exudates and Meningioma

Meningioma, is the second most frequent intracranial tumor in Malaysia and are classified according to the World Health Organization classification. The relationship of p53 protein in the determination of meningioma grading and their influencing factors were studied via immunohistochemistry studies on 77 intracranial meningiomas (67 benign, 10 atypical). The higher the p53 reaction was correlated to the poorer the histological grade (19.4% in benign and 90% in atypical meningioma) (p < 0.001). Other variables like age, sex, ethnicity, demographic location, surgical clearance, midline shift and contrast enhancement of CT Scan Brain and clinical features were found not to be significant.

Topics: Aged; Brain Neoplasms; Cross-Sectional Studies; Female; Humans; Immunohistochemistry; Malaysia; Male; Meningioma; Middle Aged; Neurosurgery; Tumor Suppressor Protein p53

Precision Radiotherapy at high doses require a fixed, referable target point. The frame system fulfills the required criteria by making the target point relocatable and fixed within a stereotactic space. Since December 2001, we have treated 28 central and peripheral nervous system lesions using either radiosurgery as a single high dose fraction or fractionated 3-dimensional conformal radiotherapy using a lower dose and a multi-leaf collimator. Various pathological lesions either benign or malignant were treated. Eighty six percent of our treated lesions showed growth restraint, preventing them from causing new symptoms with a median follow-up duration of 20.5 months. However, the true benefit from this technique would require a long-term follow-up to document the progress.

Topics: Adolescent; Adult; Aged; Arteriovenous Malformations; Brain Neoplasms; Female; Head and Neck Neoplasms; Humans; Intracranial Arteriovenous Malformations; Malaysia; Male; Meningioma; Middle Aged; Neuroma, Acoustic; Prospective Studies; Radiosurgery; Radiotherapy, Conformal

The aim of this study was to determine the factors for the large size of intracranial meningiomas at the time of presentation to the Sarawak General Hospital. The data was collected prospectively from 1/3/2000 to 28/2/2001. During this period a total of 57 cases of intracranial tumours were operated upon. Twenty of these cases (35%) were meningioma, making meningioma the most common intracranial tumour operated in the Neurosurgery service here with one to two cases operated per month. Headache was the most common symptom. The average duration of symptoms before the diagnosis was made was twenty-five months, the longest being fifteen years. The patients needed an average of seven visits prior to the diagnosis.

Topics: Brain Neoplasms; Female; Hospitals, General; Humans; Malaysia; Male; Meningioma; Middle Aged

Topics: Adenoma; Adolescent; Adult; Attitude to Health; Brain Neoplasms; Child; Craniopharyngioma; Ependymoma; Ethnicity; Female; Geography; Glioma; Hemangiosarcoma; Humans; Malaysia; Male; Meningioma; Neoplasm Metastasis; Neurilemmoma; Pinealoma; Pituitary Neoplasms; Sarcoma; Skull Neoplasms; Socioeconomic Factors; Time Factors