exp-3179 and Hypertension

exp-3179 has been researched along with Hypertension* in 2 studies

Reviews

1 review(s) available for exp-3179 and Hypertension

Article	Year
Angiotensin II AT1 receptor antagonists. Clinical implications of active metabolites. Journal of medicinal chemistry, 2003, Jun-05, Volume: 46, Issue:12 Topics: Acrylates; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Benzimidazoles; Biphenyl Compounds; Growth Hormone; Humans; Hypertension; Imidazoles; Irbesartan; Losartan; Models, Molecular; Receptor, Angiotensin, Type 1; Tetrazoles; Thiophenes; Thromboxane A2	2003

Article

Year

Angiotensin II AT1 receptor antagonists. Clinical implications of active metabolites.

Journal of medicinal chemistry, 2003, Jun-05, Volume: 46, Issue:12

Topics: Acrylates; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Benzimidazoles; Biphenyl Compounds; Growth Hormone; Humans; Hypertension; Imidazoles; Irbesartan; Losartan; Models, Molecular; Receptor, Angiotensin, Type 1; Tetrazoles; Thiophenes; Thromboxane A2

2003

Other Studies

1 other study(ies) available for exp-3179 and Hypertension

Article	Year
Nonpeptide angiotensin II receptor antagonists: the discovery of a series of N-(biphenylylmethyl)imidazoles as potent, orally active antihypertensives. Journal of medicinal chemistry, 1991, Volume: 34, Issue:8 A new series of nonpeptide angiotensin II (AII) receptor antagonists has been prepared. These N-(biphenylyl-methyl)imidazoles, e.g. 2-butyl-1-[(2'-carboxybiphenyl-4-yl)methyl]-4-chloro-5- (hydroxymethyl)imidazole, differ from the previously reported N-(benzamidobenzyl)imidazoles and related compounds in that they produce a potent antihypertensive effect upon oral administration; the earlier series generally were active only when administered intravenously. It has been found that the acidic group at the 2'-position of the biphenyl is essential. Only ortho-substituted acids possess both high affinity for the AII receptor and good oral antihypertensive potency. The carboxylic acid group has been replaced with a variety of acidic isosteres, and the tetrazole ring has been found to be the most effective. The tetrazole derivative, DuP 753, is currently in development for the treatment of hypertension. Topics: Administration, Oral; Adrenal Glands; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Biphenyl Compounds; Chemical Phenomena; Chemistry; Hypertension; Imidazoles; Losartan; Male; Molecular Structure; Rats; Rats, Inbred Strains; Receptors, Angiotensin; Structure-Activity Relationship; Tetrazoles	1991

Article

Year

Nonpeptide angiotensin II receptor antagonists: the discovery of a series of N-(biphenylylmethyl)imidazoles as potent, orally active antihypertensives.

Journal of medicinal chemistry, 1991, Volume: 34, Issue:8

A new series of nonpeptide angiotensin II (AII) receptor antagonists has been prepared. These N-(biphenylyl-methyl)imidazoles, e.g. 2-butyl-1-[(2'-carboxybiphenyl-4-yl)methyl]-4-chloro-5- (hydroxymethyl)imidazole, differ from the previously reported N-(benzamidobenzyl)imidazoles and related compounds in that they produce a potent antihypertensive effect upon oral administration; the earlier series generally were active only when administered intravenously. It has been found that the acidic group at the 2'-position of the biphenyl is essential. Only ortho-substituted acids possess both high affinity for the AII receptor and good oral antihypertensive potency. The carboxylic acid group has been replaced with a variety of acidic isosteres, and the tetrazole ring has been found to be the most effective. The tetrazole derivative, DuP 753, is currently in development for the treatment of hypertension.

Topics: Administration, Oral; Adrenal Glands; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Biphenyl Compounds; Chemical Phenomena; Chemistry; Hypertension; Imidazoles; Losartan; Male; Molecular Structure; Rats; Rats, Inbred Strains; Receptors, Angiotensin; Structure-Activity Relationship; Tetrazoles

1991