eupatilin and Dermatitis--Atopic

eupatilin has been researched along with Dermatitis--Atopic* in 1 studies

Other Studies

1 other study(ies) available for eupatilin and Dermatitis--Atopic

Article	Year
Eupatilin, an activator of PPARα, inhibits the development of oxazolone-induced atopic dermatitis symptoms in Balb/c mice. Biochemical and biophysical research communications, 2018, 02-05, Volume: 496, Issue:2 Eupatilin (5,7-dihydroxy-3',4',6-trimethoxyflavone) is the main lipophilic flavonoid obtained from the Artemisia species. Eupatilin has been reported to have anti-apoptotic, anti-oxidative and anti-inflammatory activities. Previously, we found that eupatilin increases transcriptional activity and expression of peroxisome proliferator-activated receptor α (PPARα) in a keratinocyte cell line and acts as an agonist of PPARα. PPARα agonists ameliorate atopic dermatitis (AD) and restore the skin barrier function. In this study, we confirmed that the effects of eupatilin improved AD-like symptoms in an oxazolone-induced AD-like mouse model. Furthermore, we found that eupatilin suppressed the levels of serum immunoglobulin E (IgE), interleukin-4 (IL-4), and AD involved cytokines, such as tumor necrosis factor α (TNFα), interferon-γ (IFN-γ), IL-1β, and thymic stromal lymphopoietin (TSLP), IL-33, IL-25 and increased the levels of filaggrin and loricrin in the oxazolone-induced AD-like mouse model. Taken together, our data suggest that eupatilin is a potential candidate for the treatment of AD. Topics: Animals; Cell Line, Tumor; Cytokines; Dermatitis, Atopic; Dermatologic Agents; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Female; Filaggrin Proteins; Flavonoids; Gene Expression Regulation; Immunoglobulin E; Interferon-gamma; Interleukin-1beta; Interleukin-33; Interleukin-4; Interleukins; Intermediate Filament Proteins; Membrane Proteins; Mice; Mice, Inbred BALB C; Oxazolone; PPAR alpha; Rats; Signal Transduction; Thymic Stromal Lymphopoietin; Tumor Necrosis Factor-alpha	2018

Article

Year

Eupatilin, an activator of PPARα, inhibits the development of oxazolone-induced atopic dermatitis symptoms in Balb/c mice.

Biochemical and biophysical research communications, 2018, 02-05, Volume: 496, Issue:2

Eupatilin (5,7-dihydroxy-3',4',6-trimethoxyflavone) is the main lipophilic flavonoid obtained from the Artemisia species. Eupatilin has been reported to have anti-apoptotic, anti-oxidative and anti-inflammatory activities. Previously, we found that eupatilin increases transcriptional activity and expression of peroxisome proliferator-activated receptor α (PPARα) in a keratinocyte cell line and acts as an agonist of PPARα. PPARα agonists ameliorate atopic dermatitis (AD) and restore the skin barrier function. In this study, we confirmed that the effects of eupatilin improved AD-like symptoms in an oxazolone-induced AD-like mouse model. Furthermore, we found that eupatilin suppressed the levels of serum immunoglobulin E (IgE), interleukin-4 (IL-4), and AD involved cytokines, such as tumor necrosis factor α (TNFα), interferon-γ (IFN-γ), IL-1β, and thymic stromal lymphopoietin (TSLP), IL-33, IL-25 and increased the levels of filaggrin and loricrin in the oxazolone-induced AD-like mouse model. Taken together, our data suggest that eupatilin is a potential candidate for the treatment of AD.

Topics: Animals; Cell Line, Tumor; Cytokines; Dermatitis, Atopic; Dermatologic Agents; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Female; Filaggrin Proteins; Flavonoids; Gene Expression Regulation; Immunoglobulin E; Interferon-gamma; Interleukin-1beta; Interleukin-33; Interleukin-4; Interleukins; Intermediate Filament Proteins; Membrane Proteins; Mice; Mice, Inbred BALB C; Oxazolone; PPAR alpha; Rats; Signal Transduction; Thymic Stromal Lymphopoietin; Tumor Necrosis Factor-alpha

2018