eupatilin and Melanoma

eupatilin has been researched along with Melanoma* in 1 studies

Reviews

1 review(s) available for eupatilin and Melanoma

ArticleYear
Combining Activity Profiling with Advanced Annotation to Accelerate the Discovery of Natural Products Targeting Oncogenic Signaling in Melanoma.
    Journal of natural products, 2022, 06-24, Volume: 85, Issue:6

    The discovery of bioactive natural products remains a time-consuming and challenging task. The ability to link high-confidence metabolite annotations in crude extracts with activity would be highly beneficial to the drug discovery process. To address this challenge, HPLC-based activity profiling and advanced UHPLC-HRMS/MS metabolite profiling for annotation were combined to leverage the information obtained from both approaches on a crude extract scaled down to the submilligram level. This strategy was applied to a subset of an extract library screening aiming to identify natural products inhibiting oncogenic signaling in melanoma. Advanced annotation and data organization enabled the identification of compounds that were likely responsible for the activity in the extracts. These compounds belonged to two different natural product scaffolds, namely, brevipolides from a

    Topics: Biological Products; Drug Discovery; Flavonoids; Humans; Hyptis; Melanoma; Plant Extracts

2022