exp3174 has been researched along with Disease Models, Animal in 11 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 8 (72.73) | 18.2507 |
| 2000's | 1 (9.09) | 29.6817 |
| 2010's | 2 (18.18) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bunker, AM; Connolly, C; Edmunds, JJ; Hamby, JM; Hodges, JC; Kesten, SJ; Kostlan, CR; Quin, J; Sircar, I; Winters, RT | 1 |
| Prusty, S; Sahu, PK; Singh, VK; Subudhi, BB | 1 |
| Choi, DH; Choi, JS; Yang, SH | 1 |
| Buczko, W; Kucharewicz, I; Matys, T; Pawlak, D; Pawlak, R | 1 |
| Kunihara, M; Kushida, H; Morita, O | 1 |
| Fujishima, K; Hachisu, M; Hui, C; Katano, K; Kawano, K; Konno, F; Nagura, J; Ogino, H; Yamamoto, M; Yasuda, S | 1 |
| Berdeaux, A; Ghaleh, B; Giudicelli, JF; Richard, V | 1 |
| Bai, SA; Christ, DD; Hellyer, P; Lankford, SM; Plummer, D | 1 |
| Fujimori, A; Inagaki, O; Kikuchi, K; Okazaki, T; Shibasaki, M; Suga, A; Watanabe, T; Yanagisawa, I | 1 |
| Gould, RJ; Grossman, W; Kusma, SE; Lynch, JJ; Painter, CA; Stump, GL; Thomas, JM; Wallace, AA | 1 |
| Clozel, JP; Fischli, W; Hess, P; Véniant, M | 1 |
11 other study(ies) available for exp3174 and Disease Models, Animal
| Article | Year |
|---|---|
Nonpeptide angiotensin II receptor antagonists. 2. Design, synthesis, and structure-activity relationships of 2-alkyl-4-(1H-pyrrol-1-yl)-1H-imidazole derivatives: profile of 2-propyl-1-[[2'-(1H-tetrazol-5-yl)-[1,1' -biphenyl]-4-yl]-methyl]-4-[2-(trifluoro
Topics: Angiotensin Receptor Antagonists; Animals; Aorta; Disease Models, Animal; GABA Antagonists; gamma-Aminobutyric Acid; Hypertension, Renal; Liver; Male; Muscle Contraction; Pyridines; Rabbits; Rats; Rats, Sprague-Dawley; Receptors, Angiotensin; Structure-Activity Relationship | 1993 |
Conjugation to Ascorbic Acid Enhances Brain Availability of Losartan Carboxylic Acid and Protects Against Parkinsonism in Rats.
Topics: Administration, Oral; Angiotensin II Type 1 Receptor Blockers; Animals; Ascorbic Acid; Behavior, Animal; Biological Availability; Brain; Disease Models, Animal; Drug Evaluation, Preclinical; Haloperidol; Humans; Losartan; Male; Parkinsonian Disorders; Rats; Rats, Wistar; Renin-Angiotensin System | 2018 |
Effects of HMG-CoA reductase inhibitors on the pharmacokinetics of losartan and its main metabolite EXP-3174 in rats: possible role of CYP3A4 and P-gp inhibition by HMG-CoA reductase inhibitors.
Topics: Acyl Coenzyme A; Administration, Oral; Angiotensin II Type 1 Receptor Blockers; Animals; Anticholesteremic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Line, Tumor; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Imidazoles; Injections, Intravenous; Losartan; Lovastatin; Male; Rats; Rats, Sprague-Dawley; Rhodamine 123; Simvastatin; Tetrazoles; Time Factors | 2011 |
Antithrombotic effect of captopril and losartan is mediated by angiotensin-(1-7).
Topics: Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Blood Pressure; Captopril; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Inhibitors; Epoprostenol; Fibrinolytic Agents; Hypertension, Renal; Imidazoles; Infusions, Intravenous; Losartan; Male; Nitric Oxide; Nitric Oxide Synthase; Peptide Fragments; Pyridines; Rats; Rats, Wistar; Receptor, Angiotensin, Type 1; Renin-Angiotensin System; Tetrazoles; Venous Thrombosis | 2002 |
Effects of U-97018 on pressor responses to intracerebroventricularly administered angiotensin II in conscious normotensive rats.
Topics: Administration, Oral; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Biphenyl Compounds; Blood Pressure; Disease Models, Animal; Dose-Response Relationship, Drug; Hypertension; Imidazoles; Injections, Intravenous; Injections, Intraventricular; Losartan; Male; Pyridazines; Pyridines; Rats; Rats, Inbred SHR; Rats, Sprague-Dawley; Saralasin; Tetrazoles | 1995 |
Pharmacological profile of ME3221, a novel angiotensin II receptor antagonist.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Aorta, Thoracic; Biphenyl Compounds; Blood Pressure; Bradykinin; Callithrix; Disease Models, Animal; Drug Evaluation; Female; Femoral Artery; Heart Rate; Hypertension, Renal; Imidazoles; Losartan; Male; Rabbits; Rats; Rats, Inbred SHR; Rats, Sprague-Dawley; Species Specificity; Tetrazoles | 1995 |
Comparison of the effects of EXP3174, an angiotensin II antagonist and enalaprilat on myocardial infarct size in anaesthetized dogs.
Topics: Anesthesia; Angiotensin I; Angiotensin II; Animals; Antihypertensive Agents; Blood Pressure; Coronary Circulation; Disease Models, Animal; Dogs; Enalaprilat; Female; Furosemide; Heart Rate; Imidazoles; Injections, Intravenous; Losartan; Male; Myocardial Infarction; Myocardial Ischemia; Myocardial Reperfusion Injury; Renin-Angiotensin System; Tetrazoles | 1993 |
Pharmacokinetic-pharmacodynamic relations of losartan and EXP3174 in a porcine animal model.
Topics: Angiotensin II; Animals; Anti-Arrhythmia Agents; Antihypertensive Agents; Area Under Curve; Blood Pressure; Disease Models, Animal; Half-Life; Hypertension; Imidazoles; Infusions, Intravenous; Losartan; Receptors, Angiotensin; Swine; Tetrazoles | 1997 |
Studies on nonpeptide angiotensin II receptor antagonists. IV. Synthesis and biological evaluation of 4-acrylamide-1H-imidazole derivatives.
Topics: Acrylamides; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Aorta, Thoracic; Blood Pressure; Diet, Sodium-Restricted; Disease Models, Animal; Diuretics; Dogs; Female; Furosemide; Hypertension; Imidazoles; Losartan; Male; Prodrugs; Rabbits; Rats; Rats, Wistar; Structure-Activity Relationship; Tetrazoles | 1998 |
EXP3174, the AII antagonist human metabolite of losartan, but not losartan nor the angiotensin-converting enzyme inhibitor captopril, prevents the development of lethal ischemic ventricular arrhythmias in a canine model of recent myocardial infarction.
Topics: Analysis of Variance; Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Captopril; Disease Models, Animal; Dogs; Drug Evaluation, Preclinical; Female; Heart Ventricles; Humans; Imidazoles; Losartan; Male; Myocardial Infarction; Myocardial Ischemia; Tetrazoles; Time Factors | 1999 |
Effects of renin-angiotensin system blockade in guinea pigs.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Biphenyl Compounds; Blood Pressure; Bradykinin; Cilazapril; Cyclooxygenase Inhibitors; Disease Models, Animal; Furosemide; Guinea Pigs; Hypertension; Imidazoles; Indomethacin; Losartan; Nephrectomy; Oligopeptides; Pyridazines; Renin; Renin-Angiotensin System; Tetrazoles | 1992 |