exenatide and Foreign-Body-Reaction

Injection of high-viscosity fluids into subcutaneous tissues may lead to a granulomatous reaction called sclerosing lipogranuloma (SL). Poly-(d,l-lactide-co-glycolide) (PLG or PLGA) microspheres are used as vehicles for extended-release drugs. Here we describe the histopathologic features of a case of SL induced by exenatide extended-release injections, and the staining pattern of PLG microspheres and microsphere remnants with carbol fuchsin.

Topics: Coloring Agents; Delayed-Action Preparations; Diabetes Mellitus, Type 2; Drug Carriers; Exenatide; Female; Foreign-Body Reaction; Granuloma; Humans; Hypoglycemic Agents; Injections, Subcutaneous; Microspheres; Middle Aged; Polylactic Acid-Polyglycolic Acid Copolymer; Rosaniline Dyes