exudates and Histoplasmosis

Topics: Adolescent; Adult; Aged; Animals; Child; Diagnosis, Differential; Epidemiologic Methods; Female; Histoplasma; Histoplasmin; Histoplasmosis; Humans; India; Indonesia; Japan; Malaysia; Male; Middle Aged; Singapore; Skin Tests; Soil Microbiology; Thailand; Vietnam

Topics: Animals; Australia; Birds; Communicable Disease Control; Ecosystem; Environmental Exposure; Feces; Harm Reduction; Histoplasma; Histoplasmosis; Humans; Malaysia; Public Health Practice; Societies, Medical; Soil Microbiology

A 40-year-old man presented with chronic mouth ulcer for the last six months. Histopathological examination of the biopsy from the lesion confirmed a diagnosis of histoplasmosis. Although histoplasmosis commonly manifests in immunocompromized patients, like HIV, the present case was negative for HIV. Histoplasmosis is endemic in certain parts of the world and it is comparatively rare in the South Asian region, particularly Malaysia. Thirty-seven cases of histoplasmosis were reported from Malaysia (Ng and Siar, 1996), between July 1967 and October 1997. Despite the apparent rarity of the disease, clinicians and pathologists should be aware of the possibility of histoplasmosis when cases of oral ulcer are encountered.

Topics: Adult; Biopsy; Chronic Disease; Diagnosis, Differential; Histoplasma; Histoplasmosis; HIV Seronegativity; Humans; Malaysia; Male; Mouth Diseases; Oral Ulcer

We reviewed biopsy records for 37 cases of oral histoplasmosis for patient characteristics, clinical features, and histopathologic findings. These represented cases diagnosed in the Division of Stomatology, Institute for Medical Research, Kuala Lumpur between July 1967 and October 1994. All were male patients who ranged in age from 11 to 79 years (mean age, 56.7 years). There were 40.6% Malays, 37.8% Chinese, 18.9% Indians, and 2.7% other races. Five patients with mouth lesions as the initial presenting lesions were proven to be cases of disseminated histoplasmosis. In the remaining cases apart from the biopsy-proven oral histoplasmosis lesions, the extent of the disease elsewhere was unknown. The majority of these lesions involved the gingiva, tongue, and palate in decreasing order of frequency. The most frequent presenting symptom was oral mucosal ulceration. Squamous cell carcinoma and tuberculosis were the two most common clinical differential diagnoses. Our present findings compare favorably with published reports from other regions.

Topics: Adolescent; Adult; Carcinoma, Squamous Cell; Child; Diagnosis, Differential; Ethnicity; Histoplasmosis; Humans; Malaysia; Male; Mouth Diseases; Mouth Neoplasms; Tuberculosis, Oral

Topics: Adult; Aged; Antigen-Antibody Reactions; Drug Hypersensitivity; Ethnicity; Female; Health Surveys; Histoplasmin; Histoplasmosis; Humans; Hypersensitivity, Delayed; Malaysia; Male; Mass Screening; Middle Aged; Mycobacterium Infections; Skin Tests; Tuberculin Test

Topics: Histoplasmosis; Humans; Malaysia

Topics: Adolescent; Animals; Child; Chiroptera; Complement Fixation Tests; Culicidae; Epidemiology; Histoplasmin; Histoplasmosis; Humans; Malaysia; Radiography, Thoracic; Skin Tests; Sputum; Tuberculin Test

Topics: Adolescent; Diagnosis, Differential; Histoplasma; Histoplasmin; Histoplasmosis; Hospitals; Humans; Malaysia; Skin Tests; Thoracic Diseases

Topics: Borneo; Epidemiology; Histoplasmin; Histoplasmosis; Malaysia