Compounds > ezetimibe

Page last updated: 2024-09-04

ezetimibe and Niemann-Pick Disease

ezetimibe has been researched along with Niemann-Pick Disease in 9 studies

Research

Studies (9)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	4 (44.44)	29.6817
2010's	5 (55.56)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Altmann, SW; Braun, MP; Bull, HG; Burnett, DA; Chapman, KT; Crona, JH; Davis, HR; Dean, DC; Detmers, PA; Garcia-Calvo, M; Graziano, MP; Hawes, BE; Hughes, M; Iyer, SP; Lisnock, J; Macintyre, DE; Makarewicz, AM; O'neill, KA; Ogawa, A; Shevell, DE; Smith, MM; Tang, YS; Thornberry, NA; Ujjainwalla, F	1
Betters, JL; Yu, L	1
Abuasal, B; Kaddoumi, A; Sylvester, PW	1
Inui, K; Iwayanagi, Y; Suzuki, H; Takada, T; Terada, T; Tomura, F; Yamanashi, Y	1
Adams, MR; Cash, JG; Hui, DY; Konaniah, E	1
Ge, L; Li, BL; Miao, HH; Qi, W; Qu, YX; Song, BL; Wang, LJ	1
Davies, JP; Ioannou, YA	1
Altmann, SW; Crona, JH; Davis, HR; Graziano, MP; Hawes, BE; O'neill, KA; Yao, X	1
Davis, HR; Veltri, EP	1

Reviews

3 review(s) available for ezetimibe and Niemann-Pick Disease

Article	Year
Transporters as drug targets: discovery and development of NPC1L1 inhibitors. Clinical pharmacology and therapeutics, 2010, Volume: 87, Issue:1 Topics: Amino Acid Sequence; Animals; Azetidines; Drug Delivery Systems; Drug Discovery; Ezetimibe; Humans; Membrane Proteins; Membrane Transport Proteins; Molecular Sequence Data; Niemann-Pick Diseases; Technology, Pharmaceutical	2010
The role of the Niemann-Pick C1-like 1 protein in the subcellular transport of multiple lipids and their homeostasis. Current opinion in lipidology, 2006, Volume: 17, Issue:3 Topics: Animals; Azetidines; Biological Transport; Ezetimibe; Homeostasis; Humans; Lipid Metabolism; Membrane Transport Proteins; Niemann-Pick Diseases	2006
Zetia: inhibition of Niemann-Pick C1 Like 1 (NPC1L1) to reduce intestinal cholesterol absorption and treat hyperlipidemia. Journal of atherosclerosis and thrombosis, 2007, Volume: 14, Issue:3 Topics: Anticholesteremic Agents; Azetidines; Cholesterol, LDL; Ezetimibe; Humans; Hypercholesterolemia; Hyperlipidemias; Intestinal Absorption; Intestinal Mucosa; Intestines; Membrane Proteins; Membrane Transport Proteins; Niemann-Pick Diseases	2007

Other Studies

6 other study(ies) available for ezetimibe and Niemann-Pick Disease

Article	Year
The target of ezetimibe is Niemann-Pick C1-Like 1 (NPC1L1). Proceedings of the National Academy of Sciences of the United States of America, 2005, Jun-07, Volume: 102, Issue:23 Topics: Animals; Azetidines; Binding Sites; Cell Line; Cell Membrane; Enterocytes; Ezetimibe; Humans; Intestinal Mucosa; Intestines; Macaca mulatta; Membrane Proteins; Membrane Transport Proteins; Mice; Mice, Inbred C57BL; Microvilli; Niemann-Pick Diseases; Protein Binding; Proteins; Rats; Rats, Sprague-Dawley; Species Specificity	2005
Intestinal absorption of gamma-tocotrienol is mediated by Niemann-Pick C1-like 1: in situ rat intestinal perfusion studies. Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:6 Topics: Animals; Anticholesteremic Agents; Azetidines; Biological Transport; Chromans; Ezetimibe; Ileum; Intestinal Absorption; Intestinal Mucosa; Jejunum; Male; Niemann-Pick Diseases; Perfusion; Rats; Rats, Sprague-Dawley; Vitamin E	2010
Human NPC1L1 expression is positively regulated by PPARα. Pharmaceutical research, 2011, Volume: 28, Issue:2 Topics: Azetidines; Cholesterol; Electrophoretic Mobility Shift Assay; Enterocytes; Ezetimibe; Fenofibrate; Gene Expression Regulation; Hep G2 Cells; Humans; Intestinal Absorption; Intestinal Mucosa; Intestines; Membrane Proteins; Membrane Transport Proteins; Niemann-Pick Diseases; PPAR alpha; PPAR gamma; Protein Binding; Response Elements	2011
Use of NBD-cholesterol to identify a minor but NPC1L1-independent cholesterol absorption pathway in mouse intestine. American journal of physiology. Gastrointestinal and liver physiology, 2011, Volume: 300, Issue:1 Topics: 4-Chloro-7-nitrobenzofurazan; Animals; Azetidines; Cholesterol; Cholesterol, Dietary; Ezetimibe; Intestinal Absorption; Membrane Transport Proteins; Mice; Niemann-Pick Diseases; Poloxamer	2011
Flotillins play an essential role in Niemann-Pick C1-like 1-mediated cholesterol uptake. Proceedings of the National Academy of Sciences of the United States of America, 2011, Jan-11, Volume: 108, Issue:2 Topics: Animals; Anticholesteremic Agents; Azetidines; Cholesterol; Ezetimibe; Green Fluorescent Proteins; Homeostasis; Humans; Membrane Proteins; Membrane Transport Proteins; Mice; Microscopy, Confocal; Microscopy, Fluorescence; Niemann-Pick Diseases; Rats	2011
In vivo responsiveness to ezetimibe correlates with niemann-pick C1 like-1 (NPC1L1) binding affinity: Comparison of multiple species NPC1L1 orthologs. Molecular pharmacology, 2007, Volume: 71, Issue:1 Topics: Amino Acid Sequence; Animals; Anticholesteremic Agents; Azetidines; Binding Sites; Cells, Cultured; Cholesterol; Cloning, Molecular; DNA, Complementary; Ezetimibe; Humans; Intestinal Absorption; Membrane Proteins; Membrane Transport Proteins; Models, Molecular; Molecular Sequence Data; Niemann-Pick Diseases; Protein Conformation; Rats	2007