exp3174 has been researched along with Hypertension in 27 studies
*Hypertension: Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more. [MeSH]
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 13 (48.15) | 18.2507 |
| 2000's | 10 (37.04) | 29.6817 |
| 2010's | 2 (7.41) | 24.3611 |
| 2020's | 2 (7.41) | 2.80 |
| Authors | Studies |
|---|---|
| Belvisi, L; Caliari, S; Canevotti, R; Cirillo, R; Fici, F; Paleari, F; Poma, D; Renzetti, AR; Salimbeni, A; Subissi, A | 1 |
| Benfield, P; Carini, DJ; Chiu, AT; Herblin, WF; Lee, RJ; Saye, JA; Smith, RD; Timmermans, PB; Wexler, RR; Wong, PC | 1 |
| Schieffer, B; Schmidt, B | 1 |
| Balsamo, A; Breschi, MC; Calderone, V; Digiacomo, M; Macchia, M; Martelli, A; Martinotti, E; Minutolo, F; Rapposelli, S; Rossello, A; Testai, L | 1 |
| Alajarín, R; Alvarez-Builla, J; Díez-Marqués, ML; García, G; Griera, M; Rodríguez-Puyol, D; Rodríguez-Puyol, M; Sánchez-Alonso, P; Serrano, I; Vaquero, JJ | 1 |
| Akmalova, KA; Asoskova, AV; Boyarko, AV; Fisenko, VP; Grishina, EA; Mirzaev, KB; Sinitsina, II; Sozaeva, ZA; Sychev, DA; Temirbulatov, II | 1 |
| da Silva Sólon, LG; Martin-Pastor, M; Queiroz, KA; Santos, ISR; Sousa, FFO; Tavares Júnior, AG | 1 |
| Bähr, IN; Fleck, E; Fritzsche, J; Goebel, M; Gust, R; Hässle, PL; Kappert, K; Kaufmann, J; Kintscher, U; Ott, I; Stawowy, P; Tsuprykov, O; Unger, T | 1 |
| Beloqui, O; Bidegain, J; Díez, J; Fortuño, A; Hermida, J; López-Sagaseta, J; Robador, PA; Zalba, G | 1 |
| Iliodromitis, EK; Kokotos, G; Kremastinos, DT; Mavromoustakos, TM; Moutevelis-Minakakis, P; Politi, AP; Triantafyllidi, H; Zervou, MV; Zoga, AA; Zoumpoulakis, PG | 1 |
| Dominiak, P; Häuser, W | 1 |
| Daliani, I; Dimitriou, D; Kamoutsis, C; Kyrikou, I; Laggner, P; Mavromoustakos, T; Pitsas, A; Siapi, E; Zervou, M; Zoga, A; Zoumpoulakis, P | 1 |
| Ivanova, NA; Preobrazhenskiĭ, DV; Sidorenko, BA; Soplevenko, AV; Stetsenko, TM | 1 |
| de Leeuw, PW; Fuss-Lejeune, MJ; Kroon, AA; Spiering, W | 1 |
| Kunihara, M; Kushida, H; Morita, O | 1 |
| Bartholomeusz, B; Widdop, RE | 1 |
| Berman, RS; Bradstreet, DC; Jallard, N; Saenz, A; Sweet, CS; Weidler, DJ | 1 |
| Bradstreet, TE; Goldberg, MR; Höglund, P; Lo, MW; Ritter, MA | 1 |
| Goldsmith, DJ | 1 |
| Bai, SA; Christ, DD; Hellyer, P; Lankford, SM; Plummer, D | 1 |
| Fujimori, A; Inagaki, O; Kikuchi, K; Okazaki, T; Shibasaki, M; Suga, A; Watanabe, T; Yanagisawa, I | 1 |
| Coca, A; Giner, V | 1 |
| Fice, D; Jamieson, A; Pollak, PT; Smith, GJ; Yeung, PK | 1 |
| Böger, RH; Drexler, H; Forssmann, WG; Krämer, C; Luchtefeld, M; Schieffer, B; Schmidt, B; Sunkomat, J; Tsikas, D; Walden, M; Witte, J | 1 |
| Brunner, HR; Christen, Y; Lee, RJ; Munafo, A; Nussberger, J; Waeber, B | 1 |
| Clozel, JP; Fischli, W; Hess, P; Véniant, M | 1 |
| Brooks, DP; Edwards, RM; Fredrickson, TA; Gellai, M; Ruffolo, RR; Weinstock, J | 1 |
5 review(s) available for exp3174 and Hypertension
| Article | Year |
|---|---|
Angiotensin II receptors and angiotensin II receptor antagonists.
Topics: Amino Acid Sequence; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Biphenyl Compounds; Blood Pressure; Cloning, Molecular; Hemodynamics; Humans; Hypertension; Imidazoles; Kidney; Losartan; Molecular Sequence Data; Pyridines; Receptors, Angiotensin; Tetrazoles | 1993 |
Angiotensin II AT1 receptor antagonists. Clinical implications of active metabolites.
Topics: Acrylates; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Benzimidazoles; Biphenyl Compounds; Growth Hormone; Humans; Hypertension; Imidazoles; Irbesartan; Losartan; Models, Molecular; Receptor, Angiotensin, Type 1; Tetrazoles; Thiophenes; Thromboxane A2 | 2003 |
Efforts to understand the molecular basis of hypertension through drug:membrane interactions.
Topics: Amino Acids; Angiotensin II Type 1 Receptor Blockers; Antihypertensive Agents; Binding Sites; Biphenyl Compounds; Calorimetry, Differential Scanning; Cell Membrane; Humans; Hypertension; Imidazoles; Irbesartan; Losartan; Magnetic Resonance Spectroscopy; Models, Molecular; Receptor, Angiotensin, Type 1; Tetrazoles; X-Ray Diffraction | 2004 |
[Candesartan - a novel AT(1)-angiotensin receptor blocker: peculiarities of pharmacology and experience of use in arterial hypertension].
Topics: Acrylates; Angiotensin II Type 1 Receptor Blockers; Antihypertensive Agents; Benzimidazoles; Biphenyl Compounds; Diabetic Nephropathies; Humans; Hypertension; Imidazoles; Irbesartan; Losartan; Tetrazoles; Thiophenes; Valine; Valsartan | 2004 |
[Antihypertensive advantages of angiotensin II AT1 receptor antagonism].
Topics: Aged; Angiotensin II; Angiotensin Receptor Antagonists; Anti-Arrhythmia Agents; Antihypertensive Agents; Biphenyl Compounds; Blood Pressure; Clinical Trials as Topic; Heart Diseases; Heart Failure; Humans; Hypertension; Imidazoles; Irbesartan; Losartan; Renin-Angiotensin System; Tetrazoles; Valine; Valsartan | 1999 |
7 trial(s) available for exp3174 and Hypertension
| Article | Year |
|---|---|
Chronic treatment with losartan results in sufficient serum levels of the metabolite EXP3179 for PPARgamma activation.
Topics: Aged; Angiotensin II Type 1 Receptor Blockers; Benzimidazoles; Benzoates; Biphenyl Compounds; Cell Movement; Dose-Response Relationship, Drug; Female; Humans; Hypertension; Imidazoles; Irbesartan; Losartan; Male; Middle Aged; Muscle Cells; PPAR gamma; Telmisartan; Tetrazoles | 2009 |
Losartan metabolite EXP3179 blocks NADPH oxidase-mediated superoxide production by inhibiting protein kinase C: potential clinical implications in hypertension.
Topics: Aged; Angiotensin II Type 1 Receptor Blockers; Female; Humans; Hypertension; Imidazoles; Losartan; Male; Matrix Metalloproteinase 9; Middle Aged; NADPH Oxidases; Oxidative Stress; Oxygen; Phagocytes; Protein Kinase C; Signal Transduction; Superoxides; Tetrazoles | 2009 |
Genetic contribution to the acute effects of angiotensin II type 1 receptor blockade.
Topics: Angiotensin II Type 1 Receptor Blockers; Antihypertensive Agents; Blood Pressure; Diet, Sodium-Restricted; Drug Resistance; Female; Genotype; Humans; Hypertension; Imidazoles; Losartan; Male; Middle Aged; Polymorphism, Genetic; Receptor, Angiotensin, Type 1; Sodium Chloride, Dietary; Tetrazoles; Vascular Resistance | 2005 |
Pharmacodynamic activity of intravenous E-3174, an angiotensin II antagonist, in patients with essential hypertension.
Topics: Adult; Aged; Angiotensin II; Antihypertensive Agents; Blood Pressure; Double-Blind Method; Female; Heart Rate; Humans; Hypertension; Imidazoles; Injections, Intravenous; Kidney Function Tests; Losartan; Male; Middle Aged; Renin; Tetrazoles; Uric Acid | 1994 |
Effects of cimetidine on pharmacokinetics and pharmacodynamics of losartan, an AT1-selective non-peptide angiotensin II receptor antagonist.
Topics: Adult; Angiotensin Receptor Antagonists; Antihypertensive Agents; Biphenyl Compounds; Cimetidine; Cross-Over Studies; Histamine H2 Antagonists; Humans; Hypertension; Imidazoles; Losartan; Male; Tetrazoles | 1995 |
Angiotensin II receptor-independent antiinflammatory and antiaggregatory properties of losartan: role of the active metabolite EXP3179.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Arachidonic Acid; Biotransformation; Cells, Cultured; Cyclooxygenase 2; Dinoprost; Drug Design; Endothelium, Vascular; Enzyme Activation; Female; Humans; Hypertension; Imidazoles; Inflammation; Intercellular Adhesion Molecule-1; Isoenzymes; Lipopolysaccharides; Losartan; Male; Membrane Proteins; Middle Aged; Platelet Aggregation; Prostaglandin-Endoperoxide Synthases; Receptor, Angiotensin, Type 1; Receptors, Angiotensin; RNA, Messenger; Tetrazoles; Thromboxane A2; Up-Regulation; Vasoconstrictor Agents | 2002 |
Clinical experience with angiotensin II receptor antagonists.
Topics: Administration, Oral; Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Antihypertensive Agents; Biphenyl Compounds; Blood Pressure; Dose-Response Relationship, Drug; Humans; Hypertension; Imidazoles; Injections, Intravenous; Losartan; Renin-Angiotensin System; Tetrazoles; Time Factors | 1992 |
15 other study(ies) available for exp3174 and Hypertension
| Article | Year |
|---|---|
N-3-substituted pyrimidinones as potent, orally active, AT1 selective angiotensin II receptor antagonists.
Topics: Administration, Oral; Angiotensin Receptor Antagonists; Animals; Humans; Hypertension; Male; Models, Molecular; Molecular Conformation; Molecular Structure; Pyrimidinones; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship; Thiophenes | 1995 |
New NO-releasing pharmacodynamic hybrids of losartan and its active metabolite: design, synthesis, and biopharmacological properties.
Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Antihypertensive Agents; Drug Design; Drug Evaluation, Preclinical; Hypertension; In Vitro Techniques; Losartan; Male; Molecular Structure; Rats; Rats, Wistar; Receptor, Angiotensin, Type 1; Structure-Activity Relationship; Time Factors | 2006 |
New losartan-hydrocaffeic acid hybrids as antihypertensive-antioxidant dual drugs: Ester, amide and amine linkers.
Topics: Amides; Amines; Angiotensin II; Animals; Antihypertensive Agents; Antioxidants; Aorta, Thoracic; Caffeic Acids; Cells, Cultured; Esters; Hypertension; Losartan; Male; Molecular Structure; Muscle, Smooth, Vascular; Rats; Rats, Wistar; Structure-Activity Relationship; Vasoconstrictor Agents | 2012 |
Topics: Antihypertensive Agents; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP2C9; Humans; Hypertension; Losartan; Polymorphism, Genetic; Uric Acid | 2023 |
Metabolomic Profile and Its Correlation with the Plasmatic Levels of Losartan, EXP3174 and Blood Pressure Control in Hypertensive and Chronic Kidney Disease Patients.
Topics: Antihypertensive Agents; Blood Pressure; Humans; Hypertension; Losartan; Renal Insufficiency, Chronic; Urea | 2023 |
Hypertension study in anaesthetized rabbits: protocol proposal for AT1 antagonists screening.
Topics: Anesthesia; Angiotensin II Type 1 Receptor Blockers; Animals; Blood Pressure; Hypertension; Imidazoles; Losartan; Rabbits; Receptor, Angiotensin, Type 1; Reproducibility of Results; Tetrazoles; Time Factors | 2010 |
[Dosage equivalents of AT1-receptor antagonists available in Germany].
Topics: Acrylates; Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Anti-Arrhythmia Agents; Antihypertensive Agents; Benzimidazoles; Benzoates; Biphenyl Compounds; Clinical Trials as Topic; Germany; Humans; Hypertension; Imidazoles; Irbesartan; Losartan; Olmesartan Medoxomil; Placebos; Telmisartan; Tetrazoles; Therapeutic Equivalency; Thiophenes; Time Factors; Valine; Valsartan | 2003 |
Effects of U-97018 on pressor responses to intracerebroventricularly administered angiotensin II in conscious normotensive rats.
Topics: Administration, Oral; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Biphenyl Compounds; Blood Pressure; Disease Models, Animal; Dose-Response Relationship, Drug; Hypertension; Imidazoles; Injections, Intravenous; Injections, Intraventricular; Losartan; Male; Pyridazines; Pyridines; Rats; Rats, Inbred SHR; Rats, Sprague-Dawley; Saralasin; Tetrazoles | 1995 |
Effect of acute and chronic treatment with the angiotensin II subtype 1 receptor antagonist EXP 3174 on baroreflex function in conscious spontaneously hypertensive rats.
Topics: Angiotensin Receptor Antagonists; Animals; Baroreflex; Blood Pressure; Heart Rate; Hypertension; Imidazoles; Losartan; Male; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Receptors, Angiotensin; Tetrazoles | 1995 |
Angiotensin receptor antagonists.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Biphenyl Compounds; Humans; Hypertension; Imidazoles; Losartan; Scleroderma, Systemic; Tetrazoles | 1997 |
Pharmacokinetic-pharmacodynamic relations of losartan and EXP3174 in a porcine animal model.
Topics: Angiotensin II; Animals; Anti-Arrhythmia Agents; Antihypertensive Agents; Area Under Curve; Blood Pressure; Disease Models, Animal; Half-Life; Hypertension; Imidazoles; Infusions, Intravenous; Losartan; Receptors, Angiotensin; Swine; Tetrazoles | 1997 |
Studies on nonpeptide angiotensin II receptor antagonists. IV. Synthesis and biological evaluation of 4-acrylamide-1H-imidazole derivatives.
Topics: Acrylamides; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Aorta, Thoracic; Blood Pressure; Diet, Sodium-Restricted; Disease Models, Animal; Diuretics; Dogs; Female; Furosemide; Hypertension; Imidazoles; Losartan; Male; Prodrugs; Rabbits; Rats; Rats, Wistar; Structure-Activity Relationship; Tetrazoles | 1998 |
Determination of plasma concentrations of losartan in patients by HPLC using solid phase extraction and UV detection.
Topics: Antihypertensive Agents; Chromatography, High Pressure Liquid; Humans; Hypertension; Imidazoles; Losartan; Tetrazoles | 2000 |
Effects of renin-angiotensin system blockade in guinea pigs.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Biphenyl Compounds; Blood Pressure; Bradykinin; Cilazapril; Cyclooxygenase Inhibitors; Disease Models, Animal; Furosemide; Guinea Pigs; Hypertension; Imidazoles; Indomethacin; Losartan; Nephrectomy; Oligopeptides; Pyridazines; Renin; Renin-Angiotensin System; Tetrazoles | 1992 |
Antihypertensive activity of the non-peptide angiotensin II receptor antagonist, SK&F 108566, in rats and dogs.
Topics: Acrylates; Angiotensin I; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Biphenyl Compounds; Dogs; Hemodynamics; Hypertension; Imidazoles; Losartan; Male; Rats; Rats, Inbred Strains; Tetrazoles; Thiophenes | 1992 |