topics: Adult; Famotidine; Humans; Male; Peptic Ulcer; Receptors, Histamine; Schizophrenia

1990
Continuing advances in H2-antagonist therapy: focus on famotidine. Proceedings of a symposium. Nice, France, 14 October 1989.
    Hepato-gastroenterology, 1990, Volume: 37 Suppl 1

    Topics: Famotidine; Humans; Peptic Ulcer

1990
Famotidine and cardiac arrhythmia.
    DICP : the annals of pharmacotherapy, 1991, Volume: 25, Issue:3

    Topics: Adult; Arrhythmia, Sinus; Famotidine; Humans; Male; Peptic Ulcer

1991
Effects of hepatic disease on the pharmacokinetics of famotidine and effects of famotidine on hepatic hemodynamics and peptic ulcer.
    Hepato-gastroenterology, 1990, Volume: 37 Suppl 1

    Topics: Adult; Chronic Disease; Famotidine; Female; Hepatitis; Humans; Liver Circulation; Liver Cirrhosis; L

1990
Frequent non-response to histamine H2-receptor antagonists in cirrhotics.
    Gut, 1989, Volume: 30, Issue:8

    Topics: Anti-Ulcer Agents; Cimetidine; Esophagitis, Peptic; Famotidine; Female; Gastric Acidity Determinatio

1989
Famotidine: a further development in the modern treatment of peptic ulcer disease. Proceedings of a satellite symposium of the XIIth International Congress of Gastroenterology. Lisbon, September 19, 1984.
    Digestion, 1985, Volume: 32 Suppl 1

    Topics: Famotidine; Histamine H2 Antagonists; Humans; Peptic Ulcer; Thiazoles

1985
Famotidine: clinical applications of a new H2-receptor antagonist. May 16, 1986, Carmel, California.
    The American journal of medicine, 1986, Oct-24, Volume: 81, Issue:4B

    Topics: Anti-Ulcer Agents; Famotidine; Histamine H2 Antagonists; Humans; Peptic Ulcer; Thiazoles

1986
Effect of famotidine on hepatic hemodynamics and peptic ulcer.
    The American journal of gastroenterology, 1987, Volume: 82, Issue:5

    Topics: Adult; Chronic Disease; Dye Dilution Technique; Famotidine; Female; Hemodynamics; Histamine H2 Antag

1987
Famotidine: postmarketing clinical experience.
    Scandinavian journal of gastroenterology. Supplement, 1987, Volume: 134

    Topics: Adult; Famotidine; Female; Gastrointestinal Diseases; Gastrointestinal Hemorrhage; Histamine H2 Anta

1987
Plasma sex steroid transport and histamine H2-receptor antagonists. Clinical implications.
    Annals of the New York Academy of Sciences, 1988, Volume: 538

    Topics: Adult; Cimetidine; Famotidine; Gonadal Steroid Hormones; Histamine H2 Antagonists; Hormones; Humans;

1988
[New developments in ulcer therapy: famotidine, omeprazole misoprostol].
    Medizinische Klinik (Munich, Germany : 1983), 1986, Mar-18, Volume: 81, Issue:6

    Topics: Alprostadil; Anti-Ulcer Agents; Famotidine; Humans; Misoprostol; Omeprazole; Peptic Ulcer; Thiazoles

1986
[Peptic ulcer. New H2 blockers, prostaglandins, benzimidazoles].
    Fortschritte der Medizin, 1987, Apr-10, Volume: 105, Issue:10

    Topics: Alprostadil; Anti-Ulcer Agents; Famotidine; Humans; Misoprostol; Omeprazole; Peptic Ulcer; Thiazoles

1987
New H2-blockers: does more choice help?
    Drug and therapeutics bulletin, 1988, Aug-22, Volume: 26, Issue:17

    Topics: Anti-Ulcer Agents; Cimetidine; Famotidine; Humans; Nizatidine; Peptic Ulcer; Ranitidine; Thiazoles

1988