euk-134 and Parkinson-Disease

euk-134 has been researched along with Parkinson-Disease* in 1 studies

Other Studies

1 other study(ies) available for euk-134 and Parkinson-Disease

Article	Year
Superoxide dismutase/catalase mimetics are neuroprotective against selective paraquat-mediated dopaminergic neuron death in the substantial nigra: implications for Parkinson disease. The Journal of biological chemistry, 2005, Aug-12, Volume: 280, Issue:32 Exposure of mice to the herbicide paraquat has been demonstrated to result in the selective loss of dopaminergic neurons of the substantia nigra, pars compacta (SNpc) akin to what is observed in Parkinson disease (PD). In this study, we investigate the efficacy of two synthetic superoxide dismutase/catalase mimetics (EUK-134 and EUK-189) in protecting against paraquat-induced dopaminergic cell death in both the rat dopaminergic cell line 1RB3AN27 (N27) and primary mesencephalic cultures in vitro and in adult mice in vivo. Our data demonstrate that pretreatment with either EUK-134 or EUK-189 significantly attenuates paraquat-induced neurotoxicity in vitro in a concentration-dependent manner. Furthermore, systemic administration of EUK-189 decreases paraquat-mediated SNpc dopaminergic neuronal cell death in vivo. These findings support a role for oxidative stress in paraquat-induced neurotoxicity and suggest novel therapeutic approaches for neurodegenerative disorders associated with oxidative stress such as PD. Topics: Animals; Antioxidants; Blotting, Western; Catalase; Cells, Cultured; Dopamine; Immunohistochemistry; Male; Manganese; Manganese Compounds; Mice; Mice, Inbred C57BL; Microscopy, Fluorescence; Models, Chemical; Neurons; Neuroprotective Agents; Organometallic Compounds; Oxidative Stress; Paraquat; Parkinson Disease; Rats; Salicylates; Substantia Nigra; Superoxide Dismutase; Time Factors	2005

Article

Year

Superoxide dismutase/catalase mimetics are neuroprotective against selective paraquat-mediated dopaminergic neuron death in the substantial nigra: implications for Parkinson disease.

The Journal of biological chemistry, 2005, Aug-12, Volume: 280, Issue:32

Exposure of mice to the herbicide paraquat has been demonstrated to result in the selective loss of dopaminergic neurons of the substantia nigra, pars compacta (SNpc) akin to what is observed in Parkinson disease (PD). In this study, we investigate the efficacy of two synthetic superoxide dismutase/catalase mimetics (EUK-134 and EUK-189) in protecting against paraquat-induced dopaminergic cell death in both the rat dopaminergic cell line 1RB3AN27 (N27) and primary mesencephalic cultures in vitro and in adult mice in vivo. Our data demonstrate that pretreatment with either EUK-134 or EUK-189 significantly attenuates paraquat-induced neurotoxicity in vitro in a concentration-dependent manner. Furthermore, systemic administration of EUK-189 decreases paraquat-mediated SNpc dopaminergic neuronal cell death in vivo. These findings support a role for oxidative stress in paraquat-induced neurotoxicity and suggest novel therapeutic approaches for neurodegenerative disorders associated with oxidative stress such as PD.

Topics: Animals; Antioxidants; Blotting, Western; Catalase; Cells, Cultured; Dopamine; Immunohistochemistry; Male; Manganese; Manganese Compounds; Mice; Mice, Inbred C57BL; Microscopy, Fluorescence; Models, Chemical; Neurons; Neuroprotective Agents; Organometallic Compounds; Oxidative Stress; Paraquat; Parkinson Disease; Rats; Salicylates; Substantia Nigra; Superoxide Dismutase; Time Factors

2005