exudates and Endocarditis--Bacterial

Heart valve disease comprises a cluster of conditions affecting the aortic, mitral, pulmonary and tricuspid valves. This paper reviews all the research on heart valve disease in Malaysia published between the years 2000- 2016.. The methodology was based on the search process described in the paper, "Bibliography of clinical research in Malaysia: methods and brief results". The search databases included PubMed, Scopus and several Malaysian journals such as MyJurnal and UKM Journal Repository, by using the following keywords: (heart valve disease OR infective endocarditis OR rheumatic heart disease) and (Malaysia).. In all 94 papers were identified of which 39 papers were selected and reviewed on the basis of their relevance. The local studies contributed to the knowledge and understanding of the epidemiology, aetiology, pathophysiology, clinical presentations, investigations, treatment, and outcomes of heart valve disease in the country.. The clinical relevance of the studies performed in the country is discussed along with recommendations for future research.

Topics: Endocarditis, Bacterial; Heart Valve Diseases; Humans; Malaysia; Rheumatic Heart Disease; Tricuspid Valve

Staphylococcus has replaced streptococcus as the most common cause of infective endocarditis (IE) in developed health care systems. The trend in developing countries is less clear.. To examine the epidemiological trends of infective endocarditis in a developing nation.. Single-centre, retrospective study of patients admitted with IE to a tertiary hospital in Malaysia over a 12-year period.. The analysis included 182 patients (n = 153 Duke's definite IE, n = 29 possible IE). The mean age was 51 years. Rheumatic heart disease was present in 42%, while 7.6% were immunocompromised. IE affected native valves in 171 (94%) cases. Health-care associated IE (HCAIE) was recorded in 68 (37.4%). IE admission rates increased from 25/100,000 admissions (2012) to 59/100,000 admissions (2017). At least one major complication on admission was detected in 59 (32.4%) patients. Left-sided IE was more common than right-sided IE [n = 159 (87.4%) vs. n = 18 (9.9%)]. Pathogens identified by blood culture were staphylococcus group [n = 58 (40.8%)], streptococcus group [n = 51 (35.9%)] and Enterococcus species [n = 13 (9.2%)]. staphylococcus infection was highest in the HCAIE group. In-hospital death occurred in 65 (35.7%) patients. In-hospital surgery was performed for 36 (19.8%) patients. At least one complication was documented in 163 (85.7%).. Staphylococcus is the new etiologic champion, reflecting the transition of the healthcare system. Streptococcus is still an important culprit organism. The incidence rate of IE appears to be increasing. The rate of patients with underlying rheumatic heart disease is still high.

Topics: Adult; Aged; Anti-Bacterial Agents; Cross Infection; Developing Countries; Endocarditis, Bacterial; Female; Humans; Malaysia; Male; Microbial Sensitivity Tests; Middle Aged; Prevalence; Retrospective Studies; Staphylococcal Infections; Staphylococcus aureus; Streptococcus; Young Adult

Topics: Adult; Endocarditis, Bacterial; Enterococcus faecalis; Hospitals, General; Humans; Malaysia; Male; Middle Aged; Staphylococcal Infections; Streptococcal Infections; Substance-Related Disorders

Topics: Child; Child, Preschool; Dental Caries; Endocarditis, Bacterial; Female; Heart Defects, Congenital; Humans; Malaysia; Male; Rheumatic Heart Disease; Risk