exp3174 has been researched along with Blood Pressure, High in 27 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 13 (48.15) | 18.2507 |
| 2000's | 10 (37.04) | 29.6817 |
| 2010's | 2 (7.41) | 24.3611 |
| 2020's | 2 (7.41) | 2.80 |
| Authors | Studies |
|---|---|
| Belvisi, L; Caliari, S; Canevotti, R; Cirillo, R; Fici, F; Paleari, F; Poma, D; Renzetti, AR; Salimbeni, A; Subissi, A | 1 |
| Benfield, P; Carini, DJ; Chiu, AT; Herblin, WF; Lee, RJ; Saye, JA; Smith, RD; Timmermans, PB; Wexler, RR; Wong, PC | 1 |
| Schieffer, B; Schmidt, B | 1 |
| Balsamo, A; Breschi, MC; Calderone, V; Digiacomo, M; Macchia, M; Martelli, A; Martinotti, E; Minutolo, F; Rapposelli, S; Rossello, A; Testai, L | 1 |
| Alajarín, R; Alvarez-Builla, J; Díez-Marqués, ML; García, G; Griera, M; Rodríguez-Puyol, D; Rodríguez-Puyol, M; Sánchez-Alonso, P; Serrano, I; Vaquero, JJ | 1 |
| Akmalova, KA; Asoskova, AV; Boyarko, AV; Fisenko, VP; Grishina, EA; Mirzaev, KB; Sinitsina, II; Sozaeva, ZA; Sychev, DA; Temirbulatov, II | 1 |
| da Silva Sólon, LG; Martin-Pastor, M; Queiroz, KA; Santos, ISR; Sousa, FFO; Tavares Júnior, AG | 1 |
| Bähr, IN; Fleck, E; Fritzsche, J; Goebel, M; Gust, R; Hässle, PL; Kappert, K; Kaufmann, J; Kintscher, U; Ott, I; Stawowy, P; Tsuprykov, O; Unger, T | 1 |
| Beloqui, O; Bidegain, J; Díez, J; Fortuño, A; Hermida, J; López-Sagaseta, J; Robador, PA; Zalba, G | 1 |
| Iliodromitis, EK; Kokotos, G; Kremastinos, DT; Mavromoustakos, TM; Moutevelis-Minakakis, P; Politi, AP; Triantafyllidi, H; Zervou, MV; Zoga, AA; Zoumpoulakis, PG | 1 |
| Dominiak, P; Häuser, W | 1 |
| Daliani, I; Dimitriou, D; Kamoutsis, C; Kyrikou, I; Laggner, P; Mavromoustakos, T; Pitsas, A; Siapi, E; Zervou, M; Zoga, A; Zoumpoulakis, P | 1 |
| Ivanova, NA; Preobrazhenskiĭ, DV; Sidorenko, BA; Soplevenko, AV; Stetsenko, TM | 1 |
| de Leeuw, PW; Fuss-Lejeune, MJ; Kroon, AA; Spiering, W | 1 |
| Kunihara, M; Kushida, H; Morita, O | 1 |
| Bartholomeusz, B; Widdop, RE | 1 |
| Berman, RS; Bradstreet, DC; Jallard, N; Saenz, A; Sweet, CS; Weidler, DJ | 1 |
| Bradstreet, TE; Goldberg, MR; Höglund, P; Lo, MW; Ritter, MA | 1 |
| Goldsmith, DJ | 1 |
| Bai, SA; Christ, DD; Hellyer, P; Lankford, SM; Plummer, D | 1 |
| Fujimori, A; Inagaki, O; Kikuchi, K; Okazaki, T; Shibasaki, M; Suga, A; Watanabe, T; Yanagisawa, I | 1 |
| Coca, A; Giner, V | 1 |
| Fice, D; Jamieson, A; Pollak, PT; Smith, GJ; Yeung, PK | 1 |
| Böger, RH; Drexler, H; Forssmann, WG; Krämer, C; Luchtefeld, M; Schieffer, B; Schmidt, B; Sunkomat, J; Tsikas, D; Walden, M; Witte, J | 1 |
| Brunner, HR; Christen, Y; Lee, RJ; Munafo, A; Nussberger, J; Waeber, B | 1 |
| Clozel, JP; Fischli, W; Hess, P; Véniant, M | 1 |
| Brooks, DP; Edwards, RM; Fredrickson, TA; Gellai, M; Ruffolo, RR; Weinstock, J | 1 |
5 review(s) available for exp3174 and Blood Pressure, High
| Article | Year |
|---|---|
Angiotensin II receptors and angiotensin II receptor antagonists.
Topics: Amino Acid Sequence; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Biphenyl Compounds; Blood Pressure; Cloning, Molecular; Hemodynamics; Humans; Hypertension; Imidazoles; Kidney; Losartan; Molecular Sequence Data; Pyridines; Receptors, Angiotensin; Tetrazoles | 1993 |
Angiotensin II AT1 receptor antagonists. Clinical implications of active metabolites.
Topics: Acrylates; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Benzimidazoles; Biphenyl Compounds; Growth Hormone; Humans; Hypertension; Imidazoles; Irbesartan; Losartan; Models, Molecular; Receptor, Angiotensin, Type 1; Tetrazoles; Thiophenes; Thromboxane A2 | 2003 |
Efforts to understand the molecular basis of hypertension through drug:membrane interactions.
Topics: Amino Acids; Angiotensin II Type 1 Receptor Blockers; Antihypertensive Agents; Binding Sites; Biphenyl Compounds; Calorimetry, Differential Scanning; Cell Membrane; Humans; Hypertension; Imidazoles; Irbesartan; Losartan; Magnetic Resonance Spectroscopy; Models, Molecular; Receptor, Angiotensin, Type 1; Tetrazoles; X-Ray Diffraction | 2004 |
[Candesartan - a novel AT(1)-angiotensin receptor blocker: peculiarities of pharmacology and experience of use in arterial hypertension].
Topics: Acrylates; Angiotensin II Type 1 Receptor Blockers; Antihypertensive Agents; Benzimidazoles; Biphenyl Compounds; Diabetic Nephropathies; Humans; Hypertension; Imidazoles; Irbesartan; Losartan; Tetrazoles; Thiophenes; Valine; Valsartan | 2004 |
[Antihypertensive advantages of angiotensin II AT1 receptor antagonism].
Topics: Aged; Angiotensin II; Angiotensin Receptor Antagonists; Anti-Arrhythmia Agents; Antihypertensive Agents; Biphenyl Compounds; Blood Pressure; Clinical Trials as Topic; Heart Diseases; Heart Failure; Humans; Hypertension; Imidazoles; Irbesartan; Losartan; Renin-Angiotensin System; Tetrazoles; Valine; Valsartan | 1999 |
7 trial(s) available for exp3174 and Blood Pressure, High
| Article | Year |
|---|---|
Chronic treatment with losartan results in sufficient serum levels of the metabolite EXP3179 for PPARgamma activation.
Topics: Aged; Angiotensin II Type 1 Receptor Blockers; Benzimidazoles; Benzoates; Biphenyl Compounds; Cell Movement; Dose-Response Relationship, Drug; Female; Humans; Hypertension; Imidazoles; Irbesartan; Losartan; Male; Middle Aged; Muscle Cells; PPAR gamma; Telmisartan; Tetrazoles | 2009 |
Losartan metabolite EXP3179 blocks NADPH oxidase-mediated superoxide production by inhibiting protein kinase C: potential clinical implications in hypertension.
Topics: Aged; Angiotensin II Type 1 Receptor Blockers; Female; Humans; Hypertension; Imidazoles; Losartan; Male; Matrix Metalloproteinase 9; Middle Aged; NADPH Oxidases; Oxidative Stress; Oxygen; Phagocytes; Protein Kinase C; Signal Transduction; Superoxides; Tetrazoles | 2009 |
Genetic contribution to the acute effects of angiotensin II type 1 receptor blockade.
Topics: Angiotensin II Type 1 Receptor Blockers; Antihypertensive Agents; Blood Pressure; Diet, Sodium-Restricted; Drug Resistance; Female; Genotype; Humans; Hypertension; Imidazoles; Losartan; Male; Middle Aged; Polymorphism, Genetic; Receptor, Angiotensin, Type 1; Sodium Chloride, Dietary; Tetrazoles; Vascular Resistance | 2005 |
Pharmacodynamic activity of intravenous E-3174, an angiotensin II antagonist, in patients with essential hypertension.
Topics: Adult; Aged; Angiotensin II; Antihypertensive Agents; Blood Pressure; Double-Blind Method; Female; Heart Rate; Humans; Hypertension; Imidazoles; Injections, Intravenous; Kidney Function Tests; Losartan; Male; Middle Aged; Renin; Tetrazoles; Uric Acid | 1994 |
Effects of cimetidine on pharmacokinetics and pharmacodynamics of losartan, an AT1-selective non-peptide angiotensin II receptor antagonist.
Topics: Adult; Angiotensin Receptor Antagonists; Antihypertensive Agents; Biphenyl Compounds; Cimetidine; Cross-Over Studies; Histamine H2 Antagonists; Humans; Hypertension; Imidazoles; Losartan; Male; Tetrazoles | 1995 |
Angiotensin II receptor-independent antiinflammatory and antiaggregatory properties of losartan: role of the active metabolite EXP3179.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Arachidonic Acid; Biotransformation; Cells, Cultured; Cyclooxygenase 2; Dinoprost; Drug Design; Endothelium, Vascular; Enzyme Activation; Female; Humans; Hypertension; Imidazoles; Inflammation; Intercellular Adhesion Molecule-1; Isoenzymes; Lipopolysaccharides; Losartan; Male; Membrane Proteins; Middle Aged; Platelet Aggregation; Prostaglandin-Endoperoxide Synthases; Receptor, Angiotensin, Type 1; Receptors, Angiotensin; RNA, Messenger; Tetrazoles; Thromboxane A2; Up-Regulation; Vasoconstrictor Agents | 2002 |
Clinical experience with angiotensin II receptor antagonists.
Topics: Administration, Oral; Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Antihypertensive Agents; Biphenyl Compounds; Blood Pressure; Dose-Response Relationship, Drug; Humans; Hypertension; Imidazoles; Injections, Intravenous; Losartan; Renin-Angiotensin System; Tetrazoles; Time Factors | 1992 |
15 other study(ies) available for exp3174 and Blood Pressure, High
| Article | Year |
|---|---|
N-3-substituted pyrimidinones as potent, orally active, AT1 selective angiotensin II receptor antagonists.
Topics: Administration, Oral; Angiotensin Receptor Antagonists; Animals; Humans; Hypertension; Male; Models, Molecular; Molecular Conformation; Molecular Structure; Pyrimidinones; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship; Thiophenes | 1995 |
New NO-releasing pharmacodynamic hybrids of losartan and its active metabolite: design, synthesis, and biopharmacological properties.
Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Antihypertensive Agents; Drug Design; Drug Evaluation, Preclinical; Hypertension; In Vitro Techniques; Losartan; Male; Molecular Structure; Rats; Rats, Wistar; Receptor, Angiotensin, Type 1; Structure-Activity Relationship; Time Factors | 2006 |
New losartan-hydrocaffeic acid hybrids as antihypertensive-antioxidant dual drugs: Ester, amide and amine linkers.
Topics: Amides; Amines; Angiotensin II; Animals; Antihypertensive Agents; Antioxidants; Aorta, Thoracic; Caffeic Acids; Cells, Cultured; Esters; Hypertension; Losartan; Male; Molecular Structure; Muscle, Smooth, Vascular; Rats; Rats, Wistar; Structure-Activity Relationship; Vasoconstrictor Agents | 2012 |
Topics: Antihypertensive Agents; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP2C9; Humans; Hypertension; Losartan; Polymorphism, Genetic; Uric Acid | 2023 |
Metabolomic Profile and Its Correlation with the Plasmatic Levels of Losartan, EXP3174 and Blood Pressure Control in Hypertensive and Chronic Kidney Disease Patients.
Topics: Antihypertensive Agents; Blood Pressure; Humans; Hypertension; Losartan; Renal Insufficiency, Chronic; Urea | 2023 |
Hypertension study in anaesthetized rabbits: protocol proposal for AT1 antagonists screening.
Topics: Anesthesia; Angiotensin II Type 1 Receptor Blockers; Animals; Blood Pressure; Hypertension; Imidazoles; Losartan; Rabbits; Receptor, Angiotensin, Type 1; Reproducibility of Results; Tetrazoles; Time Factors | 2010 |
[Dosage equivalents of AT1-receptor antagonists available in Germany].
Topics: Acrylates; Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Anti-Arrhythmia Agents; Antihypertensive Agents; Benzimidazoles; Benzoates; Biphenyl Compounds; Clinical Trials as Topic; Germany; Humans; Hypertension; Imidazoles; Irbesartan; Losartan; Olmesartan Medoxomil; Placebos; Telmisartan; Tetrazoles; Therapeutic Equivalency; Thiophenes; Time Factors; Valine; Valsartan | 2003 |
Effects of U-97018 on pressor responses to intracerebroventricularly administered angiotensin II in conscious normotensive rats.
Topics: Administration, Oral; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Biphenyl Compounds; Blood Pressure; Disease Models, Animal; Dose-Response Relationship, Drug; Hypertension; Imidazoles; Injections, Intravenous; Injections, Intraventricular; Losartan; Male; Pyridazines; Pyridines; Rats; Rats, Inbred SHR; Rats, Sprague-Dawley; Saralasin; Tetrazoles | 1995 |
Effect of acute and chronic treatment with the angiotensin II subtype 1 receptor antagonist EXP 3174 on baroreflex function in conscious spontaneously hypertensive rats.
Topics: Angiotensin Receptor Antagonists; Animals; Baroreflex; Blood Pressure; Heart Rate; Hypertension; Imidazoles; Losartan; Male; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Receptors, Angiotensin; Tetrazoles | 1995 |
Angiotensin receptor antagonists.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Biphenyl Compounds; Humans; Hypertension; Imidazoles; Losartan; Scleroderma, Systemic; Tetrazoles | 1997 |
Pharmacokinetic-pharmacodynamic relations of losartan and EXP3174 in a porcine animal model.
Topics: Angiotensin II; Animals; Anti-Arrhythmia Agents; Antihypertensive Agents; Area Under Curve; Blood Pressure; Disease Models, Animal; Half-Life; Hypertension; Imidazoles; Infusions, Intravenous; Losartan; Receptors, Angiotensin; Swine; Tetrazoles | 1997 |
Studies on nonpeptide angiotensin II receptor antagonists. IV. Synthesis and biological evaluation of 4-acrylamide-1H-imidazole derivatives.
Topics: Acrylamides; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Aorta, Thoracic; Blood Pressure; Diet, Sodium-Restricted; Disease Models, Animal; Diuretics; Dogs; Female; Furosemide; Hypertension; Imidazoles; Losartan; Male; Prodrugs; Rabbits; Rats; Rats, Wistar; Structure-Activity Relationship; Tetrazoles | 1998 |
Determination of plasma concentrations of losartan in patients by HPLC using solid phase extraction and UV detection.
Topics: Antihypertensive Agents; Chromatography, High Pressure Liquid; Humans; Hypertension; Imidazoles; Losartan; Tetrazoles | 2000 |
Effects of renin-angiotensin system blockade in guinea pigs.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Biphenyl Compounds; Blood Pressure; Bradykinin; Cilazapril; Cyclooxygenase Inhibitors; Disease Models, Animal; Furosemide; Guinea Pigs; Hypertension; Imidazoles; Indomethacin; Losartan; Nephrectomy; Oligopeptides; Pyridazines; Renin; Renin-Angiotensin System; Tetrazoles | 1992 |
Antihypertensive activity of the non-peptide angiotensin II receptor antagonist, SK&F 108566, in rats and dogs.
Topics: Acrylates; Angiotensin I; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Biphenyl Compounds; Dogs; Hemodynamics; Hypertension; Imidazoles; Losartan; Male; Rats; Rats, Inbred Strains; Tetrazoles; Thiophenes | 1992 |