Compounds > fadrozole
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fadrozole and Heart Failure

fadrozole has been researched along with Heart Failure in 5 studies

Research

Studies (5)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's5 (100.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Antes, I; Barassin, C; Biemel, K; Hartmann, RW; Marchais-Oberwinkler, S; Müller-Vieira, U; Scherer, C; Voets, M1
Antes, I; Biemel, K; Hartmann, RW; Marchais-Oberwinkler, S; Müller-Vieira, U; Scherer, C; Voets, M1
Birk, B; Grombein, CM; Hartmann, RW; Heim, R; Lucas, S; Müller-Vieira, U; Negri, M; Ries, C; Schewe, KE1
Favre, J; Henry, JP; Jeng, AY; Mellin, V; Monteil, C; Mulder, P; Remy-Jouet, I; Renet, S; Richard, V; Thuillez, C; Vercauteren, M; Webb, RL1
Beugels, IP; Cohuet, GM; de Gooyer, ME; Emmen, JM; Hermans, JJ; Hilbers, PA; Minnaard-Huiban, M; Ottenheijm, HC; Pieterse, K; Plate, R; Roumen, L; Ruijters, E; Smits, JF; van Essen, H1

Other Studies

5 other study(ies) available for fadrozole and Heart Failure

ArticleYear
Heteroaryl-substituted naphthalenes and structurally modified derivatives: selective inhibitors of CYP11B2 for the treatment of congestive heart failure and myocardial fibrosis.
    Journal of medicinal chemistry, 2005, Oct-20, Volume: 48, Issue:21

    Topics: Aromatase; Aromatase Inhibitors; Caco-2 Cells; Cell Membrane Permeability; Cytochrome P-450 CYP11B2; Fibrosis; Heart Failure; Humans; In Vitro Techniques; Liver; Microsomes, Liver; Models, Molecular; Myocardium; Naphthalenes; Schizosaccharomyces; Steroid 11-beta-Hydroxylase; Steroid 17-alpha-Hydroxylase; Structure-Activity Relationship

2005
Synthesis and evaluation of heteroaryl-substituted dihydronaphthalenes and indenes: potent and selective inhibitors of aldosterone synthase (CYP11B2) for the treatment of congestive heart failure and myocardial fibrosis.
    Journal of medicinal chemistry, 2006, Apr-06, Volume: 49, Issue:7

    Topics: Animals; Binding Sites; Cell Line; Cell Membrane Permeability; Cricetinae; Cricetulus; Cytochrome P-450 CYP11B2; Fibrosis; Heart Failure; Humans; Indenes; Models, Molecular; Myocardium; Naphthalenes; Schizosaccharomyces; Structure-Activity Relationship

2006
Overcoming undesirable CYP1A2 inhibition of pyridylnaphthalene-type aldosterone synthase inhibitors: influence of heteroaryl derivatization on potency and selectivity.
    Journal of medicinal chemistry, 2008, Aug-28, Volume: 51, Issue:16

    Topics: Animals; Cytochrome P-450 CYP11B2; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP1A2 Inhibitors; Fibrosis; Heart Failure; Humans; Male; Myocardium; Naphthalenes; Rats; Rats, Wistar; Structure-Activity Relationship

2008
Aldosterone synthase inhibition improves cardiovascular function and structure in rats with heart failure: a comparison with spironolactone.
    European heart journal, 2008, Volume: 29, Issue:17

    Topics: Angiotensin Receptor Antagonists; Animals; Cytochrome P-450 CYP11B2; Endothelium, Vascular; Fadrozole; Heart Failure; Hemodynamics; Ligation; Male; Mineralocorticoid Receptor Antagonists; Oxidative Stress; Rats; Rats, Wistar; Spironolactone; Ventricular Dysfunction, Left; Ventricular Remodeling

2008
Fadrozole reverses cardiac fibrosis in spontaneously hypertensive heart failure rats: discordant enantioselectivity versus reduction of plasma aldosterone.
    Endocrinology, 2008, Volume: 149, Issue:1

    Topics: Aldosterone; Animals; Canrenoic Acid; Collagen Type I; Collagen Type I, alpha 1 Chain; Collagen Type III; Drug Evaluation, Preclinical; Fadrozole; Fibrosis; Gene Expression Regulation; Heart; Heart Failure; Male; Mineralocorticoid Receptor Antagonists; Myocardium; Rats; Rats, Inbred SHR; Stereoisomerism; Structure-Activity Relationship; Treatment Outcome

2008