ex-527 and Aortic-Aneurysm--Abdominal

Acetylation levels of FOXP3 could influence its expression level and SIRT1 is a deacetylase, which could regulate the acetylation level of FOXP3. We aimed to investigate the mechanism of Treg dysfunction, which might be caused by abnormal acetylation of FOXP3 regulated by SIRT1 in abdominal aortic aneurysm (AAA) patients.. Peripheral CD4. AAA patients had significantly lower CD4. Our data demonstrate that reduced FOXP3 expression and Treg function in AAA patients are regulated by SIRT1-induced FOXP3 deacetylation. EX-527 could up-regulate FOXP3 acetylation and increase number and suppressive function of Treg in AAA patients.

Topics: Acetylation; Aged; Aged, 80 and over; Aorta, Abdominal; Aortic Aneurysm, Abdominal; Carbazoles; Case-Control Studies; CD4 Lymphocyte Count; Cells, Cultured; Female; Forkhead Transcription Factors; Histone Deacetylase Inhibitors; Humans; Male; Middle Aged; Protein Processing, Post-Translational; Sirtuin 1; T-Lymphocytes, Regulatory