euk-189 and Ataxia-Telangiectasia

euk-189 has been researched along with Ataxia-Telangiectasia* in 1 studies

Other Studies

1 other study(ies) available for euk-189 and Ataxia-Telangiectasia

ArticleYear
Treatment with a catalytic antioxidant corrects the neurobehavioral defect in ataxia-telangiectasia mice.
    Free radical biology & medicine, 2004, Apr-01, Volume: 36, Issue:7

    Ataxia-telangiectasia is caused by mutations in the ATM gene, the protein product of which is essential for effective response to double-stranded DNA breaks. Loss of ATM function explains most aspects of the disease, but not the cerebellar neurodegeneration characteristic of the disease. Mice lacking ATM provide an excellent model of the human disorder. In addition to deficient response to DNA damage, these mice exhibit oxidative stress, which we hypothesized is the cause of cerebellar dysfunction. We show that treatment with a catalytic antioxidant corrects the neurobehavioral deficit in these mice.

    Topics: Animals; Antioxidants; Ataxia Telangiectasia; Ataxia Telangiectasia Mutated Proteins; Brain; Catalysis; Cell Cycle Proteins; Disease Models, Animal; DNA-Binding Proteins; Fatty Acids; Mice; Mice, Knockout; Organometallic Compounds; Oxidation-Reduction; Protein Serine-Threonine Kinases; Rotarod Performance Test; Salicylates; Tumor Suppressor Proteins

2004