Page last updated: 2024-09-04

ezetimibe and Niemann-Pick Diseases

ezetimibe has been researched along with Niemann-Pick Diseases in 9 studies

*Niemann-Pick Diseases: A group of autosomal recessive disorders in which harmful quantities of lipids accumulate in the viscera and the central nervous system. They can be caused by deficiencies of enzyme activities (SPHINGOMYELIN PHOSPHODIESTERASE) or defects in intracellular transport, resulting in the accumulation of SPHINGOMYELINS and CHOLESTEROL. There are various subtypes based on their clinical and genetic differences. [MeSH]

Research

Studies (9)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	4 (44.44)	29.6817
2010's	5 (55.56)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Altmann, SW; Braun, MP; Bull, HG; Burnett, DA; Chapman, KT; Crona, JH; Davis, HR; Dean, DC; Detmers, PA; Garcia-Calvo, M; Graziano, MP; Hawes, BE; Hughes, M; Iyer, SP; Lisnock, J; Macintyre, DE; Makarewicz, AM; O'neill, KA; Ogawa, A; Shevell, DE; Smith, MM; Tang, YS; Thornberry, NA; Ujjainwalla, F	1
Betters, JL; Yu, L	1
Abuasal, B; Kaddoumi, A; Sylvester, PW	1
Inui, K; Iwayanagi, Y; Suzuki, H; Takada, T; Terada, T; Tomura, F; Yamanashi, Y	1
Adams, MR; Cash, JG; Hui, DY; Konaniah, E	1
Ge, L; Li, BL; Miao, HH; Qi, W; Qu, YX; Song, BL; Wang, LJ	1
Davies, JP; Ioannou, YA	1
Altmann, SW; Crona, JH; Davis, HR; Graziano, MP; Hawes, BE; O'neill, KA; Yao, X	1
Davis, HR; Veltri, EP	1

Reviews

3 review(s) available for ezetimibe and Niemann-Pick Diseases

Article	Year
Transporters as drug targets: discovery and development of NPC1L1 inhibitors. Clinical pharmacology and therapeutics, 2010, Volume: 87, Issue:1 Topics: Amino Acid Sequence; Animals; Azetidines; Drug Delivery Systems; Drug Discovery; Ezetimibe; Humans; Membrane Proteins; Membrane Transport Proteins; Molecular Sequence Data; Niemann-Pick Diseases; Technology, Pharmaceutical	2010
The role of the Niemann-Pick C1-like 1 protein in the subcellular transport of multiple lipids and their homeostasis. Current opinion in lipidology, 2006, Volume: 17, Issue:3 Topics: Animals; Azetidines; Biological Transport; Ezetimibe; Homeostasis; Humans; Lipid Metabolism; Membrane Transport Proteins; Niemann-Pick Diseases	2006
Zetia: inhibition of Niemann-Pick C1 Like 1 (NPC1L1) to reduce intestinal cholesterol absorption and treat hyperlipidemia. Journal of atherosclerosis and thrombosis, 2007, Volume: 14, Issue:3 Topics: Anticholesteremic Agents; Azetidines; Cholesterol, LDL; Ezetimibe; Humans; Hypercholesterolemia; Hyperlipidemias; Intestinal Absorption; Intestinal Mucosa; Intestines; Membrane Proteins; Membrane Transport Proteins; Niemann-Pick Diseases	2007

Other Studies

6 other study(ies) available for ezetimibe and Niemann-Pick Diseases

Article	Year
The target of ezetimibe is Niemann-Pick C1-Like 1 (NPC1L1). Proceedings of the National Academy of Sciences of the United States of America, 2005, Jun-07, Volume: 102, Issue:23 Topics: Animals; Azetidines; Binding Sites; Cell Line; Cell Membrane; Enterocytes; Ezetimibe; Humans; Intestinal Mucosa; Intestines; Macaca mulatta; Membrane Proteins; Membrane Transport Proteins; Mice; Mice, Inbred C57BL; Microvilli; Niemann-Pick Diseases; Protein Binding; Proteins; Rats; Rats, Sprague-Dawley; Species Specificity	2005
Intestinal absorption of gamma-tocotrienol is mediated by Niemann-Pick C1-like 1: in situ rat intestinal perfusion studies. Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:6 Topics: Animals; Anticholesteremic Agents; Azetidines; Biological Transport; Chromans; Ezetimibe; Ileum; Intestinal Absorption; Intestinal Mucosa; Jejunum; Male; Niemann-Pick Diseases; Perfusion; Rats; Rats, Sprague-Dawley; Vitamin E	2010
Human NPC1L1 expression is positively regulated by PPARα. Pharmaceutical research, 2011, Volume: 28, Issue:2 Topics: Azetidines; Cholesterol; Electrophoretic Mobility Shift Assay; Enterocytes; Ezetimibe; Fenofibrate; Gene Expression Regulation; Hep G2 Cells; Humans; Intestinal Absorption; Intestinal Mucosa; Intestines; Membrane Proteins; Membrane Transport Proteins; Niemann-Pick Diseases; PPAR alpha; PPAR gamma; Protein Binding; Response Elements	2011
Use of NBD-cholesterol to identify a minor but NPC1L1-independent cholesterol absorption pathway in mouse intestine. American journal of physiology. Gastrointestinal and liver physiology, 2011, Volume: 300, Issue:1 Topics: 4-Chloro-7-nitrobenzofurazan; Animals; Azetidines; Cholesterol; Cholesterol, Dietary; Ezetimibe; Intestinal Absorption; Membrane Transport Proteins; Mice; Niemann-Pick Diseases; Poloxamer	2011
Flotillins play an essential role in Niemann-Pick C1-like 1-mediated cholesterol uptake. Proceedings of the National Academy of Sciences of the United States of America, 2011, Jan-11, Volume: 108, Issue:2 Topics: Animals; Anticholesteremic Agents; Azetidines; Cholesterol; Ezetimibe; Green Fluorescent Proteins; Homeostasis; Humans; Membrane Proteins; Membrane Transport Proteins; Mice; Microscopy, Confocal; Microscopy, Fluorescence; Niemann-Pick Diseases; Rats	2011
In vivo responsiveness to ezetimibe correlates with niemann-pick C1 like-1 (NPC1L1) binding affinity: Comparison of multiple species NPC1L1 orthologs. Molecular pharmacology, 2007, Volume: 71, Issue:1 Topics: Amino Acid Sequence; Animals; Anticholesteremic Agents; Azetidines; Binding Sites; Cells, Cultured; Cholesterol; Cloning, Molecular; DNA, Complementary; Ezetimibe; Humans; Intestinal Absorption; Membrane Proteins; Membrane Transport Proteins; Models, Molecular; Molecular Sequence Data; Niemann-Pick Diseases; Protein Conformation; Rats	2007