falcarindiol has been researched along with Aberrant-Crypt-Foci* in 1 studies
1 other study(ies) available for falcarindiol and Aberrant-Crypt-Foci
| Article | Year |
|---|---|
Dietary Polyacetylenic Oxylipins Falcarinol and Falcarindiol Prevent Inflammation and Colorectal Neoplastic Transformation: A Mechanistic and Dose-Response Study in A Rat Model.
Falcarinol (FaOH) and falcarindiol (FaDOH) are cytotoxic and anti-inflammatory polyacetylenic oxylipins, which are commonly found in the carrot family (Apiaceae). FaOH and FaDOH have previously demonstrated a chemopreventive effect on precursor lesions of colorectal cancer (CRC) in azoxymethane (AOM)-induced rats. The purpose of the present study was to elucidate possible mechanisms of action for the preventive effect of FaOH and FaDOH on colorectal precancerous lesions and to determine how this effect was dependent on dose. Gene expression studies performed by RT-qPCR of selected cancer biomarkers in tissue from biopsies of neoplastic tissue revealed that FaOH and FaDOH downregulated NF-κβ and its downstream inflammatory markers TNFα, IL-6, and COX-2. The dose-dependent anti-neoplastic effect of FaOH and FaDOH in AOM-induced rats was investigated in groups of 20 rats receiving a standard rat diet (SRD) supplemented with 0.16, 0.48, 1.4, 7 or 35 µg FaOH and FaDOH g Topics: Aberrant Crypt Foci; Animals; Anti-Inflammatory Agents; Antineoplastic Agents; Colon; Colorectal Neoplasms; Cytokines; Diynes; Fatty Alcohols; Gene Expression Regulation, Neoplastic; Inflammation; Male; Neoplasms, Experimental; Rats; Rats, Inbred F344; Signal Transduction | 2019 |