ex-527 and Graft-vs-Host-Disease

Graft-versus-host disease (GVHD) remains one of the major complications after allogeneic bone marrow transplantation (allo-BMT). Sirtuin-1 (Sirt-1) plays a crucial role in various biological processes including cellular senescence, metabolism, and inflammatory responses. Sirt-1 deacetylation regulates different transcription factors that are important for modulating immune responses. In the current study, we addressed the role of Sirt-1 in GVHD induction by employing Sirt-1 conditional knockout mice as well as a pharmacological Sirt-1 inhibitor. Using major histocompatibility complex (MHC)-mismatched and MHC-matched murine BMT models, we found that Sirt-1

Topics: Acetylation; Animals; B-Lymphocytes; Bone Marrow Transplantation; Carbazoles; Cell Differentiation; Female; Graft vs Host Disease; Graft vs Leukemia Effect; Lymphocyte Activation; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Knockout; Sirtuin 1; T-Lymphocytes, Regulatory; Transplantation, Homologous; Tumor Suppressor Protein p53