exudates and Carcinoma--Basal-Cell

There has been a rising incidence of skin cancers among Asians in recent years. We present a retrospective analysis of 106 skin cancers and analysed the demography, clinical subtypes of skin cancers and surgical techniques used for skin cancer treatment. In our population, skin cancers were most frequently basal cell carcinomas and diagnosed among ethnic Chinese patients.

Topics: Aged; Aged, 80 and over; Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Ethnicity; Female; Humans; Lymphoma, T-Cell, Cutaneous; Malaysia; Male; Middle Aged; Paget Disease, Extramammary; Retrospective Studies; Sarcoma, Kaposi; Sex Distribution; Skin Neoplasms; Urban Population

Basal cell carcinoma (BCC) is the most common skin cancer among Orientals. Data on this malignancy is lacking in Malaysia, prompting a retrospective study to determine the clinical characteristics in the skin clinic, Sarawak General Hospital between 2000 and 2008.. Demographic data and clinical features of 64 histopathologically proven BCC from 43 patients were retrieved. Statistical analysis was performed comparing the clinical characteristics based on the region of involvement and gender.. The mean age of presentation was 60.9 years. Male to female ratio was 1.05. Majority of the patients were Chinese (44.2%) followed by Malays (32.6%), Bidayuhs (14.0%) and Ibans (6.9%). Nodular BCC accounted for 95.3% of cases while 4.7% were superficial BCC. All the nodular BCC were pigmented. Ulceration was noted in 18%. There were 82.8% of BCC on the head and neck region and 17.2% on the trunk and limb region. BCC on the latter region were larger (mean 35.0 cf. 14.4 mm, p < 0.001) and ulcerated (45.5% cf. 11.3%, p = 0.01). Superficial BCC were also more frequently encountered in this region (18.2% cf. 1.9%, p = 0.02). Compared to women, men had larger BCC (mean 21.1 cf. 13.3 mm, p = 0.03) and kept them for a longer duration (mean 21.6 cf. 13.3 months, p = 0.04).. Clinical characteristics of BCC in Sarawak were similar to other Asian studies. Additionally, BCC on the trunk and limbs and in men were larger, ulcerative and long standing warranting better efforts for earlier detection.

Topics: Age Distribution; Aged; Biopsy, Needle; Carcinoma, Basal Cell; Chi-Square Distribution; Cohort Studies; Developing Countries; Female; Hospitals, General; Humans; Immunohistochemistry; Incidence; Malaysia; Male; Middle Aged; Neoplasm Staging; Probability; Prognosis; Retrospective Studies; Risk Assessment; Sex Distribution; Skin Neoplasms; Statistics, Nonparametric

Congo red screening of tumour material examined at the Department of Pathology, University of Malaya revealed intratumour deposits of amyloid in 12% of nasopharyngeal carcinomas, 66% of basal cell carcinomas, 100% of medullary carcinomas of the thyroid, 56% of islet cell tumours of the pancreas, 1 out of 16 carcinoids and 1 out of 100 thyroid adenomas. All the deposits were permanganate resistant and did not contain AA protein, indicating that what was encountered was not secondary amyloid. The deposits showed variable staining for immunoglobulin light chains and amyloid P component with a standard peroxidase antiperoxidase method. The possibility that intratumour amyloid has a neoplastic origin is discussed.

Topics: Adenoma, Islet Cell; Amyloid; Amyloidosis; Carcinoid Tumor; Carcinoma, Basal Cell; Histocytochemistry; Humans; Immunochemistry; Malaysia; Nasopharyngeal Neoplasms; Neoplasms; Pancreatic Neoplasms; Thyroid Neoplasms

Congo-red screening demonstrated intratumor deposits of amyloid in 35 of 53 unselected cases of basal cell carcinoma. Male subjects had a higher amyloid positivity rate than female subjects. The amyloid deposits were permanganate-resistant and located in the stroma between clumps of tumor cells, as well as abutting the advancing front of the neoplasm. Solar elastosis was often observed in the overlying and adjacent subepidermis. The relationship between amyloid positivity and the different histological subtypes of basal cell carcinoma, tumor ulceration, and density of the lymphoplasmacytic stromal infiltrate were also studied. The possibility that amyloid originates from the tumor cells and is a result of tumor apoptosis (degeneration) is discussed.

Topics: Amyloid; Amyloidosis; Carcinoma, Basal Cell; Congo Red; Female; Humans; Malaysia; Male; Microscopy, Electron; Racial Groups; Sex Factors; Skin Neoplasms; Time Factors

Topics: Adenocarcinoma; Adenolymphoma; Adolescent; Adult; Age Factors; Aged; Angiokeratoma; Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Child; Child, Preschool; Female; Humans; Infant; Malaysia; Male; Middle Aged; Racial Groups; Salivary Gland Neoplasms; Salivary Glands; Sex Factors