famotidine has been researched along with Disease Models, Animal in 34 studies
Famotidine: A competitive histamine H2-receptor antagonist. Its main pharmacodynamic effect is the inhibition of gastric secretion.
Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Histamine has a positive inotropic effect on ventricular myocardium and stimulation of histamine H₂ receptors increases the intracellular cAMP level via Gs protein, as dose stimulation of β-adrenergic receptors, and worsens heart failure." | 7.76 | A histamine H₂ receptor blocker ameliorates development of heart failure in dogs independently of β-adrenergic receptor blockade. ( Asakura, M; Asanuma, H; Fujita, M; Kim, J; Kitakaze, M; Komamura, K; Minamino, T; Sanada, S; Sasaki, H; Sugimachi, M; Takahama, H; Takashima, S; Wakeno, M, 2010) |
| "Gastric ulcer is a multifaceted process including acid secretion, reactive oxygen species generation, prostaglandin inhibition, and extracellular matrix (ECM) degradation." | 5.34 | Novel role of famotidine in downregulation of matrix metalloproteinase-9 during protection of ethanol-induced acute gastric ulcer. ( Ganguly, K; Kundu, P; Mishra, A; Pradeepkumar Singh, L; Swarnakar, S, 2007) |
| " The purpose of the present work was to characterize the interaction and investigate the protective effect of H2 blocker famotidine and gallic acid in combination against experimentally induced peptic ulcer." | 3.80 | Synergistic effect of the combination of gallic acid and famotidine in protection of rat gastric mucosa. ( Asokkumar, K; Sen, S; Sivashanmugam, AT; Subhadradevi, V; Umamaheswari, M, 2014) |
| "Histamine has a positive inotropic effect on ventricular myocardium and stimulation of histamine H₂ receptors increases the intracellular cAMP level via Gs protein, as dose stimulation of β-adrenergic receptors, and worsens heart failure." | 3.76 | A histamine H₂ receptor blocker ameliorates development of heart failure in dogs independently of β-adrenergic receptor blockade. ( Asakura, M; Asanuma, H; Fujita, M; Kim, J; Kitakaze, M; Komamura, K; Minamino, T; Sanada, S; Sasaki, H; Sugimachi, M; Takahama, H; Takashima, S; Wakeno, M, 2010) |
| " Chronic gastric ulcers were induced by serosa-searing with a hot metal bar, and the ulcer healing and recurrence after treatment with FRG-8813 or famotidine were evaluated by endoscopy for 160 days." | 3.70 | Effect of FRG-8813, a new-type histamine H(2)-receptor antagonist, on the recurrence of gastric ulcer after healing by drug treatment in rats. ( Ajioka, H; Matsuura, N; Miyake, H, 2000) |
| "Histamine is a key immunoregulatory mediator in immediate-type hypersensitivity reactions and chronic inflammatory responses, in particular histamine suppresses proinflammatory responses to bacterial ligands, through histamine receptor 2 (H2R)." | 1.43 | Histamine Receptor 2 is Required to Suppress Innate Immune Responses to Bacterial Ligands in Patients with Inflammatory Bowel Disease. ( Akdis, CA; Ferstl, R; Frei, R; Groeger, D; Jutel, M; Konieczna, P; OʼMahony, L; Perez, NR; Schiavi, E; Smolinska, S, 2016) |
| "Montelukast is an anti-asthmatic drug, a selective reversible cysteinyl leukotriene D4 receptor antagonist." | 1.39 | Histopathologic evaluation of anti-ulcerogenic effect of montelukast in indomethacin-induced experimental ulcer model. ( Cadırcı, E; Ozbakış-Dengiz, G; Yurdakan, G, 2013) |
| "Omeprazole (100 mg/kg) was given p." | 1.36 | Protective effect of lafutidine, a histamine H2 receptor antagonist, against loxoprofen-induced small intestinal lesions in rats. ( Amagase, K; Kato, S; Ochi, A; Sugihara, T; Takeuchi, K, 2010) |
| "In indomethacin-treated animals, esomeprazole was more effective than famotidine or the antioxidant melatonin in promoting ulcer healing." | 1.35 | Characterization of mechanisms underlying the effects of esomeprazole on the impairment of gastric ulcer healing with addition of NSAID treatment. ( Antonioli, L; Blandizzi, C; Colucci, R; Del Tacca, M; Fornai, M; Ghisu, N; Tuccori, M, 2009) |
| "Gastric ulcer is a multifaceted process including acid secretion, reactive oxygen species generation, prostaglandin inhibition, and extracellular matrix (ECM) degradation." | 1.34 | Novel role of famotidine in downregulation of matrix metalloproteinase-9 during protection of ethanol-induced acute gastric ulcer. ( Ganguly, K; Kundu, P; Mishra, A; Pradeepkumar Singh, L; Swarnakar, S, 2007) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (8.82) | 18.2507 |
| 2000's | 15 (44.12) | 29.6817 |
| 2010's | 14 (41.18) | 24.3611 |
| 2020's | 2 (5.88) | 2.80 |
| Authors | Studies |
|---|---|
| Abrams, RPM | 1 |
| Yasgar, A | 1 |
| Teramoto, T | 1 |
| Lee, MH | 1 |
| Dorjsuren, D | 1 |
| Eastman, RT | 1 |
| Malik, N | 1 |
| Zakharov, AV | 1 |
| Li, W | 1 |
| Bachani, M | 1 |
| Brimacombe, K | 1 |
| Steiner, JP | 1 |
| Hall, MD | 1 |
| Balasubramanian, A | 1 |
| Jadhav, A | 1 |
| Padmanabhan, R | 1 |
| Simeonov, A | 1 |
| Nath, A | 1 |
| Zhang, MN | 1 |
| Zhao, XO | 1 |
| Cui, Q | 1 |
| Zhu, DM | 1 |
| Wisal, MA | 1 |
| Yu, HD | 1 |
| Kong, LC | 1 |
| Ma, HX | 1 |
| Ozbakış-Dengiz, G | 1 |
| Cadırcı, E | 1 |
| Yurdakan, G | 1 |
| Asokkumar, K | 2 |
| Sen, S | 1 |
| Umamaheswari, M | 2 |
| Sivashanmugam, AT | 2 |
| Subhadradevi, V | 2 |
| Yue, JX | 1 |
| Wang, RR | 1 |
| Yu, J | 1 |
| Tang, YY | 1 |
| Hou, WW | 1 |
| Lou, GD | 1 |
| Zhang, SH | 1 |
| Chen, Z | 1 |
| Lim, SAO | 1 |
| Xia, R | 1 |
| Ding, Y | 1 |
| Won, L | 1 |
| Ray, WJ | 1 |
| Hitchcock, SA | 1 |
| McGehee, DS | 1 |
| Kang, UJ | 1 |
| Smolinska, S | 1 |
| Groeger, D | 1 |
| Perez, NR | 1 |
| Schiavi, E | 1 |
| Ferstl, R | 1 |
| Frei, R | 1 |
| Konieczna, P | 1 |
| Akdis, CA | 1 |
| Jutel, M | 1 |
| OʼMahony, L | 1 |
| Fornai, M | 3 |
| Colucci, R | 3 |
| Antonioli, L | 3 |
| Ghisu, N | 2 |
| Tuccori, M | 3 |
| Blandizzi, C | 3 |
| Del Tacca, M | 2 |
| Inan, A | 1 |
| Sen, M | 1 |
| Sürgit, O | 1 |
| Ergin, M | 1 |
| Bozer, M | 1 |
| Ahmadi, A | 1 |
| Ebrahimzadeh, MA | 1 |
| Ahmad-Ashrafi, S | 1 |
| Karami, M | 1 |
| Mahdavi, MR | 1 |
| Saravi, SS | 1 |
| Johnston, TH | 1 |
| van der Meij, A | 1 |
| Brotchie, JM | 1 |
| Fox, SH | 1 |
| Amagase, K | 2 |
| Ochi, A | 1 |
| Sugihara, T | 1 |
| Kato, S | 1 |
| Takeuchi, K | 2 |
| Umegaki, E | 1 |
| Yoda, Y | 1 |
| Tokioka, S | 1 |
| Murano, M | 1 |
| Higuchi, K | 1 |
| Nagaraju, R | 1 |
| Prathusha, AP | 1 |
| Subhash Chandra Bose, P | 1 |
| Kaza, R | 1 |
| Bharathi, K | 1 |
| Takahama, H | 1 |
| Asanuma, H | 1 |
| Sanada, S | 1 |
| Fujita, M | 1 |
| Sasaki, H | 1 |
| Wakeno, M | 1 |
| Kim, J | 1 |
| Asakura, M | 1 |
| Takashima, S | 1 |
| Minamino, T | 1 |
| Komamura, K | 1 |
| Sugimachi, M | 1 |
| Kitakaze, M | 1 |
| Awwad, O | 1 |
| Ugolini, C | 1 |
| Fulceri, F | 1 |
| Natale, G | 1 |
| Basolo, F | 1 |
| Polat, B | 1 |
| Albayrak, Y | 1 |
| Suleyman, B | 1 |
| Dursun, H | 1 |
| Odabasoglu, F | 1 |
| Yigiter, M | 1 |
| Halici, Z | 1 |
| Suleyman, H | 2 |
| Özer, M | 1 |
| Duman, M | 1 |
| Taş, Ş | 1 |
| Demırcı, Y | 1 |
| Aydin, MF | 1 |
| Reyhan, E | 1 |
| Atici, AE | 1 |
| Bostanci, EB | 1 |
| Akoğlu, M | 1 |
| Genç, E | 1 |
| Celik, I | 1 |
| Stinner, B | 1 |
| Lorenz, W | 1 |
| Dietz, W | 1 |
| Sauer, S | 1 |
| Duda, D | 1 |
| Sitter, H | 1 |
| Junge, A | 1 |
| Nomura, S | 1 |
| Suzuki, H | 1 |
| Masaoka, T | 1 |
| Kurabayashi, K | 1 |
| Ishii, H | 1 |
| Kitajima, M | 1 |
| Nomoto, K | 1 |
| Hibi, T | 1 |
| Ozbakiş Dengiz, G | 1 |
| Gürsan, N | 1 |
| Kotani, T | 1 |
| Fujimura, T | 1 |
| Okabe, S | 1 |
| Rathidevi, R | 1 |
| Ravi, TK | 1 |
| Harada, N | 1 |
| Okajima, K | 1 |
| Spasov, AA | 1 |
| Chernikov, MV | 1 |
| Speranskaia, AS | 1 |
| Zaĭchenko, SI | 1 |
| Pradeepkumar Singh, L | 1 |
| Kundu, P | 1 |
| Ganguly, K | 1 |
| Mishra, A | 1 |
| Swarnakar, S | 1 |
| Tukov, FF | 1 |
| Luyendyk, JP | 1 |
| Ganey, PE | 1 |
| Roth, RA | 1 |
| Matsunaga, Y | 1 |
| Yamamoto, O | 1 |
| Ueki, S | 1 |
| Haga, N | 1 |
| Mizusawa, F | 1 |
| Mizumoto, A | 1 |
| Sano, I | 1 |
| Itoh, Z | 1 |
| Watanabe, H | 1 |
| Yamada, S | 1 |
| Yoshikawa, N | 1 |
| Kasanuki, J | 1 |
| Yoshida, S | 1 |
| Tokunaga, A | 1 |
| Ajioka, H | 1 |
| Miyake, H | 1 |
| Matsuura, N | 1 |
| Icatlo, FC | 1 |
| Kimura, N | 1 |
| Goshima, H | 1 |
| Kodama, Y | 1 |
| Sener-Muratoğlu, G | 1 |
| Paskaloğlu, K | 1 |
| Arbak, S | 1 |
| Hürdağ, C | 1 |
| Ayanoğlu-Dülger, G | 1 |
| Demirezer, LO | 1 |
| Büyükokuroglu, ME | 1 |
| Akcay, MF | 1 |
| Gepdiremen, A | 1 |
| Banoglu, ZN | 1 |
| Göçer, F | 1 |
34 other studies available for famotidine and Disease Models, Animal
| Article | Year |
|---|---|
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Dr | 2020 |
Famotidine Enhances Rifampicin Activity against Acinetobacter baumannii by Affecting OmpA.
Topics: Acinetobacter baumannii; Animals; Anti-Bacterial Agents; Disease Models, Animal; Drug Resistance, Mu | 2023 |
Histopathologic evaluation of anti-ulcerogenic effect of montelukast in indomethacin-induced experimental ulcer model.
Topics: Acetates; Animals; Anti-Ulcer Agents; Cyclopropanes; Disease Models, Animal; Famotidine; Gastric Muc | 2013 |
Synergistic effect of the combination of gallic acid and famotidine in protection of rat gastric mucosa.
Topics: Animals; Anti-Ulcer Agents; Antioxidants; Disease Models, Animal; Drug Synergism; Drug Therapy, Comb | 2014 |
Histamine upregulates Nav1.8 expression in primary afferent neurons via H2 receptors: involvement in neuropathic pain.
Topics: Animals; Cells, Cultured; Disease Models, Animal; Dose-Response Relationship, Drug; Famotidine; Gang | 2014 |
Enhanced histamine H2 excitation of striatal cholinergic interneurons in L-DOPA-induced dyskinesia.
Topics: Action Potentials; Animals; Cholinergic Neurons; Corpus Striatum; Dicyclomine; Disease Models, Anima | 2015 |
Histamine Receptor 2 is Required to Suppress Innate Immune Responses to Bacterial Ligands in Patients with Inflammatory Bowel Disease.
Topics: Adult; Animals; Case-Control Studies; Cells, Cultured; Colitis, Ulcerative; Crohn Disease; Cytokines | 2016 |
Effects of pantoprazole on ulcer healing delay associated with NSAID treatment.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Acetic Acid; Animals; Anti-Inflammatory Agents, Non-Steroid | 2009 |
Characterization of mechanisms underlying the effects of esomeprazole on the impairment of gastric ulcer healing with addition of NSAID treatment.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Antioxidants; Caspase 3; Dinopr | 2009 |
Effects of the histamine H2 receptor antagonist famotidine on the healing of colonic anastomosis in rats.
Topics: Anastomosis, Surgical; Animals; Colon; Disease Models, Animal; Famotidine; Histamine H2 Antagonists; | 2009 |
Hepatoprotective, antinociceptive and antioxidant activities of cimetidine, ranitidine and famotidine as histamine H2 receptor antagonists.
Topics: Analgesics; Animals; Antioxidants; Carbon Tetrachloride; Cimetidine; Disease Models, Animal; Dose-Re | 2011 |
Effect of histamine H2 receptor antagonism on levodopa-induced dyskinesia in the MPTP-macaque model of Parkinson's disease.
Topics: Akathisia, Drug-Induced; Animals; Antiparkinson Agents; Behavior, Animal; Disease Models, Animal; Do | 2010 |
Protective effect of lafutidine, a histamine H2 receptor antagonist, against loxoprofen-induced small intestinal lesions in rats.
Topics: 16,16-Dimethylprostaglandin E2; Acetamides; Ampicillin; Animals; Anti-Bacterial Agents; Anti-Ulcer A | 2010 |
Protective effect of roxatidine against indomethacin-induced small intestinal mucosal injury in rats.
Topics: Animals; Anti-Ulcer Agents; Cimetidine; Disease Models, Animal; Famotidine; Histamine H2 Antagonists | 2010 |
Preparation and evaluation of famotidine polymorphs.
Topics: Animals; Anti-Ulcer Agents; Crystallization; Disease Models, Animal; Drug Stability; Excipients; Fam | 2010 |
A histamine H₂ receptor blocker ameliorates development of heart failure in dogs independently of β-adrenergic receptor blockade.
Topics: Adrenergic beta-Antagonists; Animals; Carbazoles; Cardiac Catheterization; Cardiac Pacing, Artificia | 2010 |
Effects of esomeprazole on healing of nonsteroidal anti-inflammatory drug (NSAID)-induced gastric ulcers in the presence of a continued NSAID treatment: Characterization of molecular mechanisms.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulce | 2011 |
Antiulcerative effect of dexmedetomidine on indomethacin-induced gastric ulcer in rats.
Topics: Adrenergic alpha-2 Receptor Agonists; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer A | 2011 |
In vitro effects of famotidine and ranitidine on lower esophageal sphincter tone in rats.
Topics: Animals; Disease Models, Animal; Esophageal Sphincter, Lower; Famotidine; Gastroesophageal Reflux; H | 2012 |
[Reduction of cardiovascular disorders by preventive perioperative antihistamine administration in general surgery: are the drugs interchangeable?].
Topics: Animals; Cardiovascular Diseases; Cimetidine; Dimethindene; Disease Models, Animal; Drug Evaluation, | 1998 |
Effect of dietary anti-urease immunoglobulin Y on Helicobacter pylori infection in Mongolian gerbils.
Topics: Animals; Anti-Ulcer Agents; Diet; Disease Models, Animal; Famotidine; Gastric Mucosa; Gerbillinae; H | 2005 |
Effects of Momordica charantia L. (Cucurbitaceae) on indomethacin-induced ulcer model in rats.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Dietary Fats, Unsaturated; D | 2005 |
A novel gastric lesion model induced in rats by partial gastric vascular ligation.
Topics: Administration, Oral; Animals; Anti-Ulcer Agents; Disease Models, Animal; Dose-Response Relationship | 2005 |
Antiulcer and in vitro antioxidant activities of Jasminum grandiflorum L.
Topics: Animals; Anti-Ulcer Agents; Antioxidants; Disease Models, Animal; Dose-Response Relationship, Drug; | 2007 |
Inhibition of neutrophil activation by lafutidine, an H2-receptor antagonist, through enhancement of sensory neuron activation contributes to the reduction of stress-induced gastric mucosal injury in rats.
Topics: 6-Ketoprostaglandin F1 alpha; Acetamides; Animals; Anti-Ulcer Agents; Arachidonic Acids; Calcitonin | 2007 |
[Gastroprotective effects of histamine H2-receptor blockers in Helicobacter-like gastric mucosa lesions].
Topics: Animals; Disease Models, Animal; Famotidine; Female; Gastric Mucosa; Helicobacter Infections; Histam | 2005 |
Novel role of famotidine in downregulation of matrix metalloproteinase-9 during protection of ethanol-induced acute gastric ulcer.
Topics: Acute Disease; Animals; Anti-Ulcer Agents; Cytokines; Disease Models, Animal; Ethanol; Famotidine; G | 2007 |
The role of tumor necrosis factor alpha in lipopolysaccharide/ranitidine-induced inflammatory liver injury.
Topics: Animals; Cells, Cultured; Chemical and Drug Induced Liver Injury; Chemokine CXCL2; Coculture Techniq | 2007 |
Inhibition of phase III activity by acid in canine stomach.
Topics: Animals; Disease Models, Animal; Dogs; Duodenal Ulcer; Electrodes; Electrophysiology; Famotidine; Fe | 1994 |
Effect of famotidine on gastric mucosal lesions induced by gold thioglucose in rats.
Topics: Animals; Aurothioglucose; Disease Models, Animal; Famotidine; Gastric Acid; Gastric Juice; Gastric M | 1993 |
Effect of FRG-8813, a new-type histamine H(2)-receptor antagonist, on the recurrence of gastric ulcer after healing by drug treatment in rats.
Topics: Acetamides; Animals; Disease Models, Animal; Endoscopy, Gastrointestinal; Famotidine; Gastric Acidit | 2000 |
Enhanced reduction of Helicobacter pylori load in precolonized mice treated with combined famotidine and urease-binding polysaccharides.
Topics: Animals; Anticoagulants; Dextran Sulfate; Disease Models, Animal; Drug Therapy, Combination; Famotid | 2000 |
Protective effect of famotidine, omeprazole, and melatonin against acetylsalicylic acid-induced gastric damage in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Antioxidants; Aspirin; Disease | 2001 |
Antiulcerogenic effect of Hippophae rhamnoides L.
Topics: Animals; Anti-Ulcer Agents; Disease Models, Animal; Famotidine; Fruit; Indomethacin; Male; Misoprost | 2001 |