euphol and Stomach-Neoplasms

euphol has been researched along with Stomach-Neoplasms* in 2 studies

Other Studies

2 other study(ies) available for euphol and Stomach-Neoplasms

Article	Year
Euphol from Euphorbia tirucalli Negatively Modulates TGF-β Responsiveness via TGF-β Receptor Segregation inside Membrane Rafts. PloS one, 2015, Volume: 10, Issue:10 Transforming growth factor-β (TGF-β) responsiveness in cultured cells can be modulated by TGF-β partitioning between lipid raft/caveolae- and clathrin-mediated endocytosis pathways. Lipid rafts are plasma membrane microdomains with an important role in cell survival signaling, and cholesterol is necessary for the lipid rafts' structure and function. Euphol is a euphane-type triterpene alcohol that is structurally similar to cholesterol and has a wide range of pharmacological properties, including anti-inflammatory and anti-cancer effects. In the present study, euphol suppressed TGF-β signaling by inducing TGF-β receptor movement into lipid-raft microdomains and degrading TGF-β receptors. Topics: Cell Line, Tumor; Euphorbia; Fibronectins; Gene Expression; Humans; Lanosterol; Membrane Microdomains; Phosphorylation; Plant Extracts; Protein Processing, Post-Translational; Protein Transport; Proteolysis; Receptors, Transforming Growth Factor beta; Stomach Neoplasms; Transcriptional Activation; Transforming Growth Factor beta	2015
Euphol from Euphorbia tirucalli selectively inhibits human gastric cancer cell growth through the induction of ERK1/2-mediated apoptosis. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2012, Volume: 50, Issue:12 Gastric cancer is one of the most common malignancies worldwide, and the main cause of cancer-related death in Asia. The present study assessed the anticancer effects of euphol, a triterpene alcohol with anti-inflammatory and antiviral activities on human gastric cancer cells. Euphol showed higher cytotoxicity activity against human gastric CS12 cancer cells than against noncancer CSN cells. In addition, it up-regulated the pro-apoptotic protein BAX and down-regulated the prosurvival protein Bcl-2, causing mitochondrial dysfunction, possibly by caspase-3 activation. The anti-proliferative effects of euphol were associated with the increased p27(kip1) levels and decreased cyclin B1 levels. Inhibition of ERK1/2 activation by PD98059 reversed euphol-induced pro-apoptotic protein expression and cell death. Taken together, these findings suggest that euphol selectively induced gastric cancer cells apoptosis by modulation of ERK signaling, and could thus be of value for cancer therapy. Topics: Apoptosis; Apoptosis Regulatory Proteins; bcl-2-Associated X Protein; Caspase 3; Cell Death; Cell Line, Tumor; Cell Proliferation; Cyclin B1; Cyclin-Dependent Kinase Inhibitor p27; Down-Regulation; Euphorbia; Humans; Lanosterol; MAP Kinase Signaling System; Mitochondria; Phosphorylation; Signal Transduction; Stomach Neoplasms; Up-Regulation	2012

Article

Year

Euphol from Euphorbia tirucalli Negatively Modulates TGF-β Responsiveness via TGF-β Receptor Segregation inside Membrane Rafts.

PloS one, 2015, Volume: 10, Issue:10

Transforming growth factor-β (TGF-β) responsiveness in cultured cells can be modulated by TGF-β partitioning between lipid raft/caveolae- and clathrin-mediated endocytosis pathways. Lipid rafts are plasma membrane microdomains with an important role in cell survival signaling, and cholesterol is necessary for the lipid rafts' structure and function. Euphol is a euphane-type triterpene alcohol that is structurally similar to cholesterol and has a wide range of pharmacological properties, including anti-inflammatory and anti-cancer effects. In the present study, euphol suppressed TGF-β signaling by inducing TGF-β receptor movement into lipid-raft microdomains and degrading TGF-β receptors.

Topics: Cell Line, Tumor; Euphorbia; Fibronectins; Gene Expression; Humans; Lanosterol; Membrane Microdomains; Phosphorylation; Plant Extracts; Protein Processing, Post-Translational; Protein Transport; Proteolysis; Receptors, Transforming Growth Factor beta; Stomach Neoplasms; Transcriptional Activation; Transforming Growth Factor beta

2015

Euphol from Euphorbia tirucalli selectively inhibits human gastric cancer cell growth through the induction of ERK1/2-mediated apoptosis.

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2012, Volume: 50, Issue:12

Gastric cancer is one of the most common malignancies worldwide, and the main cause of cancer-related death in Asia. The present study assessed the anticancer effects of euphol, a triterpene alcohol with anti-inflammatory and antiviral activities on human gastric cancer cells. Euphol showed higher cytotoxicity activity against human gastric CS12 cancer cells than against noncancer CSN cells. In addition, it up-regulated the pro-apoptotic protein BAX and down-regulated the prosurvival protein Bcl-2, causing mitochondrial dysfunction, possibly by caspase-3 activation. The anti-proliferative effects of euphol were associated with the increased p27(kip1) levels and decreased cyclin B1 levels. Inhibition of ERK1/2 activation by PD98059 reversed euphol-induced pro-apoptotic protein expression and cell death. Taken together, these findings suggest that euphol selectively induced gastric cancer cells apoptosis by modulation of ERK signaling, and could thus be of value for cancer therapy.

Topics: Apoptosis; Apoptosis Regulatory Proteins; bcl-2-Associated X Protein; Caspase 3; Cell Death; Cell Line, Tumor; Cell Proliferation; Cyclin B1; Cyclin-Dependent Kinase Inhibitor p27; Down-Regulation; Euphorbia; Humans; Lanosterol; MAP Kinase Signaling System; Mitochondria; Phosphorylation; Signal Transduction; Stomach Neoplasms; Up-Regulation

2012