exudates and Hyperplasia

Labisia pumila (Myrsinaceae), is a popular herb among the women in Malaysia known locally as "Kacip Fatimah". Recently many nutraceutical products containing the powdered or extracted parts of the plant have become available for women's health care. However no evaluation of the effect of the repeated dosing of any herbal product of this plant had been undertaken prior to a 28-day sub-acute study presented in this report. The results showed that a dose of 50mg/kg of an aqueous extract of L. pumila corresponded to no-adverse-effect-level (NOAEL), whereas higher doses were associated with some toxicity concerns.

Topics: Animals; Bile Ducts, Intrahepatic; Clinical Chemistry Tests; Dietary Supplements; Dose-Response Relationship, Drug; Female; Hematologic Tests; Hyperplasia; Kidney; Liver; Longevity; Lung; Malaysia; Male; No-Observed-Adverse-Effect Level; Plant Extracts; Plants, Medicinal; Primulaceae; Rats; Rats, Wistar; Toxicity Tests; Urinalysis

Some two-thirds of colorectal carcinomas arise from adenomatous polyps, and as such, screening by colonoscopy and polyp removal should significantly reduce colorectal cancer. This has not been the case, as evidenced by recent studies, which revealed that endoscopy failed to prevent up to 50% of all subsequent carcinomas. Flat or depressed adenomas, frequently reported from Japan but rarely elsewhere, might explain the 'missed carcinomas.' Detection of flat adenomas has not been previously reported from Malaysia.. In the present prospective study, 426 consecutive patients underwent colonoscopic examination between March 1997 and January 2000, for a variety of bowel symptoms. The examinations were performed by an experienced endoscopist using a standard colonoscope and methylene blue dye spraying technique. Macroscopically, flat adenomas were defined using the criteria proposed by Sawada.. Twenty-nine adenomas were identified in 12 patients, of which 15 were polypoid and 14 were flat, with no depressed lesions. Eight polypoidal lesions and all the flat adenomas contained mild or moderate areas of epithelial dysplasia. Seven severely dysplastic polyps were identified. One Duke's A polypoidal cancer and two advanced carcinomas were also found. All the severely dysplastic lesions and Duke's A carcinomas were found in polyps greater than 10 mm in mean size. The flat adenomas were all less than 5 mm in size.. A significant proportion of colonic adenomas in Malaysian patients appear as small flat lesions, which could easily be missed during endoscopy. Increased recognition and treatment of flat adenomas among colonoscopists is warranted.

Topics: Adenoma; Adult; Aged; Aged, 80 and over; Colonic Neoplasms; Colonic Polyps; Colonoscopy; Female; Humans; Hyperplasia; Malaysia; Male; Middle Aged; Prospective Studies; Severity of Illness Index

Topics: Aged; Antibodies, Bacterial; Diagnosis, Differential; Facial Dermatoses; Female; Hemagglutination Tests; Humans; Hyperplasia; Leprosy; Malaysia; Male; Middle Aged; Sebaceous Gland Diseases; Treponema pallidum; Yaws