ex-527 has been researched along with Retinal-Degeneration* in 1 studies
1 other study(ies) available for ex-527 and Retinal-Degeneration
| Article | Year |
|---|---|
Naringenin protects RPE cells from NaIO
Dry age-related macular degeneration (dAMD) leads to serious burden of visual impairment and there is no definitive treatment. Previous studies have showed that naringenin (NAR) significantly increased electroretinography (ERG) c-wave in sodium iodate (NaIO. We tested the hypothesis that anti-oxidation mediated by Sirtuin 1 (SIRT1) was important to the protective effect of NAR on dAMD.. NaIO. NAR eye drops improved retinal function and morphology and normalized the protein expression of SIRT1 in mice exposed to NaIO. Our findings indicate that SIRT1-mediated anti-oxidation contributes to the protective effect of NAR eye drops on dAMD. Topics: Animals; Carbazoles; Cell Line; Cell Survival; Female; Flavanones; Humans; Iodates; L-Lactate Dehydrogenase; Male; Mice; Ophthalmic Solutions; Protective Agents; Reactive Oxygen Species; Retinal Degeneration; Retinal Pigment Epithelium; Sirtuin 1; Up-Regulation | 2021 |