famotidine has been researched along with Achlorhydria in 6 studies
Famotidine: A competitive histamine H2-receptor antagonist. Its main pharmacodynamic effect is the inhibition of gastric secretion.
Achlorhydria: A lack of HYDROCHLORIC ACID in GASTRIC JUICE despite stimulation of gastric secretion.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The bioavailability of dipyridamole, a poorly soluble weak base, was evaluated in 11 healthy, older subjects (> or = 65 years), 6 with a low fasting gastric pH (control) and 5 with a fasting gastric pH > 5 (achlorhydric), in a randomized, crossover design." | 2.67 | pH-related changes in the absorption of dipyridamole in the elderly. ( Barnett, JL; Berardi, RR; Dressman, JB; O'Sullivan, TL; Russell, TL; Wagner, JG, 1994) |
| " Since such reduction in exposure can lead to significant loss of efficacy, it is imperative to (1) understand the behavior of the compound as a function of stomach pH to inform of any risk of bioavailability loss in clinical studies and (2) develop a robust formulation which can provide adequate exposure in achlorhydric patients." | 2.49 | Impaired drug absorption due to high stomach pH: a review of strategies for mitigation of such effect to enable pharmaceutical product development. ( Kesisoglou, F; Mitra, A, 2013) |
| "Famotidine pretreatment lowered GDC-0941 exposure by 5-fold, and decreased dasatinib measurable concentrations 30-fold, compared to the pentagastrin-treated dogs." | 1.39 | Pharmacokinetics and absorption of the anticancer agents dasatinib and GDC-0941 under various gastric conditions in dogs--reversing the effect of elevated gastric pH with betaine HCl. ( Dalziel, G; Dean, B; Pang, J; Salphati, L; Ware, JA, 2013) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (33.33) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 4 (66.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Mitra, A | 2 |
| Kesisoglou, F | 3 |
| Pang, J | 1 |
| Dalziel, G | 1 |
| Dean, B | 1 |
| Ware, JA | 1 |
| Salphati, L | 1 |
| Litou, C | 1 |
| Vertzoni, M | 1 |
| Goumas, C | 1 |
| Vasdekis, V | 1 |
| Xu, W | 1 |
| Reppas, C | 1 |
| Beauchamp, M | 1 |
| Zhu, W | 1 |
| Chiti, F | 1 |
| Wu, Y | 1 |
| Russell, TL | 1 |
| Berardi, RR | 1 |
| Barnett, JL | 1 |
| O'Sullivan, TL | 1 |
| Wagner, JG | 1 |
| Dressman, JB | 1 |
| Kuno, M | 1 |
| Sogabe, H | 1 |
| Ito, H | 1 |
| Matsuo, T | 1 |
| Satoh, Y | 1 |
| Motoyama, Y | 1 |
| Tanaka, H | 1 |
1 review available for famotidine and Achlorhydria
| Article | Year |
|---|---|
Impaired drug absorption due to high stomach pH: a review of strategies for mitigation of such effect to enable pharmaceutical product development.
Topics: Absorption; Achlorhydria; Animals; Chemistry, Pharmaceutical; Dogs; Famotidine; Gastric Mucosa; Huma | 2013 |
2 trials available for famotidine and Achlorhydria
| Article | Year |
|---|---|
Characteristics of the Human Upper Gastrointestinal Contents in the Fasted State Under Hypo- and A-chlorhydric Gastric Conditions Under Conditions of Typical Drug - Drug Interaction Studies.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Achlorhydria; Administration, Oral; Adult; Bile Acids and S | 2016 |
pH-related changes in the absorption of dipyridamole in the elderly.
Topics: Achlorhydria; Aged; Aged, 80 and over; Chromatography, High Pressure Liquid; Dipyridamole; Famotidin | 1994 |
3 other studies available for famotidine and Achlorhydria
| Article | Year |
|---|---|
Pharmacokinetics and absorption of the anticancer agents dasatinib and GDC-0941 under various gastric conditions in dogs--reversing the effect of elevated gastric pH with betaine HCl.
Topics: Absorption; Achlorhydria; Animals; Antineoplastic Agents; Betaine; Dasatinib; Dogs; Famotidine; Gast | 2013 |
Using absorption simulation and gastric pH modulated dog model for formulation development to overcome achlorhydria effect.
Topics: Achlorhydria; Animals; Chemistry, Pharmaceutical; Dogs; Famotidine; Humans; Hydrogen-Ion Concentrati | 2011 |
Augmentation of the inhibitory effect of FK480, a CCK-A receptor antagonist, on pancreatic exocrine secretion by achlorhydria.
Topics: Achlorhydria; Amylases; Animals; Benzodiazepines; Benzodiazepinones; Caseins; Dose-Response Relation | 1998 |