ezogabine has been researched along with Seizures in 39 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (7.69) | 18.2507 |
| 2000's | 4 (10.26) | 29.6817 |
| 2010's | 24 (61.54) | 24.3611 |
| 2020's | 8 (20.51) | 2.80 |
| Authors | Studies |
|---|---|
| Gao, ZB; Li, JL; Zhao, WM | 1 |
| Bakshi, T; Bhamidipati, R; Brady, P; Cato, M; Chapman, M; Chaudhary, KW; Donovan, B; Dougherty, RW; Downie, D; Fu, T; Higgins, GA; Holenz, J; Kuppusamy, BM; Lin, H; Lluel, P; Madhyastha, N; Matsuoka, Y; Mohd, Z; Morrow, D; Pasikanti, K; Rajagopal, S; Rouget, C; Samanta, SK; Seefeld, MA; Zhen, W | 1 |
| Chen, F; Gao, ZB; Hu, HN; Liu, HN; Liu, J; Nan, FJ; Pi, XP; Tian, FY; Xu, HY; Zhan, L; Zhang, YM | 1 |
| Bankstahl, J; Bankstahl, M; Bloms-Funke, P; Kneip, C; Löscher, W; Schröder, W | 1 |
| Hotta, N; Miyamoto, M; Suzuki, K | 1 |
| Bleakley, LE; McKenzie, CE; Reid, CA | 1 |
| Bazaldua, II; Belchior, H; Bozdemir, E; Brenner, R; Bugay, V; Cavazos, JE; Chun, SH; Dantas, DC; Farmer, A; Holstein, DM; Lechleiter, JD; Shapiro, MS; Stoja, A; Vigil, FA | 1 |
| Kelly, M; Knight, D; Mahida, S; Olson, HE; Poduri, A | 1 |
| Boll, MC; Brickel, N; Cooper, J; Daniluk, J; De'Ath, J; Hewett, K; Joshi, K; McDonald, S; Rayner, K; Tiamkao, S; Vorobyeva, O | 1 |
| Allison, WT; Kanyo, R; Kurata, HT; Li, J; Locskai, LF; Wang, CK | 1 |
| Adamczuk, P; Czuczwar, SJ; Florek-Luszczki, M; Kondrat-Wrobel, MW; Luszczki, JJ; Miziak, B; Wroblewska-Luczka, P; Zagaja, M; Zaluska, K | 1 |
| Dawson-Scully, K; Jia, K; Kelly, SP; Minnerly, J; Risley, MG | 1 |
| Abbott, GW; Manville, RW | 1 |
| Pietrzak, B; Zwierzyńska, E | 1 |
| Ali, SS; Friedman, LK; Naseer, Z; Slomko, AM; Wongvravit, JP | 1 |
| Chen, F; Chen, X; Gao, Z; Li, X; Nan, F; Pi, X; Wang, L; Xu, H; Zhan, L; Zhang, Y; Zhou, P | 1 |
| Assadpour, E; Boehm, S; Gantumur, E; Hilber, K; Koenig, X; Kubista, H; Meyer, C; Treven, M | 1 |
| Czuczwar, SJ; Florek-Luszczki, M; Luszczki, JJ; Miziak, B; Zagaja, M | 1 |
| Cheng, Y; Jia, Q; Li, H; Zhang, F; Zhang, H; Zhao, S | 1 |
| Brandt, C; Daniluk, J; DeRossett, S; Edwards, S; Lerche, H; Lotay, N | 1 |
| Chen, Y; Cheng, Y; Duan, R; Li, H; Li, J; Yuan, J; Zhao, S | 1 |
| Greene, DL; Hoshi, N; Kang, S; Kay, HY; Kosenko, A | 1 |
| Elger, CE; Graf, W; Hamer, HM; Kasper, B; Kull, A; Kurth, C; Nass, RD; Rosenow, F; Steinhoff, BJ; Strzelczyk, A; Surges, R | 1 |
| Deshimaru, M; Hirose, S; Ihara, Y; Ishii, A; Tomonoh, Y; Uchida, T; Zhang, B | 1 |
| Kwan, P; Lim, KS; Lotay, N; White, R | 1 |
| Bastin, ML; Cook, AM; Oyler, DR; Smetana, KS | 1 |
| Czuczwar, SJ; Luszczki, JJ; Raszewski, G; Wu, JZ | 1 |
| Deeks, ED | 1 |
| Forcelli, PA; Gale, K; Kondratyev, A; Lakhkar, A; Soper, C | 1 |
| Hopkins, CR | 1 |
| Craig, D; Fox, D; Paton, F; Rice, S; Woolacott, N | 1 |
| Amabile, CM; Vasudevan, A | 1 |
| Frankel, WN; Otto, JF; White, HS; Wilcox, KS; Yang, Y | 1 |
| Johnson, BN; Qiu, C; Tallent, MK | 1 |
| Bartsch, R; Engel, J; Hönack, D; Kutscher, B; Löscher, W; Polymeropoulos, EE; Rostock, A; Rundfeldt, C; Tober, C; White, HS; Wolf, HH | 1 |
| Bartsch, R; Rostock, A; Rundfeldt, C; Tober, C | 1 |
| Armand, V; Heinemann, U; Rundfeldt, C | 1 |
| Conte, G; De Sarro, A; De Sarro, G; Di Paola, ED; Pasculli, MP | 1 |
6 review(s) available for ezogabine and Seizures
| Article | Year |
|---|---|
[Retigabine - a new antiepileptic drug with a different mechanism of action].
Topics: Adult; Anticonvulsants; Carbamates; Drug Interactions; GABA Modulators; Humans; Lamotrigine; Membrane Transport Modulators; Phenylenediamines; Potassium Channels; Seizures; Triazines | 2013 |
Antiepileptic dosing for critically ill adult patients receiving renal replacement therapy.
Topics: Acetamides; Acute Kidney Injury; Amines; Anticonvulsants; Carbamates; Critical Illness; Cyclohexanecarboxylic Acids; Dibenzazepines; Dose-Response Relationship, Drug; Ethosuximide; Felbamate; Fructose; Gabapentin; gamma-Aminobutyric Acid; Humans; Isoxazoles; Lacosamide; Lamotrigine; Levetiracetam; Phenobarbital; Phenylcarbamates; Phenylenediamines; Phenytoin; Piracetam; Propylene Glycols; Renal Dialysis; Renal Replacement Therapy; Seizures; Topiramate; Triazines; Valproic Acid; Zonisamide | 2016 |
Retigabine (ezogabine): in partial-onset seizures in adults with epilepsy.
Topics: Anticonvulsants; Carbamates; Clinical Trials, Phase II as Topic; Clinical Trials, Phase III as Topic; Epilepsy; Humans; Phenylenediamines; Randomized Controlled Trials as Topic; Seizures | 2011 |
ACS chemical neuroscience molecule spotlight on Potiga (Ezogabine).
Topics: Anticonvulsants; Carbamates; Epilepsy; Humans; KCNQ Potassium Channels; Phenylenediamines; Potassium Channels; Randomized Controlled Trials as Topic; Seizures; United States; United States Food and Drug Administration | 2012 |
Retigabine for the adjunctive treatment of adults with partial-onset seizures in epilepsy with and without secondary generalization : a NICE single technology appraisal.
Topics: Adolescent; Adult; Anticonvulsants; Carbamates; Cost-Benefit Analysis; Decision Support Techniques; Drug Industry; Epilepsies, Partial; Humans; Models, Theoretical; Phenylenediamines; Randomized Controlled Trials as Topic; Seizures; Young Adult | 2013 |
Ezogabine: a novel antiepileptic for adjunctive treatment of partial-onset seizures.
Topics: Animals; Anticonvulsants; Carbamates; Drug Therapy, Combination; Humans; Phenylenediamines; Randomized Controlled Trials as Topic; Seizures | 2013 |
3 trial(s) available for ezogabine and Seizures
| Article | Year |
|---|---|
Safety of retigabine in adults with partial-onset seizures after long-term exposure: focus on unexpected ophthalmological and dermatological events.
Topics: Adult; Anticonvulsants; Carbamates; Double-Blind Method; Drug Administration Schedule; Drug Therapy, Combination; Eye Diseases; Female; Follow-Up Studies; Humans; Male; Middle Aged; Phenylenediamines; Seizures; Skin Diseases; Treatment Outcome | 2020 |
Efficacy and safety of ezogabine/retigabine as adjunctive therapy to specified single antiepileptic medications in an open-label study of adults with partial-onset seizures.
Topics: Aged; Anticonvulsants; Carbamates; Carbamazepine; Dose-Response Relationship, Drug; Drug Therapy, Combination; Epilepsies, Partial; Female; Humans; Kaplan-Meier Estimate; Lamotrigine; Levetiracetam; Male; Middle Aged; Oxcarbazepine; Phenylenediamines; Piracetam; Seizures; Treatment Outcome; Triazines; Valproic Acid | 2015 |
Efficacy and safety of retigabine/ezogabine as adjunctive therapy in adult Asian patients with drug-resistant partial-onset seizures: A randomized, placebo-controlled Phase III study.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Carbamates; Double-Blind Method; Drug Resistant Epilepsy; Epilepsies, Partial; Female; Humans; Male; Middle Aged; Phenylenediamines; Seizures; Skin Pigmentation; Treatment Outcome; Young Adult | 2016 |
30 other study(ies) available for ezogabine and Seizures
| Article | Year |
|---|---|
Identification and Evaluation of Antiepileptic Activity of C21 Steroidal Glycosides from the Roots of Cynanchum wilfordii.
Topics: Animals; Anticonvulsants; Cynanchum; Disease Models, Animal; Glycosides; Mice; Molecular Structure; Plant Roots; Pregnanes; Saponins; Seizures | 2016 |
Novel K
Topics: Animals; Anticonvulsants; Epilepsy; Humans; KCNQ Potassium Channels; Mice; Muscle Contraction; Muscle, Smooth; Protein Isoforms; Seizures; Urinary Bladder | 2018 |
Discovery of HN37 as a Potent and Chemically Stable Antiepileptic Drug Candidate.
Topics: Animals; Anticonvulsants; Carbamates; Disease Models, Animal; Dogs; Drug Design; Drug Evaluation, Preclinical; Drug Stability; Electroshock; Half-Life; Humans; KCNQ Potassium Channels; Mice; Phenylenediamines; Protein Isoforms; Rats; Rats, Sprague-Dawley; Seizures; Structure-Activity Relationship | 2021 |
The novel dual-mechanism Kv7 potassium channel/TSPO receptor activator GRT-X is more effective than the Kv7 channel opener retigabine in the 6-Hz refractory seizure mouse model.
Topics: Animals; Anticonvulsants; Carbamates; CHO Cells; Cricetulus; Dose-Response Relationship, Drug; Electroshock; Male; Mice; Mice, Inbred DBA; Mice, Transgenic; Phenylenediamines; Potassium Channels, Voltage-Gated; Rats; Rats, Sprague-Dawley; Rats, Wistar; Receptors, GABA; Seizures; Treatment Outcome | 2022 |
Lamotrigine and retigabine increase motor threshold in transcranial magnetic stimulation at the dose required to produce an antiepileptic effect against maximal electroshock-induced seizure in rats.
Topics: Animals; Anticonvulsants; Carbamates; Electroshock; Evoked Potentials, Motor; Lamotrigine; Male; Phenylenediamines; Rats; Rats, Sprague-Dawley; Seizures; Transcranial Magnetic Stimulation | 2022 |
Efficacy of antiseizure medication in a mouse model of HCN1 developmental and epileptic encephalopathy.
Topics: Animals; Anticonvulsants; Epilepsy; Epilepsy, Generalized; Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels; Lamotrigine; Mice; Potassium Channels; Seizures; Valproic Acid | 2023 |
Acute Treatment with the M-Channel (K
Topics: Animals; Brain Injuries, Traumatic; Carbamates; Epilepsy, Post-Traumatic; Mice; Seizures | 2023 |
Ezogabine impacts seizures and development in patients with KCNQ2 developmental and epileptic encephalopathy.
Topics: Child, Preschool; Epilepsy; Epilepsy, Generalized; Humans; Infant; KCNQ2 Potassium Channel; Mutation; Retrospective Studies; Seizures | 2023 |
Functional and behavioral signatures of Kv7 activator drug subtypes.
Topics: Anilides; Animals; Animals, Genetically Modified; Anticonvulsants; Bridged Bicyclo Compounds; Calcium; Carbamates; Disease Models, Animal; Drug Resistance; Epilepsy; In Vitro Techniques; KCNQ Potassium Channels; KCNQ2 Potassium Channel; KCNQ3 Potassium Channel; Luminescent Proteins; Membrane Potentials; Mutation; Neurons; Optical Imaging; Patch-Clamp Techniques; Phenylenediamines; Seizures; Zebrafish | 2020 |
Beneficial Combination of Lacosamide with Retigabine in Experimental Animals: An Isobolographic Analysis.
Topics: Acetamides; Animals; Anticonvulsants; Brain; Carbamates; Dose-Response Relationship, Drug; Drug Combinations; Electroshock; Lacosamide; Male; Mice; Phenylenediamines; Psychomotor Performance; Seizures | 2018 |
egl-4 modulates electroconvulsive seizure duration in C. elegans.
Topics: Animals; Anticonvulsants; Caenorhabditis elegans; Caenorhabditis elegans Proteins; Carbamates; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Disease Models, Animal; Electroshock; Phenylenediamines; Recovery of Function; Seizures; Signal Transduction | 2018 |
Ancient and modern anticonvulsants act synergistically in a KCNQ potassium channel binding pocket.
Topics: Animals; Anticonvulsants; Carbamates; Drug Synergism; Hemiterpenes; KCNQ Potassium Channels; Mallotus Plant; Mice; Pentanoic Acids; Phenylenediamines; Phytotherapy; Seizures; Xenopus laevis | 2018 |
Retigabine calms seizure-induced behavior following status epilepticus.
Topics: Animals; Anticonvulsants; Anxiety; Behavior, Animal; Carbamates; Convulsants; Hippocampus; Hyperkinesis; Kainic Acid; Male; Phenylenediamines; Rats; Rats, Sprague-Dawley; Seizures; Status Epilepticus | 2014 |
P-retigabine: an N-propargyled retigabine with improved brain distribution and enhanced antiepileptic activity.
Topics: Action Potentials; Animals; Anticonvulsants; Carbamates; Cells, Cultured; CHO Cells; Cricetulus; Disease Models, Animal; Dose-Response Relationship, Drug; Hippocampus; KCNQ Potassium Channels; Male; Mice; Phenylenediamines; Seizures | 2015 |
The anticonvulsant retigabine is a subtype selective modulator of GABAA receptors.
Topics: Animals; Anticonvulsants; Carbamates; Cells, Cultured; Dose-Response Relationship, Drug; GABA Modulators; Hippocampus; Phenylenediamines; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Seizures | 2015 |
Synergistic Interaction of Retigabine with Levetiracetam in the Mouse Maximal Electroshock-Induced Seizure Model: A Type II Isobolographic Analysis.
Topics: Animals; Brain; Carbamates; Dose-Response Relationship, Drug; Drug Synergism; Drug Therapy, Combination; Electroshock; Levetiracetam; Male; Mice; Models, Statistical; Phenylenediamines; Piracetam; Seizures | 2015 |
Inhibition of Kv7/M Channel Currents by the Local Anesthetic Chloroprocaine.
Topics: Anesthetics, Local; Animals; Carbamates; Dose-Response Relationship, Drug; Ganglia, Spinal; HEK293 Cells; Humans; KCNQ2 Potassium Channel; KCNQ3 Potassium Channel; Membrane Potentials; Neurons; Patch-Clamp Techniques; Phenylenediamines; Potassium Channel Blockers; Procaine; Rats; Rats, Sprague-Dawley; Seizures | 2015 |
Effectiveness of retigabine against levobupivacaine-induced central nervous system toxicity: a prospective, randomized animal study.
Topics: Animals; Anticonvulsants; Bupivacaine; Carbamates; Central Nervous System; KCNQ2 Potassium Channel; Levobupivacaine; Neurons; Phenylenediamines; Prospective Studies; Rabbits; Random Allocation; Seizures | 2016 |
M-current preservation contributes to anticonvulsant effects of valproic acid.
Topics: A Kinase Anchor Proteins; Action Potentials; Animals; Anthracenes; Anticonvulsants; Carbamates; Cells, Cultured; Drug Interactions; Female; Hippocampus; Humans; Kainic Acid; KCNQ2 Potassium Channel; Lipoylation; Male; Mice; Mice, Inbred C57BL; Muscarinic Agonists; Muscarinic Antagonists; Neurons; Phenylenediamines; Phosphorylation; Potassium Channel Blockers; Protein Processing, Post-Translational; Rats; Receptor, Muscarinic M1; Recombinant Fusion Proteins; Seizures; Signal Transduction; Superior Cervical Ganglion; Valproic Acid | 2015 |
Adjunctive retigabine in refractory focal epilepsy: Postmarketing experience at four tertiary epilepsy care centers in Germany.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Carbamates; Child; Death, Sudden, Cardiac; Drug Resistant Epilepsy; Electrocardiography; Epilepsies, Partial; Female; Germany; Humans; Incidence; Male; Middle Aged; Phenylenediamines; Product Surveillance, Postmarketing; Retrospective Studies; Seizures; Tertiary Care Centers; Treatment Outcome; Young Adult | 2016 |
Retigabine, a Kv7.2/Kv7.3-Channel Opener, Attenuates Drug-Induced Seizures in Knock-In Mice Harboring Kcnq2 Mutations.
Topics: Animals; Carbamates; Gene Knock-In Techniques; Humans; Ion Channel Gating; Kainic Acid; KCNQ2 Potassium Channel; KCNQ3 Potassium Channel; Mice; Models, Molecular; Mutation; Phenylenediamines; Protein Structure, Tertiary; Seizures | 2016 |
Isobolographic characterization of interactions of retigabine with carbamazepine, lamotrigine, and valproate in the mouse maximal electroshock-induced seizure model.
Topics: Animals; Anticonvulsants; Avoidance Learning; Behavior, Animal; Brain; Carbamates; Carbamazepine; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Drug Therapy, Combination; Electroshock; Injections, Intraperitoneal; Lamotrigine; Male; Memory; Mice; Motor Activity; Muscle Strength; Phenylenediamines; Psychomotor Performance; Seizures; Triazines; Valproic Acid | 2009 |
Anticonvulsant effect of retigabine during postnatal development in rats.
Topics: Aging; Animals; Animals, Newborn; Anticonvulsants; Carbamates; Convulsants; Dose-Response Relationship, Drug; Epilepsy; Female; Injections, Subcutaneous; Kindling, Neurologic; Pentylenetetrazole; Phenylenediamines; Pregnancy; Rats; Rats, Sprague-Dawley; Seizures | 2012 |
Treating seizures. Achievable control.
Topics: Anticonvulsants; Carbamates; Electric Stimulation Therapy; Humans; Neurosurgical Procedures; Phenylenediamines; Risk Factors; Seizures | 2012 |
Mice carrying the szt1 mutation exhibit increased seizure susceptibility and altered sensitivity to compounds acting at the m-channel.
Topics: Animals; Anticonvulsants; Carbamates; Disease Models, Animal; Electroshock; Female; Genetic Predisposition to Disease; Indoles; KCNQ2 Potassium Channel; KCNQ3 Potassium Channel; Male; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Mice, Mutant Strains; Mutation; Nerve Tissue Proteins; Phenylenediamines; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Voltage-Gated; Pyridines; Receptors, Nicotinic; Seizures; Sequence Deletion | 2004 |
K+ M-current regulates the transition to seizures in immature and adult hippocampus.
Topics: Action Potentials; Animals; Anticonvulsants; Carbamates; Disease Models, Animal; Epilepsy, Benign Neonatal; Hippocampus; Humans; Indoles; Male; Mutation; Phenylenediamines; Potassium Channel Blockers; Potassium Channels, Voltage-Gated; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Seizures | 2007 |
D-23129: a new anticonvulsant with a broad spectrum activity in animal models of epileptic seizures.
Topics: Administration, Oral; Animals; Anticonvulsants; Behavior, Animal; Bicuculline; Carbamates; Dyskinesia, Drug-Induced; Electroshock; Female; Injections, Intraperitoneal; Injections, Subcutaneous; Male; Mice; Mice, Inbred DBA; N-Methylaspartate; Pentylenetetrazole; Phenylenediamines; Postural Balance; Rats; Rats, Wistar; Seizures; Strychnine | 1996 |
D-23129: a potent anticonvulsant in the amygdala kindling model of complex partial seizures.
Topics: Animals; Anticonvulsants; Carbamates; Female; Kindling, Neurologic; Phenylenediamines; Rats; Rats, Wistar; Seizures; Valproic Acid | 1996 |
Effects of retigabine (D-23129) on different patterns of epileptiform activity induced by 4-aminopyridine in rat entorhinal cortex hippocampal slices.
Topics: 4-Aminopyridine; Animals; Anticonvulsants; Bicuculline; Carbamates; Convulsants; Electrophysiology; Entorhinal Cortex; Epilepsy; Excitatory Amino Acid Antagonists; In Vitro Techniques; Phenylenediamines; Rats; Rats, Wistar; Seizures | 1999 |
Influence of retigabine on the anticonvulsant activity of some antiepileptic drugs against audiogenic seizures in DBA/2 mice.
Topics: Animals; Anticonvulsants; Body Temperature; Carbamates; Dose-Response Relationship, Drug; Drug Synergism; Female; Male; Mice; Mice, Inbred DBA; Motor Activity; Phenylenediamines; Seizures | 2001 |