exudates and Cystic-Fibrosis

exudates has been researched along with Cystic-Fibrosis* in 8 studies

Reviews

1 review(s) available for exudates and Cystic-Fibrosis

ArticleYear
International perspectives on the implementation of reproductive carrier screening.
    Prenatal diagnosis, 2020, Volume: 40, Issue:3

    Reproductive carrier screening started in some countries in the 1970s for hemoglobinopathies and Tay-Sachs disease. Cystic fibrosis carrier screening became possible in the late 1980s and with technical advances, screening of an ever increasing number of genes has become possible. The goal of carrier screening is to inform people about their risk of having children with autosomal recessive and X-linked recessive disorders, to allow for informed decision making about reproductive options. The consequence may be a decrease in the birth prevalence of these conditions, which has occurred in several countries for some conditions. Different programs target different groups (high school, premarital, couples before conception, couples attending fertility clinics, and pregnant women) as does the governance structure (public health initiative and user pays). Ancestry-based offers of screening are being replaced by expanded carrier screening panels with multiple genes that is independent of ancestry. This review describes screening in Australia, Cyprus, Israel, Italy, Malaysia, the Netherlands, Saudi Arabia, the United Kingdom, and the United States. It provides an insight into the enormous variability in how reproductive carrier screening is offered across the globe. This largely relates to geographical variation in carrier frequencies of genetic conditions and local health care, financial, cultural, and religious factors.

    Topics: Abortion, Induced; Australia; Cyprus; Cystic Fibrosis; Female; Genetic Carrier Screening; Genetic Testing; Hemoglobinopathies; Heterozygote; Humans; Internationality; Israel; Italy; Malaysia; Netherlands; Pregnancy; Preimplantation Diagnosis; Prenatal Diagnosis; Saudi Arabia; Tay-Sachs Disease; Thalassemia; United Kingdom; United States

2020

Other Studies

7 other study(ies) available for exudates and Cystic-Fibrosis

ArticleYear
Relapse of chronic melioidosis in a paediatric cystic fibrosis patient: first case report from Malaysia.
    BMC infectious diseases, 2018, Sep-05, Volume: 18, Issue:1

    Burkholderia pseudomallei is the causative agent of melioidosis, which is a potentially life threatening disease endemic in Southeast Asian countries. In Malaysia, cystic fibrosis (CF) is an uncommon condition. The association between CF and B.pseudomallei infections has been reported previously. However, this is the first case report of a pediatric melioidosis relapse and co-infection with other Gram-negative bacteria in Malaysia.. A 14-year-old Chinese Malaysian boy presented with a history of recurrent pneumonia, poor growth and steatorrhoea since childhood, and was diagnosed with CF. B. pseudomallei was cultured from his sputum during three different admissions between 2013 and 2016. However, the patient succumbed to end stage of respiratory failure in 2017 despite antibiotics treatment against B.pseudomallei. The isolates were compared using multilocus-sequence typing and repetitive-element polymerase chain reaction (PCR), and confirmed that two of the isolates were of same sequence type, which may indicate relapse.. CF patients should be aware of melioidosis in endemic regions, as it is an emerging infectious disease, especially when persistent or recurrent respiratory symptoms and signs of infection occur. The high prevalence rates of melioidosis in Malaysia warrants better management options to improve quality of life, and life expectancy in patients with CF. Travel activities to endemic regions should also be given more consideration, as this would be crucial to identify and initiate appropriate empiric treatment.

    Topics: Adolescent; Anti-Bacterial Agents; Burkholderia pseudomallei; Chronic Disease; Cystic Fibrosis; DNA, Bacterial; Humans; Malaysia; Male; Melioidosis; Multilocus Sequence Typing; Pneumonia; Recurrence; Sputum; Tomography, X-Ray Computed

2018
Chronic suppurative lung disease in a developing country: impact on child and parent.
    Pediatric pulmonology, 2014, Volume: 49, Issue:5

    To investigate the impact of chronic suppurative lung disease (CSLD) on growth and lung function in the child as well as quality of life of the child and parent.. Cross-sectional study in 60 children with CSLD, bronchiectasis (including cystic fibrosis) and bronchiolitis obliterans. Thirty-five parents were interviewed while the remaining patients' data were collated from medical notes. Anthropometric measurements at first diagnosis and at interview were compared. The most recent lung function was also collected. The Parent Cough-Specific Quality of Life (PC-QOL) and the Depression, Anxiety and Stress (DASS21) questionnaires were administered to parents.. The median (range) age at diagnosis was 1.3 (0.2-11) years. The median (IQR) duration between anthropometric measurements was 35 (15, 59) months. Children with cystic fibrosis (CF) had improvements both in weight and BMI, whereas children with non-CF CSLD had no improvements in any growth parameter. Seventy-eight percent of children who performed spirometry had values <80% of normal predicted value. PC-QOL scores were low. Frequent exacerbations (more than twice in the past 6 months) and cough (more than 2 days/week) were not associated with significantly lower PC-QOL scores. Seventy-seven percent of interviewed parents had abnormal DASS21 scores with 54% being stressed and 51% being depressed. Mental health was better in parents of children with CF.. CSLD had a negative impact on growth, lung function, and quality of life. Children with CF had a better outcome in growth as well as better parental mental health compared to children with other etiologies. Pediatr Pulmonol. 2014; 49:435-440. © 2013 Wiley Periodicals, Inc.

    Topics: Adolescent; Anxiety; Bronchiectasis; Bronchiolitis Obliterans; Child; Child Development; Child, Preschool; Cough; Cross-Sectional Studies; Cystic Fibrosis; Depression; Developing Countries; Female; Humans; Infant; Malaysia; Male; Parents; Quality of Life; Spirometry; Stress, Psychological; Surveys and Questionnaires

2014
First study of the F508del mutation in Malaysian children diagnosed with cystic fibrosis.
    Journal of paediatrics and child health, 2011, Volume: 47, Issue:8

    Topics: Child; Child, Preschool; Consanguinity; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; DNA Primers; Female; Genotype; Humans; Infant; Malaysia; Male; Mutation; Retrospective Studies; Sequence Deletion

2011
Detection of F508del mutation in cystic fibrosis transmembrane conductance regulator gene mutation among Malays.
    Singapore medical journal, 2006, Volume: 47, Issue:2

    Cystic fibrosis (CF) is one of the common genetic disorders in the western world. It has been reported to be very rare in Asian populations. According to the Cystic Fibrosis Genetic Analysis Consortium, more than 1,000 mutations of the CF gene have been identified. The CF gene, named the cystic fibrosis transmembrane conductance regulator (CFTR), is located on chromosome 7 and composed of 27 exons. This study aims to detect possible CFTR gene mutations in Malays.. We analysed 50 blood samples from healthy Malays with no symptoms of CF. DNA was extracted from blood using commercially available extraction kits (Eppendorf, Germany). Identification of CFTR gene mutation was performed using the CF OLA (Oligonucleotide Ligation Assay) kit (Applied Biosystems, USA). The PCR-ligation products were electrophoresed on eight percent sequagel using an ABI PRISM 377 genetic analyser (Applied Biosystems, USA). Electrophoresis data was analysed using the Genotyper software and a report of the CF genotype for all loci tested was created using the CF Genotyper Template software. Out of 50, one sample (two percent) was detected to have the F508del mutation (3bp deletion at exon 10), which is one of the most common CFTR gene mutations in Caucasians.. The F508del mutation allele was detected in one subject. This indicates that she was a CF carrier.. We report the finding of a carrier of the F508del mutation of the CFTR gene in the Malay population. Our finding revealed that CF could also affect the Malay population. Larger studies are necessary to determine the exact gene frequency of this population.

    Topics: Asian People; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Heterozygote; Humans; Malaysia; Mutation

2006
Unrecognised infection in a cystic fibrosis patient.
    Journal of paediatrics and child health, 2006, Volume: 42, Issue:4

    We report a 17-year-old Malay boy with cystic fibrosis who over a 14-month period experienced worsening respiratory symptoms and deteriorating lung function. Burkholderia pseudomallei was eventually isolated from his sputum. He improved clinically following treatment for meliodosis and his lung function returned to normal.

    Topics: Adolescent; Anti-Bacterial Agents; Burkholderia pseudomallei; Cystic Fibrosis; Humans; Malaysia; Male; Melioidosis; Pseudomonas; Sputum; Staphylococcus aureus

2006
Cystic fibrosis in Malaysian children.
    The Medical journal of Malaysia, 2005, Volume: 60, Issue:1

    Cystic fibrosis (CF) is an autosomal recessive disease commonly found among the Caucasian population. The availability of sweat test and with increasing experience have made it possible to diagnose more cases of CF. Our first case of CF was diagnosed 16 years ago and to date we have managed sixteen cases of CF. Sixteen children were diagnosed with CF in our units at the Paediatric Institute and University Malaya Medical Centre (UMMC). They were referred with either one or all of the following symptoms: i) recurrent pneumonia, ii) bronchiectasis, iii) failure to thrive, iii) malabsorption or iv) history of meconium ileus obstruction during the neonatal period. When the clinical features suggested strongly of CF, sweat tests will be performed in duplicates and considered positive when the sweat chloride or sweat sodium was more than 60 mmol/l for both results. Seventy- two hours fecal fat excretion or stool for fat globule was performed to document malabsorption. From the year 1987 to 2003, 16 patients were confirmed to have cystic fibrosis in Malaysia by positive sweat tests. Thirteen patients were diagnosed in Paediatric Institute while the remaining three were diagnosed in UMMC. On follow-up two patients died due to severe bronchopneumonia at the age of two years old. Although once considered rare, CF should now be considered in any children with clinical presentations of recurrent chest infections, bronchiectasis, in the presence or absence of malabsoption stmptoms and in neonates with meconium ileus obstruction.

    Topics: Child; Child, Preschool; Cystic Fibrosis; Female; Humans; Infant; Malaysia; Male

2005
Analysis of fliC variation among clinical isolates of Burkholderia cepacia.
    Journal of medical microbiology, 1999, Volume: 48, Issue:7

    PCR and restriction fragment length polymorphism (RFLP) typing of flagellin genes (fliC) from 57 clinical isolates of Burkholderia cepacia indicated that only type 11 flagellins were present. Twenty-two isolates previously identified as the epidemic UK cystic fibrosis strain were indistinguishable by this method, as were 11 isolates from a pseudo-outbreak in Senegal. Other clinical isolates, including 19 from disparate sources in Malaysia, were separated into nine fliC RFLP groups, exhibiting a large degree of divergence. When isolates were indistinguishable by fliC genotyping, their similarity was confirmed by whole genome macro-restriction analysis with pulsed-field gel electrophoresis following XbaI digestion. The variation in fliC sequences of B. cepacia was far greater than that with B. pseudomallei, supporting the view that 'B. cepacia', as currently defined, may comprise several different genomic species.

    Topics: Burkholderia cepacia; Burkholderia Infections; Cystic Fibrosis; Deoxyribonucleases, Type II Site-Specific; DNA Primers; Electrophoresis, Agar Gel; Electrophoresis, Gel, Pulsed-Field; Flagellin; Genetic Variation; Humans; Image Processing, Computer-Assisted; Malaysia; Phylogeny; Polymerase Chain Reaction; Polymorphism, Restriction Fragment Length; RNA, Bacterial; Senegal; United Kingdom

1999