exudates and Activated-Protein-C-Resistance

Resistance to activated protein C (APC-R) is the commonest inherited cause of thrombosis among Caucasians. Few studies have been carried out on its prevalence in Asians. We conducted a prospective study on 60 patients with thromboembolism to determine its prevalence in our local population. The Factor V Leiden (VaQ506) mutation associated with this condition was detected by amplification of the Factor V gene by polymerase chain reaction (PCR) and digestion of the fragment with Mnl I. Three patients were found to be heterozygous for this mutation. None of the 3 patients had other concomitant hypercoagulable states. In addition, we studied the prevalence of this condition in Malays which was found to be 0.5%. Our study suggests that the incidence of APC-R is much lower here compared to the West.

Topics: Activated Protein C Resistance; Adult; Aged; Aged, 80 and over; Asian People; China; Cohort Studies; Deoxyribonucleases, Type II Site-Specific; Factor V; Female; Heterozygote; Humans; Incidence; India; Malaysia; Male; Middle Aged; Point Mutation; Polymerase Chain Reaction; Prevalence; Prospective Studies; Singapore; Thromboembolism; White People