etoposide has been researched along with Neoplasms in 603 studies
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 83 (13.76) | 18.7374 |
1990's | 228 (37.81) | 18.2507 |
2000's | 112 (18.57) | 29.6817 |
2010's | 138 (22.89) | 24.3611 |
2020's | 42 (6.97) | 2.80 |
Authors | Studies |
---|---|
Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J | 1 |
Guziec, FS; Guziec, LJ; Hasinoff, BB; Liang, H; Marshall, K; Wu, X; Yalowich, JC | 1 |
Bolognese, A; Correale, G; Esposito, A; Lavecchia, A; Manfra, M; Novellino, E | 1 |
Chang, CY; Chang, JY; Chiang, YK; Coumar, MS; Hsieh, HP; Kuo, CC; Lai, MJ; Liou, JP; Reddy, GR; Tan, UK; Wu, SY; Yeh, JY | 1 |
Jahng, Y; Jung, MJ; Karki, R; Kwon, Y; Lee, ES; Na, Y; Nam, JM; Thapa, P; Thapa, U | 1 |
Cho, HJ; Jung, MJ; Kim, J; Kwon, Y; Lee, ES; Na, Y; Woo, S | 1 |
Ballestrero, A; Bello, C; Cea, M; Cirmena, G; Dal Bello, G; Duchosal, MA; Dupuis, M; Fruscione, F; Garuti, A; Grossi, F; Moran, E; Nahimana, A; Nencioni, A; Patrone, F; Pronzato, P; Rocco, I; Sordat, B; Vogel, P | 1 |
Kamiie, K; Kidachi, Y; Noshita, T; Ryoyama, K; Umetsu, H; Yamaguchi, H; Yu, T | 1 |
Fang, JH; Ge, CW; Wang, CN; Wu, ZH; Zhao, Y; Zhu, L | 1 |
Juvekar, A; Kamal, A; Kumar, BA; Suresh, P; Zingde, S | 1 |
Cho, WJ; Choi, JH; Ha, EM; Jahng, Y; Jeon, KH; Karki, R; Kwon, Y; Lee, E; Lee, ES; Na, Y; Thapa, P; Thapa, U; Yun, M | 1 |
Janaki Ramaiah, M; Kamal, A; Kumar, BA; Lavanya, A; Mallareddy, A; Pal-Bhadra, M; Pushpavalli, SN; Raju, P; Sarma, P; Suresh, P; Vinay Gopal, J | 1 |
Cikotiene, I; Díaz-Rodríguez, E; Domínguez-Kelly, R; Freire, R; León, LG; Padrón, JM; Pandiella, A; Ríos-Luci, C | 1 |
Chen, SW; Ding, YL; Huang, WT; Hui, L; Liu, J; Liu, JF | 1 |
Cho, WJ; Choi, H; Jeon, KH; Kadayat, TM; Karki, R; Kwon, Y; Lee, E; Lee, ES; Na, Y; Park, PH; Thapa, P; Yoo, HY | 1 |
Bose, DS; Idrees, M; Jakka, NM; Rao, JV; Todewale, IK | 1 |
Li, N; Li, X; Liu, ZY; Wu, CF; Xu, XY; Zhao, YQ | 1 |
Imthiajali, S; Kamal, A; Lavanya, A; Mallareddy, A; Pal-Bhadra, M; Pushpavalli, SN; Ramaiah, MJ; Suresh, P | 1 |
Addepally, U; Chinta Rao, TS; Chiranjeevi, T; Patro, B; Saha, S; Venkata Ramana Reddy, Ch | 1 |
Banerjee, UC; Baviskar, AT; Das, D; Guchhait, SK; Kandekar, S; Kashyap, M; Kundu, CN; Mohapatra, P; Preet, R; Satapathy, SR; Siddharth, S | 1 |
Chang, CY; Chang, JY; Chang, YT; Kuo, CC; Lai, MJ; Lee, HY; Liou, JP; Liu, YM; Mehndiratta, S; Nien, CY; Pan, SL; Su, MC; Wu, JS; Wu, SY | 1 |
Aleksić, M; Bertoša, B; David-Cordonnier, MH; Depauw, S; Karminski-Zamola, G; Kralj, M; Martin-Kleiner, I; Nhili, R; Tomić, S | 1 |
Kou, L; Lee, KH; Liu, YQ; Morris-Natschke, SL; Nan, X; Wang, LT; Wang, MJ; Yang, L; Zhao, XB | 1 |
Jee, JG; Jun, KY; Kadayat, TM; Karki, R; Kwon, Y; Lee, ES; Lee, JH; Park, C; Thapa, P | 1 |
Encío, I; Palop, JA; Plano, D; Romano, B; Sanmartín, C | 1 |
Chandra, G; Chang, TS; Choi, S; Jang, JY; Jeong, LS; Kim, G; Lee, SK; Lee, Y; Moon, YW; Mulamoottil, VA; Nayak, A; Noh, M; Oh, K; Sahu, PK; Song, J | 1 |
Choi, SU; Kim, CS; Kim, SY; Kwon, OK; Lee, KR; Subedi, L; Yeo, EJ | 1 |
Ayad, T; Fahy, J; Maillos, P; Perez, M; Poughon, V; Ratovelomanana-Vidal, V | 1 |
Jones, AT; Kandil, S; Kariuki, BM; McGuigan, C; Westwell, AD; Wymant, JM | 1 |
Dezhenkova, LG; Kalinina, AA; Kaluzhny, DN; Kubbutat, M; Luzikov, YN; Pommier, Y; Preobrazhenskaya, MN; Romanenko, VI; Schols, D; Shchekotikhin, AE; Shtil, AA; Tatarskiy, VV; Treshalin, MI; Treshalina, HM; Tsvetkov, VB; Volodina, YL | 1 |
Bahulayan, AK; Kabeer, FA; Madhusoodhanan, AR; Nair, MS; Prakasan, N; Prathapan, R; Rajalekshmi, DS; Varughese, S | 1 |
Dai, SJ; Han, QT; Xiao, K; Zhang, L | 1 |
Jung, SJ; Lee, YH; Lee, YS; Park, KT; Yun, BH | 1 |
Crespín, GD; Daranas, AH; Febles, M; Fernández, JJ; Montalvão, S; Norte, M; Padrón, JM; Tammela, P | 1 |
Battu, S; Bethu, MS; Iska, VBR; Janapala, VR; Katangoor, V; Pottabathini, N; Poudapally, S; Sen, S; Sharma, S; Velatooru, LR | 1 |
Bist, G; Kwon, Y; Lee, ES; Park, S; Shrestha, A; Song, C; Thapa Magar, TB | 1 |
Ding, Q; Han, X; Li, S; Liu, Z; Qi, H; Qiao, X; Song, Y; Zhong, Y; Zhou, G | 1 |
Bist, G; Kadayat, TM; Kwon, Y; Lee, ES; Lee, HJ; Park, S; Shrestha, A; Thapa Magar, TB | 1 |
Asiri, AM; Manukumar, HM; Marwani, HM; Qin, HL; Rakesh, KP; Shantharam, CS; Zhang, X | 1 |
Cai, B; Cui, CB; Li, CW; Wang, N; Xu, LL; Zhu, HJ | 1 |
Tang, YJ; Zhang, QY; Zhao, W | 1 |
Gao, F; Wang, T; Xiao, J; Zhang, X | 1 |
Ann, J; Byun, WS; Kim, C; Kim, JH; Kim, S; Kim, SE; Lee, J; Lee, S; Tran, PT; Yoon, I; Yoon, S | 1 |
Kamal, A; Kankala, S; Nerella, S; Paidakula, S; Vadde, R | 1 |
Xu, Z; Zhang, L | 1 |
Liu, Y; Xu, Z; Zhao, SJ | 1 |
Bansal, R; Malhotra, A | 1 |
Chen, S; Dong, G; Huang, Y; Liu, D; Ma, Z; Sheng, C; Wan, K; Zhu, F | 1 |
Chen, G; Huang, G; Zhou, S | 1 |
Dou, X; Huang, H; Jiang, L; Jiao, N; Jin, H; Jin, Z; Li, Z; Liu, Y; Liu, Z; Sun, X; Zhang, L; Zhu, G; Zou, Y | 1 |
Guo, D; Kong, X; Liu, S; Yu, C; Zhu, Y | 1 |
Boutros, SW; Holden, S; Krenik, D; Raber, J; Unni, VK | 1 |
Chen, J; Feng, J; Guo, J; Hu, L; Li, K; Liu, Y; Lu, Y; Ma, C; Pang, X; Wu, Z; Yuan, K | 1 |
Chang, HH; Chang, JY; Chen, HH; Chen, YT; Chuang, YJ; Kuo, CC; Tang, YC; Yao, JY | 1 |
Bilston, L; Croden, J; Grossman, J; Sun, HL; Taparia, M | 1 |
Bourzikat, O; Daniellou, R; El Abbouchi, A; El Brahmi, N; El Fahime, E; El Kazzouli, S; Ghammaz, H; Guillaumet, G; Paris, A; Suzenet, F | 1 |
Feng, X; Han, R; Liu, Q; Qin, Y; Ren, Z; Sun, Y; Wang, J; Wang, X | 1 |
Albert, MH; Bader, P; Basu, O; Beier, R; Burkhardt, B; Classen, CF; Claviez, A; Corbacioglu, S; Deubzer, HE; Eichinger, A; Glogova, E; Greil, J; Gruhn, B; Güngör, T; Kafa, K; Kühl, JS; Lang, P; Lange, BS; Meisel, R; Müller, I; Peters, C; Poetschger, U; Sauer, MG; Schlegel, PG; Schulz, A; Stachel, D; Strahm, B; Wawer, A | 1 |
Chang, R; Chen, X; Guo, AY; Han, L; He, Y; Jing, Y; Li, S; Liu, C; Liu, H; Liu, Y; Luo, M; Ruan, H; Xue, Y; Ye, L; Ye, Y; Zhang, G; Zhang, Z | 1 |
Dodier, K; Laverdière, I; Roy, MJ | 1 |
Aulenbacher, K; Bartzsch, S; Dimroth, A; Matejcek, C; Natour, G; Winter, J | 1 |
Fukushima, H; Hosaka, S; Inaba, M; Masumoto, K; Mizumoto, M; Muroi, A; Okunushi, T; Sakurai, H; Suzuki, R; Tagawa, M; Takada, H; Watanabe, A; Yamaki, Y | 1 |
Ahmed, AAS; Binsuwaidan, R; El Sayed, IET; Elmongy, EI; Hassan, EA; Nofal, AE; Sakr, M; Tousson, E | 1 |
Benedetti, DJ; Kao, PC; Ma, C; Marcus, KJ; Mullen, EA; Wong, CI | 1 |
Hu, Y; Li, Q; Liang, T; Ma, S; Shen, C; Wei, X; Yang, H | 1 |
Bandak, AF; Berger, JM; Blower, TR; Guha, R; Gupta, R; Lau, AY; Nitiss, JL; Nitiss, KC | 1 |
Soejima, T | 1 |
Arshad, R; Behzadmehr, R; Fathi-Karkan, S; Ghotekar, S; Pandey, S; Rahdar, A; Ramezani, A | 1 |
Baker, JHE; Banáth, JP; Kyle, AH; Liu, NA; Minchinton, AI; Wang, T | 1 |
Gandhi, K; Garg, M; Gota, V; Gurjar, M; Jadhav, SM | 1 |
Cai, G; Chen, J; Guo, J; Kong, L; Ren, Y; Song, D; Wan, C; Yu, W; Zhang, W; Zhu, J | 1 |
Cash, T; Goldsmith, KC; Katzenstein, HM; Kean, L; MacDonald, TJ; Qayed, M; Suessmuth, Y; Tanos, R; Tighiouart, M; Watkins, B; Wetmore, C | 1 |
Adachi, S; Hiramatsu, H; Horikoshi, Y; Kato, I; Kawaguchi, K; Ogura, T; Saida, S; Takachi, T; Takita, J; Umeda, K; Watanabe, K | 1 |
Fujiwara, K; Goto, K; Harada, T; Hayashi, T; Kaneda, H; Kenmotsu, H; Kimura, M; Kogure, Y; Koike, T; Matsui, R; Nishio, M; Nogami, N; Seto, T; Shimizu, S; Shimokawa, M; Suzuki, K; Takiguchi, T | 1 |
Annereau, M; Bally, M; Corvis, Y; Fleury, T; Lai-Kuen, R; Lam, A; Martin, B; Mignet, N; Neri, G; Seguin, J | 1 |
Fazal, F; Gupta, N; Mittal, A; Ray, A | 1 |
Gao, S; Leng, SX; Meng, X; Miao, Y; Tao, Y; Wang, B; Yue, P; Zhang, H | 1 |
Kirov, I; Lam, F; Nguyen, T; Stockton, W | 1 |
Ali, S; Allsopp, RC; Buluwela, L; Charmsaz, S; Coombes, RC; Cunnea, P; Farzan, R; Gemma, C; Győrffy, B; Periyasamy, M; Shaw, JA; Singh, AK; Young, LS | 1 |
Bush, R; Buxton, A; Constine, LS; Friedman, DL; Giulino-Roth, L; Kelly, KM; Pei, Q; Schwartz, CL; Wolden, SL; Wu, Y | 1 |
Aschauer, L; Behan, C; Janus, J; Kelly, M; Le Quesne, J; Mackay, H; Muller, PAJ; Norman, JC; Officer, L; Phatak, V; Pinon, L; von Grabowiecki, Y; Zanivan, S | 1 |
Bellet, MM; Castelli, M; Costantini, C; Della-Fazia, MA; Gargaro, M; Pieroni, S; Piobbico, D; Romani, L; Sassone-Corsi, P; Servillo, G; Stincardini, C | 1 |
Duty, AM; Goldman, JL; Kelley, KL; Miles, N; Suppes, SL; Tillman, EM | 1 |
Du, Z; Pian, Y; Ren, S; Xu, C | 1 |
Kluska, M; Woźniak, K | 1 |
Bosch, M; Danyluk, P; Dusyk, T; Elemary, M; Hahn, L; Lim, H; Sabry, W; Stakiw, J | 1 |
Beijersbergen, RL; Bernards, R; De Conti, G; Groot, K; Jansen, R; Jin, H; Jochems, F; Leite de Oliveira, R; Pogacar, Z; Schepers, A; Thijssen, B; Wang, C; Wang, L; Wessels, LFA | 1 |
Agarwala, S; Bakhshi, S; Batra, A; Dhawan, D; Gupta, YK; Pramanik, R; Thulkar, S; Vishnubhatla, S | 1 |
Abou Karam, P; Biran, A; Krizhanovsky, V; Ovadya, Y; Porat, Z; Roitman, L; Vadai, E; Zada, L | 1 |
Li, JC; Liang, L; Sun, L; Tian, Y; Zhang, HM; Zhu, JX; Zhu, N | 1 |
Keilholz, U; Klinghammer, K; Knoedler, M; Kümmerlen, V; Lassus, M; Machacek, M; Mehlitz, P; Rohde, L; Schmittel, A; Steventon, G; Treasure, P; Utku, N | 1 |
Bansal, R; Kumar, P | 1 |
Bruni, E; De Nicola, M; Ghibelli, L; Traversa, E | 1 |
Apel-Sarid, L; Ayyathan, DM; Blank, M; Borroni, AP; Emanuelli, A; Koganti, P; Levy-Cohen, G; Shah, PA | 1 |
Frank, JP; Martin, AL; Waggoner, ML | 1 |
Lei, KF; Liu, TK; Tsang, NM | 1 |
Aston, WJ; Hope, DE; Lake, RA; Lesterhuis, WJ; Nowak, AK; Robinson, BW | 1 |
Engel, C; Loeffler, M; Loibl, S; Schirm, S; Scholz, M | 1 |
Hu, B; Ji, Y; Liu, Z; Luo, A; Tang, Z; Xu, R; Yang, C; Yang, Y; Zang, W; Zhang, Z; Zheng, X | 1 |
Boddy, AV; Chatelut, E; Osborne, C; Paci, A; Veal, GJ; White-Koning, M | 1 |
Adamkiewicz-Drożynska, E; Bączek, T; Bień, E; Kowalski, P; Krawczyk, MA; Maliszewska, O; Miękus, N; Olędzka, I; Plenis, A | 1 |
Aksenov, ND; Druzhilovskiy, DS; Guzhova, IV; Komarova, EY; Lazarev, VF; Margulis, BA; Mikhaylova, ER; Mitkevich, VA; Nikotina, AD; Poroikov, VV; Suezov, R; Sverchinsky, DV | 1 |
Atrafi, F; Byers, LA; Calles, A; Camidge, DR; Chae, YK; Gabrail, NY; Garralda, E; Groen, HJM; He, L; Hoening, E; Hu, B; Komarnitsky, P; Lolkema, MP; Nuthalapati, S; Sangha, RS; Tian, T; Viteri, S | 1 |
Andersen, MØ; Arnspang, EC; Code, C; Notabi, MK; Popova, P | 1 |
Castellano, G; Torrens, F | 1 |
Cai, K; Chen, Q; Hou, Y; Hu, Y; Li, K; Li, M; Li, Y; Luo, Z; Song, G; Xue, C; Zhou, J | 1 |
Casti, P; Comes, MC; Corsi, F; Di Giuseppe, D; Di Natale, C; Ghibelli, L; Martinelli, E; Mencattini, A | 1 |
Atar, N; Özkan, A; Yola, ML | 1 |
Dhagat, S; Eswari, JS; Yadav, M | 1 |
Bai, J; He, N; Hu, P; Li, X; Liu, F; Liu, M; Lu, X; Shao, Y; Tang, Q; Tian, Y; Wang, J; Xue, B; Zhu, G | 1 |
Bianco, S; Bouwman, BAM; Chiariello, AM; Cittaro, D; Crosetto, N; De Conti, G; Dellino, GI; Faretta, M; Furia, L; Giacò, L; Guido, D; Luzi, L; Melloni, G; Nicodemi, M; Palluzzi, F; Pelicci, PG; Piccioni, R | 1 |
Bhattacharjee, S; Chatterjee, S; Espey, MG; Jiang, J; Kumar, A; Mason, RP; Motten, AG; Sinha, BK | 1 |
Brady, D; de Koning, CB; Kolesnikova, NI; Qwebani-Ogunleye, T; Wellington, KW | 1 |
Batey, MA; Curtin, NJ; Kyle, S; Lau, A; Martin, NM; Newell, DR; Richardson, C; Slade, A; Zhao, Y | 1 |
Kokache, A; Mahmoud, S; Sambasivan, K; Savage, P; Seckl, M | 1 |
Lee, SH; Lee, SJ; Park, BJ; Yoon, MH | 1 |
Alberti, DB; Eickhoff, J; Keppen, M; Kolesar, JM; Liu, G; Marnocha, RM; Mohammed, TA; Schelman, WR; Takebe, N; Traynor, AM; Wilding, G | 1 |
Friis, R; Maskey, D; Perren, A; Schmid, I; Simon, HU; Yousefi, S; Zlobec, I | 1 |
Bokemeyer, C; Budach, W; de Zwart, P; Eckert, F; Hartmann, JT; Horger, M; Kluba, T; Königsrainer, A; von Weyhern, CH | 1 |
Kumar, D; Kumari, A; Yadav, R; Yadav, SK | 1 |
Allen, JC; Bendel, AE; Campigotto, F; Chi, SN; Chordas, CA; Comito, MA; Goldman, S; Hubbs, SM; Isakoff, MS; Khatib, ZA; Kieran, MW; Kondrat, L; Manley, PE; Neuberg, DS; Pan, WJ; Pietrantonio, JB; Robison, NJ; Rubin, JB; Turner, CD; Werger, AM; Zimmerman, MA | 1 |
Mulchandani, M; Sankaranarayanan, A; Tirupati, S | 1 |
Boren, J; Brindle, KM; Mahajan, S; Patel, II; Reichelt, S; Schreiner, A; Steuwe, C; Ul-Hasan, M | 1 |
WOOD, CA | 2 |
CHARTERIS, AA | 1 |
Blower, PJ; Diocou, S; Fruhwirth, GO; Mullen, GE; Ng, T | 1 |
Desmaris, R; Grill, J; Kessari, R; Klasen, A; Mercier, L; Paci, A; Valade, C | 1 |
Bean, AJ; Brown, BS; Celia, C; Mobli, K; Patanam, T; Tasciotti, E; Zage, PE | 1 |
Furman, WL; Ivy, P; Lam, CG; McGregor, LM; Santana, VM; Spunt, SL; Wang, C; Wu, J | 1 |
Chamani, E; Rabbani-Chadegani, A; Zahraei, Z | 1 |
Li, M; Mi, J; Shi, Z; Zhang, D | 1 |
Acikelli, AH; Aldinger, C; Araúzo-Bravo, MJ; Bardenheuer, W; Dammann, P; Dembinski, U; Díaz-Carballo, D; Gustmann, S; Jastrow, H; Klein, J; Malak, S; Schultheis, B; Strumberg, D | 1 |
Dalla Costa, T; Mossmann, DL; Pigatto, MC | 1 |
Hasinoff, BB; Patel, D; Wu, X; Yadav, AA; Yalowich, JC | 1 |
Adiguzel, R; Andreana, PR; Arslan, Z; Ates, M; Bemis, T; Bercovitch, LG; Bögli, S; Boucherez, J; Boudouf, S; Briat, JF; Brown, BM; Busemann, A; Buters, J; Byers, JS; Cairo, MS; Carrier, F; Chalmers, JJ; Chang, E; Chen, J; Chen, Y; Christenson, MK; Cielecka-Piontek, J; Cole, PA; Cooper, BS; Davis, PH; De Silva, RA; Decato, S; DeFries, RS; Demir, V; Denic, A; Deserno, M; Dickey, AM; Diss, E; Eberlein, B; Eyerich, S; Faluvegi, G; Farlow, MR; Fletcher, JW; Francetic, T; Furlan, L; Garbacki, P; Gartung, A; Garvin, JH; Gates, L; Gaymard, F; Ghetti, B; Gibson, MP; Griffin, RG; Hamed, M; Hammad, LA; Hammond, GB; Han, J; Hann, R; Hao, N; Harrison, LA; Heidecke, CD; Hutchins, GD; Inlow, M; Irmer, H; Jani, P; Jara-Cavieres, A; Jawadi, H; Jiang, Q; Jiang, Y; Kameda, T; Keeler, EG; Kim, H; Kim, R; Kim, S; Kinney, PL; Krause, A; Kumar, V; Kwok, Y; Lam, T; Lanni, F; Le May, M; Lee, A; Lee, JF; Lee, MJ; Leontyev, IV; Li, Q; Li, X; Liu, J; Liu, NK; Lominadze, D; Lösche, M; Lu, QB; Lu, Y; Lu, Z; Mach, H; Madsen, E; Marletta, M; Marlier, ME; McDonald, BC; McKay, IS; Mckenzie, CL; Mecozzi, S; Menges, P; Meyers, D; Michaelis, VK; Montooth, KL; Moore, LR; Morgan, JK; Morris, E; Movahed, M; Nalabothula, N; Narayanan, S; Nguyen, D; Nho, K; Oken, B; Ong, TC; Osborne, LS; Paczkowska, M; Park, EK; Pennino, D; Peters, S; Potluri, LP; Qin, C; Radhakrishnan, K; Randerson, JT; Rantanen, J; Reyt, G; Ring, J; Risacher, SL; Rodriguez, M; Saykin, AJ; Schmidt-Weber, CB; Sengelaub, DR; Shatters, RG; Shen, L; Shen, V; Shindell, DT; Stuchebrukhov, AA; Swaminathan, S; Takahashi, K; Talaczyńska, A; Tallman, EF; Tan, C; Terry, SF; Trabbic, KR; Trease, AJ; Tretter, C; Uitto, J; Váradi, A; von Bernstorff, W; Voulgarakis, A; Wagenhofer, M; Wahbeh, H; Wang, EN; Wang, X; Wells, RJ; West, JD; Williams, PS; Wolff, JE; Wootla, B; Xu, B; Xu, XM; Yoder, KK; Zalewski, P; Zan, GH; Zborowski, M; Zhang, HH; Zhang, W; Zhao, J; Zoecklein, L | 1 |
Fukao, T; Fukuda-Yuzawa, Y; Kiga, K; Sasakawa, C; Tanabe, M; Tsuji, S | 1 |
Leifert, WR; Siddiqui, SM | 1 |
de Jong, J; Neefjes, J; Pang, B; Qiao, X; Wessels, LF | 1 |
Abriola, L; Fernandez, RJ; Glazer, PM; Hoyer, D; Hungerford, W; Liu, Y; Merkel, J; Peterson-Roth, E; Pike, LR; Qian, JM; Stachelek, GC | 1 |
Jiang, Z; Liu, R; Shen, Z; Wang, P; Yao, Y; Zhu, J | 1 |
Clement, F; Fattaccioli, A; Genin, M; Michiels, C; Raes, M | 1 |
Al-Nedawi, K; Garnier, D; Guha, A; Lee, TH; Lee, WJ; Meehan, B; Montermini, L; Rak, J | 1 |
Balasubramaniam, S; Bates, SE; Bryla, C; Ehrlich, S; Figg, WD; Goey, AK; Lee, MJ; Peer, CJ; Piekarz, R; Sissung, TM; Steinberg, SM; Tomita, Y; Trepel, JB | 1 |
Huang, RC; Kimura, K | 1 |
Adam, V; Eckschlager, T; Jimenez, AM; Kizek, R; Kopel, P; Kremplova, M; Kudr, J; Masarik, M; Nejdl, L; Ruttkay-Nedecky, B; Skalickova, S; Stiborova, M | 1 |
Dalla Costa, T; de Araujo, BV; Magni, P; Pigatto, MC; Schmidt, S; Torres, BG | 1 |
Inanami, O; Suzuki, M; Yamamori, T; Yasui, H | 1 |
Agarwal, P; Jackson, SP | 1 |
Bohgaki, M; Bohgaki, T; Bristow, R; Cheung, P; El Ghamrasni, S; Eldin, MS; Guturi, KKN; Hakem, A; Hakem, R; Jeon, J; Kumareswaran, R; Ng, D; Patel, P; Raught, B; Srikumar, T; Stewart, GS | 1 |
Beyer, M; Dietrich, S; Göder, A; Heinzel, T; Kiweler, N; Krämer, OH; Linnebacher, M; Mahboobi, S; Mahendrarajah, N; Nikolova, T; Rauch, A; Reich, TR; Schäfer, C; Schneider, G; Sellmer, A; Sonnemann, J; Stojanovic, N; Tomicic, MT; Wieczorek, M | 1 |
Abbadie, C; Dehennaut, V; Dubuissez, M; Harmon, BT; Leprince, D; Loison, I; Nassour, J; Paget, S; Rood, BR; Spruyt, N | 1 |
Atwal, M; Austin, CA; Cowell, IG; Lishman, EL | 1 |
Fu, W; Hou, T; Li, R; Li, X; Lu, X; Ma, K; Tang, M; Wang, L; Wang, Y; Zhang, C; Zhang, L; Zhao, Y; Zhou, J; Zhu, WG | 1 |
Cassaday, RD; Chamberlain, MC; Floeter, AE; Gopal, AK; Hendrie, PC; Patel, A; Tran, M | 1 |
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Albert, E; Igwemezie, LN; Morgenthien, E; Randolph, J; Santabárbara, P; Schacter, LP; Seyedsadr, M | 1 |
Kobayashi, K; Ratain, MJ | 1 |
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Crist, WM; Pratt, CB; Pui, CH; Rivera, GK; Santana, VM | 1 |
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de Souza, P; Friedlander, M; Kirsten, F; Ryan, M; Wilde, C | 1 |
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Colnan, L; Kannourakis, G; Kellie, S; Lockwood, L; McCowage, G; Nayanar, V; Seshadri, R; Shaw, P; Tiedemann, K; White, L | 1 |
Elfenbein, GJ; Fields, KK; Hiemenz, JW; Kronish, LE; Zorsky, PE | 1 |
Bowman, LC; Furman, W; Jones, DP; Marina, NM; Meyer, WH; Murry, DJ; Pratt, CB; Rodman, JH; Shema, SJ | 1 |
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Greco, FA; Hainsworth, JD; Hande, KR; Holzmer, M; Thompson, DS | 1 |
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Andersson, M; Daugaard, G; Ersbøll, J; Hansen, SW; Hou-Jensen, K; Larsen, SO; Nielsen, D; Pedersen-Bjergaard, J; Philip, P; Sigsgaard, TC | 1 |
Brugger, W; Kanz, L; Mertelsmann, R | 1 |
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Ferguson, J; Holdsworth, MT; Martinez, L; Neidhart, JA; Roon, R; Stidley, CA | 1 |
Greco, FA; Hainsworth, JD; Hande, KR; Holzmer, MC; Thompson, DS | 1 |
Kohno, K; Kuwano, M; Matsuo, K; Sato, S; Tanimura, H; Uchiumi, T; Yamada, Y | 1 |
Beaujean, F; Bourhis, JH; Chazard, M; Hayat, M; Ibrahim, A; Lhomme, C; Maraninchi, D; Ostronoff, M; Viens, P; Zambon, E | 1 |
Alcaraz, J; Andrews, P; Braly, P; Goel, R; Gorelick, S; Hoff, S; Kim, S; Kirmani, S; McClay, EF; Plaxe, S | 1 |
Cole, M; Lowis, SP; Newell, DR; Pearson, AD | 1 |
Mick, R; Ratain, MJ | 1 |
Fritsch, HW; Hahn, M; Havemann, K; Holz, JB; Jungclas, H; Köhl, P; Pflüger, KH; Schmidt, L | 1 |
Bowman, LC; Douglass, E; Furman, W; Hudson, M; Marina, NM; Meyer, W; Rodman, J; Santana, VM; Shema, SJ; Wilimas, J | 1 |
Grosh, WW; Lowry, P; Quesenberry, PJ; Stewart, FM; Temeles, D; Thraves, T | 1 |
Confer, DL; Epstein, RB; Saez, RA; Selby, GB; Slease, RB; Strnad, C | 1 |
Fritsch, HW; Holz, JB; Jungclas, H; Köppler, H; Pflüger, KH; Schmidt, L | 1 |
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Asbury, RF; Boros, L; Chang, AY; Garrow, GC; Hui, L | 1 |
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Arbuck, SG; DeMaria, D; Ford, PA; Miller, LL; Minniti, C; O'Dwyer, PJ | 1 |
Abe, T; Hisano, T; Kohno, K; Koike, K; Kubo, T; Kuwano, M; Wada, M | 1 |
Avery, L; Fang, L; Furman, WL; Luo, X; Marina, N; Pratt, CB | 1 |
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Aguilar-Ponce, L; Dueñas-Gonzalez, A; Frias-Mendivil, M; Gallardo-Rincon, D; Lara-Medina, F; Miranda-Lopez, E; Reynoso-Gomez, E; Sobrevilla-Calvo, P; Zinser-Sierra, J | 1 |
Izrael, V; Lotz, JP | 1 |
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Barbhaiya, RH; Calvert, AH; Igwemezie, LN; Kaul, S; Mummaneni, V; Newell, DR; Porter, D; Thomas, H; Winograd, B | 1 |
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Belasco, JB; Geyer, JR; Goldwein, JW; Herman-Liu, A; Molloy, PT; Needle, MN; Phillips, PC; Sutton, L | 1 |
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Carpenter, P; Lockwood, L; McCowage, GB; Shaw, PJ; Tiedemann, K; Toogood, I; White, L | 1 |
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Carpenter, PA; Lockwood, L; McCowage, GB; Nayanar, V; Shaw, PJ; Tiedemann, K; Toogood, I; White, L | 1 |
Buhles, W; Hersh, E; Issell, B; Neidhart, J; Rinehart, J; Triozzi, P | 1 |
Agaliotis, DP; Ballester, OF; Elfenbein, GJ; Fields, KK; Goldstein, SC; Hiemenz, JW; Mattox, T; Perkins, JB; Rosen, RM; Zorsky, PE | 1 |
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Bajera, I; Chciałowski, A; Jahnz-Rózyk, K; Targowski, T | 1 |
Bachaud, JM; Bugat, R; Canal, P; Chatelut, E; Chevreau, C; Houin, G; Lochon, I; Nguyen, L; Pujol, A; Tranchand, B | 1 |
Arnold, B; Furman, WL; Garrison, L; Hanna, R; Luo, X; Marina, N; Meyer, WH; Pratt, CB; Rodman, JH; Tonda, ME | 1 |
Davidson, A; Dicks-Mireaux, C; Gowing, R; Lewis, I; Lowis, S; Newell, D; Pinkerton, CR | 1 |
Greco, FA; Hainsworth, JD; Utley, SM | 1 |
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Rowinsky, EK; Siu, LL | 1 |
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Cole, M; Lowis, SP; Newell, DR; Pearson, AD; Price, L | 1 |
Fojo, T; Kunishio, K; Matsumoto, Y; Morisaki, K; Nagao, S; Takano, H | 1 |
Blumenstengel, K; Fricke, HJ; Höffken, K; Kath, R; Kunert, C; Sayer, HG; Vogel, W | 1 |
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Fukuda, H; Kunitoh, H; Saijo, N; Sekine, I | 1 |
Barbhaiya, RH; Fields, SZ; Himpler, BS; Igwemezie, LN; Kaul, S; Litam, PP; McAleer, C; Schacter, LP; Schilder, RJ; Wright, J | 1 |
Campion, M; Hersh, E; Levitt, D; Margolin, KA; Resta, D; Rinehart, J; Triozzi, P | 1 |
Oltersdorf, T; Reed, JC; Sausville, E; Scudiero, DA; Tamm, I; Vigna, N; Wang, Y | 1 |
Armand, JP; Couteau, C | 1 |
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Bramwell, V; Rusthoven, J; Stephenson, B | 1 |
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Bishop, WR; Izbicka, E; Lawrence, RA; Petit, T; Von Hoff, DD; Weitman, S | 1 |
Beijnen, JH; de Wit, R; Lieverst, J; Nannan Panday, VR; Rosing, H; Schellens, JH; Schornagel, JH; Schot, M; ten Bokkel Huinink, WW | 1 |
Chao, Y; Chen, LL; Chen, LT; Chen, MH; Huang, TS; Lee, CC; Shu, CH; Whang-Peng, J; Yuan, CC | 1 |
Caramatti, C; Cesana, C; Garau, D; Mangoni, L; Regazzi, E; Rizzoli, V | 1 |
Vastag, B | 1 |
Joseph, CD; Kuttan, G; Kuttan, R; Praveenkumar, V | 1 |
Hainsworth, JD | 1 |
Bamias, A; Katsimbri, P; Pavlidis, N | 1 |
Bash, RO; Herrera, L; Kamen, BA; Leavey, PJ; Mantadakis, E; Winick, NJ | 1 |
Chen, CL; Uckun, FM | 1 |
Pappo, AS; Spunt, SL | 1 |
Durand, RE; Olive, PL | 1 |
Chow, W; Coluzzi, P; Doroshow, JH; Hamasaki, V; Leong, LA; Margolin, KA; Morgan, RJ; Raschko, JW; Shibata, SI; Somlo, G; Synold, TW; ter Veer, A; Tetef, ML; Yen, Y | 1 |
Bauer, M; Blatt, J; Blazar, BR; Cairo, MS; Frierdich, S; Krailo, MD; Liu-Mares, W; Miser, JS; Reaman, GH; Sato, JK; Shen, V | 1 |
Ames, MM; Bergeron, S; Blazar, BR; Bracho, F; Cairo, MS; Davenport, V; Krailo, MD; Liu-Mares, W; Panoskaltsis-Mortari, A; Reaman, GH; Reid, JM; Secola, R; Shen, V; van de Ven, C | 1 |
Cannizzaro, L; Chin, L; DePinho, RA; Greenberg, RA; Ju, YJ; Lee, KH; Rudolph, KL; Weiler, SR | 1 |
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Herman, ZS; Machalski, M; Scieszka, M; Zielinski, M | 1 |
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Ratain, MJ; Sawyer, M | 1 |
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Dixon, JE; Donner, DB; Durden, DL; Mayo, LD; Tonks, NK | 1 |
Adamson, ED; Baron, V; Birle, D; de Belle, I; Mercola, D; Mustelin, T; Virolle, T | 1 |
Aiba, K; Akaza, H; Blackledge, G; Boku, N; Ikeda, T; Isonishi, S; Kato, M; Kawai, K; Mikami, O; Ohashi, Y; Saeki, T; Saijo, N; Sone, S; Stribling, D; Tsukagoshi, S; Tsuruo, T | 1 |
Gawron, A; Jakubowicz-Gil, J; Kandefer-Szerszeń, M; Paduch, R | 1 |
Christodoulou, C; Efstathiou, E; Klouvas, G; Papazachariou, E; Plyta, M; Skarlos, DV; Zervakis, D | 1 |
Boos, J; Klingebiel, T; Kranz, K; Krümpelmann, S; Lanvers, C; Metz, M; Schwenker, K; Würthwein, G | 1 |
Herrera, P; Jodra, MH; Laraña, JG; López, J; Navarro, JL; Odriozola, J; Pérez de Oteyza, J; Ramos, ML; Ramos, P; Roldán, E; Villalón, L; Zamora, C | 1 |
Lichtman, SM; Skirvin, JA | 1 |
Carter, SK; Slavik, M | 1 |
Adamson, RH; Mead, JA; Sieber, SM | 1 |
Carter, SK; Muggia, FM; Rozencweig, M; Slavik, M | 1 |
Beckmann, C; Flury, R; Frei, P; Holdener, E; Jungi, WF; Senn, HJ | 1 |
Barlogie, B; Corry, PM; Dosik, G; Freireich, EJ; Hankenson, R; Johnston, DA; Khalil, K; Lawson, R; Lippman, L; Reilly, E; Rigor, B; Tenczynski, TF; Yip, E | 1 |
Hansen, HH; Lau, ME; Nissen, NI; Pedersen, H | 1 |
Crooke, ST; Issell, BF | 1 |
Arnold, AM | 1 |
Crooke, ST; Gutierrez, ML | 1 |
Brunner, KW; Cavalli, F; Ryssel, HJ; Sonntag, RW | 1 |
Allen, LM; Creaven, PJ | 1 |
Arnold, BA; Cain, AM; Crist, WM; Fairclough, D; Furman, WL; Meyer, WH; Pratt, CB | 1 |
Loehrer, PJ | 1 |
Carmichael, J; Harris, AL; Houlbrook, S; Kirk, J; Lien, EA; Philip, P; Stuart, NS; Tonkin, K | 1 |
Bross, K; Brugger, W; Dern, P; Frisch, J; Kanz, L; Mertelsmann, R; Weber, B | 1 |
Weiss, RB | 1 |
Alder, KM; Brophy, NA; Fisher, GA; Gosland, MP; Halsey, J; Hardy, RI; Lum, BL; Sikic, BI; Yahanda, AM | 1 |
Adler, KM; Brophy, NA; Ehsan, MN; Gosland, MP; Halsey, J; Jew, L; Kaubisch, S; Lum, BL; Sikic, BI; Yahanda, AM | 1 |
Bryant, G; Carter, C; Cottler-Fox, M; Cowan, KH; Goldspiel, B; Jain, V; Longo, DL; Steinberg, SM; Wilson, WH; Wittes, RE | 1 |
Fay, JW; Harden, EA; Herzig, GP; Herzig, RH; Heye, MM; Meagher, RC; Montes, VM; Stevens, DA | 1 |
Kok, TC; Splinter, TA; van der Gaast, A | 1 |
Kok, TC; Splinter, TA; van der Gaast, A; Vlastuin, M | 1 |
Crist, WM; Crom, WR; Evans, WE; Groom, S; McLeod, HL; Relling, MV; Rivera, GK; Rodman, JH; Silverstein, K | 1 |
Anderson, N; Bern, M; Gonsalves, L; Lokich, J; Moore, C; Zipoli, T | 1 |
Brugger, W; Frisch, J; Kanz, L; Mertelsmann, R; Pressler, K; Schulz, G | 1 |
Cantwell, BM; Carmichael, J; Harris, AL; Lien, EA; Millward, MJ | 1 |
Bokemeyer, C; Harstrick, A; Hohnloser, J; Illiger, HJ; Metzner, B; Osternamm, A; Preiss, J; Ruther, U; Schmoll, HJ; Wilke, H | 1 |
Andersson, BS; Dicke, K; Dunphy, FR; Hester, J; Huan, SD; LeMaistre, CF; Spencer, V; Spitzer, G; Wallerstein, RO; Yau, JC | 1 |
Madden, T; Rodman, JH; Santana, VM; Sunderland, M | 1 |
de Vries, EG; Meijer, C; Mulder, NH; Mulder, PO; Nanninga, AG; Uges, DR; van der Graaf, WT; Vellenga, E | 1 |
Kohno, K; Kuwano, M; Ono, M; Takano, H; Uchida, Y | 1 |
Bremer, K; Uhlenbusch, R | 1 |
Buscema, J; Currie, JL; McLellan, R; Woodruff, JD | 1 |
Carmichael, J; Dolega-Ossowski, E; Harris, AL; Idle, JR; Joel, S; Monkman, SC; Philip, PA; Tonkin, K | 1 |
Hausamen, TU; Loeffler, TM; Weber, FW | 1 |
Einhorn, LH | 1 |
Deisseroth, AB; Dicke, K; Dunphy, FR; Holmes, FA; Hortobagyi, GN; Huan, SD; LeMaistre, CF; Spencer, V; Wallerstein, RO; Yau, JC | 1 |
Havemann, K; Köppler, H; Pflüger, KH | 1 |
Arbuck, SG; Evans, WE; Fleming, RA; Stewart, CF | 3 |
D'Incalci, M; Garattini, S | 1 |
Emminger, W; Emminger-Schmidmeier, W; Gadner, H; Hawliczek, R; Höcker, P; Peters, C | 1 |
Albertini, M; Saphner, T; Tormey, DC | 1 |
Von Hoff, DD | 1 |
Aisner, J; Lee, EJ | 1 |
Herzig, RH | 1 |
Carney, DN | 1 |
Greco, FA; Hainsworth, JD; Johnson, DH | 2 |
Slevin, ML | 1 |
Berthelot, P; Boboc, B; Carnot, F; Housset, C; Tourani, JM; Tran, A | 1 |
Kiue, A; Kohno, K; Kuwano, M; Takano, H; Watanabe, Y | 1 |
Berezin, F; Mick, R; Ratain, MJ; Schilsky, RL; Vogelzang, NJ | 1 |
Brenner, DE | 1 |
Miller, AA; Stewart, CF; Tolley, EA | 1 |
Creger, RJ; Fox, RM; Lazarus, HM | 1 |
Brogden, RN; Henwood, JM | 1 |
Dhingra, HM; Engineer, MS; Holmes, FA; Holoye, PY; Jeffries, DG; Newman, RA; Raber, M | 1 |
Castello, MA; Clerico, A; Dominici, C; Jenkner, A | 1 |
Anderson, T; Kohler, W; Mangalik, A; Neidhart, JA; Plauche, A; Quenzer, RW; Rinehart, JJ; Stidley, C | 1 |
Akiyama, Y; Ito, M; Kamiya, H; Kawa, K; Mikawa, H; Miyazaki, S; Sakurai, M; Tujino, G; Ueda, K | 1 |
Cattan, A; Desoize, B; Marechal, F | 1 |
Laurell, G; Skedinger, M | 1 |
Chauvenet, AR; Cruz, JM; Jackson, DV; Muss, HB; White, DR | 1 |
Markman, M | 1 |
Bagshawe, KD; Begent, RH; Crawford, SM; Ledermann, JA; Newlands, ES; Rustin, GJ; Turkie, W | 1 |
Bregni, M; Gianni, AM; Siena, S; Tarella, C | 1 |
Ishitani, KP; Kaiser, DL; Niskanen, E; Pirsch, GW; Stewart, FM | 1 |
Alimonti, A; Caroli, S; Castello, MA; Dominici, C; La Torre, F; Petrucci, F | 1 |
Caponera, ME; Cruz, JM; Jackson, DV; Muss, HB; Richards, F; Spurr, CL; White, DR; Zekan, PJ | 1 |
McVie, G; Muggia, FM | 1 |
Arbuck, SG; Evans, WE; Pieper, JA; Stewart, CF | 1 |
Frazier, SR; Greco, FA; Hainsworth, JD; Johnson, DH | 1 |
Kimura, K; Niitani, H; Yamada, K | 1 |
Peters, W; Souhami, R | 1 |
Cummings, J; Cunningham, D; Forrest, GJ; McTaggart, L; Soukop, M; Stuart, JF | 1 |
Helson, L | 1 |
Beekhuis, H; de Jong, R; de Vries, EG; Mulder, NH; Piers, DA | 1 |
Dallorso, S; De Bernardi, B; Dini, G; Moroni, C; Perin, G; Rogers, D; Stura, M | 1 |
Ratain, MJ; Schilsky, RL; Senekjian, EK; Simon, T; Vogelzang, NJ; Wojack, BR | 1 |
Berger, NA; Lazarus, HM | 1 |
Berry, DH; Brodeur, G; Dubowy, R; Hayes, FA; Krischer, J; Kung, F; Leventhal, B; Mahoney, D; Toledano, S | 1 |
Betcher, D; Burnham, N | 1 |
Appelbaum, FR; Buckner, CD | 1 |
Lampkin, BC; Wong, KY | 1 |
Havemann, K; Jungclas, H; Merkel, M; Pflüger, KH; Schmidt, L | 1 |
Cummings, J; Cunningham, D; Forrest, GJ; Gilchrist, NL; Soukop, M | 1 |
Arbuck, SG; Cooper, C; Crom, WR; Douglass, HO; Evans, WE; Goodwin, P; Silk, Y | 1 |
Maroun, JA; Nundy, D; Prior, J; Stewart, DJ; Tetreault, L | 1 |
de Gast, GC; Dekker, AW; Rozenberg-Arska, M; Schornagel, JH; van Kempen, ML; Vendrik, CP; Verdonck, LF | 1 |
Hashimoto, S; Kano, A; Kawamoto, K; Konno, K; Sakata, Y; Sato, S; Takahashi, H; Wakui, A; Yokoyama, M; Yoshida, Y | 1 |
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Topics: Alkaloids; Antineoplastic Agents; Cell Proliferation; Drug Screening Assays, Antitumor; Humans; Molecular Structure; Neoplasms | 2021 |
Clinical factors of PICC-RVT in cancer patients: a meta-analysis.
Topics: Catheters; China; Databases, Factual; Etoposide; Humans; Neoplasms | 2023 |
Radiation therapy of cancer in the adolescent and young adult (AYA) generation.
Topics: Adolescent; Child; Etoposide; Fertility; Humans; Neoplasms; Young Adult | 2023 |
Recent advancements in the targeted delivery of etoposide nanomedicine for cancer therapy: A comprehensive review.
Topics: Antineoplastic Agents; Drug Carriers; Drug Delivery Systems; Etoposide; Humans; Liposomes; Nanomedicine; Nanoparticles; Neoplasms | 2023 |
Haemophagocytic lymphohistiocytosis in human immunodeficiency virus: a systematic review of literature.
Topics: Adult; Anti-Retroviral Agents; Etoposide; Female; HIV; HIV Infections; Humans; Lymphohistiocytosis, Hemophagocytic; Male; Middle Aged; Neoplasms; Opportunistic Infections; Retrospective Studies; Steroids; Topoisomerase II Inhibitors | 2020 |
Natural Polyphenols as Modulators of Etoposide Anti-Cancer Activity.
Topics: Animals; Antineoplastic Agents, Phytogenic; Biomarkers; Cell Line, Tumor; Cell Proliferation; Cell Survival; Disease Models, Animal; Drug Synergism; Etoposide; Humans; Neoplasms; Polyphenols; Structure-Activity Relationship; Topoisomerase II Inhibitors; Xenograft Model Antitumor Assays | 2021 |
Window-of-opportunity trials to evaluate clinical activity of new molecular entities in oncology.
Topics: Adult; Antineoplastic Agents; Child; Clinical Trials as Topic; Epirubicin; Etoposide; Humans; Melphalan; Molecular Targeted Therapy; Neoplasms; Topotecan | 2011 |
TT-232: a somatostatin structural derivative as a potent antitumor drug candidate.
Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Cell Line, Tumor; Dacarbazine; Etoposide; Humans; Neoplasms; Peptides, Cyclic; Somatostatin | 2003 |
Pharmacokinetic optimisation of treatment with oral etoposide.
Topics: Administration, Oral; Aged; Antineoplastic Agents, Phytogenic; Area Under Curve; Biological Availability; Etoposide; Half-Life; Humans; Intestinal Absorption; Neoplasms; Structure-Activity Relationship; Tissue Distribution | 2004 |
Topoisomerase II inhibitors.
Topics: Anthracyclines; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; DNA Damage; Enzyme Inhibitors; Etoposide; Humans; Neoplasms; Topoisomerase II Inhibitors | 2003 |
Etoposide, topoisomerase II and cancer.
Topics: Animals; DNA Damage; DNA Topoisomerases, Type II; Etoposide; Humans; Neoplasms; Structure-Activity Relationship; Topoisomerase II Inhibitors | 2005 |
Topoisomerase II inhibitors.
Topics: Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Enzyme Inhibitors; Etoposide; Humans; Neoplasms; Topoisomerase II Inhibitors | 2005 |
Pulmonary complications of novel antineoplastic agents for solid tumors.
Topics: Antibiotics, Antineoplastic; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antimetabolites, Antineoplastic; Antineoplastic Agents; Bevacizumab; Deoxycytidine; Doxorubicin; Epirubicin; Etoposide; Everolimus; Gemcitabine; Humans; Lung; Lung Diseases; Mitoxantrone; Neoplasms; Pneumonia; Pyrimidines; Risk Factors; Sirolimus; Teniposide; Trastuzumab | 2008 |
[New antineoplastic agents, their value and use].
Topics: Aminacrine; Antineoplastic Agents; Aspartic Acid; Cisplatin; Etoposide; Humans; Ifosfamide; Interferons; Medroxyprogesterone; Medroxyprogesterone Acetate; Methyltestosterone; Neoplasms; Phosphonoacetic Acid; Razoxane; Tamoxifen; Teniposide; Vinca Alkaloids | 1982 |
Therapeutic progress--review VIII. Do the newer cytotoxic drugs represent a significant advance in the treatment of cancer?
Topics: Animals; Antineoplastic Agents; Cisplatin; Etoposide; Humans; Neoplasms | 1983 |
Review of etoposide single-agent activity.
Topics: Animals; Drug Administration Schedule; Etoposide; Female; Humans; Male; Neoplasms; Podophyllotoxin | 1982 |
Intensive chemotherapy for solid tumours--current clinical applications.
Topics: Antineoplastic Agents; Carmustine; Cyclophosphamide; Drug Administration Schedule; Drug Therapy, Combination; Etoposide; Forecasting; Humans; Melphalan; Neoplasms | 1982 |
The podophyllotoxin derivatives VP16-213 and VM26.
Topics: Animals; Chemical Phenomena; Chemistry; Drug Therapy, Combination; Etoposide; Humans; Neoplasms; Podophyllotoxin; Teniposide | 1982 |
VP16-213 (etoposide). A critical review of its activity.
Topics: Drug Evaluation; Etoposide; Humans; Neoplasms; Podophyllotoxin; Research Design | 1982 |
[Myeloablative chemotherapy with autologous bone marrow and/or peripheral blood stem cell transplantation in children with high-risk solid tumor].
Topics: Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Purging; Bone Marrow Transplantation; Carboplatin; Child; Combined Modality Therapy; Cryopreservation; Doxorubicin; Etoposide; Hematopoietic Stem Cell Transplantation; Humans; Kidney Neoplasms; Neoplasms; Neuroblastoma; Rhabdomyosarcoma; Wilms Tumor | 1995 |
The use of ifosfamide, carboplatin, and etoposide in children with solid tumors.
Topics: Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Child; Etoposide; Humans; Ifosfamide; Lymphoma, Non-Hodgkin; Neoplasms; Neuroblastoma; Neutropenia; Sarcoma; Thrombocytopenia; Wilms Tumor | 1995 |
Etoposide: twenty years later.
Topics: Drug Administration Schedule; Drug Synergism; Etoposide; Humans; Neoplasms | 1995 |
Clinical reversal of multidrug resistance.
Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport, Active; Clinical Trials as Topic; Cyclosporine; Drug Resistance, Multiple; Etoposide; Gene Expression; Gene Expression Regulation, Neoplastic; Humans; Neoplasm Proteins; Neoplasms; Paclitaxel; Pharmaceutical Preparations; Verapamil | 1994 |
Clinical trials of modulation of multidrug resistance. Pharmacokinetic and pharmacodynamic considerations.
Topics: Antineoplastic Combined Chemotherapy Protocols; ATP Binding Cassette Transporter, Subfamily B, Member 1; Carrier Proteins; Clinical Trials as Topic; Cyclosporine; Drug Resistance; Etoposide; Gene Expression Regulation, Neoplastic; Humans; Membrane Glycoproteins; Neoplasm Proteins; Neoplasms | 1993 |
Chemotherapy administration: doses, infusions and choice of schedule.
Topics: Antineoplastic Agents; Camptothecin; Drug Administration Schedule; Etoposide; Fluorouracil; Humans; Infusions, Intravenous; Neoplasms | 1994 |
Prolonged administration of low-daily-dose etoposide: a superior dosing schedule?
Topics: Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Small Cell; Clinical Trials, Phase II as Topic; Drug Administration Schedule; Etoposide; Humans; Lung Neoplasms; Neoplasms; Pilot Projects; Time Factors | 1994 |
7-Ethyl-10-[4-(1-piperidino)-1-piperidino] carbonyloxy camptothecin: mechanism of resistance and clinical trials.
Topics: Amino Acid Sequence; Animals; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Base Sequence; Camptothecin; Carcinoma, Non-Small-Cell Lung; Cell Line; Cell Survival; CHO Cells; Clinical Trials, Phase I as Topic; Cricetinae; DNA Topoisomerases, Type I; Drug Resistance; Etoposide; Female; Humans; Irinotecan; Lung Neoplasms; Molecular Sequence Data; Neoplasms; Ovarian Neoplasms; Point Mutation; Topoisomerase I Inhibitors; Tumor Cells, Cultured | 1994 |
Etoposide: current status and future perspectives in the management of malignant neoplasms.
Topics: Acquired Immunodeficiency Syndrome; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Non-Small-Cell Lung; Carcinoma, Small Cell; Etoposide; Germinoma; Humans; Leukemia, Myeloid, Acute; Lung Neoplasms; Lymphoma; Neoplasms; Sarcoma, Kaposi; Stomach Neoplasms | 1994 |
Teniposide: overview of its therapeutic potential in adult cancers.
Topics: Acquired Immunodeficiency Syndrome; Adult; Brain Neoplasms; Carcinoma, Non-Small-Cell Lung; Carcinoma, Small Cell; Clinical Trials as Topic; Clinical Trials, Phase I as Topic; Etoposide; Female; Genital Neoplasms, Female; Hodgkin Disease; Humans; Leukemia; Lung Neoplasms; Lymphoma; Lymphoma, Non-Hodgkin; Neoplasms; Sarcoma, Kaposi; Teniposide | 1994 |
Pharmacodynamics and long-term toxicity of etoposide.
Topics: Child; Etoposide; Humans; Leukemia; Leukemia, Myeloid, Acute; Male; Neoplasms; Podophyllotoxin; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Testicular Neoplasms | 1994 |
Use of etoposide in patients with organ dysfunction: pharmacokinetic and pharmacodynamic considerations.
Topics: Etoposide; Humans; Intestinal Absorption; Kidney; Liver; Neoplasms; Renal Dialysis | 1994 |
Schedule-dependent topoisomerase II-inhibiting drugs.
Topics: Amsacrine; Antibiotics, Antineoplastic; Antineoplastic Agents; Cell Cycle; Clinical Trials, Phase I as Topic; DNA Repair; Drug Administration Schedule; Etoposide; Humans; Metabolic Clearance Rate; Neoplasms; Teniposide; Topoisomerase II Inhibitors | 1994 |
Epipodophyllotoxins in the treatment of childhood cancer.
Topics: Antineoplastic Combined Chemotherapy Protocols; Child; Clinical Trials, Phase I as Topic; Clinical Trials, Phase II as Topic; Cytarabine; Etoposide; Humans; Leukemia, Myeloid, Acute; Lymphoma, Non-Hodgkin; Neoplasms; Neoplasms, Second Primary; Neuroblastoma; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Teniposide | 1994 |
Hypersensitivity reactions to etoposide. A report of three cases and review of the literature.
Topics: Adult; Drug Hypersensitivity; Etoposide; Female; Humans; Neoplasms | 1994 |
Clinical pharmacokinetics and pharmacodynamics of epipodophyllotoxins.
Topics: Antineoplastic Combined Chemotherapy Protocols; Drug Resistance; Etoposide; Humans; Leukemia; Neoplasms; Neoplasms, Second Primary; Teniposide; Topoisomerase II Inhibitors | 1993 |
Chronic etoposide administration: overview of clinical experience.
Topics: Antineoplastic Combined Chemotherapy Protocols; Biological Availability; Drug Administration Schedule; Etoposide; Female; Germinoma; Humans; Lung Neoplasms; Lymphoma, Non-Hodgkin; Male; Neoplasms; Ovarian Neoplasms | 1993 |
Haematopoietic growth factors and peripheral blood stem cells as supportive agents in dose intensification.
Topics: Antineoplastic Combined Chemotherapy Protocols; Blood Cell Count; Blood Transfusion, Autologous; Cisplatin; Drug Administration Schedule; Etoposide; Hematopoietic Cell Growth Factors; Hematopoietic Stem Cells; Humans; Ifosfamide; Neoplasms | 1993 |
[Etoposide: specificity of prolonged oral administration].
Topics: Administration, Oral; Antineoplastic Agents, Phytogenic; Dose-Response Relationship, Drug; Drug Administration Schedule; Etoposide; Humans; Neoplasms; Quality of Life; Remission Induction; Treatment Outcome | 1996 |
[On the novel differentiation-apoptosis inducers in tumor cells].
Topics: Animals; Antineoplastic Agents; Apoptosis; Bufanolides; Camptothecin; Cell Differentiation; Etoposide; Humans; Neoplasms; Sodium-Potassium-Exchanging ATPase; Topoisomerase I Inhibitors; Topoisomerase II Inhibitors | 1996 |
[Clinical studies on combination of ifosfamide, carboplatin and etoposide (ICE) with whole body hyperthermia].
Topics: Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Combined Modality Therapy; Etoposide; Humans; Hyperthermia, Induced; Ifosfamide; Neoplasms; Treatment Outcome | 1996 |
Peripheral blood progenitor cell transplantation: a single centre experience comparing two mobilisation regimens in 67 patients.
Topics: Adolescent; Adult; Amyloidosis; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow; Carmustine; Cell Movement; Colony-Forming Units Assay; Cyclophosphamide; Cytarabine; Etoposide; Female; Granulocyte Colony-Stimulating Factor; Hematologic Neoplasms; Hematopoietic Stem Cell Transplantation; Hematopoietic Stem Cells; Humans; Kidney Diseases; Leukapheresis; Leukocyte Count; Male; Melphalan; Middle Aged; Neoplasms; Podophyllotoxin; Retrospective Studies; Thiotepa; Transplantation Conditioning | 1996 |
The importance of drug scheduling in cancer chemotherapy: etoposide as an example.
Topics: Antineoplastic Agents, Phytogenic; Clinical Trials as Topic; Drug Administration Schedule; Etoposide; Humans; Neoplasms | 1996 |
The clinical pharmacology of etoposide: an update.
Topics: Adult; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Child; Drug Administration Schedule; Drug Resistance, Neoplasm; Drug Synergism; Etoposide; Humans; Neoplasms; Neoplasms, Second Primary | 1996 |
[Mechanism of the induction of apoptosis in cancer cells].
Topics: Animals; Antineoplastic Agents; Apoptosis; Bufanolides; Diterpenes; Drug Design; Etoposide; Humans; Neoplasms; Protein Prenylation; Signal Transduction; Topoisomerase I Inhibitors; Ultraviolet Rays | 1996 |
Mutational specificity and cancer chemoprevention.
Topics: Animals; Animals, Genetically Modified; Biomarkers, Tumor; Chemoprevention; DNA Mutational Analysis; Etoposide; Genetic Testing; Humans; Hypoxanthine Phosphoribosyltransferase; Mutagenicity Tests; Neoplasms; T-Lymphocytes; Tumor Suppressor Protein p53 | 1996 |
Etoposide for the treatment of paediatric tumours: what is the best way to give it?
Topics: Administration, Oral; Adolescent; Adult; Antineoplastic Agents, Phytogenic; Child; Child, Preschool; Etoposide; Humans; Infant; Infusions, Intravenous; Neoplasms | 1996 |
[DNA topoisomerases targeting anticancer agents and mechanism for acquirement of drug resistance].
Topics: Antineoplastic Agents, Phytogenic; Camptothecin; DNA Topoisomerases, Type I; DNA Topoisomerases, Type II; Drug Resistance, Neoplasm; Etoposide; Humans; Irinotecan; Mutation; Neoplasms; Teniposide; Topoisomerase I Inhibitors; Topoisomerase II Inhibitors; Tumor Cells, Cultured | 1997 |
Combination chemotherapy studies with gemcitabine.
Topics: Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Cell Division; Cisplatin; Deoxycytidine; Drug Synergism; Etoposide; Gemcitabine; Humans; Mitomycin; Neoplasms; Ribonucleotide Reductases; Tumor Cells, Cultured | 1997 |
[Tumor necrosis factor-alpha--phase I and phase II clinical trials].
Topics: Clinical Trials, Phase I as Topic; Clinical Trials, Phase II as Topic; Cyclophosphamide; Drug Synergism; Etoposide; Humans; Immunotherapy; Interferon-gamma; Interleukin-2; Neoplasms; Tumor Necrosis Factor-alpha | 1997 |
Eukaryotic DNA topoisomerase II beta.
Topics: Amino Acid Sequence; Animals; Antineoplastic Agents; Cell Cycle; DNA Topoisomerases, Type II; DNA-Binding Proteins; DNA, Superhelical; Etoposide; Humans; Mice; Molecular Sequence Data; Neoplasms; Sequence Alignment; Sequence Homology, Amino Acid | 1998 |
Cancer chemotherapy in the elderly.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Anthraquinones; Antineoplastic Agents; Breast Neoplasms; Busulfan; Daunorubicin; Doxorubicin; Etoposide; Female; Fluorouracil; Heart; Hematologic Neoplasms; Humans; Lung; Male; Middle Aged; Neoplasms; Pyrazoles | 1998 |
Etoposide: four decades of development of a topoisomerase II inhibitor.
Topics: Administration, Oral; Anthracyclines; Antineoplastic Agents, Phytogenic; Etoposide; Humans; Mitoxantrone; Neoplasms; Technology, Pharmaceutical; Teniposide; Topoisomerase II Inhibitors | 1998 |
[Irinotecan-containing combinations in solid tumors, except colonic carcinomas].
Topics: Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Carboplatin; Carcinoma, Non-Small-Cell Lung; Carcinoma, Small Cell; Cisplatin; Clinical Trials, Phase I as Topic; Clinical Trials, Phase II as Topic; Diarrhea; Docetaxel; Enzyme Inhibitors; Etoposide; Female; Genital Neoplasms, Female; Humans; Irinotecan; Lung Neoplasms; Lymphoma, Non-Hodgkin; Male; Neoplasm Proteins; Neoplasms; Neutropenia; Paclitaxel; Stomach Neoplasms; Taxoids; Topoisomerase I Inhibitors; Treatment Outcome | 1998 |
[Combination chemotherapy--present status and problems].
Topics: Administration, Oral; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Cisplatin; Cyclophosphamide; Doxorubicin; Drug Administration Schedule; Etoposide; Fluorouracil; Humans; Infusions, Intravenous; Injections, Intravenous; Mitomycin; Neoplasms | 1999 |
Extended-schedule oral etoposide in selected neoplasms and overview of administration and scheduling issues.
Topics: Administration, Oral; Animals; Antineoplastic Agents, Phytogenic; Clinical Trials, Phase II as Topic; Drug Administration Schedule; Etoposide; Humans; Neoplasms; Neoplasms, Experimental | 1999 |
DNA topoisomerase II inhibitors.
Topics: Amsacrine; Antineoplastic Agents; Carcinogens; Disease Models, Animal; Etoposide; Evidence-Based Medicine; Humans; Intestinal Absorption; Mitoxantrone; Neoplasms; Nucleic Acid Synthesis Inhibitors; Research Design; Risk Factors; Teniposide; Tissue Distribution; Topoisomerase II Inhibitors | 2000 |
Body surface area as a determinant of pharmacokinetics and drug dosing.
Topics: Adult; Animals; Anthropometry; Antineoplastic Agents; Area Under Curve; Body Surface Area; Carboplatin; Cardiac Output; Child; Docetaxel; Dose-Response Relationship, Drug; Drug Administration Schedule; Etoposide; Humans; Kidney; Liver; Medical Oncology; Neoplasms; Paclitaxel; Taxoids | 2001 |
Pharmacokinetic considerations of oral chemotherapy in elderly patients with cancer.
Topics: Administration, Oral; Aged; Antineoplastic Agents; Antineoplastic Agents, Alkylating; Complementary Therapies; Cytochrome P-450 Enzyme System; Dacarbazine; Etoposide; Humans; Idarubicin; Neoplasms; Tamoxifen; Temozolomide; Thalidomide; Topotecan | 2002 |
Investigational drugs under study by the United States National Cancer Institute.
Topics: Acrylates; Alkylating Agents; Ancitabine; Animals; Antibiotics, Antineoplastic; Antimetabolites, Antineoplastic; Antineoplastic Agents; Azacitidine; Chemical Phenomena; Chemistry; Chromomycins; Cisplatin; DNA, Neoplasm; Drug Evaluation, Preclinical; Etoposide; Humans; Ifosfamide; Leukemia L1210; Mice; Mitosis; National Institutes of Health (U.S.); Neoplasms; Neoplasms, Experimental; Razoxane; Tegafur; Teniposide; United States | 1976 |
Pharmacology of antitumor agents from higher plants.
Topics: Animals; Antineoplastic Agents, Phytogenic; Aporphines; Camptothecin; Carcinoma, Squamous Cell; Chemical Phenomena; Chemistry; Etoposide; Humans; Leukemia L1210; Leukemia, Experimental; Leukemia, Lymphoid; Maytansine; Melanoma; Naphthoquinones; Nasopharyngeal Neoplasms; Neoplasms; Neoplasms, Experimental; Phenanthrenes; Structure-Activity Relationship; Teniposide; Vinblastine; Vincristine | 1976 |
[New substances in oncologic therapy].
Topics: Alkylating Agents; Altretamine; Antimetabolites, Antineoplastic; Cisplatin; Dacarbazine; Doxorubicin; Drug Evaluation; Drug Evaluation, Preclinical; Etoposide; Humans; Neoplasms; Nitrosourea Compounds; Razoxane; Tamoxifen; Vinca Alkaloids; Zinostatin | 1978 |
Etoposide (VP-16-213).
Topics: Adult; Animals; Bone Marrow; Cell Cycle; Child; Digestive System; Drug Therapy, Combination; Etoposide; Female; Humans; Leukemia; Lung Neoplasms; Lymphoma; Male; Mice; Neoplasms; Neoplasms, Experimental; Podophyllotoxin; Rats | 1979 |
Podophyllotoxin derivative VP 16-213.
Topics: Animals; Bronchial Neoplasms; Carcinoma; Clinical Trials as Topic; Drug Administration Schedule; Drug Evaluation; Drug Therapy, Combination; Etoposide; Humans; In Vitro Techniques; Leukemia, Monocytic, Acute; Leukemia, Myeloid; Lymphoma; Mice; Neoplasms; Podophyllotoxin; Rabbits; Rats; Sarcoma | 1979 |
Pediatric cancer chemotherapy: an updated review. I. Cis-Diammine--dichloroplatinum II (cisplatin), VM-26 (teniposide), VP-16 (etoposide), mitomycin C.
Topics: Child; Cisplatin; Clinical Trials as Topic; Drug Administration Schedule; Etoposide; Humans; Leukemia; Mitomycins; Neoplasms; Podophyllotoxin; Teniposide | 1979 |
Chronic oral etoposide: trials at Indiana University and with the Hoosier Oncology Group.
Topics: Administration, Oral; Carcinoma, Non-Small-Cell Lung; Carcinoma, Small Cell; Clinical Trials as Topic; Drug Administration Schedule; Etoposide; Female; Humans; Lung Neoplasms; Male; Neoplasms; Neoplasms, Germ Cell and Embryonal; Testicular Neoplasms | 1992 |
Hypersensitivity reactions.
Topics: Antibiotics, Antineoplastic; Antineoplastic Agents; Asparaginase; Aziridines; Benzoquinones; Bleomycin; Chlorambucil; Cisplatin; Cyclophosphamide; Cytarabine; Dacarbazine; Drug Hypersensitivity; Etoposide; Fluorouracil; Humans; Ifosfamide; Melphalan; Methotrexate; Mitomycins; Neoplasms; Paclitaxel; Pentostatin; Procarbazine; Teniposide | 1992 |
Etoposide: seeking the best dose and schedule.
Topics: Clinical Trials as Topic; Drug Administration Schedule; Etoposide; Humans; Neoplasms | 1992 |
Disposition of antineoplastic agents in the very young child.
Topics: Age Factors; Antineoplastic Agents; Blood Proteins; Child; Child, Preschool; Doxorubicin; Etoposide; Humans; Infant; Infant, Newborn; Liver; Mercaptopurine; Methotrexate; Neoplasms; Nervous System; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Teniposide | 1992 |
Podophyllotoxin derivatives.
Topics: Animals; Drug Interactions; Drug Resistance; Etoposide; Humans; Neoplasms; Teniposide | 1991 |
Etoposide. Current and future status.
Topics: Antineoplastic Combined Chemotherapy Protocols; Etoposide; Humans; Neoplasms | 1991 |
High-dose etoposide and marrow transplantation.
Topics: Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Transplantation; Combined Modality Therapy; Etoposide; Humans; Neoplasms | 1991 |
The pharmacology of intravenous and oral etoposide.
Topics: Administration, Oral; Etoposide; Humans; Injections, Intravenous; Neoplasms | 1991 |
Chronic oral etoposide.
Topics: Drug Administration Schedule; Etoposide; Humans; Neoplasms; Time Factors | 1991 |
Future directions for etoposide therapy.
Topics: Drug Administration Schedule; Etoposide; Forecasting; Humans; Neoplasms | 1991 |
The clinical pharmacology of etoposide.
Topics: Etoposide; Humans; Neoplasms | 1991 |
Antitumor antibiotics, epipodophyllotoxins, and vinca alkaloids: clinical developments.
Topics: Antibiotics, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Drug Resistance; Etoposide; Humans; Neoplasms; Vinca Alkaloids | 1990 |
Etoposide. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in combination chemotherapy of cancer.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Etoposide; Humans; Neoplasms | 1990 |
[Use of recombinant hematopoietic growth factors after chemotherapy and high-dose chemo-radiotherapy].
Topics: Anemia, Aplastic; Antineoplastic Agents; Colony-Stimulating Factors; Combined Modality Therapy; Cyclophosphamide; Cytarabine; Drug Evaluation; Etoposide; Hematopoietic Stem Cell Transplantation; Humans; Leukemia; Melphalan; Neoplasms; Radiotherapy | 1989 |
High dose chemotherapy in solid tumours in adults.
Topics: Adult; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow; Bone Marrow Transplantation; Breast Neoplasms; Carcinoma, Small Cell; Carmustine; Cell Separation; Cisplatin; Colonic Neoplasms; Cyclophosphamide; Etoposide; Glioma; Humans; Lung Neoplasms; Male; Melanoma; Melphalan; Neoplasms; Testicular Neoplasms; Whole-Body Irradiation | 1986 |
Chemotherapy of malignant disease: an update.
Topics: Amsacrine; Antineoplastic Agents; Cisplatin; Coformycin; Etoposide; Female; Humans; Ifosfamide; Male; Mitoxantrone; Neoplasms; Pentostatin; Pregnancy | 1988 |
Overview of the clinical relevance of autologous bone marrow transplantation.
Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Transplantation; Carmustine; Clinical Trials as Topic; Combined Modality Therapy; Cyclophosphamide; Cytarabine; Drug Evaluation; Drug Resistance; Etoposide; Hodgkin Disease; Humans; Leukemia; Leukemia, Lymphoid; Lymphoma; Melphalan; Neoplasm Recurrence, Local; Neoplasms; Thioguanine; Transplantation, Autologous | 1986 |
Indications for and benefits of intensive therapies in treatment of childhood cancers.
Topics: Acute Disease; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Child; Cytarabine; Etoposide; Humans; Leukemia; Leukemia, Lymphoid; Lymphoma; Melphalan; Methotrexate; Neoplasms; Osteosarcoma; Risk; Sarcoma, Ewing | 1986 |
149 trial(s) available for etoposide and Neoplasms
Article | Year |
---|---|
A phase I study of sirolimus in combination with metronomic therapy (CHOAnome) in children with recurrent or refractory solid and brain tumors.
Topics: Administration, Metronomic; Adolescent; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Celecoxib; Child; Child, Preschool; Cyclophosphamide; Dose-Response Relationship, Drug; Etoposide; Female; Humans; Male; Maximum Tolerated Dose; Neoplasms; Sirolimus; Young Adult | 2020 |
Subsequent malignant neoplasms among children with Hodgkin lymphoma: a report from the Children's Oncology Group.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Child; Cisplatin; Cyclophosphamide; Cytarabine; Doxorubicin; Etoposide; Female; Hodgkin Disease; Humans; Incidence; Male; Neoplasms; Prednisone; Vincristine | 2021 |
Metronomic Chemotherapy vs Best Supportive Care in Progressive Pediatric Solid Malignant Tumors: A Randomized Clinical Trial.
Topics: Administration, Metronomic; Administration, Oral; Adolescent; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Celecoxib; Child; Child, Preschool; Cyclophosphamide; Disease Progression; Disease-Free Survival; Double-Blind Method; Etoposide; Female; Follow-Up Studies; Humans; Male; Neoplasms; Response Elements; Retreatment; Sarcoma, Ewing; Survival Rate; Thalidomide; Time Factors | 2017 |
First-in-man dose escalation and pharmacokinetic study of CAP7.1, a novel prodrug of etoposide, in adults with refractory solid tumours.
Topics: Adult; Aged; Dose-Response Relationship, Drug; Etoposide; Female; Humans; Male; Maximum Tolerated Dose; Middle Aged; Neoplasms; Prodrugs | 2017 |
A Phase I Dose-Escalation Study of Veliparib Combined with Carboplatin and Etoposide in Patients with Extensive-Stage Small Cell Lung Cancer and Other Solid Tumors.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Benzimidazoles; Carboplatin; Etoposide; Female; Humans; Male; Maximum Tolerated Dose; Middle Aged; Neoplasm Staging; Neoplasms; Small Cell Lung Carcinoma; Treatment Outcome | 2019 |
A phase I study of AT-101 with cisplatin and etoposide in patients with advanced solid tumors with an expanded cohort in extensive-stage small cell lung cancer.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Etoposide; Female; Gossypol; Humans; Male; Maximum Tolerated Dose; Middle Aged; Neoplasms | 2014 |
A non-comparative phase II study of dose intensive chemotherapy with doxorubicin and ifosfamide followed by high dose ICE consolidation with PBSCT in non-resectable, high grade, adult type soft tissue sarcomas.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Doxorubicin; Etoposide; Female; Humans; Ifosfamide; Male; Middle Aged; Neoplasms; Young Adult | 2013 |
A phase II trial of a multi-agent oral antiangiogenic (metronomic) regimen in children with recurrent or progressive cancer.
Topics: Adolescent; Adult; Angiogenesis Inhibitors; Antineoplastic Combined Chemotherapy Protocols; Celecoxib; Child; Child, Preschool; Cyclophosphamide; Etoposide; Female; Fenofibrate; Follow-Up Studies; Humans; Infant; Male; Neoplasm Recurrence, Local; Neoplasm Staging; Neoplasms; Neovascularization, Pathologic; Prognosis; Prospective Studies; Pyrazoles; Sulfonamides; Survival Rate; Thalidomide; Young Adult | 2014 |
Phase I clinical trial of ifosfamide, oxaliplatin, and etoposide (IOE) in pediatric patients with refractory solid tumors.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Etoposide; Female; Humans; Ifosfamide; Infant; Male; Maximum Tolerated Dose; Neoplasms; Organoplatinum Compounds; Oxaliplatin | 2015 |
Effects of UGT1A1 genotype on the pharmacokinetics, pharmacodynamics, and toxicities of belinostat administered by 48-hour continuous infusion in patients with cancer.
Topics: Adult; Aged; Area Under Curve; Cisplatin; Etoposide; Female; Genotype; Glucuronosyltransferase; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Male; Middle Aged; Neoplasms; Polymorphism, Single Nucleotide; Sulfonamides | 2016 |
A phase I study of bortezomib, etoposide and carboplatin in patients with advanced solid tumors refractory to standard therapy.
Topics: Adult; Aged; Anemia; Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Boronic Acids; Bortezomib; Carboplatin; Dose-Response Relationship, Drug; Drug Administration Schedule; Etoposide; Female; Humans; Male; Maximum Tolerated Dose; Middle Aged; Nausea; Neoplasms; Neutropenia; Pyrazines; Thrombocytopenia | 2009 |
Phase 1 study of an oxaliplatin and etoposide regimen in pediatric patients with recurrent solid tumors.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Drug Administration Schedule; Etoposide; Female; Humans; Infant; Magnetic Resonance Imaging; Male; Maximum Tolerated Dose; Neoplasms; Neutropenia; Organoplatinum Compounds; Oxaliplatin; Recurrence | 2009 |
Developmental pharmacokinetics of etoposide in 67 children: lack of dexamethasone effect.
Topics: Adolescent; Antiemetics; Antineoplastic Combined Chemotherapy Protocols; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Body Weight; Carboplatin; Child; Child, Preschool; Cytochrome P-450 CYP3A; Dexamethasone; Drug Interactions; Etoposide; Humans; Infant; Models, Biological; Neoplasms; Nonlinear Dynamics; Ondansetron; Polymorphism, Single Nucleotide | 2011 |
Duration: escalation study of oral etoposide with carboplatin in patients with varied solid tumors.
Topics: Administration, Oral; Adult; Anemia; Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Interactions; Etoposide; Female; Humans; Infusions, Intravenous; Male; Maximum Tolerated Dose; Neoplasms; Neutropenia; Salvage Therapy; Thrombocytopenia | 2010 |
Phase I Study of Topotecan, Ifosfamide, and Etoposide (TIME) with autologous stem cell transplant in refractory cancer: pharmacokinetic and pharmacodynamic correlates.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Area Under Curve; Combined Modality Therapy; DNA Topoisomerases, Type I; Drug Administration Schedule; Drug Resistance, Neoplasm; Etoposide; Female; Hematopoietic Stem Cell Transplantation; Humans; Ifosfamide; Kaplan-Meier Estimate; Male; Mesna; Metabolic Clearance Rate; Middle Aged; Mucositis; Multivariate Analysis; Neoplasms; Proportional Hazards Models; Topotecan; Transplantation, Autologous; Treatment Outcome | 2011 |
Clinical pharmacology of etoposide in children undergoing autologous stem cell transplantation for various solid tumours.
Topics: Adolescent; Age Distribution; Body Weight; Child; Child, Preschool; Confidence Intervals; Etoposide; Female; Hematopoietic Stem Cell Transplantation; Humans; Male; Models, Biological; Neoplasms; Transplantation, Autologous; Young Adult | 2013 |
Clinical and pharmacokinetic study of fractionated doses of oral etoposide in pediatric patients with advanced malignancies.
Topics: Administration, Oral; Adolescent; Antineoplastic Agents, Phytogenic; Area Under Curve; Child; Child, Preschool; Etoposide; Female; Humans; Male; Neoplasms; Time Factors; Treatment Outcome | 2002 |
Phase I evaluation of sequential topoisomerase targeting with irinotecan/cisplatin followed by etoposide in patients with advanced malignancy.
Topics: Adult; Aged; Antigens, Neoplasm; Antineoplastic Combined Chemotherapy Protocols; Area Under Curve; Camptothecin; Cisplatin; Cohort Studies; DNA Topoisomerases, Type I; DNA Topoisomerases, Type II; DNA-Binding Proteins; Etoposide; Female; Humans; Irinotecan; Male; Maximum Tolerated Dose; Middle Aged; Neoplasms; Topoisomerase I Inhibitors; Topoisomerase II Inhibitors | 2003 |
Sequencing topotecan and etoposide plus cisplatin to overcome topoisomerase I and II resistance: a pharmacodynamically based Phase I trial.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Cohort Studies; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Etoposide; Female; Humans; Male; Middle Aged; Neoplasms; Time Factors; Topoisomerase I Inhibitors; Topoisomerase II Inhibitors; Topotecan; Treatment Outcome | 2003 |
Two schedules of application for mesna and their influence on the thiol-metabolism.
Topics: Antineoplastic Combined Chemotherapy Protocols; Drug Administration Schedule; Epirubicin; Etoposide; Humans; Ifosfamide; Infusions, Intravenous; Injections, Intravenous; Mesna; Neoplasms; Protective Agents; Sulfhydryl Compounds | 2003 |
Outcome of pediatric recurrent and refractory malignant solid tumors following ifosfamide/carboplatin/etoposide (ICE): A phase II study in a pediatric oncology centre in Brazil.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Brazil; Carboplatin; Child; Child, Preschool; Etoposide; Feasibility Studies; Female; Granulocyte Colony-Stimulating Factor; Humans; Ifosfamide; Infant; Male; Neoplasm Recurrence, Local; Neoplasms; Remission Induction; Survival Rate; Treatment Outcome | 2004 |
Plasma etoposide catechol increases in pediatric patients undergoing multiple-day chemotherapy with etoposide.
Topics: Adolescent; Antineoplastic Agents, Phytogenic; Area Under Curve; Catechols; Child; Etoposide; Female; Hodgkin Disease; Humans; Infusions, Intravenous; Lymphoma, Non-Hodgkin; Male; Neoplasms; Sarcoma, Ewing; Time Factors | 2004 |
Glomerular dysfunction, independent of tubular dysfunction, induced by antineoplastic chemotherapy in children.
Topics: Acute Disease; Adolescent; Albuminuria; Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Child; Child, Preschool; Creatinine; Cyclophosphamide; Cytarabine; Doxorubicin; Etoposide; Glomerular Filtration Rate; Humans; Kidney Tubules; Leukemia; Lymphoma; Methotrexate; Neoplasms; Neuroblastoma; Osteosarcoma; Proteinuria; Rhabdomyosarcoma; Vincristine | 2004 |
Phase I/II dose escalation study of recombinant human interleukin-11 following ifosfamide, carboplatin and etoposide in children, adolescents and young adults with solid tumours or lymphoma: a clinical, haematological and biological study.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Child; Child, Preschool; Drug Administration Schedule; Etoposide; Female; Humans; Ifosfamide; Infant; Interleukin-11; Lymphoma; Male; Neoplasms; Platelet Count; Recombinant Proteins; Thrombocytopenia | 2005 |
A phase I clinical, pharmacologic, and biologic study of thrombopoietin and granulocyte colony-stimulating factor in children receiving ifosfamide, carboplatin, and etoposide chemotherapy for recurrent or refractory solid tumors: a Children's Oncology Gro
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Area Under Curve; Carboplatin; Child; Child, Preschool; Dose-Response Relationship, Drug; Drug Therapy, Combination; Etoposide; Female; Granulocyte Colony-Stimulating Factor; Hematopoietic Stem Cells; Humans; Ifosfamide; Male; Megakaryocytes; Neoplasms; Recombinant Proteins; Thrombopoietin | 2005 |
[An early phase II clinical study of YM 294 (rhlL-11) in patients with solid tumors and malignant lymphoma].
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Cisplatin; Drug Administration Schedule; Edema; Etoposide; Female; Fever; Humans; Interleukin-11; Lung Neoplasms; Lymphoma; Male; Middle Aged; Neoplasms; Ovarian Neoplasms; Platelet Count; Recombinant Proteins; Thrombocytopenia | 2005 |
A phase I clinical trial of continual alternating etoposide and topotecan in refractory solid tumours.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Drug Administration Schedule; Etoposide; Humans; Middle Aged; Neoplasms; Topotecan | 2005 |
A phase I and pharmacokinetic study of the selective, non-peptidic inhibitor of matrix metalloproteinase BAY 12-9566 in combination with etoposide and carboplatin.
Topics: Adult; Aged; Alopecia; Antineoplastic Combined Chemotherapy Protocols; Area Under Curve; Biphenyl Compounds; Carboplatin; Cohort Studies; Colonic Neoplasms; Enzyme Inhibitors; Etoposide; Female; Humans; Male; Matrix Metalloproteinase Inhibitors; Melanoma; Middle Aged; Neoplasms; Neoplasms, Unknown Primary; Neutropenia; Organic Chemicals; Phenylbutyrates; Thrombocytopenia; Thymoma; Treatment Outcome; Vomiting | 2005 |
Phase II trial of intracerebrospinal fluid etoposide in the treatment of neoplastic meningitis.
Topics: Adult; Aged; Antineoplastic Agents, Phytogenic; Etoposide; Female; Humans; Male; Meningitis; Middle Aged; Neoplasms | 2006 |
Influence of low-energy laser in the prevention of oral mucositis in children with cancer receiving chemotherapy.
Topics: Adolescent; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Carboplatin; Child; Child, Preschool; Cohort Studies; Etoposide; Female; Humans; Ifosfamide; Irinotecan; Low-Level Light Therapy; Male; Methotrexate; Mouth Mucosa; Neoplasms; Nutritional Status; Oral Hygiene; Severity of Illness Index; Stomatitis; Treatment Outcome | 2007 |
Combined biodifferentiating and antiangiogenic oral metronomic therapy is feasible and effective in relapsed solid tumors in children: single-center pilot study.
Topics: Administration, Oral; Adolescent; Adult; Angiogenesis Inhibitors; Antineoplastic Combined Chemotherapy Protocols; Celecoxib; Child; Child, Preschool; Dacarbazine; Drug Administration Schedule; Etoposide; Feasibility Studies; Female; Humans; Male; Neoplasm Recurrence, Local; Neoplasms; Pilot Projects; Pyrazoles; Sulfonamides; Temozolomide; Treatment Outcome; Tretinoin | 2006 |
Sequential oral 9-nitrocamptothecin and etoposide: a pharmacodynamic- and pharmacokinetic-based phase I trial.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; DNA Topoisomerases, Type I; DNA Topoisomerases, Type II; Dose-Response Relationship, Drug; Etoposide; Female; Humans; Male; Maximum Tolerated Dose; Middle Aged; Neoplasms; Treatment Outcome | 2006 |
A randomized study comparing filgrastim versus lenograstim versus molgramostim plus chemotherapy for peripheral blood progenitor cell mobilization.
Topics: Adjuvants, Immunologic; Adolescent; Adult; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Cyclophosphamide; Etoposide; Female; Filgrastim; Granulocyte Colony-Stimulating Factor; Granulocyte-Macrophage Colony-Stimulating Factor; Hematopoietic Stem Cell Mobilization; Humans; Ifosfamide; Lenograstim; Male; Middle Aged; Neoplasms; Peripheral Blood Stem Cell Transplantation; Recombinant Proteins; Time Factors; Transplantation, Autologous; Vinblastine | 2006 |
Biologic markers of angiogenesis: circulating endothelial cells in patients with advanced malignancies treated on phase I protocol with metronomic chemotherapy and celecoxib.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Celecoxib; Cyclophosphamide; Endothelial Cells; Etoposide; Female; Flow Cytometry; Humans; Male; Middle Aged; Neoplasms; Neoplastic Cells, Circulating; Neovascularization, Pathologic; Pyrazoles; Sensitivity and Specificity; Stem Cells; Sulfonamides | 2008 |
A pilot study of addition of amifostine to melphalan, carboplatin, etoposide, and cyclophosphamide with autologous hematopoietic stem cell transplantation in pediatric solid tumors-A pediatric blood and marrow transplant consortium study.
Topics: Adolescent; Adult; Amifostine; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Transplantation; Bone Neoplasms; Carboplatin; Central Nervous System Neoplasms; Child; Child, Preschool; Combined Modality Therapy; Cyclophosphamide; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug-Related Side Effects and Adverse Reactions; Etoposide; Feasibility Studies; Hematopoietic Stem Cell Transplantation; Hodgkin Disease; Humans; Hypocalcemia; Kidney Neoplasms; Melphalan; Neoplasms; Neuroblastoma; Pilot Projects; Recurrence; Risk Factors; Sarcoma; Transplantation, Autologous; Transplantation, Homologous; Treatment Outcome; Wilms Tumor | 2008 |
[New antineoplastic drugs of the podophyllotoxin derivative group].
Topics: Adult; Child; Clinical Trials as Topic; Etoposide; Female; Humans; Leukemia; Lung Neoplasms; Lymphoma; Neoplasms; Ovarian Neoplasms; Podophyllotoxin; Teniposide; Urinary Bladder Neoplasms | 1983 |
Clinical trial of VP 16--213 (NSC 141540) I.V. twice weekly in advanced neoplastic disease: a study by the Cancer and Leukemia Group B.
Topics: Adult; Bone Marrow; Child; Clinical Trials as Topic; Drug Administration Schedule; Etoposide; Female; Humans; Injections, Intravenous; Male; Neoplasms; Podophyllotoxin; Remission, Spontaneous | 1980 |
[Etoposide VP 16--213)--a podophyllotoxinderivative with high antitumor activity (author's transl)].
Topics: Animals; Chemical Phenomena; Chemistry; Clinical Trials as Topic; DNA, Neoplasm; Drug Therapy, Combination; Etoposide; Humans; Neoplasms; Neoplasms, Experimental; Podophyllotoxin; RNA, Neoplasm | 1981 |
Maturation of mobilized peripheral blood progenitor cells: preclinical and phase I clinical studies.
Topics: Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Carboplatin; Cell Differentiation; Cell Division; Colony-Forming Units Assay; Cryopreservation; Culture Techniques; Cyclophosphamide; Etoposide; Female; Granulocyte Colony-Stimulating Factor; Growth Substances; Hematopoietic Stem Cell Transplantation; Hematopoietic Stem Cells; Humans; Interleukin-3; Leukapheresis; Neoplasms; Neutropenia; Thiotepa | 1995 |
Positively selected autologous blood CD34+ cells and unseparated peripheral blood progenitor cells mediate identical hematopoietic engraftment after high-dose VP16, ifosfamide, carboplatin, and epirubicin.
Topics: Adult; Antigens, CD; Antigens, CD34; Antineoplastic Combined Chemotherapy Protocols; Biomarkers; Bleomycin; Blood Transfusion, Autologous; Breast Neoplasms; Carboplatin; Carcinoma, Small Cell; Combined Modality Therapy; Epirubicin; Etoposide; Feasibility Studies; Female; Granulocyte Colony-Stimulating Factor; Hematopoietic Stem Cell Transplantation; Hematopoietic Stem Cells; Humans; Ifosfamide; Lung Neoplasms; Male; Middle Aged; Neoplasms; Predictive Value of Tests; Vincristine | 1994 |
High-dose ifosfamide/carboplatin/etoposide: maximum tolerable doses, toxicities, and hematopoietic recovery after autologous stem cell reinfusion.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Dose-Response Relationship, Drug; Etoposide; Female; Granulocyte Colony-Stimulating Factor; Hematologic Diseases; Hematopoietic Stem Cell Transplantation; Humans; Ifosfamide; Length of Stay; Male; Middle Aged; Neoplasms; Transplantation, Autologous; Treatment Outcome | 1994 |
Reduction of the systemic toxicity of cisplatin by intra-arterial hepatic route administration for liver malignancies.
Topics: Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Cisplatin; Cyclophosphamide; Doxorubicin; Etoposide; Female; Fluorouracil; Hepatic Artery; Humans; Infusions, Intra-Arterial; Infusions, Intravenous; Kidney Diseases; Leucovorin; Liver; Liver Neoplasms; Methotrexate; Neoplasms; Nervous System Diseases; Ovarian Neoplasms; Remission Induction; Spectrophotometry, Atomic; Tumor Cells, Cultured; Vinblastine | 1995 |
Delayed commencement of granulocyte colony-stimulating factor following autologous bone marrow transplantation accelerates neutrophil recovery and is cost-effective.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Transplantation; Carboplatin; Combined Modality Therapy; Drug Administration Schedule; Etoposide; Female; Fever; Granulocyte Colony-Stimulating Factor; Humans; Male; Middle Aged; Mitoxantrone; Neoplasms; Neutrophils; Pilot Projects | 1994 |
A phase I trial of paclitaxel and etoposide for metastatic or recurrent malignancies.
Topics: Antineoplastic Combined Chemotherapy Protocols; Drug Administration Schedule; Etoposide; Granulocyte Colony-Stimulating Factor; Humans; Neoplasm Metastasis; Neoplasm Recurrence, Local; Neoplasms; Neutropenia; Paclitaxel; Thrombocytopenia | 1995 |
An analysis of engraftment kinetics as a function of the CD34 content of peripheral blood progenitor cell collections in 692 patients after the administration of myeloablative chemotherapy.
Topics: Adolescent; Adult; Aged; Antigens, CD34; Antineoplastic Combined Chemotherapy Protocols; Blood Cell Count; Bone Marrow; Carboplatin; Cell Survival; Cyclophosphamide; Etoposide; Female; Hematopoietic Stem Cell Transplantation; Hematopoietic Stem Cells; Humans; Life Tables; Male; Middle Aged; Neoplasms; Proportional Hazards Models; Retrospective Studies; Thiotepa; Time Factors; Treatment Outcome | 1995 |
Pharmacokinetics and bioequivalence of etoposide following intravenous administration of etoposide phosphate and etoposide in patients with solid tumors.
Topics: Adult; Aged; Analysis of Variance; Antineoplastic Agents; Biological Availability; Chromatography, High Pressure Liquid; Drug Administration Schedule; Etoposide; Female; Humans; Infusions, Intravenous; Male; Middle Aged; Neoplasms; Organophosphorus Compounds; Therapeutic Equivalency | 1995 |
Ifosfamide/carboplatin/etoposide (ICE) for recurrent malignant solid tumors of childhood: a Pediatric Oncology Group Phase I/II study.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Child; Child, Preschool; Etoposide; Female; Humans; Ifosfamide; Infant; Male; Neoplasms; Recurrence | 1995 |
Pilot study of a high-dose carboplatin-based salvage strategy for relapsing or refractory germ cell cancer.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Transplantation; Carboplatin; Combined Modality Therapy; Cyclophosphamide; Dose-Response Relationship, Drug; Drug Administration Schedule; Etoposide; Feasibility Studies; Female; Germinoma; Hematopoietic Stem Cell Transplantation; Humans; Male; Middle Aged; Neoplasm Recurrence, Local; Neoplasms; Pilot Projects; Reoperation; Salvage Therapy; Thiotepa | 1995 |
Pharmacokinetics and pharmacodynamics of 21-day continuous oral etoposide in pediatric patients with solid tumors.
Topics: Administration, Oral; Adolescent; Child; Child, Preschool; Dose-Response Relationship, Drug; Drug Administration Schedule; Etoposide; Female; Humans; Infant; Male; Neoplasms; Predictive Value of Tests; Regression Analysis; Serum Albumin; Solutions | 1995 |
Phase I study of CPT-11 and etoposide in patients with refractory solid tumors.
Topics: Adult; Aged; Agranulocytosis; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Drug Administration Schedule; Etoposide; Female; Granulocyte Colony-Stimulating Factor; Humans; Irinotecan; Male; Middle Aged; Neoplasms; Treatment Outcome | 1993 |
Clinical reversal of multidrug resistance.
Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport, Active; Clinical Trials as Topic; Cyclosporine; Drug Resistance, Multiple; Etoposide; Gene Expression; Gene Expression Regulation, Neoplastic; Humans; Neoplasm Proteins; Neoplasms; Paclitaxel; Pharmaceutical Preparations; Verapamil | 1994 |
Continuous-infusion verapamil with etoposide in relapsed or resistant paediatric cancers.
Topics: Adolescent; Adult; Bone Neoplasms; Child; Child, Preschool; Drug Administration Schedule; Drug Resistance, Multiple; Etoposide; Female; Hodgkin Disease; Humans; Infant; Infusions, Intravenous; Kidney Neoplasms; Male; Neoplasms; Neuroblastoma; Osteosarcoma; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Recurrence; Rhabdomyosarcoma; Sarcoma, Ewing; Verapamil; Wilms Tumor | 1995 |
A phase I trial of high-dose oral tamoxifen and CHOPE.
Topics: Administration, Oral; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Cyclophosphamide; Doxorubicin; Drug Administration Schedule; Etoposide; Female; Humans; Male; Middle Aged; Neoplasms; Neutropenia; Prednisone; Tamoxifen; Vincristine | 1995 |
A phase I study of etoposide phosphate administered as a daily 30-minute infusion for 5 days.
Topics: Adult; Aged; Antineoplastic Agents; Chromatography, High Pressure Liquid; Cohort Studies; Dose-Response Relationship, Drug; Etoposide; Female; Half-Life; Humans; Infusions, Intravenous; Leukopenia; Male; Metabolic Clearance Rate; Middle Aged; Neoplasms; Organophosphorus Compounds | 1995 |
Etoposide, ifosfamide, and cisplatin therapy for refractory childhood solid tumors. Response and toxicity.
Topics: Adolescent; Adult; Bone Marrow; Child; Child, Preschool; Cisplatin; Drug Administration Schedule; Drug Therapy, Combination; Etoposide; Female; Humans; Ifosfamide; Infant; Kidney; Male; Neoplasms; Treatment Outcome | 1995 |
Phase I study of weekly high-dose cisplatin combined with long-term oral etoposide in advanced solid tumors.
Topics: Administration, Oral; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Diseases; Cisplatin; Combined Modality Therapy; Etoposide; Female; Humans; Male; Middle Aged; Neoplasm Metastasis; Neoplasms; Remission Induction; Salvage Therapy; Treatment Outcome | 1995 |
Phase I clinical and pharmacokinetic study of oral etoposide phosphate.
Topics: Administration, Oral; Adult; Aged; Analysis of Variance; Biological Availability; Drug Administration Schedule; Etoposide; Humans; Injections, Intravenous; Lymphoma; Middle Aged; Models, Biological; Neoplasms; Neutropenia; Organophosphorus Compounds; Prodrugs | 1995 |
Idarubicin, high-dose cytarabine and etoposide for remission induction in therapy-related acute myeloid leukemia.
Topics: Acute Disease; Adult; Anemia, Refractory, with Excess of Blasts; Antineoplastic Combined Chemotherapy Protocols; Blood Transfusion; Bone Marrow Diseases; Bone Marrow Transplantation; Combined Modality Therapy; Cytarabine; Etoposide; Female; Gastrointestinal Diseases; Humans; Idarubicin; Leukemia, Myeloid; Leukemia, Radiation-Induced; Male; Middle Aged; Neoplasms; Prospective Studies; Radiotherapy; Remission Induction; Salvage Therapy; Treatment Outcome | 1994 |
Altered etoposide pharmacokinetics and time to engraftment in pediatric patients undergoing autologous bone marrow transplantation.
Topics: Adolescent; Adult; Anticonvulsants; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Transplantation; Carboplatin; Child; Child, Preschool; Drug Interactions; Etoposide; Half-Life; Humans; Infant; Metabolic Clearance Rate; Neoplasms; Transplantation, Autologous | 1994 |
High-dose ifosfamide/carboplatin/etoposide with autologous hematopoietic stem cell support: safety and future directions.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Etoposide; Forecasting; Hematologic Diseases; Hematopoietic Stem Cell Transplantation; Humans; Ifosfamide; Neoplasms; Transplantation, Autologous; Treatment Outcome | 1994 |
Phase I trial of high-dose melphalan, high-dose etoposide and autologous bone marrow re-infusion in solid tumors: an Eastern Cooperative Oncology Group (ECOG) study.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Transplantation; Combined Modality Therapy; Etoposide; Female; Follow-Up Studies; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Infusions, Intravenous; Melphalan; Middle Aged; Neoplasms; Retrospective Studies; Transplantation, Autologous | 1994 |
Phase I study of oral etoposide in children with refractory solid tumors.
Topics: Administration, Oral; Adolescent; Child; Child, Preschool; Etoposide; Female; Humans; Infant; Male; Neoplasms; Treatment Outcome | 1994 |
Calvert's formula and high-dose carboplatin.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Cisplatin; Combined Modality Therapy; Creatinine; DNA; DNA Adducts; Etoposide; Female; Glomerular Filtration Rate; Humans; Male; Middle Aged; Neoplasms; Thiotepa | 1994 |
[Phase I clinical study of 21-consecutive-day oral administration of etoposide].
Topics: Administration, Oral; Adult; Aged; Drug Tolerance; Etoposide; Female; Humans; Leukopenia; Male; Middle Aged; Neoplasms | 1994 |
Clinical and pharmacokinetic overview of parenteral etoposide phosphate.
Topics: Animals; Blood Pressure; Drug Administration Schedule; Etoposide; Humans; Infusions, Intravenous; Leukocyte Count; Neoplasms; Organophosphorus Compounds | 1994 |
Phase I evaluation of a water-soluble etoposide prodrug, etoposide phosphate, given as a 5-minute infusion on days 1, 3, and 5 in patients with solid tumors.
Topics: Adult; Aged; Alopecia; Chromatography, High Pressure Liquid; Drug Administration Schedule; Etoposide; Feasibility Studies; Female; Half-Life; Humans; Infusions, Intravenous; Male; Middle Aged; Nausea; Neoplasms; Neutropenia; Organophosphorus Compounds; Prodrugs; Regression Analysis; Solubility; Vomiting | 1994 |
Dose-intensive cyclophosphamide with etoposide and vincristine for pediatric solid tumors: a phase I/II pilot study by the Australia and New Zealand Childhood Cancer Study Group.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Cyclophosphamide; Drug Administration Schedule; Etoposide; Female; Humans; Infant; Male; Neoplasms; Pilot Projects; Treatment Outcome; Vincristine | 1994 |
Ifosfamide, carboplatin, and etoposide: a new regimen with a broad spectrum of activity.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Etoposide; Female; Hematopoiesis; Humans; Ifosfamide; Male; Middle Aged; Neoplasms; Treatment Outcome | 1994 |
Phase I study of escalating targeted doses of carboplatin combined with ifosfamide and etoposide in treatment of newly diagnosed pediatric solid tumors.
Topics: Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Diseases; Carboplatin; Child; Child, Preschool; Etoposide; Female; Humans; Ifosfamide; Infant; Male; Neoplasms; Treatment Outcome | 1994 |
Prolonged administration of low dose infusional etoposide in patients with advanced malignancies. A phase I/II study.
Topics: Adult; Bone Marrow; Carcinoma, Small Cell; Drug Administration Schedule; Drug Tolerance; Erythrocyte Transfusion; Etoposide; Female; Humans; Infusions, Parenteral; Lung Neoplasms; Lymphoma, Non-Hodgkin; Male; Middle Aged; Neoplasms; Platelet Transfusion | 1994 |
Escalating high-dose carboplatin and autologous bone marrow transplantation in solid tumors.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Transplantation; Carboplatin; Combined Modality Therapy; Cyclophosphamide; Drug Administration Schedule; Etoposide; Female; Germinoma; Hodgkin Disease; Humans; Male; Middle Aged; Neoplasms; Ovarian Neoplasms; Prospective Studies; Rhabdomyosarcoma; Transplantation, Autologous; Treatment Outcome | 1993 |
A randomized phase I trial of chronic oral etoposide with or without granulocyte-macrophage colony-stimulating factor in patients with advanced malignancies.
Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Etoposide; Female; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Male; Middle Aged; Neoplasms; Neutropenia; Prospective Studies; Thrombocytopenia | 1993 |
Granulocyte-macrophage colony-stimulating factor given before dose-intensive cyclophosphamide, etoposide, and cisplatin (DICEP).
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Cyclophosphamide; Escherichia coli; Etoposide; Female; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Male; Middle Aged; Neoplasms; Neutropenia; Recombinant Proteins; Yeasts | 1993 |
Prolonged administration of low-dose, infusional etoposide in patients with etoposide-sensitive neoplasms: a phase I/II study.
Topics: Adult; Bone Marrow Diseases; Drug Administration Schedule; Etoposide; Female; Humans; Infusions, Intravenous; Leukocyte Count; Male; Middle Aged; Neoplasms; Treatment Outcome | 1993 |
A phase I and pharmacokinetic study of intraperitoneal carboplatin and etoposide.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Etoposide; Female; Humans; Injections, Intraperitoneal; Kidney; Male; Middle Aged; Neoplasms; Neutropenia; Ovarian Neoplasms | 1993 |
Phase I study of escalating targeted doses of carboplatin combined with ifosfamide and etoposide in children with relapsed solid tumors.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Child; Child, Preschool; Drug Administration Schedule; Etoposide; Female; Humans; Ifosfamide; Infant; Least-Squares Analysis; Male; Neoplasms; Neutropenia; Thrombocytopenia; Treatment Outcome | 1993 |
Post-5-fluorouracil human marrow: stem cell characteristics and renewal properties after autologous marrow transplantation.
Topics: Antineoplastic Combined Chemotherapy Protocols; Bone Marrow; Bone Marrow Transplantation; Carmustine; Cells, Cultured; Colony-Forming Units Assay; Colony-Stimulating Factors; Cyclophosphamide; Etoposide; Fluorouracil; Growth Substances; Hematopoietic Stem Cells; Hodgkin Disease; Humans; Interleukins; Leukocyte Count; Neoplasms; Platelet Count; Transplantation, Autologous | 1993 |
High-dose carboplatin, etoposide and cyclophosphamide with autologous bone marrow transplantation for the treatment of advanced malignancies: a phase I study.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Transplantation; Carboplatin; Combined Modality Therapy; Cyclophosphamide; Etoposide; Female; Humans; Kidney; Male; Middle Aged; Neoplasms; Transplantation, Autologous | 1995 |
Oral glutamine to prevent chemotherapy induced stomatitis: a pilot study.
Topics: Acquired Immunodeficiency Syndrome; Administration, Oral; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Carboplatin; Cyclophosphamide; Dacarbazine; Double-Blind Method; Doxorubicin; Etoposide; Female; Fluorouracil; Glutamine; Humans; Ifosfamide; Male; Neoplasms; Pilot Projects; Placebos; Sarcoma, Kaposi; Stomatitis; Vincristine | 1996 |
Phase I study of etoposide with SDZ PSC 833 as a modulator of multidrug resistance in patients with cancer.
Topics: Adolescent; Adult; Aged; Antineoplastic Agents, Phytogenic; Cyclosporins; Drug Resistance, Multiple; Etoposide; Female; Half-Life; Humans; Male; Middle Aged; Neoplasms | 1996 |
Phase I and pharmacokinetic study of a water-soluble etoposide prodrug, etoposide phosphate (BMY-40481).
Topics: Adult; Aged; Antineoplastic Agents; Drug Administration Schedule; Drug Resistance, Neoplasm; Etoposide; Female; Humans; Male; Middle Aged; Neoplasms; Organophosphorus Compounds; Ovarian Neoplasms; Prodrugs | 1995 |
Pharmacokinetic evaluation of high-dose etoposide phosphate after a 2-hour infusion in patients with solid tumors.
Topics: Antineoplastic Agents; Etoposide; Female; Half-Life; Humans; Infusions, Intravenous; Linear Models; Male; Metabolic Clearance Rate; Neoplasms; Organophosphorus Compounds | 1996 |
Etoposide bioavailability after oral administration of the prodrug etoposide phosphate in cancer patients during a phase I study.
Topics: Administration, Oral; Adolescent; Adult; Aged; Antineoplastic Agents; Biological Availability; Chromatography, High Pressure Liquid; Etoposide; Female; Humans; Infusions, Intravenous; Male; Middle Aged; Neoplasms; Organophosphorus Compounds; Prodrugs | 1996 |
Phase I trial of etoposide, doxorubicin and cisplatin (EAP) in combination with GM-CSF.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Dose-Response Relationship, Drug; Doxorubicin; Etoposide; Female; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Male; Middle Aged; Neoplasms; Neutropenia; Recombinant Proteins; Thrombocytopenia | 1996 |
Response of pediatric malignant solid tumors following ifosfamide or ifosfamide/carboplatin/etoposide: a single hospital experience.
Topics: Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Child; Etoposide; Female; Humans; Ifosfamide; Male; Mesna; Neoplasms | 1996 |
Peripheral blood progenitor cell transplantation: a single centre experience comparing two mobilisation regimens in 67 patients.
Topics: Adolescent; Adult; Amyloidosis; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow; Carmustine; Cell Movement; Colony-Forming Units Assay; Cyclophosphamide; Cytarabine; Etoposide; Female; Granulocyte Colony-Stimulating Factor; Hematologic Neoplasms; Hematopoietic Stem Cell Transplantation; Hematopoietic Stem Cells; Humans; Kidney Diseases; Leukapheresis; Leukocyte Count; Male; Melphalan; Middle Aged; Neoplasms; Podophyllotoxin; Retrospective Studies; Thiotepa; Transplantation Conditioning | 1996 |
Misoprostol prophylaxis for high-dose chemotherapy-induced mucositis: a randomized double-blind study.
Topics: Adolescent; Adult; Aged; Anti-Ulcer Agents; Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Double-Blind Method; Etoposide; Female; Hematopoietic Stem Cell Transplantation; Humans; Ifosfamide; Male; Middle Aged; Misoprostol; Mouth Mucosa; Neoplasms; Stomatitis | 1996 |
Phase I study of high-dose ifosfamide, carboplatin and etoposide with autologous hematopoietic stem cell support.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Combined Modality Therapy; Etoposide; Female; Hematopoietic Stem Cell Transplantation; Humans; Ifosfamide; Neoplasms; Transplantation, Autologous | 1995 |
Phase I and pharmacologic study of 7- and 21-day continuous etoposide infusion in patients with advanced cancer.
Topics: Adult; Aged; Alopecia; Antineoplastic Agents, Phytogenic; Creatinine; Etoposide; Female; Gastrointestinal Diseases; Hematologic Diseases; Humans; Infusion Pumps; Infusions, Intravenous; Male; Middle Aged; Mouth Mucosa; Neoplasms; Statistics, Nonparametric; Stomatitis | 1996 |
A randomized phase I study of oral etoposide with or without granulocyte-macrophage colony-stimulating factor for the treatment of patients with advanced cancer.
Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Phytogenic; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Interactions; Etoposide; Female; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Male; Middle Aged; Neoplasms; Neutropenia | 1996 |
Phase I and pharmacokinetic study of etoposide phosphate.
Topics: Adult; Aged; Antineoplastic Agents; Diarrhea; Dose-Response Relationship, Drug; Etoposide; Humans; Middle Aged; Neoplasms; Organophosphorus Compounds; Regression Analysis; Thrombocytopenia | 1995 |
Phase I study of high-dose etoposide phosphate in man.
Topics: Adult; Aged; Antineoplastic Agents; Bone Marrow Transplantation; Combined Modality Therapy; Etoposide; Female; Humans; Infusions, Intravenous; Injections, Subcutaneous; Male; Middle Aged; Neoplasms; Organophosphorus Compounds | 1996 |
Bioequivalence assessment of etoposide phosphate and etoposide using pharmacodynamic and traditional pharmacokinetic parameters.
Topics: Adult; Aged; Analysis of Variance; Antineoplastic Agents, Phytogenic; Cross-Over Studies; Etoposide; Female; Humans; Infusions, Intravenous; Male; Middle Aged; Neoplasms; Organophosphorus Compounds; Prodrugs; Therapeutic Equivalency | 1996 |
Phase I and pharmacokinetic study of etoposide phosphate by protracted venous infusion in patients with advanced cancer.
Topics: Adult; Aged; Ambulatory Care; Antineoplastic Agents; Biological Availability; Etoposide; Female; Humans; Infusions, Intravenous; Male; Middle Aged; Neoplasms; Organophosphorus Compounds; Treatment Outcome | 1997 |
Randomized trial of filgrastim vs. sequential filgrastim and molgramostim after dose-intensified carboplatin, cyclophosphamide, and etoposide: a phase I pilot study.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Cyclophosphamide; Etoposide; Female; Filgrastim; Granulocyte Colony-Stimulating Factor; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Leukocyte Count; Male; Middle Aged; Neoplasms; Pilot Projects; Platelet Count; Recombinant Proteins; Survival Rate | 1997 |
Phase II study of daily oral etoposide in children with recurrent brain tumors and other solid tumors.
Topics: Administration, Oral; Adolescent; Adult; Antineoplastic Agents, Phytogenic; Brain Neoplasms; Child; Child, Preschool; Drug Administration Schedule; Etoposide; Humans; Infant; Neoplasm Recurrence, Local; Neoplasms; Treatment Outcome | 1997 |
Phase I trial of subcutaneous interleukin-1 alpha in children with malignant solid tumors.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Blood Platelets; Bone Marrow; Bone Marrow Diseases; Carboplatin; Child; Child, Preschool; Drug Administration Schedule; Etoposide; Female; Granulocytes; Humans; Ifosfamide; Infant; Injections, Subcutaneous; Interleukin-1; Male; Neoplasms; Recombinant Proteins | 1997 |
Granulocyte-macrophage colony-stimulating factor in association with high-dose chemotherapy (VETOPEC) for childhood solid tumors: a report from the Australia and New Zealand Children's Cancer Study Group.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Cyclophosphamide; Drug Administration Schedule; Etoposide; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Infant; Neoplasm Recurrence, Local; Neoplasms; Neutropenia; Vincristine | 1997 |
A dose-intensive, cyclophosphamide-based regimen for the treatment of recurrent/progressive or advanced solid tumors of childhood: a report from the Australia and New Zealand Children's Cancer Study Group.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Cyclophosphamide; Drug Administration Schedule; Etoposide; Granulocyte Colony-Stimulating Factor; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Infant; Neoplasm Metastasis; Neoplasm Recurrence, Local; Neoplasms; Survival Analysis; Vincristine | 1997 |
Phase 1 trial of recombinant human interleukin-1 beta (rhIL-1 beta), carboplatin, and etoposide in patients with solid cancers: Southwest Oncology, Group Study 8940.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Dose-Response Relationship, Drug; Drug Administration Schedule; Etoposide; Female; Humans; Interleukin-1; Male; Middle Aged; Neoplasm Metastasis; Neoplasms; Neutropenia; Recombinant Proteins; Thrombocytopenia | 1997 |
Phase I and pharmacological study of sequential intravenous topotecan and oral etoposide.
Topics: Administration, Oral; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Drug Administration Schedule; Etoposide; Female; Hematologic Diseases; Humans; Infusions, Intravenous; Male; Middle Aged; Neoplasms; Topotecan | 1997 |
Clinical effects and pharmacokinetics of the fusion protein PIXY321 in children receiving myelosuppressive chemotherapy.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Cisplatin; Drug Administration Schedule; Etoposide; Female; Granulocyte-Macrophage Colony-Stimulating Factor; Half-Life; Humans; Ifosfamide; Infant; Interleukin-3; Male; Metabolic Clearance Rate; Neoplasms; Neutropenia; Recombinant Fusion Proteins | 1998 |
Phase II study of 21 day schedule oral etoposide in children. New Agents Group of the United Kingdom Children's Cancer Study Group (UKCCSG).
Topics: Administration, Oral; Antineoplastic Agents, Phytogenic; Child; Child, Preschool; Etoposide; Humans; Neoplasms; Time Factors; Treatment Outcome | 1997 |
Phase I study of high dose etoposide phosphatase with filgrastim (G-CSF) in the treatment of advanced refractory malignancies.
Topics: Adult; Aged; Antineoplastic Agents, Phytogenic; Bone Marrow Diseases; Drug Resistance, Neoplasm; Etoposide; Female; Filgrastim; Granulocyte Colony-Stimulating Factor; Humans; Leukocyte Count; Male; Middle Aged; Neoplasms; Organophosphorus Compounds; Platelet Count; Recombinant Proteins | 1997 |
Dose escalation of the hypoxic cell sensitizer etanidazole combined with ifosfamide, carboplatin, etoposide, and autologous hematopoietic stem cell support.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Cell Hypoxia; Disease-Free Survival; Dose-Response Relationship, Drug; Etanidazole; Etoposide; Expectorants; Female; Hematopoietic Stem Cell Transplantation; Humans; Ifosfamide; Infusions, Intravenous; Male; Mesna; Middle Aged; Neoplasms; Recurrence; Survival Rate | 1998 |
A phase I and translational study of sequential administration of the topoisomerase I and II inhibitors topotecan and etoposide.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Biopsy; Dose-Response Relationship, Drug; Drug Administration Schedule; Etoposide; Female; Humans; Male; Middle Aged; Neoplasms; Topoisomerase I Inhibitors; Topoisomerase II Inhibitors; Topotecan | 1998 |
High-dose cyclosporin with etoposide--toxicity and pharmacokinetic interaction in children with solid tumours.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Cyclosporine; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Interactions; Etoposide; Female; Humans; Male; Neoplasms | 1998 |
A study of the feasibility and accuracy of pharmacokinetically guided etoposide dosing in children.
Topics: Adolescent; Antineoplastic Agents, Phytogenic; Area Under Curve; Child; Child, Preschool; Drug Administration Schedule; Etoposide; Feasibility Studies; Female; Humans; Male; Neoplasms | 1998 |
Correlation between granulocyte/macrophage-colony-forming units and CD34+ cells in apheresis products from patients treated with different chemotherapy regimens and granulocyte-colony-stimulating factor to mobilize peripheral blood progenitor cells.
Topics: Antigens, CD34; Antineoplastic Combined Chemotherapy Protocols; Blood Component Removal; Carmustine; Cell Separation; Cyclophosphamide; Cytarabine; Dexamethasone; Doxorubicin; Epirubicin; Etoposide; Female; Flow Cytometry; Granulocyte Colony-Stimulating Factor; Granulocytes; Hematopoietic Stem Cell Mobilization; Hematopoietic Stem Cells; Humans; Ifosfamide; Macrophages; Male; Melphalan; Neoplasms; Prednisolone; Vincristine | 1998 |
High risk of leukemia after short-term dose-intensive chemotherapy in young patients with solid tumors.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Child; Cyclophosphamide; Dose-Response Relationship, Drug; Doxorubicin; Drug Administration Schedule; Etoposide; Female; Humans; Ifosfamide; Leukemia; Male; Myelodysplastic Syndromes; Neoplasms; Neoplasms, Second Primary; Prospective Studies; Risk Factors; Vincristine | 1998 |
A Phase I study of granulocyte-macrophage-colony stimulating factor/interleukin-3 fusion protein (PIXY321) following ifosfamide, carboplatin, and etoposide therapy for children with recurrent or refractory solid tumors: a report of the Children's Cancer G
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Blood Cell Count; Blood Transfusion; Carboplatin; Child; Child, Preschool; Cytokines; Drug Tolerance; Etoposide; Granulocyte-Macrophage Colony-Stimulating Factor; Hematopoietic Stem Cells; Humans; Ifosfamide; Infant; Interleukin-3; Length of Stay; Neoplasm Recurrence, Local; Neoplasms; Recombinant Fusion Proteins | 1998 |
High-dose etoposide with granulocyte colony-stimulating factor for mobilization of peripheral blood progenitor cells: efficacy and toxicity at three dose levels.
Topics: Acute Disease; Adolescent; Adult; Aged; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Choriocarcinoma; Etoposide; Female; Germinoma; Granulocyte Colony-Stimulating Factor; Hematopoietic Stem Cell Mobilization; Hodgkin Disease; Humans; Leukemia; Lymphoma, Non-Hodgkin; Male; Middle Aged; Multiple Myeloma; Neoplasms | 1998 |
Phase I study of etoposide phosphate (etopophos) as a 30-minute infusion on days 1, 3, and 5.
Topics: Adult; Aged; Antineoplastic Agents; Dose-Response Relationship, Drug; Drug Administration Schedule; Etoposide; Female; Half-Life; Hemoglobins; Humans; Infusions, Intravenous; Leukopenia; Male; Metabolic Clearance Rate; Middle Aged; Neoplasms; Organophosphorus Compounds; Thrombocytopenia | 1995 |
Phase I trial of recombinant interleukin 3 before and after carboplatin/etoposide chemotherapy in patients with solid tumors: a southwest oncology group study.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Drug Administration Schedule; Etoposide; Female; Humans; Interleukin-3; Male; Middle Aged; Neoplasms; Neutrophils; Platelet Count; Platelet Transfusion; Recombinant Proteins; Thrombocytopenia | 1995 |
A limited-sampling strategy for estimation of etoposide pharmacokinetics in cancer patients.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Phytogenic; Dose-Response Relationship, Drug; Etoposide; Female; Half-Life; Humans; Infusions, Intravenous; Male; Metabolic Clearance Rate; Middle Aged; Models, Biological; Neoplasms; Reproducibility of Results; Selection Bias | 1999 |
Use of granulocyte colony-stimulating factor (G-CSF) in patients receiving myelosuppressive chemotherapy for the treatment of cancer. Provincial Systemic Treatment Disease Site Group.
Topics: Adult; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow; Canada; Cisplatin; Confidence Intervals; Disease-Free Survival; Doxorubicin; Etoposide; Female; Granulocyte Colony-Stimulating Factor; Humans; Male; Meta-Analysis as Topic; Neoplasms; Neutropenia; Odds Ratio; Quality of Life; Treatment Outcome; Vincristine | 1998 |
Pharmacokinetics of paclitaxel administered in combination with cisplatin, etoposide and bleomycin in patients with advanced solid tumours.
Topics: Adenocarcinoma; Adult; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Carcinoma; Cisplatin; Dose-Response Relationship, Drug; Drug Administration Schedule; Etoposide; Granulocyte Colony-Stimulating Factor; Humans; Middle Aged; Neoplasms; Paclitaxel | 1999 |
Myeloprotective effect of a non-toxic indigenous preparation Rasayana in cancer patients receiving chemotherapy and radiation therapy. A pilot study.
Topics: Antineoplastic Combined Chemotherapy Protocols; Antioxidants; Bone Marrow; Chemotherapy, Adjuvant; Cisplatin; Combined Modality Therapy; Cyclophosphamide; Etoposide; Female; Fluorouracil; Granulocyte-Macrophage Colony-Stimulating Factor; Hematopoietic Stem Cells; Humans; India; Leukocyte Count; Leukopenia; Lipid Peroxidation; Male; Mitoxantrone; Neoplasms; Pharmaceutical Preparations; Pilot Projects; Plant Extracts; Radiation Injuries; Radiotherapy | 1999 |
Prevention of chemotherapy-induced alopecia using an effective scalp cooling system.
Topics: Adult; Aged; Alopecia; Antibiotics, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Cryotherapy; Docetaxel; Etoposide; Female; Humans; Male; Middle Aged; Neoplasms; Paclitaxel; Scalp; Taxoids | 2000 |
Fractionated cyclophosphamide and etoposide for children with advanced or refractory solid tumors: a phase II window study.
Topics: Adolescent; Antineoplastic Agents, Alkylating; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Cyclophosphamide; Drug Administration Schedule; Etoposide; Female; Humans; Male; Neoplasms; Sarcoma | 2000 |
A phase I study of carboplatin and etoposide administered in conjunction with dipyridamole, prochlorperazine and cyclosporine A.
Topics: Adult; Aged; Antiemetics; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Cyclosporine; Dipyridamole; Etoposide; Female; Humans; Immunosuppressive Agents; Male; Middle Aged; Neoplasms; Prochlorperazine; Treatment Outcome; Vasodilator Agents | 2000 |
Prospective randomized trial between two doses of granulocyte colony-stimulating factor after ifosfamide, carboplatin, and etoposide in children with recurrent or refractory solid tumors: a children's cancer group report.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Child; Child, Preschool; Dose-Response Relationship, Drug; Etoposide; Female; Granulocyte Colony-Stimulating Factor; Humans; Ifosfamide; Infant; Leukocyte Count; Male; Neoplasms; Neutropenia; Neutrophils; Prospective Studies; Racial Groups; Recombinant Proteins; Recurrence; Survival Rate; Time Factors; United States | 2001 |
A phase I clinical, pharmacological, and biological trial of interleukin 6 plus granulocyte-colony stimulating factor after ifosfamide, carboplatin, and etoposide in children with recurrent/refractory solid tumors: enhanced hematological responses but a h
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Child; Child, Preschool; Enzyme-Linked Immunosorbent Assay; Etoposide; Female; Granulocyte Colony-Stimulating Factor; Hematopoietic Stem Cells; Humans; Ifosfamide; Infant; Infusions, Intravenous; Interleukin-6; Male; Neoplasm Recurrence, Local; Neoplasm Staging; Neoplasms; Recombinant Proteins | 2001 |
Phase I trial of a twice-daily regimen of amifostine with ifosfamide, carboplatin, and etoposide chemotherapy in children with refractory carcinoma.
Topics: Adolescent; Amifostine; Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Child; Child, Preschool; Drug Administration Schedule; Etoposide; Female; Humans; Ifosfamide; Male; Mercaptoethylamines; Neoplasms; Treatment Failure | 2001 |
Effectiveness of the MSC cold cap system in the prevention of chemotherapy-induced alopecia.
Topics: Adult; Aged; Alopecia; Antibiotics, Antineoplastic; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Etoposide; Female; Humans; Hypothermia, Induced; Ifosfamide; Male; Middle Aged; Neoplasms; Paclitaxel; Scalp; Severity of Illness Index; Treatment Outcome | 2002 |
Phase I trial of a new form of an oral administration of VP-16-213.
Topics: Administration, Oral; Adult; Aged; Capsules; Clinical Trials as Topic; Drug Evaluation; Etoposide; Female; Hematologic Diseases; Humans; Male; Middle Aged; Neoplasms; Podophyllotoxin | 1979 |
Podophyllotoxin derivative VP 16-213.
Topics: Animals; Bronchial Neoplasms; Carcinoma; Clinical Trials as Topic; Drug Administration Schedule; Drug Evaluation; Drug Therapy, Combination; Etoposide; Humans; In Vitro Techniques; Leukemia, Monocytic, Acute; Leukemia, Myeloid; Lymphoma; Mice; Neoplasms; Podophyllotoxin; Rabbits; Rats; Sarcoma | 1979 |
Pediatric cancer chemotherapy: an updated review. I. Cis-Diammine--dichloroplatinum II (cisplatin), VM-26 (teniposide), VP-16 (etoposide), mitomycin C.
Topics: Child; Cisplatin; Clinical Trials as Topic; Drug Administration Schedule; Etoposide; Humans; Leukemia; Mitomycins; Neoplasms; Podophyllotoxin; Teniposide | 1979 |
High-dose tamoxifen as an enhancer of etoposide cytotoxicity. Clinical effects and in vitro assessment in p-glycoprotein expressing cell lines.
Topics: Administration, Oral; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; ATP Binding Cassette Transporter, Subfamily B, Member 1; Dose-Response Relationship, Drug; Drug Resistance; Drug Screening Assays, Antitumor; Drug Synergism; Etoposide; Female; Humans; Male; Membrane Glycoproteins; Middle Aged; Neoplasms; Tamoxifen; Tumor Cells, Cultured; Verapamil | 1992 |
Phase I trial of etoposide with cyclosporine as a modulator of multidrug resistance.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Cyclosporine; Drug Resistance; Etoposide; Female; Gene Expression; Humans; Male; Middle Aged; Neoplasms | 1992 |
Alteration of etoposide pharmacokinetics and pharmacodynamics by cyclosporine in a phase I trial to modulate multidrug resistance.
Topics: Adult; Aged; Cyclosporine; Drug Interactions; Drug Resistance; Etoposide; Female; Humans; Infusions, Intravenous; Male; Middle Aged; Neoplasms | 1992 |
Phase I and II study of high-dose ifosfamide, carboplatin, and etoposide with autologous bone marrow rescue in lymphomas and solid tumors.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Transplantation; Carboplatin; Combined Modality Therapy; Drug Administration Schedule; Etoposide; Female; Humans; Ifosfamide; Lymphoma; Male; Middle Aged; Neoplasms; Survival Analysis; Transplantation, Autologous | 1992 |
Etoposide plus carboplatin admixture. Phase I study of five- or seven-day continuous infusion.
Topics: Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Drug Administration Schedule; Drug Evaluation; Etoposide; Female; Humans; Infusion Pumps, Implantable; Male; Middle Aged; Neoplasms | 1992 |
Sequential administration of interleukin-3 and granulocyte-macrophage colony-stimulating factor following standard-dose combination chemotherapy with etoposide, ifosfamide, and cisplatin.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Drug Administration Schedule; Drug Evaluation; Etoposide; Feasibility Studies; Female; Granulocyte-Macrophage Colony-Stimulating Factor; Hematopoiesis; Humans; Ifosfamide; Interleukin-3; Male; Middle Aged; Neoplasms; Neutrophils; Recombinant Proteins | 1992 |
Intermittent high-dose tamoxifen as a potential modifier of multidrug resistance.
Topics: Administration, Oral; Animals; Antineoplastic Combined Chemotherapy Protocols; Cricetinae; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Resistance; Drug Synergism; Etoposide; Female; Humans; Male; Neoplasms; Tamoxifen | 1992 |
[Comparison of the antiemetic effectiveness of granisetron and alizapride plus dexamethasone in cytostatic therapy].
Topics: Adult; Aged; Aged, 80 and over; Antiemetics; Cisplatin; Dexamethasone; Drug Therapy, Combination; Etoposide; Female; Granisetron; Humans; Ifosfamide; Indazoles; Male; Middle Aged; Neoplasms; Pyrrolidines; Serotonin Antagonists; Single-Blind Method | 1991 |
A phase I study on the reversal of multidrug resistance (MDR) in vivo: nifedipine plus etoposide.
Topics: Administration, Oral; Adult; Aged; Drug Administration Schedule; Drug Evaluation; Drug Interactions; Drug Resistance; Etoposide; Female; Humans; Infusions, Intravenous; Male; Middle Aged; Neoplasms; Nifedipine | 1992 |
Daily oral etoposide in the treatment of cancer.
Topics: Administration, Oral; Carcinoma, Small Cell; Drug Administration Schedule; Etoposide; Humans; Lung Neoplasms; Neoplasms; Neoplasms, Germ Cell and Embryonal | 1991 |
Impact of autologous bone marrow infusion on hematopoietic recovery after high-dose cyclophosphamide, etoposide, and cisplatin.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Transplantation; Cisplatin; Combined Modality Therapy; Cyclophosphamide; Etoposide; Hematopoiesis; Humans; Middle Aged; Neoplasms; Transplantation, Homologous | 1991 |
Continuous infusion 5-fluorouracil with escalating doses of intermittent cisplatin and etoposide. A phase I study.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cisplatin; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Evaluation; Etoposide; Female; Fluorouracil; Gastrointestinal Diseases; Hematologic Diseases; Humans; Infusions, Intravenous; Male; Middle Aged; Neoplasm Metastasis; Neoplasms; Stomatitis | 1991 |
Pharmacologically based dosing of etoposide: a means of safely increasing dose intensity.
Topics: Aged; Blood Transfusion; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Etoposide; Female; Humans; Infusions, Intravenous; Leukocyte Count; Male; Middle Aged; Models, Biological; Neoplasms; Serum Albumin | 1991 |
Intrapleural etoposide for malignant effusion.
Topics: Adult; Aged; Body Fluids; Clinical Trials as Topic; Drug Evaluation; Etoposide; Female; Humans; Male; Middle Aged; Neoplasms; Pleura; Pleural Effusion; Radiography, Thoracic | 1990 |
Treatment of pediatric malignant tumors with VP-16. West Japan Pediatric Oncology Group.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Etoposide; Histiocytosis; Humans; Infant; Leukemia, Myeloid, Acute; Lymphoma; Neoplasms; Neuroblastoma; Precursor Cell Lymphoblastic Leukemia-Lymphoma | 1990 |
Intracavitary chemotherapy.
Topics: Anthraquinones; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Carboplatin; Catheters, Indwelling; Cisplatin; Clinical Trials as Topic; Cytarabine; Doxorubicin; Etoposide; Fluorouracil; Humans; Immunotherapy; Infusions, Parenteral; Melphalan; Methotrexate; Mitomycins; Mitoxantrone; Neoplasms; Organoplatinum Compounds | 1986 |
[Phase I clinical study of NK 171 (etoposide)].
Topics: Administration, Oral; Adult; Aged; Carcinoma, Hepatocellular; Clinical Trials as Topic; Drug Administration Schedule; Drug Evaluation; Etoposide; Female; Humans; Infusions, Parenteral; Liver Neoplasms; Lung Neoplasms; Lymphoma; Male; Middle Aged; Neoplasms; Podophyllotoxin | 1985 |
How much progress has been achieved in cancer therapy?
Topics: Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Clinical Trials as Topic; Drug Therapy; Etoposide; Humans; Medical Oncology; Neoplasms; Neuroblastoma | 1988 |
Hydroxyurea and etoposide: in vitro synergy and phase I clinical trial.
Topics: Adult; Aged; Animals; Antineoplastic Combined Chemotherapy Protocols; Drug Evaluation; Drug Synergism; Etoposide; Female; Humans; Hydroxyurea; Leukemia L1210; Male; Mice; Middle Aged; Neoplasms; Tumor Cells, Cultured | 1988 |
Overview of the clinical relevance of autologous bone marrow transplantation.
Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Transplantation; Carmustine; Clinical Trials as Topic; Combined Modality Therapy; Cyclophosphamide; Cytarabine; Drug Evaluation; Drug Resistance; Etoposide; Hodgkin Disease; Humans; Leukemia; Leukemia, Lymphoid; Lymphoma; Melphalan; Neoplasm Recurrence, Local; Neoplasms; Thioguanine; Transplantation, Autologous | 1986 |
Bioavailability, pharmacokinetics, and clinical effects of an oral preparation of etoposide.
Topics: Administration, Oral; Biological Availability; Capsules; Clinical Trials as Topic; Drug Administration Schedule; Etoposide; Granulocytes; Half-Life; Humans; Infusions, Parenteral; Kinetics; Leukocyte Count; Nausea; Neoplasms; Platelet Count; Podophyllotoxin; Random Allocation | 1985 |
372 other study(ies) available for etoposide and Neoplasms
Article | Year |
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Chemical genetics reveals a complex functional ground state of neural stem cells.
Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells | 2007 |
The structure-based design, synthesis and biological evaluation of DNA-binding bisintercalating bisanthrapyrazole anticancer compounds.
Topics: Anthracyclines; Antigens, Neoplasm; Antineoplastic Agents; Cell Line; Cell Survival; DNA; DNA Topoisomerases, Type II; DNA-Binding Proteins; Drug Design; Enzyme Inhibitors; Humans; Models, Molecular; Molecular Structure; Neoplasms; Nucleic Acid Denaturation; Plasmids; Protein Binding; Quantitative Structure-Activity Relationship; Temperature; Topoisomerase II Inhibitors | 2008 |
Antitumor agents 6. Synthesis, structure-activity relationships, and biological evaluation of spiro[imidazolidine-4,3'-thieno[2,3-g]quinoline]-tetraones and spiro[thieno[2,3-g]quinoline-3,5'-[1,2,4]triazinane]-tetraones with potent antiproliferative activ
Topics: Antineoplastic Agents; Catalysis; Cell Line, Tumor; Cell Proliferation; Chemistry, Pharmaceutical; DNA; Drug Design; Drug Screening Assays, Antitumor; Enzyme Inhibitors; Humans; Inhibitory Concentration 50; Neoplasms; Quinolines; Structure-Activity Relationship; Topoisomerase II Inhibitors | 2008 |
Synthesis and structure-activity relationships of 2-amino-1-aroylnaphthalene and 2-hydroxy-1-aroylnaphthalenes as potent antitubulin agents.
Topics: Anisoles; Cell Line, Tumor; Cell Proliferation; Chemistry, Pharmaceutical; Drug Design; Drug Screening Assays, Antitumor; Humans; Indoles; Inhibitory Concentration 50; Models, Chemical; Naphthalenes; Neoplasms; Structure-Activity Relationship; Tubulin; Tubulin Modulators | 2008 |
2-Thienyl-4-furyl-6-aryl pyridine derivatives: synthesis, topoisomerase I and II inhibitory activity, cytotoxicity, and structure-activity relationship study.
Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; DNA Topoisomerases, Type I; DNA Topoisomerases, Type II; Drug Screening Assays, Antitumor; Humans; Inhibitory Concentration 50; Neoplasms; Pyrimidines; Structure-Activity Relationship; Topoisomerase I Inhibitors; Topoisomerase II Inhibitors | 2010 |
New benzoxanthone derivatives as topoisomerase inhibitors and DNA cross-linkers.
Topics: Antineoplastic Agents; Benzene Derivatives; Cell Line, Tumor; Cell Proliferation; DNA; DNA Topoisomerases; DNA Topoisomerases, Type I; DNA Topoisomerases, Type II; Drug Screening Assays, Antitumor; Humans; Molecular Structure; Neoplasms; Topoisomerase I Inhibitors; Topoisomerase II Inhibitors; Topoisomerase Inhibitors; Xanthones | 2010 |
Novel 2-[(benzylamino)methyl]pyrrolidine-3,4-diol derivatives as alpha-mannosidase inhibitors and with antitumor activities against hematological and solid malignancies.
Topics: alpha-Mannosidase; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Hematologic Neoplasms; Humans; Inhibitory Concentration 50; Molecular Structure; Neoplasms; Teprotide | 2010 |
Novel effects of glycyrrhetinic acid on the central nervous system tumorigenic progenitor cells: induction of actin disruption and tumor cell-selective toxicity.
Topics: Actins; Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Central Nervous System; Genes, myc; Genes, ras; Glycyrrhetinic Acid; Humans; Mice; Neoplasms; Stem Cells; Transfection | 2010 |
Synthesis and evaluation of aroylthiourea derivatives of 4-β-amino-4'-O-demethyl-4-desoxypodophyllotoxin as novel topoisomerase II inhibitors.
Topics: Antineoplastic Agents; Cell Cycle; Cell Proliferation; DNA Topoisomerases, Type II; HCT116 Cells; Hep G2 Cells; Humans; Neoplasms; Podophyllotoxin; Podophyllum; Thiourea; Topoisomerase II Inhibitors | 2011 |
Synthesis of 4β-carbamoyl epipodophyllotoxins as potential antitumour agents.
Topics: Antineoplastic Agents; Cell Line, Tumor; DNA Topoisomerases, Type II; Drug Screening Assays, Antitumor; Etoposide; Humans; Neoplasms; Podophyllotoxin; Topoisomerase II Inhibitors | 2011 |
Synthesis of 2,4-diaryl chromenopyridines and evaluation of their topoisomerase I and II inhibitory activity, cytotoxicity, and structure-activity relationship.
Topics: Antigens, Neoplasm; Antineoplastic Agents; Benzopyrans; Cell Line, Tumor; Cell Proliferation; DNA Topoisomerases, Type I; DNA Topoisomerases, Type II; DNA-Binding Proteins; Drug Screening Assays, Antitumor; Female; Humans; Male; Neoplasms; Pyridines; Structure-Activity Relationship; Topoisomerase I Inhibitors; Topoisomerase II Inhibitors | 2011 |
Synthesis and biological evaluation of 4β-acrylamidopodophyllotoxin congeners as DNA damaging agents.
Topics: Antineoplastic Agents; Cell Cycle; Cell Line, Tumor; Comet Assay; DNA; DNA Damage; Drug Screening Assays, Antitumor; Etoposide; Humans; Neoplasms; Podophyllotoxin | 2011 |
A modular approach to trim cellular targets in anticancer drug discovery.
Topics: Anaphase; Antineoplastic Agents; Cell Cycle; Cell Line, Tumor; Drug Discovery; Humans; Metaphase; Neoplasms; Oxidation-Reduction; Pyrimidines; Structure-Activity Relationship | 2011 |
Synthesis and biological evaluation of conjugates of deoxypodophyllotoxin and 5-FU as inducer of caspase-3 and -7.
Topics: Antineoplastic Agents; Apoptosis; Caspase 3; Caspase 7; Cell Line, Tumor; Drugs, Chinese Herbal; Enzyme Activation; Fluorouracil; G2 Phase Cell Cycle Checkpoints; Humans; M Phase Cell Cycle Checkpoints; Neoplasms; Podophyllotoxin | 2012 |
Dihydroxylated 2,4,6-triphenyl pyridines: synthesis, topoisomerase I and II inhibitory activity, cytotoxicity, and structure-activity relationship study.
Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Survival; DNA Topoisomerases, Type I; DNA Topoisomerases, Type II; Humans; Neoplasms; Pyridines; Topoisomerase Inhibitors | 2012 |
Hybrids of privileged structures benzothiazoles and pyrrolo[2,1-c] [1,4]benzodiazepin-5-one, and diversity-oriented synthesis of benzothiazoles.
Topics: Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Benzodiazepines; Benzothiazoles; Etoposide; Humans; Molecular Structure; Neoplasms; Structure-Activity Relationship; Tumor Cells, Cultured | 2012 |
Triterpenes possessing an unprecedented skeleton isolated from hydrolyzate of total saponins from Gynostemma pentaphyllum.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Cells, Cultured; Gynostemma; Humans; Magnetic Resonance Spectroscopy; Models, Chemical; Molecular Structure; Neoplasms; Plant Extracts; Quantitative Structure-Activity Relationship; Saponins; Triterpenes | 2012 |
Synthesis and biological evaluation of 4β-sulphonamido and 4β-[(4'-sulphonamido)benzamide]podophyllotoxins as DNA topoisomerase-IIα and apoptosis inducing agents.
Topics: Antigens, Neoplasm; Antineoplastic Agents; Apoptosis; Benzamides; Cell Cycle; Cell Line, Tumor; Comet Assay; DNA Breaks; DNA Topoisomerases, Type II; DNA-Binding Proteins; Drug Screening Assays, Antitumor; Etoposide; Humans; Neoplasms; Podophyllotoxin; Podophyllum | 2012 |
The first total synthesis and biological evaluation of marine natural products ma'edamines A and B.
Topics: Animals; Biological Products; Cell Line, Tumor; Comet Assay; Humans; MCF-7 Cells; Neoplasms; Porifera; Pyrazines | 2013 |
Indenoindolone derivatives as topoisomerase II-inhibiting anticancer agents.
Topics: Antineoplastic Agents; DNA Topoisomerases, Type II; Humans; Indoles; Models, Molecular; Neoplasms; Topoisomerase II Inhibitors | 2013 |
Furanylazaindoles: potent anticancer agents in vitro and in vivo.
Topics: Animals; Antineoplastic Agents; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Proliferation; Cell Survival; Dose-Response Relationship, Drug; Drug Design; Female; Heterocyclic Compounds, 2-Ring; HT29 Cells; Humans; Indoles; Inhibitory Concentration 50; Mice, Nude; Molecular Structure; Neoplasms; Polymerization; Sulfonamides; Tubulin; Xenograft Model Antitumor Assays | 2013 |
Anilides and quinolones with nitrogen-bearing substituents from benzothiophene and thienothiophene series: synthesis, photochemical synthesis, cytostatic evaluation, 3D-derived QSAR analysis and DNA-binding properties.
Topics: Anilides; Antineoplastic Agents; Cell Line, Tumor; Cytostatic Agents; DNA; Drug Screening Assays, Antitumor; Humans; Neoplasms; Nitrogen; Quantitative Structure-Activity Relationship; Quinolones; Thiophenes; Topoisomerase II Inhibitors | 2014 |
Toward synthesis of third-generation spin-labeled podophyllotoxin derivatives using isocyanide multicomponent reactions.
Topics: Antineoplastic Agents; Cell Line, Tumor; Cyanides; Drug Screening Assays, Antitumor; Etoposide; Humans; Neoplasms; Podophyllotoxin; Spin Labels; Structure-Activity Relationship | 2014 |
Synthesis, antitumor activity, and structure-activity relationship study of trihydroxylated 2,4,6-triphenyl pyridines as potent and selective topoisomerase II inhibitors.
Topics: Cell Line, Tumor; Cell Proliferation; DNA Topoisomerases, Type II; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; HEK293 Cells; Humans; Molecular Docking Simulation; Molecular Structure; Neoplasms; Phenols; Pyridines; Structure-Activity Relationship; Topoisomerase II Inhibitors | 2014 |
In vitro radical scavenging and cytotoxic activities of novel hybrid selenocarbamates.
Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Cyanates; Free Radical Scavengers; Humans; Neoplasms; Organoselenium Compounds; Selenium Compounds | 2015 |
Structure-Activity Relationships of Neplanocin A Analogues as S-Adenosylhomocysteine Hydrolase Inhibitors and Their Antiviral and Antitumor Activities.
Topics: Adenine; Adenosine; Adenosylhomocysteinase; Animals; Antineoplastic Agents; Antiviral Agents; Cell Line, Tumor; Chlorocebus aethiops; Enzyme Inhibitors; Humans; Molecular Docking Simulation; Neoplasms; Structure-Activity Relationship; Vero Cells; Virus Diseases; Viruses | 2015 |
Isolation of bioactive biphenyl compounds from the twigs of Chaenomeles sinensis.
Topics: Animals; Anti-Inflammatory Agents; Antineoplastic Agents, Phytogenic; Biphenyl Compounds; Cell Line; Cell Line, Tumor; Humans; Mice; Microglia; Neoplasms; Nerve Growth Factor; Nitric Oxide; Rosaceae | 2016 |
Synthesis and biological evaluation of new securinine analogues as potential anticancer agents.
Topics: Antineoplastic Agents; Apoptosis; Azepines; Cell Line, Tumor; Cell Proliferation; Drug Screening Assays, Antitumor; Euphorbiaceae; Heterocyclic Compounds, Bridged-Ring; Humans; Lactones; Neoplasms; Piperidines | 2016 |
Novel cis-selective and non-epimerisable C3 hydroxy azapodophyllotoxins targeting microtubules in cancer cells.
Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Crystallography, X-Ray; Humans; MCF-7 Cells; Microtubules; Molecular Docking Simulation; Neoplasms; Podophyllotoxin; Stereoisomerism; Tubulin; Tubulin Modulators | 2016 |
Discovery of antitumor anthra[2,3-b]furan-3-carboxamides: Optimization of synthesis and evaluation of antitumor properties.
Topics: Animals; Anthracenes; Antineoplastic Agents; Cell Line, Tumor; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Furans; Humans; Leukemia; Mice; Neoplasms; Protein Kinase Inhibitors; Structure-Activity Relationship; Topoisomerase Inhibitors | 2016 |
Anticancer activity studies of cubebin isolated from Piper cubeba and its synthetic derivatives.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Cell Line, Tumor; Humans; Lignans; Models, Molecular; Neoplasms; Piper; Seeds | 2016 |
New cytotoxic neo-clerodane diterpenoids from Scutellaria strigillosa.
Topics: Antineoplastic Agents, Phytogenic; Cell Line, Tumor; Cell Survival; Diterpenes, Clerodane; Drug Screening Assays, Antitumor; Humans; Neoplasms; Scutellaria | 2016 |
Synthesis of novel flavone derivatives possessing substituted benzamides and their biological evaluation against human cancer cells.
Topics: Antineoplastic Agents; Benzamides; Cell Survival; Flavanones; Flavones; Flavonoids; Hep G2 Cells; Humans; MCF-7 Cells; Neoplasms; Structure-Activity Relationship | 2016 |
Synthesis and biological evaluation of crown ether acyl derivatives.
Topics: Anti-Bacterial Agents; Anti-Infective Agents; Antifungal Agents; Antineoplastic Agents; Candida albicans; Candidiasis; Cell Line, Tumor; Cell Proliferation; Crown Ethers; Drug Screening Assays, Antitumor; Humans; Neoplasms; Staphylococcal Infections; Staphylococcus aureus; Structure-Activity Relationship | 2016 |
Synthesis and biological evaluation of novel quinazoline-sulfonamides as anti-cancer agents.
Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Cell Survival; Drug Screening Assays, Antitumor; Humans; Molecular Docking Simulation; Neoplasms; Quinazolines; Structure-Activity Relationship; Sulfonamides | 2017 |
Dihydroxylated 2,6-diphenyl-4-chlorophenylpyridines: Topoisomerase I and IIα dual inhibitors with DNA non-intercalative catalytic activity.
Topics: Antineoplastic Agents; Biphenyl Compounds; Cell Line, Tumor; Cell Proliferation; DNA Topoisomerases, Type I; Halogenation; Humans; Neoplasms; Pyridines; Topoisomerase II Inhibitors | 2017 |
Synthesis and biological evaluation of N-(carbobenzyloxy)-l-phenylalanine and N-(carbobenzyloxy)-l-aspartic acid-β-benzyl ester derivatives as potent topoisomerase IIα inhibitors.
Topics: Antigens, Neoplasm; Antineoplastic Agents; Aspartic Acid; Cell Line, Tumor; DNA Topoisomerases, Type II; DNA-Binding Proteins; HeLa Cells; Humans; Molecular Docking Simulation; Neoplasms; Phenylalanine; Structure-Activity Relationship; Topoisomerase II Inhibitors | 2017 |
2-Chlorophenyl-substituted benzofuro[3,2-b]pyridines with enhanced topoisomerase inhibitory activity: The role of the chlorine substituent.
Topics: Antineoplastic Agents; Benzofurans; Cell Line, Tumor; Cell Proliferation; DNA Topoisomerases, Type I; DNA Topoisomerases, Type II; Halogenation; Humans; Neoplasms; Pyridines; Topoisomerase Inhibitors | 2017 |
Four new antitumor metabolites isolated from a mutant 3-f-31 strain derived from Penicillium purpurogenum G59.
Topics: Animals; Antineoplastic Agents; Apoptosis; Biological Products; Cell Line, Tumor; HCT116 Cells; Humans; Mice; Models, Molecular; Mutation; Neoplasms; Penicillium | 2018 |
Discover the leading compound of 4β-S-(5-fluorobenzoxazole)-4-deoxy-4'-demethylepipodophyllotoxin with millimolar-potency toxicity by modifying the molecule structure of 4'-demethylepipodophyllotoxin.
Topics: Antineoplastic Agents; Apoptosis; Cell Line; Cell Line, Tumor; Drug Design; Halogenation; Hep G2 Cells; Humans; Models, Molecular; Neoplasms; Oxazoles; Podophyllotoxin | 2018 |
Structure-activity relationship of leucyladenylate sulfamate analogues as leucyl-tRNA synthetase (LRS)-targeting inhibitors of Mammalian target of rapamycin complex 1 (mTORC1).
Topics: Antineoplastic Agents; Cell Line, Tumor; Enzyme Inhibitors; HEK293 Cells; Humans; Leucine; Leucine-tRNA Ligase; Mechanistic Target of Rapamycin Complex 1; Neoplasms; Signal Transduction; Structure-Activity Relationship | 2019 |
Design and synthesis of 4β-Acetamidobenzofuranone-podophyllotoxin hybrids and their anti-cancer evaluation.
Topics: Antineoplastic Agents; Humans; Molecular Structure; Neoplasms; Podophyllotoxin; Structure-Activity Relationship | 2019 |
Structural simplification of evodiamine: Discovery of novel tetrahydro-β-carboline derivatives as potent antitumor agents.
Topics: Animals; Antineoplastic Agents; Apoptosis; Carbolines; Cell Proliferation; Drug Screening Assays, Antitumor; G2 Phase Cell Cycle Checkpoints; HCT116 Cells; Humans; Male; Mice, Nude; Molecular Structure; Neoplasms; Proof of Concept Study; Quinazolines; Structure-Activity Relationship; Topoisomerase I Inhibitors; Topoisomerase II Inhibitors; Xenograft Model Antitumor Assays | 2021 |
Discovery of novel ataxia telangiectasia mutated (ATM) kinase modulators: Computational simulation, biological evaluation and cancer combinational chemotherapy study.
Topics: Ataxia Telangiectasia; Ataxia Telangiectasia Mutated Proteins; Cell Cycle Proteins; Cell Line, Tumor; DNA-Binding Proteins; Humans; Neoplasms; Phosphorylation; Protein Serine-Threonine Kinases | 2022 |
A Risk-Prediction Nomogram for Neutropenia or Febrile Neutropenia after Etoposide-Based Chemotherapy in Cancer Patients: A Retrospective Cohort Study.
Topics: Aged; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy-Induced Febrile Neutropenia; Etoposide; Female; Humans; Logistic Models; Male; Middle Aged; Neoplasms; Nomograms; Predictive Value of Tests; Retrospective Studies; Risk Assessment; ROC Curve | 2022 |
Common cancer treatments targeting DNA double strand breaks affect long-term memory and relate to immediate early gene expression in a sex-dependent manner.
Topics: Amifostine; Animals; DNA; DNA Breaks, Double-Stranded; Etoposide; Female; Genes, Immediate-Early; Male; Memory, Long-Term; Mice; Neoplasms; Pharmaceutical Preparations | 2022 |
The oncoprotein BCL6 enables solid tumor cells to evade genotoxic stress.
Topics: Cell Line, Tumor; DNA Damage; Etoposide; Humans; Neoplasms; Oncogene Proteins; Proto-Oncogene Proteins c-bcl-6 | 2022 |
A novel NRF2/ARE inhibitor gossypol induces cytotoxicity and sensitizes chemotherapy responses in chemo-refractory cancer cells.
Topics: Antioxidant Response Elements; Cisplatin; Etoposide; Gossypol; Humans; Neoplasms; NF-E2-Related Factor 2 | 2021 |
Practice patterns and outcomes of hemophagocytic lymphohistiocytosis in adults: a 2-decade provincial retrospective review.
Topics: Adult; Etoposide; Female; Humans; Hyperbilirubinemia; Lymphohistiocytosis, Hemophagocytic; Male; Neoplasms; Retrospective Studies | 2022 |
Synthesis, Anticancer Activities and Molecular Docking Studies of a Novel Class of 2-Phenyl-5,6,7,8-tetrahydroimidazo [1,2-
Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Drug Screening Assays, Antitumor; Etoposide; Fluorouracil; Humans; Molecular Docking Simulation; Molecular Structure; Neoplasms; Pyridazines; Structure-Activity Relationship; Sulfanilamide; Sulfonamides | 2022 |
A single-beam of light priming the immune responses and boosting cancer photoimmunotherapy.
Topics: Adjuvants, Immunologic; Antigens, Neoplasm; B7-H1 Antigen; Etoposide; Humans; Immune Checkpoint Inhibitors; Immunity; Immunotherapy; Lipids; Neoplasms; Phototherapy; Tumor Microenvironment | 2022 |
Incidence of subsequent malignancies after total body irradiation-based allogeneic HSCT in children with ALL - long-term follow-up from the prospective ALL-SCT 2003 trial.
Topics: Busulfan; Child; Cyclophosphamide; Etoposide; Follow-Up Studies; Graft vs Host Disease; Hematopoietic Stem Cell Transplantation; Humans; Incidence; Neoplasms; Prospective Studies; Transplantation Conditioning; Transplantation, Homologous; Whole-Body Irradiation | 2022 |
Multi-omics characterization of autophagy-related molecular features for therapeutic targeting of autophagy.
Topics: Antineoplastic Agents; Autophagy; Etoposide; Humans; Neoplasms | 2022 |
Etoposide hypersensitivity reactions associated with in-line filter use: A retrospective cohort study at CHU de Québec-Université Laval.
Topics: Adult; Child; Drug Hypersensitivity; Etoposide; Humans; Neoplasms; Quebec; Retrospective Studies | 2023 |
A novel electron source for a compact x-ray tube for microbeam radiotherapy with very high dose rates.
Topics: Electrons; Etoposide; Humans; Monte Carlo Method; Neoplasms; Radiation Oncology; Radiotherapy Planning, Computer-Assisted; X-Rays | 2023 |
Gastrointestinal bleeding/ulcer among paediatric cancer patients after proton beam therapy.
Topics: Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Cyclophosphamide; Doxorubicin; Etoposide; Gastrointestinal Hemorrhage; Humans; Ifosfamide; Neoplasms; Proton Therapy; Ulcer; Vincristine | 2023 |
Impact of Synthesized Indoloquinoline Analog to Isolates from
Topics: Animals; Carcinoma, Ehrlich Tumor; Chemical and Drug Induced Liver Injury; Cryptolepis; DNA Topoisomerases, Type II; Etoposide; Female; Mice; Molecular Docking Simulation; Neoplasms; Tumor Necrosis Factor-alpha | 2023 |
Tolerability of ifosfamide-containing regimen in patients with high-risk renal and INI-1-deficient tumors.
Topics: Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Child; Child, Preschool; Cyclophosphamide; Etoposide; Humans; Ifosfamide; Infant; Kidney; Neoplasms; Vincristine | 2023 |
Naturally mutagenic sequence diversity in a human type II topoisomerase.
Topics: DNA; DNA Damage; DNA Topoisomerases, Type II; Etoposide; Humans; Mutagens; Neoplasms; Topoisomerase II Inhibitors | 2023 |
DNA-PK inhibition extends the therapeutic effects of Top2 poisoning to non-proliferating cells, increasing activity at a cost.
Topics: Animals; DNA; DNA Breaks, Double-Stranded; DNA Repair; DNA Topoisomerases, Type II; DNA-Activated Protein Kinase; DNA-Binding Proteins; Etoposide; Humans; Isomerases; Mice; Neoplasms; Topoisomerase II Inhibitors | 2023 |
Effect of Moderate Malnutrition on the Pharmacokinetics of Etoposide and Vincristine in Freshly Weaned Rats.
Topics: Animals; Child; Child, Preschool; Disease Models, Animal; Etoposide; Humans; Malnutrition; Mice; Neoplasms; Rats; Rats, Sprague-Dawley; Vincristine | 2023 |
Real-time monitoring of etoposide prodrug activated by hydrogen peroxide with improved safety.
Topics: Animals; Antineoplastic Agents, Phytogenic; Cell Line, Tumor; Cell Survival; Coumarins; Drug Liberation; Etoposide; Humans; Hydrogen Peroxide; Mice; Mice, Nude; Microscopy, Confocal; Neoplasms; Prodrugs; Reactive Oxygen Species; Survival Rate; Transplantation, Heterologous; Zebrafish | 2019 |
Effects of cryotherapy on high-dose melphalan-induced oral mucositis in pediatric patients undergoing autologous stem cell transplantation.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Child; Child, Preschool; Combined Modality Therapy; Cryotherapy; Dose-Response Relationship, Drug; Etoposide; Female; Follow-Up Studies; Hematopoietic Stem Cell Transplantation; Humans; Infant; Male; Melphalan; Neoplasms; Prognosis; Retrospective Studies; Stomatitis; Transplantation, Autologous; Young Adult | 2020 |
5-Hydroxytryptamine-3 receptor antagonist and dexamethasone as prophylaxis for chemotherapy-induced nausea and vomiting during moderately emetic chemotherapy for solid tumors: a multicenter, prospective, observational study.
Topics: Adult; Aged; Aged, 80 and over; Antiemetics; Antineoplastic Agents; Capecitabine; Carboplatin; Dexamethasone; Etoposide; Female; Humans; Male; Middle Aged; Nausea; Neoplasms; Oxaliplatin; Paclitaxel; Pre-Exposure Prophylaxis; Serotonin 5-HT3 Receptor Antagonists; Vomiting | 2020 |
Preparation of parenteral nanocrystal suspensions of etoposide from the excipient free dry state of the drug to enhance in vivo antitumoral properties.
Topics: Animals; Antineoplastic Agents; Biological Availability; Cell Line, Tumor; Disease Models, Animal; Dosage Forms; Drug Compounding; Etoposide; Mice; Nanoparticles; Nanotechnology; Neoplasms; Suspensions | 2020 |
The lncRNA MEG3/miR-16-5p/VGLL4 regulatory axis is involved in etoposide-induced senescence of tumor cells.
Topics: A549 Cells; Aging; Apoptosis; beta-Galactosidase; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Etoposide; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; HEK293 Cells; Humans; MCF-7 Cells; MicroRNAs; Models, Biological; Neoplasms; RNA, Long Noncoding; Senescence-Associated Secretory Phenotype; Transcription Factors | 2021 |
Six-step etoposide desensitization protocol: A pediatric, adolescent, and young adult case series.
Topics: Adolescent; Adult; Antineoplastic Agents, Phytogenic; Child; Child, Preschool; Desensitization, Immunologic; Drug Hypersensitivity; Etoposide; Female; Follow-Up Studies; Humans; Infant; Male; Neoplasms; Prognosis; Retrospective Studies; Young Adult | 2021 |
Induction of APOBEC3B expression by chemotherapy drugs is mediated by DNA-PK-directed activation of NF-κB.
Topics: Ataxia Telangiectasia Mutated Proteins; Cisplatin; CRISPR-Cas Systems; Cytidine Deaminase; DNA Repair; Etoposide; Fluorouracil; Gene Expression Regulation, Neoplastic; Genetic Heterogeneity; HCT116 Cells; Humans; MCF-7 Cells; Minor Histocompatibility Antigens; Mutation; Neoplasms; NF-kappa B; Transcription Factor RelA; Tumor Suppressor Protein p53 | 2021 |
Mutant p53 promotes RCP-dependent chemoresistance coinciding with increased delivery of P-glycoprotein to the plasma membrane.
Topics: Adaptor Proteins, Signal Transducing; Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B; Cell Membrane; Cisplatin; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Etoposide; HCT116 Cells; Humans; Male; Membrane Proteins; Mice, Inbred BALB C; Mice, Nude; Mutation; Neoplasms; Tumor Burden; Tumor Suppressor Protein p53; Xenograft Model Antitumor Assays | 2021 |
The Circadian Protein PER1 Modulates the Cellular Response to Anticancer Treatments.
Topics: A549 Cells; Animals; Antineoplastic Agents; Apoptosis; Carcinogenesis; Cell Cycle; Cell Line, Tumor; Circadian Rhythm; Cisplatin; Docetaxel; Drug Chronotherapy; Etoposide; Humans; Mice; Neoplasms; Period Circadian Proteins; Tumor Suppressor Protein p53; Xenograft Model Antitumor Assays | 2021 |
Risks and mitigation strategies to prevent etoposide infusion-related reactions in children.
Topics: Antineoplastic Agents; Child; Drug-Related Side Effects and Adverse Reactions; Etoposide; Humans; Infusions, Intravenous; Neoplasms; Risk Factors | 2021 |
Downregulation of GSK3B by miR-132-3p Enhances Etoposide-Induced Breast Cancer Cell Apoptosis.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Biomarkers, Tumor; Breast Neoplasms; Cell Proliferation; Etoposide; Female; Gene Expression Regulation, Neoplastic; Glycogen Synthase Kinase 3 beta; Humans; MicroRNAs; Neoplasms; Prognosis; Survival Rate; Tumor Cells, Cultured | 2021 |
BeEAM conditioning regimen is a safe, efficacious and economical alternative to BEAM chemotherapy.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carmustine; Cytarabine; Etoposide; Female; Hematopoietic Stem Cell Transplantation; Humans; Male; Melphalan; Middle Aged; Neoplasms; Outcome Assessment, Health Care; Podophyllotoxin; Transplantation Conditioning | 2021 |
The Cancer SENESCopedia: A delineation of cancer cell senescence.
Topics: Aniline Compounds; Azepines; Cell Line, Tumor; Cellular Senescence; Etoposide; Gene Expression Regulation, Neoplastic; Humans; Neoplasms; Pyrimidines; Reproducibility of Results; Senescence-Associated Secretory Phenotype; Senotherapeutics; Sulfonamides | 2021 |
Quantitative identification of senescent cells in aging and disease.
Topics: Aging; Animals; beta-Galactosidase; Biomarkers; Cellular Senescence; Epithelial Cells; Etoposide; Fibrosis; Flow Cytometry; Gene Expression; Histones; HMGB1 Protein; Humans; Image Processing, Computer-Assisted; Lymphocytes; Mice; Molecular Imaging; Neoplasms; Primary Cell Culture; Single-Cell Analysis; Staining and Labeling; Stromal Cells | 2017 |
Folic Acid-Targeted Etoposide Cubosomes for Theranostic Application of Cancer Cell Imaging and Therapy.
Topics: Animals; Calorimetry, Differential Scanning; Cell Death; Cell Survival; Diagnostic Imaging; Drug Delivery Systems; Drug Liberation; Etoposide; Folic Acid; Humans; Inhibitory Concentration 50; Liquid Crystals; MCF-7 Cells; Mice; Neoplasms; Particle Size; Proton Magnetic Resonance Spectroscopy; Static Electricity; Theranostic Nanomedicine | 2017 |
Engineered polymeric amphiphiles self-assembling into nanostructures and acting as efficient gene and drug carriers.
Topics: Alkylation; Antineoplastic Agents, Phytogenic; Cell Line, Tumor; DNA; Drug Carriers; Etoposide; Humans; Hydrophobic and Hydrophilic Interactions; Neoplasms; Plasmids; Polyethyleneimine; Surface-Active Agents; Transfection | 2017 |
Slow release of etoposide from dextran conjugation shifts etoposide activity from cytotoxicity to differentiation: A promising tool for dosage control in anticancer metronomic therapy.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Cell Differentiation; Cells, Cultured; Dextrans; Etoposide; Humans; Monocytes; Neoplasms | 2017 |
Smurf2-Mediated Stabilization of DNA Topoisomerase IIα Controls Genomic Integrity.
Topics: Animals; Antigens, Neoplasm; Cell Line, Tumor; DNA Topoisomerases, Type II; DNA-Binding Proteins; Etoposide; Genomic Instability; Humans; Interphase; Mice; Mice, Knockout; Neoplasms; Ubiquitin-Protein Ligases | 2017 |
Making moves: Transitioning R-EPOCH to the ambulatory setting.
Topics: Adult; Aged; Ambulatory Care; Antineoplastic Combined Chemotherapy Protocols; Cyclophosphamide; Doxorubicin; Etoposide; Female; Hospitalization; Humans; Male; Middle Aged; Neoplasms; Prednisone; Retrospective Studies; Rituximab; Vincristine | 2018 |
Towards a high throughput impedimetric screening of chemosensitivity of cancer cells suspended in hydrogel and cultured in a paper substrate.
Topics: Antineoplastic Agents; Cell Culture Techniques; Cell Line, Tumor; Cell Survival; Doxorubicin; Drug Screening Assays, Antitumor; Electric Impedance; Equipment Design; Etoposide; Hep G2 Cells; High-Throughput Screening Assays; Humans; Hydrogel, Polyethylene Glycol Dimethacrylate; Neoplasms; Paper | 2018 |
A systematic investigation of the maximum tolerated dose of cytotoxic chemotherapy with and without supportive care in mice.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Disease Models, Animal; Dose-Response Relationship, Drug; Etoposide; Humans; Maximum Tolerated Dose; Mice; Neoplasms | 2017 |
Model-based optimization of G-CSF treatment during cytotoxic chemotherapy.
Topics: Age Factors; Aged; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Cyclophosphamide; Doxorubicin; Drug Administration Schedule; Etoposide; Filgrastim; Granulocyte Colony-Stimulating Factor; Granulocytes; Hematopoiesis; Humans; Leukopenia; Models, Biological; Neoplasms; Polyethylene Glycols; Prednisone; Procarbazine; Randomized Controlled Trials as Topic; Reproducibility of Results; Vincristine | 2018 |
A20/TNFAIP3 Regulates the DNA Damage Response and Mediates Tumor Cell Resistance to DNA-Damaging Therapy.
Topics: Cell Line, Tumor; DNA Damage; Drug Resistance, Neoplasm; Etoposide; HEK293 Cells; HeLa Cells; Humans; MCF-7 Cells; Neoplasms; NF-kappa B; Promoter Regions, Genetic; Signal Transduction; Transfection; Tumor Necrosis Factor alpha-Induced Protein 3; Ubiquitin-Conjugating Enzymes; Ubiquitin-Protein Ligases; Ubiquitination; Up-Regulation | 2018 |
Investigating the potential impact of dose banding for systemic anti-cancer therapy in the paediatric setting based on pharmacokinetic evidence.
Topics: Adolescent; Age Factors; Antineoplastic Agents; Area Under Curve; Busulfan; Carboplatin; Child; Child, Preschool; Cyclophosphamide; Dactinomycin; Drug Dosage Calculations; Drug Monitoring; Etoposide; Humans; Infant; Models, Biological; Neoplasms; Patient Safety; Risk Factors | 2018 |
Optimization of LC method for the quantification of doxorubicin in plasma and urine samples in view of pharmacokinetic, biomedical and drug monitoring therapy studies.
Topics: Adolescent; Antibiotics, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Chromatography, High Pressure Liquid; Daunorubicin; Doxorubicin; Drug Monitoring; Etoposide; Fluorescence; Humans; Limit of Detection; Male; Neoplasms; Occupational Exposure; Personnel, Hospital; Prednisone; Reproducibility of Results; Solid Phase Extraction; Vincristine | 2018 |
Etoposide-Induced Apoptosis in Cancer Cells Can Be Reinforced by an Uncoupled Link between Hsp70 and Caspase-3.
Topics: Antineoplastic Agents; Apoptosis; Caspase 3; Cell Line, Tumor; Drug Resistance, Neoplasm; Etoposide; HSP70 Heat-Shock Proteins; Humans; Neoplasms; Protein Binding | 2018 |
Co-delivery of siRNA and etoposide to cancer cells using an MDEA esterquat based drug delivery system.
Topics: Antineoplastic Agents, Phytogenic; Cell Line, Tumor; Combined Modality Therapy; Drug Delivery Systems; Etoposide; Gene Silencing; Green Fluorescent Proteins; Humans; Neoplasms; Quaternary Ammonium Compounds; RNA, Small Interfering | 2019 |
Structure-Activity Relationships of Cytotoxic Lactones as Inhibitors and Mechanisms of Action.
Topics: Antineoplastic Agents, Phytogenic; Drug Design; Etoposide; Humans; Lactones; Ligands; Molecular Docking Simulation; Neoplasms; Paclitaxel; Sesquiterpenes; Structural Homology, Protein; Structure-Activity Relationship; Topotecan; Tubulin; Tubulin Modulators | 2020 |
Oxygenated theranostic nanoplatforms with intracellular agglomeration behavior for improving the treatment efficacy of hypoxic tumors.
Topics: Animals; Antineoplastic Agents, Phytogenic; Blood Substitutes; Drug Carriers; Drug Delivery Systems; Etoposide; Fluorocarbons; Hep G2 Cells; Humans; Hypoxia; Magnetic Resonance Imaging; Magnetite Nanoparticles; Mice, Nude; Neoplasms; Theranostic Nanomedicine; Treatment Outcome; Tumor Hypoxia | 2019 |
Learning Cancer-Related Drug Efficacy Exploiting Consensus in Coordinated Motility Within Cell Clusters.
Topics: Antineoplastic Agents, Phytogenic; Biomechanical Phenomena; Biosensing Techniques; Cell Movement; Dose-Response Relationship, Drug; Etoposide; Humans; Image Processing, Computer-Assisted; Machine Learning; Microscopy, Video; Neoplasms; PC-3 Cells; Software; Time-Lapse Imaging | 2019 |
Enhanced surface plasmon resonance (SPR) signals based on immobilization of core-shell nanoparticles incorporated boron nitride nanosheets: Development of molecularly imprinted SPR nanosensor for anticancer drug, etoposide.
Topics: Antineoplastic Agents; Biosensing Techniques; Boron Compounds; Dielectric Spectroscopy; Etoposide; Gold; Humans; Metal Nanoparticles; Molecular Imprinting; Neoplasms; Polymers; Spectroscopy, Fourier Transform Infrared; Surface Plasmon Resonance | 2019 |
Structure Based Drug Design and Molecular Docking Studies of Anticancer Molecules Paclitaxel, Etoposide and Topotecan using Novel Ligands.
Topics: Antineoplastic Agents, Phytogenic; Drug Design; Etoposide; Gene Expression Regulation, Neoplastic; Humans; Lactones; Ligands; Molecular Docking Simulation; Neoplasms; Paclitaxel; Proto-Oncogene Proteins c-myb; Sesquiterpenes; Structure-Activity Relationship; Topotecan | 2020 |
Octreotide-Conjugated Core-Cross-Linked Micelles with pH/Redox Responsivity Loaded with Etoposide for Neuroendocrine Neoplasms Therapy and Bioimaging with Photoquenching Resistance.
Topics: A549 Cells; Animals; Antineoplastic Agents; Delayed-Action Preparations; Etoposide; Humans; Hydrogen-Ion Concentration; Mice; Mice, Inbred BALB C; Micelles; Neoplasms; Octreotide; Xenograft Model Antitumor Assays | 2019 |
Release of paused RNA polymerase II at specific loci favors DNA double-strand-break formation and promotes cancer translocations.
Topics: Animals; Cell Line, Tumor; Cells, Cultured; DNA Breaks, Double-Stranded; DNA Repair; Enhancer Elements, Genetic; Etoposide; Flow Cytometry; Fluorescent Antibody Technique; Gene Expression Regulation, Neoplastic; Genetic Loci; Genomics; Introns; Neoplasms; Promoter Regions, Genetic; RNA Polymerase II; RNA Splice Sites; Topoisomerase Inhibitors; Transcription Initiation Site | 2019 |
Role of nitric oxide in the chemistry and anticancer activity of etoposide (VP-16,213).
Topics: Animals; Antineoplastic Agents; Cell Line; Drug Resistance, Neoplasm; Electron Spin Resonance Spectroscopy; Etoposide; HL-60 Cells; Humans; Mice; Neoplasms; Nitric Oxide; Spectrophotometry, Ultraviolet | 2013 |
One-pot laccase-catalysed synthesis of 5,6-dihydroxylated benzo[b]furans and catechol derivatives, and their anticancer activity.
Topics: Antineoplastic Agents; Benzofurans; Catechols; Cell Line, Tumor; Etoposide; HeLa Cells; Humans; Laccase; Lethal Dose 50; MCF-7 Cells; Neoplasms | 2013 |
Preclinical evaluation of a novel ATM inhibitor, KU59403, in vitro and in vivo in p53 functional and dysfunctional models of human cancer.
Topics: Animals; Ataxia Telangiectasia Mutated Proteins; Camptothecin; Clinical Trials as Topic; DNA-Binding Proteins; Doxorubicin; Drug Evaluation, Preclinical; Drug Resistance, Neoplasm; Etoposide; Gene Expression Regulation, Neoplastic; HCT116 Cells; Heterocyclic Compounds, 3-Ring; Humans; Mice; Neoplasms; Pyrones; Radiation-Sensitizing Agents; Tumor Suppressor Protein p53; Xenograft Model Antitumor Assays | 2013 |
Hypersensitivity reactions to etoposide phosphate.
Topics: Adult; Antineoplastic Agents; Drug Hypersensitivity; Etoposide; Female; Humans; Infusions, Intravenous; Middle Aged; Neoplasms; Organophosphorus Compounds; Young Adult | 2014 |
A new p53 target gene, RKIP, is essential for DNA damage-induced cellular senescence and suppression of ERK activation.
Topics: Antineoplastic Agents; Cell Line, Tumor; Cellular Senescence; DNA Damage; Doxorubicin; Enzyme Activation; Etoposide; Extracellular Signal-Regulated MAP Kinases; Gene Expression Regulation, Neoplastic; Humans; Neoplasms; Phosphatidylethanolamine Binding Protein; Phosphorylation; Signal Transduction; Topoisomerase II Inhibitors; Tumor Suppressor Protein p53 | 2013 |
ATG5 is induced by DNA-damaging agents and promotes mitotic catastrophe independent of autophagy.
Topics: Active Transport, Cell Nucleus; Antineoplastic Agents; Aurora Kinase B; Autophagy; Autophagy-Related Protein 5; Cell Line, Tumor; Cell Nucleus; Cisplatin; DNA Damage; Etoposide; HeLa Cells; HSP90 Heat-Shock Proteins; Humans; Inhibitor of Apoptosis Proteins; Jurkat Cells; M Phase Cell Cycle Checkpoints; Microtubule-Associated Proteins; Mitosis; Neoplasms; RNA Interference; RNA, Small Interfering; Signal Transduction; Survivin | 2013 |
Encapsulation of podophyllotoxin and etoposide in biodegradable poly-D,L-lactide nanoparticles improved their anticancer activity.
Topics: Animals; Antineoplastic Agents, Phytogenic; CHO Cells; Cricetinae; Cricetulus; Delayed-Action Preparations; Drug Screening Assays, Antitumor; Etoposide; Humans; Nanoparticles; Neoplasms; Podophyllotoxin; Polyesters | 2014 |
Clozapine, cancer chemotherapy and neutropenia - dilemmas in management.
Topics: Adult; Antineoplastic Agents; Antipsychotic Agents; Bleomycin; Breast Neoplasms; Carcinoma; Cisplatin; Clozapine; Etoposide; Female; Humans; Intestinal Neoplasms; Male; Middle Aged; Neoplasms; Neutropenia; Schizophrenia; Seminoma; Testicular Neoplasms | 2013 |
CARS based label-free assay for assessment of drugs by monitoring lipid droplets in tumour cells.
Topics: Algorithms; Antineoplastic Agents; Apoptosis; Camptothecin; Cell Line, Tumor; Cell Proliferation; Cytoplasm; Drug Screening Assays, Antitumor; Etoposide; Fluorescent Dyes; HCT116 Cells; Humans; Lipid Droplets; Lipids; Microscopy, Fluorescence; Neoplasms; Spectrum Analysis, Raman; Staurosporine | 2014 |
Radium beam therapy.
Topics: Carmustine; Etoposide; Humans; Melphalan; Neoplasms; Radium | 1951 |
Radium beam therapy at the Western Infirmary of Glasgow, 1938-48.
Topics: Carmustine; Etoposide; Humans; Melphalan; Neoplasms; Radium | 1951 |
A whole-body dual-modality radionuclide optical strategy for preclinical imaging of metastasis and heterogeneous treatment response in different microenvironments.
Topics: Adenocarcinoma; Antineoplastic Agents, Phytogenic; Breast Neoplasms; Cell Line, Tumor; DNA Damage; Environment; Etoposide; Female; Fluorescence; Humans; Lymph Nodes; Microscopy, Confocal; Neoadjuvant Therapy; Neoplasm Metastasis; Neoplasms; Positron-Emission Tomography; Radiopharmaceuticals; Reproducibility of Results; Sodium Pertechnetate Tc 99m; Symporters; Tissue Distribution; Tomography, Emission-Computed, Single-Photon; Treatment Outcome; Whole Body Imaging | 2014 |
Stability of etoposide solutions in disposable infusion devices for day hospital cancer practices.
Topics: Antineoplastic Agents, Phytogenic; Chemical Precipitation; Chromatography, High Pressure Liquid; Disposable Equipment; Drug Stability; Etoposide; Infusions, Intravenous; Neoplasms | 2014 |
Etoposide-loaded immunoliposomes as active targeting agents for GD2-positive malignancies.
Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Murine-Derived; Antineoplastic Agents; Cell Proliferation; Clathrin; Endocytosis; Etoposide; Gangliosides; Humans; Immunoglobulin G; Liposomes; Neoplasms; Topoisomerase Inhibitors; Tumor Cells, Cultured | 2014 |
Spectroscopic detection of etoposide binding to chromatin components: the role of histone proteins.
Topics: Antineoplastic Agents, Phytogenic; Chromatin; DNA; Etoposide; Histones; Humans; Intercalating Agents; Neoplasms; Protein Structure, Secondary; Spectrum Analysis | 2014 |
Hypoxia-induced miR-424 decreases tumor sensitivity to chemotherapy by inhibiting apoptosis.
Topics: Animals; Antibiotics, Antineoplastic; Antineoplastic Agents, Phytogenic; Apoptosis; Cell Hypoxia; Cell Line, Tumor; Doxorubicin; Drug Resistance, Neoplasm; Etoposide; Humans; Mice; Mice, Nude; MicroRNAs; Neoplasms; RNA, Neoplasm | 2014 |
Atypical cell populations associated with acquired resistance to cytostatics and cancer stem cell features: the role of mitochondria in nuclear encapsulation.
Topics: Animals; Antineoplastic Agents, Phytogenic; Biological Transport; Cell Nucleus; Cytostatic Agents; Drug Resistance, Neoplasm; Etoposide; Female; Humans; Mice; MicroRNAs; Mitochondria; Neoplasms; Neoplastic Stem Cells; Tumor Cells, Cultured | 2014 |
HPLC-UV method for quantifying etoposide in plasma and tumor interstitial fluid by microdialysis: application to pharmacokinetic studies.
Topics: Animals; Antineoplastic Agents; Chromatography, High Pressure Liquid; Etoposide; Extracellular Fluid; Male; Microdialysis; Neoplasms; Rats | 2015 |
Structure-based design, synthesis and biological testing of etoposide analog epipodophyllotoxin-N-mustard hybrid compounds designed to covalently bind to topoisomerase II and DNA.
Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; DNA; DNA Breaks, Double-Stranded; DNA Topoisomerases, Type II; Etoposide; Humans; Leukemia; Molecular Docking Simulation; Mustard Compounds; Neoplasms; Podophyllotoxin; Topoisomerase II Inhibitors | 2014 |
Topics: Adolescent; Adult; Animals; Antineoplastic Agents; Arachidonic Acids; Asbestos; Asbestosis; Attitude of Health Personnel; Carboplatin; Child; Child, Preschool; Curriculum; Databases, Factual; Education, Medical; Enzyme Inhibitors; Etoposide; Europe; Female; General Surgery; Germany; Hospitals, University; Humans; Ifosfamide; Lung Neoplasms; Male; Medical History Taking; Mesothelioma; Mice; Mice, Inbred C57BL; Mice, Knockout; Motor Neurons; Muscular Atrophy; Neoplasms; Neuroprotective Agents; Phospholipase A2 Inhibitors; Phospholipases A2, Cytosolic; Physical Examination; Quality Improvement; Spinal Cord Injuries; Topotecan; Universities; World Health Organization; Young Adult | 2014 |
Comprehensive silencing of target-sharing microRNAs is a mechanism for SIRT1 overexpression in cancer.
Topics: 3' Untranslated Regions; Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Blotting, Western; Cell Line, Tumor; CpG Islands; DNA Methylation; Etoposide; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; HeLa Cells; Humans; Mice; MicroRNAs; Neoplasms; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; Sirtuin 1; Tumor Suppressor Protein p53 | 2014 |
γH2AX is a biomarker of modulated cytostatic drug resistance.
Topics: Apoptosis; Biomarkers; Cytostatic Agents; DNA Damage; Drug Resistance; Etoposide; Histones; Humans; Neoplasms | 2015 |
Chemical profiling of the genome with anti-cancer drugs defines target specificities.
Topics: Aclarubicin; Antineoplastic Agents; Cell Line, Tumor; Chromatin; Daunorubicin; DNA Damage; DNA, Neoplasm; Etoposide; Gene Expression Regulation, Neoplastic; Genome, Human; Histones; Humans; Molecular Targeted Therapy; Neoplasms; Organ Specificity; Protein Transport; Structure-Activity Relationship; Topoisomerase Inhibitors; Topotecan | 2015 |
YU238259 Is a Novel Inhibitor of Homology-Dependent DNA Repair That Exhibits Synthetic Lethality and Radiosensitization in Repair-Deficient Tumors.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Benzamides; Bone Neoplasms; Cell Line, Tumor; Circular Dichroism; Colorectal Neoplasms; DNA Breaks, Double-Stranded; DNA Repair; Drug Synergism; Etoposide; Glioma; High-Throughput Screening Assays; Humans; Intercalating Agents; Mice; Mice, Nude; Molecular Structure; Neoplasms; Osteosarcoma; Poly(ADP-ribose) Polymerase Inhibitors; Radiation-Sensitizing Agents; Small Molecule Libraries; Sulfonamides; Xenograft Model Antitumor Assays | 2015 |
Optimization of drug regimen in chemotherapy based on semi-mechanistic model for myelosuppression.
Topics: Antineoplastic Agents; Etoposide; Humans; Models, Theoretical; Neoplasms; Neutropenia | 2015 |
M1 and M2 macrophages derived from THP-1 cells differentially modulate the response of cancer cells to etoposide.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Cell Communication; Cell Differentiation; Cell Line, Tumor; Cytokines; Drug Resistance, Neoplasm; Etoposide; Humans; Inflammation Mediators; Macrophage Activation; Macrophages; Neoplasms | 2015 |
Inhibition of oncogenic epidermal growth factor receptor kinase triggers release of exosome-like extracellular vesicles and impacts their phosphoprotein and DNA content.
Topics: Animals; Antineoplastic Agents; Biomarkers; Brain Neoplasms; Cell Line, Tumor; Cetuximab; Culture Media, Conditioned; DNA; ErbB Receptors; Etoposide; Exosomes; Extracellular Vesicles; Glioma; Humans; Mice; Mice, SCID; Morpholines; Neoplasm Transplantation; Neoplasms; Phosphoproteins; Phosphorylation; Proteomics; Quinazolinones; Transfection | 2015 |
Tetra-O-Methyl Nordihydroguaiaretic Acid Broadly Suppresses Cancer Metabolism and Synergistically Induces Strong Anticancer Activity in Combination with Etoposide, Rapamycin and UCN-01.
Topics: Antineoplastic Agents; Autophagy; Carbohydrate Metabolism; Caspase 7; Cell Line, Tumor; Down-Regulation; Drug Synergism; Energy Metabolism; Etoposide; Glutathione; Humans; Lipid Metabolism; Male; Masoprocol; Metabolic Networks and Pathways; Metabolome; Neoplasms; Oxidative Stress; Reactive Oxygen Species; Sirolimus; Staurosporine | 2016 |
Fluorescence Characterization of Gold Modified Liposomes with Antisense N-myc DNA Bound to the Magnetisable Particles with Encapsulated Anticancer Drugs (Doxorubicin, Ellipticine and Etoposide).
Topics: DNA, Antisense; Doxorubicin; Drug Delivery Systems; Ellipticines; Etoposide; Fluorescence; Gold; Humans; Liposomes; Magnetite Nanoparticles; N-Myc Proto-Oncogene Protein; Neoplasms | 2016 |
Population Pharmacokinetic Modeling of Etoposide Free Concentrations in Solid Tumor.
Topics: Animals; Etoposide; Male; Microdialysis; Neoplasms; Rats; Rats, Wistar; Tissue Distribution | 2016 |
Effect of MPS1 Inhibition on Genotoxic Stress Responses in Murine Tumour Cells.
Topics: Animals; Cell Cycle; Cell Line, Tumor; Centrosome; DNA Damage; Etoposide; Mice; Mitosis; Neoplasms; Protein Serine-Threonine Kinases | 2016 |
G9a inhibition potentiates the anti-tumour activity of DNA double-strand break inducing agents by impairing DNA repair independent of p53 status.
Topics: Antibiotics, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Cell Proliferation; DNA Breaks, Double-Stranded; DNA End-Joining Repair; Dose-Response Relationship, Drug; Enzyme Inhibitors; Etoposide; HCT116 Cells; Histocompatibility Antigens; Histone-Lysine N-Methyltransferase; Humans; Neoplasms; Phleomycins; Quinazolines; RNA Interference; Signal Transduction; Time Factors; Topoisomerase II Inhibitors; Transfection; Tumor Suppressor Protein p53 | 2016 |
RNF168 and USP10 regulate topoisomerase IIα function via opposing effects on its ubiquitylation.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Chromosome Segregation; Craniofacial Abnormalities; DNA Topoisomerases, Type II; DNA, Catenated; Drug Resistance, Neoplasm; Etoposide; Fibroblasts; Gene Knockdown Techniques; HEK293 Cells; Humans; Immunologic Deficiency Syndromes; Learning Disabilities; Mice; Mutagenesis, Site-Directed; Neoplasms; Poly-ADP-Ribose Binding Proteins; Primary Immunodeficiency Diseases; Proteomics; RNA, Small Interfering; Topoisomerase II Inhibitors; Ubiquitin Thiolesterase; Ubiquitin-Protein Ligases; Ubiquitination | 2016 |
Class I histone deacetylases regulate p53/NF-κB crosstalk in cancer cells.
Topics: Apoptosis; Cell Cycle Checkpoints; Cell Line, Tumor; Cellular Senescence; DNA Damage; DNA, Neoplasm; Etoposide; Gene Expression Regulation, Neoplastic; Histone Deacetylase Inhibitors; Histone Deacetylases; Humans; Hydroxyurea; Models, Biological; Mutation; Neoplasms; NF-kappa B; Signal Transduction; Tumor Suppressor Protein p53; Vidarabine | 2017 |
HIC1 (hypermethylated in cancer 1) SUMOylation is dispensable for DNA repair but is essential for the apoptotic DNA damage response (DDR) to irreparable DNA double-strand breaks (DSBs).
Topics: Antineoplastic Agents; Apoptosis; Ataxia Telangiectasia Mutated Proteins; Cell Line, Tumor; Checkpoint Kinase 2; DNA Breaks, Double-Stranded; DNA Repair; Etoposide; Histone Deacetylases; Humans; Kruppel-Like Transcription Factors; Models, Molecular; Neoplasms; Promoter Regions, Genetic; Protein Binding; Repressor Proteins; Sirtuin 1; Sumoylation; Trans-Activators; Tumor Suppressor Protein p53 | 2017 |
Myeloperoxidase Enhances Etoposide and Mitoxantrone-Mediated DNA Damage: A Target for Myeloprotection in Cancer Chemotherapy.
Topics: Antigens, Neoplasm; Antineoplastic Agents; Cell Line, Tumor; Cytoprotection; DNA; DNA Damage; DNA Topoisomerases, Type II; DNA-Binding Proteins; Enzyme Inhibitors; Etoposide; Glutathione; Histones; Humans; Mitoxantrone; Myeloid Cells; Neoplasms; Peroxidase; Phosphorylation; Poly-ADP-Ribose Binding Proteins; Small Molecule Libraries | 2017 |
PTK2-mediated degradation of ATG3 impedes cancer cells susceptible to DNA damage treatment.
Topics: Adaptor Proteins, Signal Transducing; Animals; Apoptosis Regulatory Proteins; Autophagy-Related Proteins; Cell Line, Tumor; Cell Proliferation; DNA Damage; Etoposide; Focal Adhesion Kinase 1; Mice; Mice, Knockout; Mitosis; Neoplasms; Phosphorylation; Proteolysis; Ubiquitin-Conjugating Enzymes | 2017 |
Posterior Reversible Encephalopathy Syndrome Associated With Dose-adjusted EPOCH (Etoposide, Prednisone, Vincristine, Cyclophosphamide, Doxorubicin) Chemotherapy.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Central Nervous System; Cyclophosphamide; Doxorubicin; Etoposide; Female; Humans; Male; Middle Aged; Neoplasms; Posterior Leukoencephalopathy Syndrome; Prednisone; Retrospective Studies; Risk Factors; Rituximab; Vincristine | 2017 |
Disruption of the p53-Mdm2 complex by Nutlin-3 reveals different cancer cell phenotypes.
Topics: Antineoplastic Agents, Phytogenic; Cell Line, Tumor; Cloning, Molecular; DNA Damage; Etoposide; Flow Cytometry; Genotype; Humans; Imidazoles; Neoplasms; Phenotype; Piperazines; Polymorphism, Single Nucleotide; Proto-Oncogene Proteins c-mdm2; Reverse Transcriptase Polymerase Chain Reaction; Tumor Suppressor Protein p53 | 2008 |
Metronomic etoposide/cyclophosphamide/celecoxib regimen given to children and adolescents with refractory cancer: a preliminary monocentric study.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Celecoxib; Child; Child, Preschool; Cyclophosphamide; Drug Administration Schedule; Drug Resistance; Etoposide; Humans; Neoplasms; Pyrazoles; Retrospective Studies; Sulfonamides | 2008 |
Loss of the epigenetic tumor suppressor SNF5 leads to cancer without genomic instability.
Topics: Animals; Cell Line, Tumor; Chromosomal Proteins, Non-Histone; Cisplatin; Cyclin D1; Diploidy; DNA Damage; DNA Repair; DNA-Binding Proteins; Epigenesis, Genetic; Etoposide; G2 Phase; Genomic Instability; Histones; Humans; Mice; Neoplasms; Phenotype; Polymorphism, Single Nucleotide; Protein Transport; Rhabdoid Tumor; SMARCB1 Protein; Transcription Factors | 2008 |
Oral bioavailability of etoposide after administration of a single dose to tumor-bearing dogs.
Topics: Administration, Oral; Animals; Area Under Curve; Biological Availability; Cross-Over Studies; Dog Diseases; Dogs; Etoposide; Infusions, Intravenous; Kinetics; Neoplasms | 2008 |
High-dose etoposide: from phase I to a component of curative therapy.
Topics: Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Etoposide; Humans; Neoplasms | 2008 |
F14512, a potent antitumor agent targeting topoisomerase II vectored into cancer cells via the polyamine transport system.
Topics: Animals; Binding, Competitive; Biogenic Polyamines; Breast Neoplasms; Cell Line, Tumor; CHO Cells; Cricetinae; Cricetulus; DNA Damage; DNA Topoisomerases, Type II; DNA, Neoplasm; Drug Delivery Systems; Etoposide; Female; Humans; Leukemia L1210; Lung Neoplasms; Mice; Mice, Nude; Neoplasms; Podophyllotoxin; Topoisomerase II Inhibitors; Xenograft Model Antitumor Assays | 2008 |
Inhibition of RNA-dependent protein kinase (PKR) leads to cancer cell death and increases chemosensitivity.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Caspases, Initiator; Cell Line, Tumor; Cisplatin; Drug Resistance, Neoplasm; eIF-2 Kinase; Endoplasmic Reticulum; Etoposide; Female; Gene Deletion; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; Humans; JNK Mitogen-Activated Protein Kinases; Male; Neoplasms; Signal Transduction; Stress, Physiological | 2009 |
Self-reported experience of mucositis in cancer patients who underwent conditioning regimen and stem cell transplantation.
Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Carmustine; Cyclophosphamide; Cytarabine; Etoposide; Female; Hematopoietic Stem Cell Transplantation; Hodgkin Disease; Humans; Ifosfamide; Lymphoma, Non-Hodgkin; Male; Melphalan; Middle Aged; Mucositis; Multiple Myeloma; Neoplasms; Severity of Illness Index; Whole-Body Irradiation; Young Adult | 2009 |
On the role of topoisomerase I in mediating the cytotoxicity of 9-aminoacridine-based anticancer agents.
Topics: Acridines; Aminacrine; Antineoplastic Agents; Cell Line; Chemistry, Pharmaceutical; DNA Topoisomerases, Type I; Dose-Response Relationship, Drug; Doxorubicin; Drug Design; Drug Screening Assays, Antitumor; Etoposide; Humans; Models, Chemical; Neoplasms; RNA, Small Interfering | 2009 |
Cytotoxic activity and cell cycle analysis of quinoline alkaloids isolated from Haplophyllum canaliculatum Boiss.
Topics: Alkaloids; Antineoplastic Agents, Phytogenic; Cell Cycle; Cell Line, Tumor; Dose-Response Relationship, Drug; Etoposide; Flow Cytometry; G1 Phase; HL-60 Cells; Humans; Jurkat Cells; Neoplasms; Phytotherapy; Plant Extracts; Quinolines; Rutaceae | 2009 |
Downregulation of uridine-cytidine kinase like-1 decreases proliferation and enhances tumor susceptibility to lysis by apoptotic agents and natural killer cells.
Topics: Apoptosis; Caspase 3; Caspase 7; Cell Cycle; Cell Proliferation; Cytotoxicity, Immunologic; Down-Regulation; Etoposide; Gene Expression Regulation, Neoplastic; Gene Silencing; Green Fluorescent Proteins; Humans; K562 Cells; Killer Cells, Natural; Neoplasms; RNA, Messenger; RNA, Small Interfering; Staurosporine; Time Factors; Uridine Kinase | 2009 |
Limited inter-occasion variability in relation to inter-individual variability in chemotherapy-induced myelosuppression.
Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow; Cell Count; Cell Enlargement; Cell Proliferation; Docetaxel; Dose-Response Relationship, Drug; Epirubicin; Etoposide; Fluorouracil; Humans; Models, Biological; Myelopoiesis; Neoplasms; Neutrophils; Observation; Paclitaxel; Precision Medicine; Taxoids; Topotecan | 2010 |
Chemotherapy induces ATP release from tumor cells.
Topics: Adenosine Triphosphate; Animals; Antineoplastic Agents; Apoptosis; Cadmium; Cell Line, Tumor; Cisplatin; Etoposide; Flow Cytometry; Fluorescent Antibody Technique; Mice; Mitomycin; Mitoxantrone; Neoplasms; Organoplatinum Compounds; Oxaliplatin; Sphingosine; Thapsigargin | 2009 |
Production of hyperpolarized [1,4-13C2]malate from [1,4-13C2]fumarate is a marker of cell necrosis and treatment response in tumors.
Topics: Animals; Antineoplastic Agents, Phytogenic; Biomarkers, Tumor; Carbon Isotopes; Etoposide; Female; Fumarate Hydratase; Fumarates; Lymphoma; Malates; Mice; Mice, Inbred C57BL; Necrosis; Neoplasm Transplantation; Neoplasms; Nuclear Magnetic Resonance, Biomolecular; Tissue Extracts; Treatment Outcome | 2009 |
Hypoxic enlarged mitochondria protect cancer cells from apoptotic stimuli.
Topics: Adenosine Triphosphate; Antineoplastic Agents, Phytogenic; Apoptosis; Cell Hypoxia; Cell Proliferation; Drug Resistance, Neoplasm; Etoposide; GTP Phosphohydrolases; HeLa Cells; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Membrane Potential, Mitochondrial; Membrane Proteins; Membrane Transport Proteins; Mitochondria; Mitochondrial Membrane Transport Proteins; Mitochondrial Proteins; Mitochondrial Swelling; Neoplasms; Phenotype; Proto-Oncogene Proteins; RNA Interference; Staurosporine; Time Factors; Transfection; Tumor Suppressor Proteins | 2010 |
Synergistic enhancement of cancer therapy using a combination of carbon nanotubes and anti-tumor drug.
Topics: Antineoplastic Agents; Cell Line, Tumor; Drug Synergism; Etoposide; Flow Cytometry; HeLa Cells; Humans; Microscopy, Electron, Transmission; Nanotubes, Carbon; Neoplasms | 2009 |
Deubiquitinase USP9X stabilizes MCL1 and promotes tumour cell survival.
Topics: Animals; Apoptosis; Biphenyl Compounds; Cell Line; Cell Line, Tumor; Cell Survival; DNA Damage; Docetaxel; Etoposide; Female; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; Half-Life; Humans; Lysine; Mice; Mice, SCID; Myeloid Cell Leukemia Sequence 1 Protein; Neoplasms; Nitrophenols; Phosphorylation; Piperazines; Polyubiquitin; Prognosis; Protein Binding; Protein Stability; Proto-Oncogene Proteins c-bcl-2; RNA Interference; Sulfonamides; Taxoids; Ubiquitin Thiolesterase; Ubiquitination; Ultraviolet Rays; Xenograft Model Antitumor Assays | 2010 |
Novel 4 beta-anilino-podophyllotoxin derivatives: design synthesis and biological evaluation as potent DNA-topoisomerase II poisons and anti-MDR agents.
Topics: Aniline Compounds; Animals; Apoptosis; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Cycle; Cell Line, Tumor; Drug Screening Assays, Antitumor; Enzyme Inhibitors; Etoposide; Humans; Mice; Neoplasms; Podophyllotoxin; Topoisomerase II Inhibitors; Xenograft Model Antitumor Assays | 2010 |
Opposing effects of hMOF and SIRT1 on H4K16 acetylation and the sensitivity to the topoisomerase II inhibitor etoposide.
Topics: Acetylation; Animals; Cell Death; Cell Line, Tumor; DNA Damage; Down-Regulation; Drug Resistance, Neoplasm; Enzyme Inhibitors; Etoposide; Histone Acetyltransferases; Histone Deacetylase Inhibitors; Histones; Humans; Hydroxamic Acids; Lysine; Male; Neoplasms; Sirtuin 1; Topoisomerase II Inhibitors; Valproic Acid | 2010 |
In vitro interaction of high-LET heavy-ion irradiation and chemotherapeutic agents in two cell lines with different radiosensitivities and different p53 status.
Topics: Animals; Antineoplastic Agents; Carbon; Cell Line, Tumor; Combined Modality Therapy; Dose-Response Relationship, Radiation; Etoposide; Genes, p53; Heavy Ion Radiotherapy; Linear Energy Transfer; Neoplasms; Radiation Tolerance; Rats | 2010 |
Differential regulation of MRN (Mre11-Rad50-Nbs1) complex subunits and telomerase activity in cancer cells.
Topics: Acid Anhydride Hydrolases; Antineoplastic Agents, Phytogenic; Cell Cycle Proteins; Cell Line, Tumor; DNA Breaks, Double-Stranded; DNA Repair Enzymes; DNA-Binding Proteins; Etoposide; Humans; MRE11 Homologue Protein; Neoplasms; Nuclear Proteins; RNA, Small Interfering; Telomerase | 2010 |
Peroxiredoxin II restrains DNA damage-induced death in cancer cells by positively regulating JNK-dependent DNA repair.
Topics: Antineoplastic Agents, Phytogenic; Antioxidants; Cell Death; Cell Nucleus; Cell Survival; DNA Damage; DNA Repair; Etoposide; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; HeLa Cells; Humans; MAP Kinase Kinase 4; Neoplasms; Peroxiredoxins; Proto-Oncogene Proteins c-jun | 2011 |
Praf2 is a novel Bcl-xL/Bcl-2 interacting protein with the ability to modulate survival of cancer cells.
Topics: Apoptosis; bcl-X Protein; Carrier Proteins; Cell Line; Cell Line, Tumor; Cell Survival; Etoposide; Gene Expression Regulation, Neoplastic; Humans; Membrane Potentials; Membrane Proteins; Mitochondria; Models, Biological; Mutation; Neoplasms; Protein Structure, Tertiary; Proto-Oncogene Proteins c-bcl-2 | 2010 |
DNA damaging agents and p53 do not cause senescence in quiescent cells, while consecutive re-activation of mTOR is associated with conversion to senescence.
Topics: Cell Cycle; Cell Line; Cell Proliferation; Cell Shape; Cellular Senescence; DNA Damage; Doxorubicin; Enzyme Activation; Etoposide; Humans; Imidazoles; Neoplasms; Piperazines; Protein Kinase Inhibitors; Retinal Pigment Epithelium; Serum; Sirolimus; Time Factors; TOR Serine-Threonine Kinases; Tumor Suppressor Protein p53; Up-Regulation | 2010 |
Polyploid tumour cells elicit paradiploid progeny through depolyploidizing divisions and regulated autophagic degradation.
Topics: Autophagy; Cell Line, Tumor; Chromatin; Chromatin Assembly and Disassembly; DNA Fragmentation; DNA Replication; Etoposide; Gamma Rays; Genome, Human; Homeodomain Proteins; Humans; Mitosis; Nanog Homeobox Protein; Neoplasms; Octamer Transcription Factor-3; Paclitaxel; Ploidies; Tumor Suppressor Protein p53 | 2011 |
Permanent alopecia after systemic chemotherapy: a clinicopathological study of 10 cases.
Topics: Alopecia; Antineoplastic Agents; Busulfan; Cisplatin; Dermis; Diagnosis, Differential; Docetaxel; Etoposide; Female; Hair; Humans; Male; Neoplasms; Taxoids | 2011 |
Copy number polymorphisms and anticancer pharmacogenomics.
Topics: Antineoplastic Agents; Biomarkers, Pharmacological; Carboplatin; Cell Line, Tumor; Cisplatin; Daunorubicin; Etoposide; Gene Dosage; Gene Expression; Genetic Predisposition to Disease; Genetic Variation; Genome-Wide Association Study; Genome, Human; Humans; Inhibitory Concentration 50; Neoplasms; Oligonucleotide Array Sequence Analysis; Pharmacogenetics; Phenotype; Polymorphism, Single Nucleotide; Quantitative Trait Loci; Topoisomerase II Inhibitors | 2011 |
Physiologically based pharmacokinetic modelling of high- and low-dose etoposide: from adults to children.
Topics: Adolescent; Adult; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Busulfan; Carboplatin; Child; Child, Preschool; Computer Simulation; Cyclophosphamide; Cytochrome P-450 CYP3A; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Interactions; Etoposide; Female; Humans; Infant; Male; Melphalan; Metabolic Clearance Rate; Middle Aged; Models, Biological; Neoplasms; Protein Binding | 2012 |
The role of heat shock protein 90 in the regulation of tumor cell apoptosis.
Topics: Apoptosis; Benzoquinones; Caspase 3; Etoposide; HSP90 Heat-Shock Proteins; Humans; Jurkat Cells; Lactams, Macrocyclic; Neoplasms | 2011 |
Nrf2 protein up-regulates antiapoptotic protein Bcl-2 and prevents cellular apoptosis.
Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Cell Survival; Down-Regulation; Drug Resistance, Neoplasm; Etoposide; Gamma Rays; Gene Expression Regulation, Neoplastic; HEK293 Cells; Hep G2 Cells; Humans; Mice; Mutagenesis; Neoplasms; NF-E2-Related Factor 2; Proto-Oncogene Proteins c-bcl-2; Response Elements; Ultraviolet Rays; Up-Regulation | 2012 |
Cdt1 is differentially targeted for degradation by anticancer chemotherapeutic drugs.
Topics: Antineoplastic Agents; Cell Cycle Proteins; Cisplatin; Doxorubicin; Etoposide; Fluorouracil; HeLa Cells; Hep G2 Cells; Humans; Methyl Methanesulfonate; Neoplasms; Proteolysis; Tamoxifen; Ultraviolet Rays | 2012 |
Comparison of caspase-3 activation in tumor cells upon treatment of chemotherapeutic drugs using capillary electrophoresis.
Topics: Antineoplastic Agents; Camptothecin; Caspase 3; Cisplatin; Drug Screening Assays, Antitumor; Electrophoresis, Capillary; Enzyme Activation; Etoposide; HeLa Cells; Hep G2 Cells; Humans; Neoplasms; Time Factors; Tumor Necrosis Factor-alpha | 2012 |
Metronomic chemotherapy with the COMBAT regimen in advanced pediatric malignancies: a multicenter experience.
Topics: Administration, Metronomic; Adolescent; Adult; Angiogenesis Inhibitors; Antineoplastic Combined Chemotherapy Protocols; Celecoxib; Child; Child, Preschool; Dacarbazine; Etoposide; Europe; Feasibility Studies; Female; Fenofibrate; Humans; Infant; Isotretinoin; Male; Neoplasms; Pyrazoles; Registries; Sulfonamides; Temozolomide; Vitamin D; Young Adult | 2012 |
Nature and dynamics of nucleosome release from neoplastic and non-neoplastic cells.
Topics: Apoptosis; Blast Crisis; Cytarabine; Etoposide; Hep G2 Cells; Humans; L-Lactate Dehydrogenase; Leukemia; Neoplasms; Neutrophils; Nucleosomes; Tetradecanoylphorbol Acetate; TNF-Related Apoptosis-Inducing Ligand | 2012 |
Interaction between serotonin reuptake inhibitors, 5-HT3 antagonists, and NK1 antagonists in cancer patients receiving highly emetogenic chemotherapy: a case-control study.
Topics: Adult; Aged; Antiemetics; Antineoplastic Agents, Phytogenic; Aprepitant; Case-Control Studies; Drug Interactions; Drug Therapy, Combination; Etoposide; Female; Humans; Male; Middle Aged; Morpholines; Nausea; Neoplasms; Platinum; Selective Serotonin Reuptake Inhibitors; Serotonin Antagonists; Vomiting | 2012 |
iASPPsv antagonizes apoptosis induced by chemotherapeutic agents in MCF-7 cells and mouse thymocytes.
Topics: Animals; Apoptosis; Cell Line, Tumor; Dexamethasone; DNA Breaks, Double-Stranded; Etoposide; Humans; Intracellular Signaling Peptides and Proteins; Mice; Mice, Transgenic; Neoplasms; Repressor Proteins; T-Lymphocytes | 2012 |
The polyoma virus large T binding protein p150 is a transcriptional repressor of c-MYC.
Topics: Antineoplastic Agents, Phytogenic; Base Sequence; Cell Line, Tumor; DNA-Binding Proteins; Etoposide; Gene Expression Regulation, Neoplastic; Genes, Tumor Suppressor; Humans; Molecular Sequence Data; Neoplasms; Promoter Regions, Genetic; Protein Binding; Proto-Oncogene Proteins c-myc; Transcription Factors; Transcription, Genetic | 2012 |
A novel carbazole derivative, MHY407, sensitizes cancer cells to doxorubicin-, etoposide-, and radiation treatment via DNA damage.
Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Carbazoles; Cell Survival; Cyclin D1; Cyclin-Dependent Kinase Inhibitor p21; DNA Damage; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Doxorubicin; Epoxy Compounds; Etoposide; Female; G1 Phase Cell Cycle Checkpoints; Humans; MCF-7 Cells; Neoplasms; Radiation-Sensitizing Agents; S Phase Cell Cycle Checkpoints; Time Factors | 2012 |
Hypoxia-induced modulation of apoptosis and BCL-2 family proteins in different cancer cell types.
Topics: Antineoplastic Agents; Apoptosis; Cell Hypoxia; Cell Line, Tumor; DNA Damage; Etoposide; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Gene Silencing; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Models, Biological; Neoplasms; Paclitaxel; Proto-Oncogene Proteins c-bcl-2; RNA, Messenger; Signal Transduction; Tumor Suppressor Protein p53 | 2012 |
STK295900, a dual inhibitor of topoisomerase 1 and 2, induces G(2) arrest in the absence of DNA damage.
Topics: Aniline Compounds; Antineoplastic Agents, Phytogenic; Benzimidazoles; Camptothecin; CDC2 Protein Kinase; Cell Line, Tumor; Cell Proliferation; Cell Survival; DNA Damage; DNA Topoisomerases, Type I; DNA Topoisomerases, Type II; DNA, Neoplasm; Dose-Response Relationship, Drug; Etoposide; G2 Phase Cell Cycle Checkpoints; HCT116 Cells; HeLa Cells; Hep G2 Cells; HT29 Cells; Humans; Immunoblotting; MCF-7 Cells; Molecular Structure; Neoplasms; Phosphorylation; Topoisomerase Inhibitors | 2013 |
Advancement towards tin-based anticancer chemotherapeutics: structural modification and computer modeling approach to drug-enzyme interactions.
Topics: Antineoplastic Agents; Binding Sites; Cell Line, Tumor; Cell Survival; Cisplatin; Computer Simulation; Computer-Aided Design; Crystallography, X-Ray; Drug Design; Drug Screening Assays, Antitumor; Etoposide; Fluorouracil; Humans; Molecular Docking Simulation; Neoplasms; Organotin Compounds; Protein Binding | 2012 |
Synthesis and characterization of a catalytic antibody-HPMA copolymer-Conjugate as a tool for tumor selective prodrug activation.
Topics: Antibodies, Catalytic; Cell Division; Etoposide; Humans; Immunoconjugates; Inhibitory Concentration 50; Methacrylates; Neoplasms; Prodrugs; Tumor Cells, Cultured | 2002 |
Predictive value of circulating immature cell counts in peripheral blood for timing of peripheral blood progenitor cell collection after G-CSF plus chemotherapy-induced mobilization.
Topics: Adolescent; Adult; Aged; Antigens, CD34; Antineoplastic Combined Chemotherapy Protocols; Blood Cell Count; Cellular Senescence; Combined Modality Therapy; Cytarabine; Dexamethasone; Etoposide; Female; Granulocyte Colony-Stimulating Factor; Hematopoietic Stem Cell Mobilization; Hematopoietic Stem Cells; Humans; Ifosfamide; Leukapheresis; Male; Middle Aged; Neoplasms; Peripheral Blood Stem Cell Transplantation; Predictive Value of Tests; ROC Curve; Transplantation, Autologous | 2002 |
[Salvage thermochemotherapy in advanced refractory malignant tumors in children].
Topics: Adolescent; Antibiotics, Antineoplastic; Antineoplastic Agents; Antineoplastic Agents, Alkylating; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Child; Cyclophosphamide; Dactinomycin; Doxorubicin; Etoposide; Female; Humans; Hyperthermia, Induced; Interleukin-2; Male; Melphalan; Monitoring, Immunologic; Neoplasms; Neuroleptanalgesia; Salvage Therapy; Time Factors; Vincristine | 2002 |
EVE/cyclosporin (etoposide, vincristine, epirubicin with high-dose cyclosporin)-chemotherapy selected for multidrug resistance modulation.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Cyclosporine; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Epirubicin; Etoposide; Female; Gastrointestinal Diseases; Heart Diseases; Hematologic Diseases; Humans; Kidney Diseases; Male; Neoplasms; Vincristine | 2002 |
Risk of secondary leukemia after a solid tumor in childhood according to the dose of epipodophyllotoxins and anthracyclines: a case-control study by the Société Française d'Oncologie Pédiatrique.
Topics: Adolescent; Adult; Antibiotics, Antineoplastic; Antineoplastic Agents, Phytogenic; Bone Marrow; Case-Control Studies; Chemotherapy, Adjuvant; Child; Child, Preschool; Drug Administration Schedule; Etoposide; Female; France; Humans; Leukemia; Male; Multivariate Analysis; Neoplasms; Neoplasms, Second Primary; Radiotherapy, Adjuvant; Risk Assessment; Risk Factors | 2003 |
RADIO-COBALT beam therapy.
Topics: Carmustine; Cobalt; Cobalt Radioisotopes; Etoposide; Humans; Neoplasms; Radioactivity | 1953 |
[Utilization of contiguous orthogonal beams in the treatment of semi-deep-seated tumors].
Topics: Carmustine; Etoposide; Humans; Melphalan; Neoplasms | 1953 |
[The use of moving beam irradiation in gynecology].
Topics: Etoposide; Genitalia; Genitalia, Female; Gynecology; Neoplasms; Radiotherapy | 1954 |
[Contribution to the study of convergence beam radiotherapy].
Topics: Carmustine; Etoposide; Humans; Melphalan; Neoplasms; Radiotherapy | 1956 |
Cobalt 60 beam therapy: some impressions after five years.
Topics: Carmustine; Cobalt; Cobalt Radioisotopes; Etoposide; Humans; Melphalan; Neoplasms; Radioactivity | 1957 |
Arc therapy with wedge-filtered beams of cobalt 60 radiation.
Topics: Cobalt; Cobalt Radioisotopes; Etoposide; Humans; Neoplasms; Radioactivity | 1962 |
Our experience with cobalt beam unit GUT-CO-400-2.
Topics: Cobalt; Cobalt Isotopes; Etoposide; Melphalan; Neoplasms | 1963 |
Enhancement of chemotherapeutic response of tumor cells by a heme oxygenase inhibitor, pegylated zinc protoporphyrin.
Topics: Animals; Annexin A5; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Apoptosis; Body Weight; Camptothecin; Cell Line, Tumor; Cisplatin; Coloring Agents; Dose-Response Relationship, Drug; Doxorubicin; Drug Synergism; Etoposide; Heme Oxygenase (Decyclizing); Humans; Hydrogen Peroxide; Male; Metalloporphyrins; Mice; Mitomycin; Neoplasms; Oxidants; Oxidation-Reduction; Oxidative Stress; Oxygen; Polyethylene Glycols; Proline; Reactive Oxygen Species; Tetrazolium Salts; Thiazoles | 2004 |
Antiadhesive antibodies targeting E-cadherin sensitize multicellular tumor spheroids to chemotherapy in vitro.
Topics: Animals; Antibodies; Cadherins; Cell Cycle; Cell Line, Tumor; Drug Resistance; Etoposide; Fluorouracil; Humans; Mice; Neoplasms; Paclitaxel; Protein Kinase C; Protein Kinase C beta; Spheroids, Cellular; Vinblastine | 2004 |
Hypoxia-mediated down-regulation of Bid and Bax in tumors occurs via hypoxia-inducible factor 1-dependent and -independent mechanisms and contributes to drug resistance.
Topics: Animals; Apoptosis; bcl-2-Associated X Protein; BH3 Interacting Domain Death Agonist Protein; Carrier Proteins; Cell Line, Tumor; DNA-Binding Proteins; Down-Regulation; Drug Resistance, Neoplasm; Etoposide; Female; Humans; Hypoxia; Hypoxia-Inducible Factor 1; Hypoxia-Inducible Factor 1, alpha Subunit; Mice; Mice, Nude; Neoplasms; Nuclear Proteins; Nucleic Acid Synthesis Inhibitors; Promoter Regions, Genetic; Protein Binding; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Transcription Factors; Transplantation, Heterologous | 2004 |
A phase I study of sequential administration of escalating doses of intravenous paclitaxel, oral topotecan, and fixed-dose oral etoposide in patients with solid tumors.
Topics: Administration, Oral; Adult; Antineoplastic Combined Chemotherapy Protocols; DNA Topoisomerases, Type I; Drug Administration Schedule; Etoposide; Female; Hematologic Diseases; Humans; Infusions, Intravenous; Lymphocytes; Male; Middle Aged; Neoplasms; Paclitaxel; Topotecan | 2004 |
The DNA double-stranded break repair protein endo-exonuclease as a therapeutic target for cancer.
Topics: Animals; Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Carcinoma, Lewis Lung; Cell Line, Tumor; Cell Survival; Cisplatin; Coloring Agents; DNA; DNA Damage; DNA Repair; Down-Regulation; Drug Evaluation, Preclinical; Endonucleases; Etoposide; Exonucleases; Fluorouracil; HeLa Cells; Humans; Kinetics; Mice; Mitomycin; Neoplasms; Pentamidine; Plasmids; Recombination, Genetic; RNA, Small Interfering; Tetrazolium Salts; Thiazoles; Time Factors | 2004 |
Downregulation of peroxiredoxin V stimulates formation of etoposide-induced double-strand DNA breaks.
Topics: Base Sequence; Carcinoma, Non-Small-Cell Lung; Cell Line; Cell Nucleus; Clone Cells; Cloning, Molecular; DNA Damage; DNA Polymerase II; DNA Primers; Etoposide; Flow Cytometry; Gene Expression Regulation; HeLa Cells; Histones; Humans; Lung Neoplasms; Neoplasms; Peroxidases; Peroxiredoxins; Phospholipases A; Phosphorylation | 2004 |
The role of telomeres in Etoposide induced tumor cell death.
Topics: Adaptation, Physiological; Antineoplastic Agents, Phytogenic; Apoptosis; Cell Line, Tumor; DNA; DNA Damage; DNA Topoisomerases, Type II; Dose-Response Relationship, Drug; Etoposide; Genes, cdc; Humans; Neoplasms; Telomerase; Telomere; Topoisomerase II Inhibitors | 2004 |
The technique and results of treatment of cancer of the tongue with a 10 gram radium beam unit.
Topics: Etoposide; Humans; Melphalan; Neoplasms; Radium; Tongue; Tongue Neoplasms | 1950 |
Cyclic exposure to hypoxia and reoxygenation selects for tumor cells with defects in mitochondrial apoptotic pathways.
Topics: Apoptosis; Apoptosis Regulatory Proteins; bcl-2-Associated X Protein; Cell Cycle Proteins; Cell Hypoxia; Cell Line, Tumor; Cell Respiration; Cyclin-Dependent Kinase Inhibitor p21; Etoposide; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Membrane Glycoproteins; Mitochondria; Neoplasms; Periodicity; Proto-Oncogene Proteins c-bcl-2; Radiation, Ionizing; Signal Transduction; TNF-Related Apoptosis-Inducing Ligand; Transcription Factors; Tumor Necrosis Factor-alpha; Tumor Suppressor Protein p53 | 2004 |
Particular cutaneous side effects with etoposide-containing courses: is VP16 or etoposide phosphate responsible?
Topics: Adolescent; Anal Canal; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Etoposide; Fingers; Humans; Infant; Infant, Newborn; Neoplasms; Organophosphorus Compounds; Retrospective Studies; Skin Diseases; Toes | 2005 |
Immune thrombocytopenia following successful treatment of cancer in children.
Topics: Antineoplastic Combined Chemotherapy Protocols; Asparaginase; Bone Marrow Cells; Carmustine; Child, Preschool; Cyclophosphamide; Daunorubicin; Etoposide; Female; Humans; Infant; Male; Neoplasms; Platelet Count; Prednisone; Purpura, Thrombocytopenic, Idiopathic; Vincristine | 2006 |
Optimizing drug regimens in cancer chemotherapy.
Topics: Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Etoposide; Humans; Neoplasms | 2005 |
Suppression of RAD21 gene expression decreases cell growth and enhances cytotoxicity of etoposide and bleomycin in human breast cancer cells.
Topics: Antimetabolites, Antineoplastic; Antineoplastic Agents, Phytogenic; Apoptosis; Bleomycin; Breast; Breast Neoplasms; Cell Cycle Proteins; Cell Line, Tumor; Cell Proliferation; Cell Survival; DNA Damage; DNA-Binding Proteins; Dose-Response Relationship, Drug; Drug Synergism; Etoposide; Gene Expression Regulation, Neoplastic; Genetic Predisposition to Disease; Genome; Humans; Neoplasms; Nuclear Proteins; Phosphoproteins; Polymorphism, Single Nucleotide; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; RNA, Small Interfering; Time Factors; Transfection | 2005 |
High cumulative rate of secondary leukemia after continuous etoposide treatment for solid tumors in children and young adults.
Topics: Adolescent; Antineoplastic Agents, Phytogenic; Case-Control Studies; Child; Child, Preschool; Drug Administration Schedule; Etoposide; Female; Follow-Up Studies; France; Humans; Incidence; Infant; Leukemia; Male; Neoplasms; Neoplasms, Second Primary; Palliative Care; Survival Rate | 2005 |
Sensitization for anticancer drug-induced apoptosis by betulinic Acid.
Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Betulinic Acid; Caspases; Cells, Cultured; Cisplatin; Complement Membrane Attack Complex; Complement System Proteins; Cytochromes c; Dactinomycin; Doxorubicin; Drug Synergism; Enzyme Activation; Etoposide; Fibroblasts; Glycoproteins; Humans; Membrane Potentials; Mitochondria; Mutation; Neoplasms; Paclitaxel; Pentacyclic Triterpenes; Proto-Oncogene Proteins c-bcl-2; Triterpenes; Tumor Stem Cell Assay; Tumor Suppressor Protein p53 | 2005 |
Ku protein targeting by Ku70 small interfering RNA enhances human cancer cell response to topoisomerase II inhibitor and gamma radiation.
Topics: Animals; Antigens, Nuclear; Antineoplastic Agents, Phytogenic; Apoptosis; Blotting, Western; Cell Line, Tumor; Cricetinae; Dimerization; DNA Damage; DNA Repair; DNA-Binding Proteins; Dose-Response Relationship, Radiation; Etoposide; Gamma Rays; HeLa Cells; Humans; Ku Autoantigen; Microscopy, Fluorescence; Neoplasms; Phenotype; RNA, Messenger; RNA, Small Interfering; Telomere; Time Factors; Topoisomerase II Inhibitors; Transfection; VDJ Recombinases | 2005 |
NHS76/PEP2, a fully human vasopermeability-enhancing agent to increase the uptake and efficacy of cancer chemotherapy.
Topics: Animals; Antibodies, Monoclonal; Antineoplastic Agents; Capillary Permeability; Cell Line, Tumor; Docetaxel; Dose-Response Relationship, Drug; Doxorubicin; Etoposide; Female; Fluorouracil; Humans; Injections, Intravenous; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasms; Paclitaxel; Peptide Fragments; Taxoids; Time Factors; Tissue Distribution; Treatment Outcome; Vinblastine; Xenograft Model Antitumor Assays | 2005 |
Phosphorylations of DEAD box p68 RNA helicase are associated with cancer development and cell proliferation.
Topics: Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Benzamides; Blotting, Western; Caco-2 Cells; Cell Line, Tumor; Cell Proliferation; Etoposide; HeLa Cells; Humans; Imatinib Mesylate; K562 Cells; Neoplasms; Paclitaxel; Phosphorus Radioisotopes; Phosphorylation; Piperazines; Precipitin Tests; Pyrimidines; RNA Helicases; RNA Interference; Stilbenes; Tumor Necrosis Factor-alpha | 2005 |
Induction of apoptotic cell death specifically in rat and human cancer cells by pancratistatin.
Topics: Amaryllidaceae Alkaloids; Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Cell Line, Tumor; Dose-Response Relationship, Drug; Etoposide; Fibroblasts; Humans; Isoquinolines; Neoplasms; Paclitaxel; Rats | 2005 |
A novel isoform of TUCAN is overexpressed in human cancer tissues and suppresses both caspase-8- and caspase-9-mediated apoptosis.
Topics: Adaptor Proteins, Signal Transducing; Adult; Amino Acid Sequence; Apoptosis; CARD Signaling Adaptor Proteins; Caspase 8; Caspase 9; Caspase Inhibitors; Caspases; Cell Line, Tumor; Down-Regulation; Drug Resistance, Neoplasm; Enzyme Activation; Etoposide; fas Receptor; Fas-Associated Death Domain Protein; Humans; Jurkat Cells; Molecular Sequence Data; Neoplasm Proteins; Neoplasms; Protein Isoforms; Protein Structure, Tertiary; RNA, Messenger; RNA, Small Interfering; Staurosporine; Transfection | 2005 |
Reversing hypoxic cell chemoresistance in vitro using genetic and small molecule approaches targeting hypoxia inducible factor-1.
Topics: Adenoviridae; Antineoplastic Agents, Phytogenic; Cell Hypoxia; Cell Line, Tumor; Cell Nucleus; Drug Resistance, Neoplasm; Etoposide; Genetic Vectors; Green Fluorescent Proteins; Humans; Hypoxia-Inducible Factor 1; Hypoxia-Inducible Factor 1, alpha Subunit; Isoquinolines; Neoplasms; Oxygen; Sequence Deletion; Topotecan; Transcriptional Activation | 2006 |
Long-term survival following a phase I/II trial with VETOPEC for solid tumors in childhood.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Clinical Trials, Phase I as Topic; Clinical Trials, Phase II as Topic; Cyclophosphamide; Etoposide; Follow-Up Studies; Humans; Infant; Medical Records; Neoplasms; Prognosis; Survival Rate; Time Factors; Vincristine | 2006 |
Interaction of the epidermal growth factor receptor and the DNA-dependent protein kinase pathway following gefitinib treatment.
Topics: Androstadienes; Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Cell Line, Tumor; Cell Nucleus; Cisplatin; Cytosol; DNA; DNA-Activated Protein Kinase; ErbB Receptors; Etoposide; Gefitinib; Humans; Neoplasms; Protein Kinase Inhibitors; Quinazolines; Rats; RNA, Small Interfering; Wortmannin | 2006 |
Synthesis of variously substituted 3-phenoxymethyl quinoxalin-2-ones and quinoxalines capable to potentiate in vitro the antiproliferative activity of anticancer drugs in multi-drug resistant cell lines.
Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Line; Cell Proliferation; Doxorubicin; Drug Resistance, Multiple; Drug Synergism; Etoposide; Humans; KB Cells; Neoplasms; Quinoxalines; Tumor Cells, Cultured; Vincristine | 2006 |
Genotoxic-activated G2-M checkpoint exit is dependent on CDC25B phosphatase expression.
Topics: Antineoplastic Agents, Phytogenic; Blotting, Western; cdc25 Phosphatases; Cell Cycle Proteins; Cell Division; Cell Survival; DNA Damage; Etoposide; Flow Cytometry; Fluorescent Antibody Technique, Indirect; G2 Phase; Humans; Neoplasms; Tetracycline; Tumor Cells, Cultured; Tumor Stem Cell Assay | 2006 |
Information sources used by New South Wales cancer clinicians: a qualitative study.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Cyclophosphamide; Doxorubicin; Drug Information Services; Etoposide; Female; Health Personnel; Hodgkin Disease; Hospitals, Public; Humans; Internet; Interviews as Topic; Male; Medical Oncology; Middle Aged; Neoplasms; New South Wales; Online Systems; Prednisone; Procarbazine; Vincristine | 2006 |
Chemotherapy-related secondary leukemias: A role for DNA repair by error-prone non-homologous end joining in topoisomerase II - Induced chromosomal rearrangements.
Topics: Antineoplastic Agents, Phytogenic; Chromatin Immunoprecipitation; Chromosome Aberrations; Chromosome Breakage; Core Binding Factor Alpha 2 Subunit; DNA Breaks, Double-Stranded; DNA Repair; DNA Topoisomerases, Type II; Drug-Related Side Effects and Adverse Reactions; Etoposide; Humans; Jurkat Cells; Leukemia; Neoplasms; Protein Binding; Rad52 DNA Repair and Recombination Protein; Recombination, Genetic; Topoisomerase II Inhibitors | 2007 |
Chemotherapy and zoledronate sensitize solid tumour cells to Vgamma9Vdelta2 T cell cytotoxicity.
Topics: Adenocarcinoma; Antineoplastic Agents; Apoptosis; Breast Neoplasms; Burkitt Lymphoma; Carcinoma; Cell Line, Tumor; Cisplatin; Colorectal Neoplasms; Concanavalin A; Cytotoxicity, Immunologic; Diphosphonates; Doxorubicin; Drug Screening Assays, Antitumor; Drug Synergism; Etoposide; Female; Genes, T-Cell Receptor delta; Genes, T-Cell Receptor gamma; Humans; Imidazoles; Interferon-gamma; Lovastatin; Lung Neoplasms; Male; Membrane Glycoproteins; Neoplasms; Perforin; Pore Forming Cytotoxic Proteins; Prostatic Neoplasms; Receptors, Antigen, T-Cell, gamma-delta; T-Lymphocyte Subsets; Urinary Bladder Neoplasms; Vincristine; Zoledronic Acid | 2007 |
Clock and ATF4 transcription system regulates drug resistance in human cancer cell lines.
Topics: Activating Transcription Factor 4; Antineoplastic Agents; Blotting, Northern; Blotting, Western; Cell Line, Tumor; Cell Survival; Chromatin Immunoprecipitation; Cisplatin; CLOCK Proteins; Drug Resistance, Neoplasm; Etoposide; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Glutathione; Humans; Neoplasms; Oxidation-Reduction; RNA Interference; Trans-Activators; Transcription, Genetic | 2007 |
The role of cordycepin in cancer treatment via induction or inhibition of apoptosis: implication of polyadenylation in a cell type specific manner.
Topics: Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Apoptosis; Blotting, Western; Caspase 6; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Deoxyadenosines; DNA Fragmentation; Etoposide; Flow Cytometry; Fluorescent Dyes; Humans; Image Processing, Computer-Assisted; Indoles; Leukemia; Membrane Potentials; Mitochondrial Membranes; Neoplasms; Poly A | 2008 |
Restoration of p53 expression in human cancer cell lines upregulates the expression of Notch1: implications for cancer cell fate determination after genotoxic stress.
Topics: Apoptosis; Cell Line, Tumor; DNA Damage; Etoposide; Female; Gene Expression Regulation, Neoplastic; Humans; Male; Neoplasms; Receptor, Notch1; RNA, Messenger; Tumor Suppressor Protein p53; Up-Regulation | 2007 |
Gambogic acid inhibits the catalytic activity of human topoisomerase IIalpha by binding to its ATPase domain.
Topics: Adenosine Triphosphatases; Adenosine Triphosphate; Antigens, Neoplasm; Antineoplastic Agents; Apoptosis; Blotting, Western; Cell Proliferation; DNA Damage; DNA Topoisomerases, Type II; DNA-Binding Proteins; Drug Resistance, Neoplasm; Etoposide; Flow Cytometry; Genes, MDR; HeLa Cells; Humans; Hydrolysis; JNK Mitogen-Activated Protein Kinases; Neoplasms; Phosphorylation; RNA Interference; Surface Plasmon Resonance; Topoisomerase II Inhibitors; Tumor Stem Cell Assay; Xanthones | 2007 |
Differential effects of hypoxia on etoposide-induced apoptosis according to the cancer cell lines.
Topics: Apoptosis; Cell Hypoxia; Cell Line, Tumor; DNA; DNA Damage; Etoposide; Gene Expression Profiling; Gene Expression Regulation; Humans; Hypoxia-Inducible Factor 1; Neoplasms; Oligonucleotide Array Sequence Analysis; Tumor Suppressor Protein p53 | 2007 |
Hypoxia induces autophagic cell death in apoptosis-competent cells through a mechanism involving BNIP3.
Topics: Apoptosis; Autophagy; Caspases; Cell Hypoxia; Cells, Cultured; Etoposide; Humans; Membrane Proteins; Neoplasms; Proto-Oncogene Proteins; RNA Interference; Time Factors | 2008 |
Hemophagocytic lymphohistiocytosis as severe adverse event of antineoplastic treatment in children.
Topics: Adolescent; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Child; Daclizumab; Dexamethasone; Etoposide; Female; Humans; Immunoglobulin G; Infant; Infliximab; Lymphohistiocytosis, Hemophagocytic; Male; Neoplasms; Retrospective Studies; Stem Cell Transplantation; Transplantation, Homologous | 2008 |
Cutaneous effects of thiotepa in pediatric patients receiving high-dose chemotherapy with autologous stem cell transplantation.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Cyclophosphamide; Erythema; Etoposide; Humans; Infant; Neoplasms; Pigmentation Disorders; Retrospective Studies; Skin; Skin Diseases; Stem Cell Transplantation; Thiotepa | 2008 |
Wilms' tumor gene WT1-shRNA as a potent apoptosis-inducing agent for solid tumors.
Topics: Antineoplastic Agents; Apoptosis; Doxorubicin; Drug Synergism; Etoposide; Exons; Gene Expression Regulation, Neoplastic; Genes, bcl-2; Genes, Wilms Tumor; Genetic Therapy; HeLa Cells; Humans; Neoplasms; Protein Isoforms; RNA, Small Interfering; Signal Transduction; TNF-Related Apoptosis-Inducing Ligand; Transfection; Tumor Cells, Cultured; WT1 Proteins | 2008 |
Successful treatment with etoposide phosphate in patients with previous etoposide hypersensitivity.
Topics: Adolescent; Adult; Aged; Anti-Allergic Agents; Anti-Inflammatory Agents; Antineoplastic Agents; Chlorpheniramine; Drug Hypersensitivity; Etoposide; Female; Humans; Hydrocortisone; Infusions, Intravenous; Male; Middle Aged; Neoplasms; Organophosphorus Compounds | 2008 |
Novel function of the thyroid hormone analog tetraiodothyroacetic acid: a cancer chemosensitizing and anti-cancer agent.
Topics: Animals; Antineoplastic Agents, Hormonal; Antineoplastic Combined Chemotherapy Protocols; Cell Proliferation; Cisplatin; Doxorubicin; Drug Resistance, Neoplasm; Drug Synergism; Etoposide; Humans; Hydroxamic Acids; Mice; Mice, Nude; Neoplasms; Thyroid Hormones; Thyroxine; Tumor Cells, Cultured; Xenograft Model Antitumor Assays | 2008 |
Cathepsin D overexpressed by cancer cells can enhance apoptosis-dependent chemo-sensitivity independently of its catalytic activity.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Caspase 3; Caspase 9; Catalysis; Cathepsin D; Cytochromes c; Cytosol; Drug Resistance, Neoplasm; Etoposide; Humans; Neoplasms; Pepstatins; Protease Inhibitors; Tumor Cells, Cultured | 2008 |
Cyclophosphamide and VP 16-213 with autologous bone marrow transplantation. A dose escalation study.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Transplantation; Carcinoma, Small Cell; Combined Modality Therapy; Cyclophosphamide; Dose-Response Relationship, Drug; Drug Evaluation; Etoposide; Female; Humans; Lung Neoplasms; Male; Middle Aged; Neoplasms; Neoplasms, Germ Cell and Embryonal; Ovarian Neoplasms; Transplantation, Autologous | 1984 |
Etoposide: a new anti-cancer agent.
Topics: Animals; Drug Evaluation; Etoposide; Female; Humans; Kinetics; Lung Neoplasms; Male; Mitosis; Neoplasms; Podophyllotoxin; Testicular Neoplasms | 1981 |
A novel dye exclusion method for testing in vitro chemosensitivity of human tumors.
Topics: Antineoplastic Agents; Cell Line; Cell Survival; Doxorubicin; Drug Evaluation, Preclinical; Eosine Yellowish-(YS); Etoposide; Fluorouracil; Hematoxylin; Humans; Leukemia, Myeloid, Acute; Mechlorethamine; Melphalan; Neoplasms; Staining and Labeling | 1983 |
Drug testing using a soft agar stem cell assay on patient and xenograft tumor material.
Topics: Animals; Antineoplastic Agents; Bleomycin; Cisplatin; Colony-Forming Units Assay; Drug Synergism; Etoposide; Female; Granulosa Cell Tumor; Humans; Melphalan; Methotrexate; Mice; Misonidazole; Neoplasm Transplantation; Neoplasms; Ovarian Neoplasms; Transplantation, Heterologous; Tumor Stem Cell Assay; Vinblastine | 1984 |
Etoposide single-agent chemotherapy for solid tumors.
Topics: Carcinoma, Hepatocellular; Etoposide; Female; Head and Neck Neoplasms; Humans; Liver Neoplasms; Neoplasms; Ovarian Neoplasms; Podophyllotoxin; Sarcoma; Soft Tissue Neoplasms | 1982 |
High-dose VP-16-213 and autologous bone marrow transplantation for refractory malignancies: a phase I study.
Topics: Adolescent; Adult; Aged; Blood Cell Count; Bone Marrow; Bone Marrow Transplantation; Combined Modality Therapy; Dose-Response Relationship, Drug; Drug Evaluation; Drug Resistance; Etoposide; Female; Humans; Male; Middle Aged; Neoplasms; Podophyllotoxin | 1983 |
Perspectives for the use of high-dose chemotherapy in the treatment of solid malignant tumors.
Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Transplantation; Carmustine; Combined Modality Therapy; Cyclophosphamide; Drug Evaluation; Etoposide; Humans; Melphalan; Neoplasms; Whole-Body Irradiation | 1984 |
[Current clinical status of new anticancer drugs].
Topics: Altretamine; Anthraquinones; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Cyclophosphamide; Doxorubicin; Epirubicin; Etoposide; Humans; Mitoxantrone; Neoplasms | 1983 |
Data recycling and misreading: two potential errors in pooled data from small studies.
Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Communication; Cyclophosphamide; Doxorubicin; Drug Evaluation; Etoposide; Female; Humans; Neoplasms; Ovarian Neoplasms; Research Design; Statistics as Topic; Uterine Neoplasms | 1984 |
Penetration of VP-16 (etoposide) into human intracerebral and extracerebral tumors.
Topics: Brain Neoplasms; Etoposide; Glioma; Half-Life; Humans; Kinetics; Necrosis; Neoplasms; Podophyllotoxin | 1984 |
High-dose etoposide for refractory malignancies: a phase I study.
Topics: Adult; Aged; Bone Marrow; Diarrhea; Drug Evaluation; Erythema; Etoposide; Female; Humans; Male; Middle Aged; Mouth Diseases; Neoplasm Metastasis; Neoplasms; Paresthesia; Podophyllotoxin; Reflex | 1984 |
Pharmacokinetics of etoposide (VP16) in children and adolescents with refractory solid tumors.
Topics: Adolescent; Adult; Child; Child, Preschool; Cisplatin; Etoposide; Female; Humans; Kinetics; Leukemia; Male; Metabolic Clearance Rate; Neoplasms; Podophyllotoxin | 1984 |
Pharmacokinetics of high-dose etoposide (VP-16-213) administered to cancer patients.
Topics: Etoposide; Half-Life; Humans; Kinetics; Neoplasms; Podophyllotoxin | 1984 |
New anticancer drug class.
Topics: Child; Etoposide; Humans; Legislation, Drug; Neoplasms; Podophyllotoxin; Teniposide; United States | 1983 |
Pilot studies of various combinations of dibromodulcitol, VP-16, and AMSA.
Topics: Aged; Aminoacridines; Amsacrine; Drug Evaluation; Drug Therapy, Combination; Etoposide; Female; Humans; Male; Middle Aged; Mitolactol; Neoplasms; Pilot Projects; Podophyllotoxin | 1982 |
[Prospects of new chemotherapies].
Topics: Aminoacridines; Amsacrine; Antineoplastic Agents; Cisplatin; Drug Evaluation; Drug Therapy, Combination; Etoposide; Female; Humans; Male; Neoplasms; Podophyllotoxin; Vinblastine; Vindesine | 1982 |
High-dose combination chemotherapy with autologous bone marrow transplantation in adult solid tumors.
Topics: Adult; Aged; Antineoplastic Agents; Bone Marrow Transplantation; Carmustine; Cyclophosphamide; Drug Evaluation; Etoposide; Female; Humans; Ifosfamide; Leukocyte Count; Male; Middle Aged; Neoplasms; Pilot Projects; Platelet Count; Time Factors; Transplantation, Autologous; Vincristine | 1980 |
Etoposide (VP16-213) and teniposide (VM26) comparative in vitro activities in human tumors.
Topics: Antineoplastic Agents; Cells, Cultured; Etoposide; Humans; Neoplasms; Neoplasms, Experimental; Podophyllotoxin; Teniposide | 1982 |
Pharmacokinetics of Teniposide (VM26) and etoposide (VP16-213) in children with cancer.
Topics: Biotransformation; Child; Chromatography, High Pressure Liquid; Etoposide; Humans; Kinetics; Leukemia; Models, Biological; Neoplasms; Podophyllotoxin; Teniposide | 1982 |
A phase I trial of continuous infusion VP16-213 (etoposide).
Topics: Adult; Aged; Drug Evaluation; Etoposide; Female; Heart Diseases; Hematologic Diseases; Humans; Infusions, Parenteral; Male; Middle Aged; Neoplasms; Podophyllotoxin | 1982 |
Proceedings of the German Cancer Society (Clinical Oncology Section) and Bristol-Myers GmbH Symposium on Etoposide (VP-16). Current status and new developments. Frankfurt, 21-22 May 1981.
Topics: Etoposide; Humans; Neoplasms; Podophyllotoxin | 1982 |
[Etoposide: VP-16].
Topics: Etoposide; Humans; Lung Neoplasms; Lymphoma; Neoplasms; Podophyllotoxin | 1982 |
Preliminary study of the combination, dianhydrogalactitol, cis-diaminedichloroplatinum (II), and VP-16-213 in patients with advanced cancer.
Topics: Brain Neoplasms; Carcinoma, Squamous Cell; Cisplatin; Dianhydrogalactitol; Drug Evaluation; Drug Therapy, Combination; Etoposide; Female; Humans; Lung Neoplasms; Male; Middle Aged; Neoplasms; Pilot Projects; Podophyllotoxin; Sugar Alcohols | 1981 |
VP-16-213. A phase II trial using a weekly schedule.
Topics: Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Evaluation; Etoposide; Humans; Neoplasms; Podophyllotoxin | 1981 |
[Relations between hematological toxicity and total and free plasma levels of etoposide in daily oral administration].
Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Biological Availability; Drug Administration Schedule; Etoposide; Female; Humans; Leukocyte Count; Male; Middle Aged; Neoplasms; Neutropenia; Neutrophils | 1995 |
Double-cycle high-dose chemotherapy with peripheral blood stem cells and hematopoietic growth factor support in patients with advanced solid tumor. A pilot study by the Hong Kong Biotherapy Group.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow; Bone Marrow Transplantation; Cisplatin; Cyclophosphamide; Drug Administration Schedule; Etoposide; Female; Granulocyte Colony-Stimulating Factor; Granulocyte-Macrophage Colony-Stimulating Factor; Granulocytes; Hematopoietic Stem Cell Transplantation; Humans; Leukapheresis; Leukocyte Count; Male; Middle Aged; Neoplasms; Pilot Projects; Remission Induction; Survival Rate | 1994 |
Enrichment of human hematopoietic stem cell activity in the CD34+Thy-1+Lin- subpopulation from mobilized peripheral blood.
Topics: Animals; Antigens, CD; Antigens, CD34; Blood Cell Count; Bone Marrow; Chimera; Cyclophosphamide; Etoposide; Flow Cytometry; Graft Survival; Granulocyte Colony-Stimulating Factor; Hematopoiesis; Hematopoietic Stem Cell Transplantation; Hematopoietic Stem Cells; Humans; Mice; Mice, SCID; Neoplasms; Thy-1 Antigens; Time Factors; Transplantation, Heterologous | 1995 |
New method for stem cell quantification: applications to the management of peripheral blood stem cell transplantation.
Topics: Adult; Blood Cell Count; Cell Division; Cyclophosphamide; DNA; Etoposide; Female; Filgrastim; Flow Cytometry; Granulocyte Colony-Stimulating Factor; Hematopoietic Stem Cell Transplantation; Humans; Male; Middle Aged; Neoplasms; Recombinant Proteins; Retrospective Studies; Stem Cells | 1995 |
Analysis of human hematopoietic stem cell populations.
Topics: Animals; Antigens, CD; Antigens, CD34; Biomarkers; Bone Marrow; Bone Marrow Cells; Bone Transplantation; Chimera; Cyclophosphamide; Etoposide; Fetal Tissue Transplantation; Granulocyte Colony-Stimulating Factor; Granulocyte-Macrophage Colony-Stimulating Factor; Hematopoiesis; Hematopoietic Stem Cell Transplantation; Hematopoietic Stem Cells; Humans; Immunophenotyping; Mice; Mice, SCID; Neoplasms; Thy-1 Antigens; Thymus Gland; Transplantation, Heterologous | 1994 |
Harvesting, characterization, and culture of CD34+ cells from human bone marrow, peripheral blood, and cord blood.
Topics: Adult; Antibodies, Monoclonal; Antigens, CD; Antigens, CD34; Blood Cells; Bone Marrow Cells; Cell Differentiation; Cell Separation; Cells, Cultured; Colony-Forming Units Assay; Culture Techniques; Cyclophosphamide; Etoposide; Fetal Blood; Flow Cytometry; Granulocyte Colony-Stimulating Factor; Hematopoiesis; Hematopoietic Cell Growth Factors; Hematopoietic Stem Cells; Humans; Immunomagnetic Separation; Infant, Newborn; Neoplasms | 1994 |
Expression of adhesion molecules on CD34+ cells: CD34+ L-selectin+ cells predict a rapid platelet recovery after peripheral blood stem cell transplantation.
Topics: Adult; Antigens, CD; Antigens, CD34; Antineoplastic Combined Chemotherapy Protocols; Biomarkers; Bone Marrow; Bone Marrow Cells; Carboplatin; Carmustine; Cell Adhesion Molecules; Cell Movement; Combined Modality Therapy; Cyclophosphamide; Cytarabine; Epirubicin; Etoposide; Female; Fluorouracil; Gene Expression; Granulocyte Colony-Stimulating Factor; Hematopoiesis; Hematopoietic Stem Cell Transplantation; Hematopoietic Stem Cells; Humans; Ifosfamide; L-Selectin; Leukocyte Count; Male; Melphalan; Middle Aged; Neoplasms; Neutrophils; Platelet Count; Podophyllotoxin; Receptors, Very Late Antigen; Thiotepa | 1995 |
Etoposide protein binding in cancer patients.
Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Analysis of Variance; Antineoplastic Agents, Phytogenic; Carcinoma, Small Cell; Chromatography, High Pressure Liquid; Drug Administration Schedule; Etoposide; Female; Humans; Infusions, Intravenous; Male; Middle Aged; Neoplasms; Ovarian Neoplasms; Protein Binding; Regression Analysis | 1995 |
Adenovirus E1a-mediated tumor suppression by a c-erbB-2/neu-independent mechanism.
Topics: Adenovirus E1A Proteins; Animals; Apoptosis; Cisplatin; Etoposide; Gene Expression Regulation, Neoplastic; Genes, erbB-2; Genes, Tumor Suppressor; Humans; Mice; Mice, Nude; Neoplasm Proteins; Neoplasms; Receptor, ErbB-2; Tumor Cells, Cultured | 1995 |
Bone marrow transplantation through standard central venous catheters.
Topics: Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Transplantation; Carmustine; Catheterization, Central Venous; Catheters, Indwelling; Cyclophosphamide; Etoposide; Humans; Neoplasms; Transplantation, Autologous; Transplantation, Homologous; Transplantation, Isogeneic; Whole-Body Irradiation | 1995 |
[Influence of cytotoxic chemotherapy on superoxide production by neutrophils in cancer patients].
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Cisplatin; Cyclophosphamide; Doxorubicin; Etoposide; Female; Humans; Luminescent Measurements; Male; Neoplasms; Neutrophils; Superoxides | 1993 |
[Chemotherapy for older cancer patients].
Topics: Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Non-Small-Cell Lung; Carcinoma, Small Cell; Drug Administration Schedule; Etoposide; Female; Floxuridine; Granulocyte Colony-Stimulating Factor; Humans; Lung Neoplasms; Lymphoma, Non-Hodgkin; Male; Neoplasms; Neoplasms, Multiple Primary; Palliative Care; Quality of Life | 1993 |
Peripheral blood progenitor cells mobilized by chemotherapy plus granulocyte-colony stimulating factor accelerate both neutrophil and platelet recovery after high-dose VP16, ifosfamide and cisplatin.
Topics: Adult; Aged; Antigens, CD; Antigens, CD34; Antineoplastic Combined Chemotherapy Protocols; Blood Platelets; Blood Transfusion, Autologous; Cisplatin; Drug Administration Schedule; Etoposide; Female; Granulocyte Colony-Stimulating Factor; Hematopoietic Stem Cells; Humans; Ifosfamide; Leukapheresis; Leukocyte Count; Male; Middle Aged; Neoplasms; Neutrophils; Platelet Count | 1993 |
Inhibition of CFU-C growth by VP-16 containing plasma samples obtained from patients after conditioning therapy for bone marrow transplantation.
Topics: Adolescent; Adult; Bone Marrow Transplantation; Child; Etoposide; Hematopoietic Stem Cells; Humans; Infusions, Intravenous; Middle Aged; Neoplasms; Tumor Cells, Cultured; Tumor Stem Cell Assay | 1995 |
ALL-1 gene rearrangements in DNA topoisomerase II inhibitor-related leukemia in children.
Topics: Acute Disease; Adolescent; Bone Marrow Transplantation; Child; Child, Preschool; Chromosome Aberrations; Chromosome Deletion; Chromosomes, Human, Pair 11; Combined Modality Therapy; Dactinomycin; DNA-Binding Proteins; Etoposide; Female; Genes; Histone-Lysine N-Methyltransferase; Humans; Infant; Leukemia; Leukemia, Myeloid; Leukemia, Radiation-Induced; Male; Myelodysplastic Syndromes; Myeloid-Lymphoid Leukemia Protein; Neoplasm Proteins; Neoplasms; Neoplasms, Second Primary; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Proto-Oncogenes; Radiotherapy; Teniposide; Topoisomerase II Inhibitors; Transcription Factors; Translocation, Genetic; Whole-Body Irradiation | 1995 |
Prolonged impairment of hematopoiesis after high-dose therapy followed by autologous bone marrow transplantation.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow; Bone Marrow Transplantation; Busulfan; Carmustine; Cell Count; Child; Child, Preschool; Cisplatin; Combined Modality Therapy; Cyclophosphamide; Cytarabine; Etoposide; Female; Follow-Up Studies; Hematopoiesis; Hematopoietic Cell Growth Factors; Humans; Male; Melphalan; Methotrexate; Middle Aged; Mitoxantrone; Multivariate Analysis; Neoplasms; Prognosis; Radiation Injuries; Treatment Outcome; Vincristine; Whole-Body Irradiation | 1995 |
Collection and transplantation of peripheral blood stem cells in very small children weighting 20 kg or less.
Topics: Antineoplastic Combined Chemotherapy Protocols; Blood Component Removal; Blood Preservation; Body Weight; Bone Marrow Diseases; Carboplatin; Catheterization, Central Venous; Catheters, Indwelling; Child, Preschool; Cisplatin; Colony-Forming Units Assay; Combined Modality Therapy; Contraindications; Cyclophosphamide; Cytarabine; Doxorubicin; Etoposide; Female; Graft Survival; Hematopoietic Stem Cell Transplantation; Humans; Infant; Leukemia; Male; Neoplasms; Platelet Transfusion; Retrospective Studies; Safety | 1995 |
Current sample handling methods for measurement of platinum-DNA adducts in leucocytes in man lead to discrepant results in DNA adduct levels and DNA repair.
Topics: Antineoplastic Combined Chemotherapy Protocols; Blood Specimen Collection; Carboplatin; Cisplatin; DNA Adducts; DNA Repair; DNA, Neoplasm; Etoposide; Humans; Kinetics; Leukocytes; Neoplasms; Platinum | 1995 |
Effect of granulocyte-macrophage colony-stimulating factor on oral mucositis after hematopoietic stem-cell transplantation.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Combined Modality Therapy; Cyclophosphamide; Etoposide; Female; Granulocyte-Macrophage Colony-Stimulating Factor; Hematopoietic Stem Cell Transplantation; Humans; Male; Mouth Mucosa; Neoplasms; Stomatitis; Thiotepa; Whole-Body Irradiation | 1994 |
Busulfan-containing pre-transplant regimens for the treatment of solid tumors.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Transplantation; Breast Neoplasms; Busulfan; Combined Modality Therapy; Cyclophosphamide; Etoposide; Female; Follow-Up Studies; Humans; Middle Aged; Neoplasms; Ovarian Neoplasms; Pilot Projects; Retrospective Studies; Sarcoma | 1994 |
Pharmacokinetics of undiluted or diluted high-dose etoposide with or without busulfan administered to patients with hematologic malignancies.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Busulfan; Child; Chromatography, High Pressure Liquid; Drug Interactions; Etoposide; Female; Hematologic Diseases; Humans; Male; Middle Aged; Neoplasms; Phenytoin; Therapeutic Equivalency | 1994 |
Genistein modulates the decreased drug accumulation in non-P-glycoprotein mediated multidrug resistant tumour cells.
Topics: Alkaloids; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Carrier Proteins; Daunorubicin; Doxorubicin; Drug Resistance; Etoposide; Genistein; Humans; Hydrogen-Ion Concentration; Isoflavones; Lung Neoplasms; Membrane Glycoproteins; Neoplasms; Protein-Tyrosine Kinases; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1993 |
Therapy-related myelodysplasia and acute myeloid leukemia. Cytogenetic characteristics of 115 consecutive cases and risk in seven cohorts of patients treated intensively for malignant diseases in the Copenhagen series.
Topics: Adult; Age Factors; Aged; Aged, 80 and over; Antineoplastic Agents; Chromosome Aberrations; Cisplatin; Cohort Studies; Denmark; DNA Topoisomerases, Type II; DNA, Neoplasm; Etoposide; Female; Germinoma; Humans; Leukemia, Myeloid, Acute; Male; Middle Aged; Myelodysplastic Syndromes; Neoplasms; Neoplasms, Second Primary; Regression Analysis; Risk | 1993 |
Enhanced expression of the DNA topoisomerase II gene in response to heat shock stress in human epidermoid cancer KB cells.
Topics: Camptothecin; DNA Topoisomerases, Type II; Etoposide; Gene Expression; Hot Temperature; Humans; Irinotecan; KB Cells; Neoplasms; RNA, Messenger; Teniposide | 1993 |
High-dose chemotherapy with etoposide, cyclophosphamide and escalating dose of carboplatin followed by autologous bone marrow transplantation in cancer patients. A pilot study.
Topics: Adolescent; Adult; Agranulocytosis; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Transplantation; Carboplatin; Combined Modality Therapy; Cyclophosphamide; Etoposide; Female; Humans; Male; Middle Aged; Neoplasms; Pilot Projects; Prognosis; Prospective Studies; Salvage Therapy; Thrombocytopenia | 1993 |
Etoposide pharmacokinetics in children: the development and prospective validation of a dosing equation.
Topics: Adolescent; Brain Neoplasms; Child; Child, Preschool; Etoposide; Female; Humans; Infant; Male; Metabolic Clearance Rate; Neoplasms; Neuroblastoma; Pineal Gland; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Sarcoma; Soft Tissue Neoplasms; Teratoma | 1993 |
Model-guided determination of maximum tolerated dose in phase I clinical trials: evidence for increased precision.
Topics: Clinical Trials, Phase I as Topic; Dose-Response Relationship, Drug; Etoposide; Humans; Models, Statistical; Neoplasms | 1993 |
Pharmacokinetics of etoposide: correlation of pharmacokinetic parameters with clinical conditions.
Topics: Adult; Aged; Etoposide; Female; Half-Life; Humans; Male; Middle Aged; Neoplasms | 1993 |
Limited sampling models for reliable estimation of etoposide area under the curve.
Topics: Adult; Aged; Analysis of Variance; Antineoplastic Agents, Phytogenic; Etoposide; Female; Humans; Infusions, Intravenous; Male; Middle Aged; Models, Chemical; Neoplasms | 1995 |
Investigation of the comparative effects of 2-chlorodeoxyadenosine on tumor colony forming units in vitro.
Topics: Antineoplastic Agents; Cell Division; Cisplatin; Cladribine; Dose-Response Relationship, Drug; Doxorubicin; Drugs, Investigational; Etoposide; Fluorouracil; Humans; Mitomycin; Neoplasms; Neoplastic Stem Cells; Tumor Stem Cell Assay; Vinblastine | 1995 |
Etoposide, ifosfamide, and cisplatin therapy for refractory childhood solid tumors.
Topics: Antineoplastic Combined Chemotherapy Protocols; Child; Cisplatin; Etoposide; Humans; Ifosfamide; Neoplasms; Remission Induction | 1995 |
Ifosfamide, carboplatin, etoposide, and paclitaxel chemotherapy: a dose-escalation study.
Topics: Adult; Aged; Alopecia; Antineoplastic Agents; Antineoplastic Agents, Alkylating; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Carboplatin; Etoposide; Female; Fever; Granulocyte Colony-Stimulating Factor; Humans; Ifosfamide; Leukopenia; Male; Middle Aged; Neoplasms; Neutropenia; Paclitaxel; Pilot Projects; Remission Induction; Sarcoma; Thrombocytopenia | 1996 |
Overexpression of multidrug resistance protein gene in human cancer cell lines selected for drug resistance to epipodophyllotoxins.
Topics: Antineoplastic Agents, Phytogenic; ATP-Binding Cassette Transporters; Drug Resistance, Multiple; Etoposide; Gene Expression Regulation, Neoplastic; Humans; Multidrug Resistance-Associated Proteins; Neoplasms; Teniposide; Tumor Cells, Cultured | 1996 |
Chemotherapy enhancer passes first test.
Topics: Adult; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; ATP Binding Cassette Transporter, Subfamily B, Member 1; Clinical Trials, Phase I as Topic; Cyclosporins; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Etoposide; Female; Humans; Male; Neoplasms; Paclitaxel | 1995 |
Dual modes of death induced by etoposide in human epithelial tumor cells allow Bcl-2 to inhibit apoptosis without affecting clonogenic survival.
Topics: Apoptosis; Cell Death; Cell Survival; Epithelium; Etoposide; HeLa Cells; Humans; Neoplasms; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Transfection | 1996 |
Absence of correlation between chemo- and radioresistance in a range of human tumour cell lines.
Topics: Animals; Antibiotics, Antineoplastic; Antineoplastic Agents, Phytogenic; Carcinoma; Carcinoma, Squamous Cell; Cell Division; Cisplatin; Clone Cells; Cricetinae; Cricetulus; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Doxorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Etoposide; Female; HeLa Cells; Humans; Laryngeal Neoplasms; Lung Neoplasms; Neoplasms; Ovarian Neoplasms; Radiation Tolerance; Selection, Genetic; Tumor Cells, Cultured; Uterine Cervical Neoplasms; Vincristine | 1996 |
Improved priming for mobilization of and optimal timing for harvest of peripheral blood stem cells.
Topics: Adolescent; Adult; Antigens, CD34; Antineoplastic Combined Chemotherapy Protocols; Blood Cells; Blood Transfusion, Autologous; Bone Marrow; Carmustine; Cyclophosphamide; Cytarabine; Drug Administration Schedule; Drug Synergism; Epirubicin; Etoposide; Female; Filgrastim; Fluorouracil; Granulocyte Colony-Stimulating Factor; Hematologic Neoplasms; Hematopoietic Stem Cells; Humans; Injections, Subcutaneous; Leukapheresis; Leukocyte Count; Male; Melphalan; Middle Aged; Neoplasms; Recombinant Proteins | 1996 |
Mobilized peripheral blood progenitor cells (PBPC) in support of tandem cycles of high-dose chemotherapy (HDC).
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Diseases; Bone Marrow Transplantation; Carboplatin; Cyclophosphamide; Drug Administration Schedule; Etoposide; Feasibility Studies; Female; Granulocyte Colony-Stimulating Factor; Hematopoietic Stem Cell Transplantation; Humans; Leukapheresis; Male; Melphalan; Middle Aged; Mitoxantrone; Neoplasms; Patient Acceptance of Health Care; Remission Induction; Salvage Therapy; Thiotepa; Transplantation Conditioning; Transplantation, Autologous; Treatment Outcome | 1996 |
Plasma concentrations of polysorbate 80 measured in patients following administration of docetaxel or etoposide.
Topics: Aged; Antineoplastic Agents, Phytogenic; Docetaxel; Etoposide; Female; Humans; Male; Middle Aged; Neoplasms; Paclitaxel; Polysorbates; Surface-Active Agents; Taxoids | 1997 |
Circulating immature cell counts on the harvest day predict the yields of CD34+ cells collected after granulocyte colony-stimulating factor plus chemotherapy-induced mobilization of peripheral blood stem cell.
Topics: Adolescent; Adult; Aged; Antigens, CD34; Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Carboplatin; Cytarabine; Epirubicin; Etoposide; Female; Granulocyte Colony-Stimulating Factor; Hematopoiesis; Hematopoietic Stem Cell Transplantation; Hematopoietic Stem Cells; Humans; Leukapheresis; Leukocyte Count; Male; Middle Aged; Neoplasms | 1997 |
Nephrotoxicity of high-dose ifosfamide/carboplatin/etoposide in adults undergoing autologous stem cell transplantation.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bicarbonates; Carboplatin; Creatinine; Etoposide; Female; Hematopoietic Stem Cell Transplantation; Humans; Ifosfamide; Kidney; Magnesium; Male; Middle Aged; Neoplasms; Potassium; Retrospective Studies | 1997 |
Antithrombin-III for the treatment of chemotherapy-induced organ dysfunction following bone marrow transplantation.
Topics: Adolescent; Adult; Anticoagulants; Antithrombin III; Bone Marrow Transplantation; Busulfan; Child; Child, Preschool; Cyclophosphamide; Etoposide; Female; Hematologic Diseases; Hematopoietic Stem Cell Transplantation; Hepatic Veno-Occlusive Disease; Humans; Infant; Life Tables; Male; Multiple Organ Failure; Neoplasms; Severity of Illness Index; Survival Analysis; Thrombophilia; Transplantation Conditioning; Treatment Outcome | 1997 |
[Expression of DNA topoisomerases (I, II alpha, II beta) mRNA in etoposide- and mAMSA-resistant cell lines].
Topics: Amsacrine; Antigens, Neoplasm; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Blotting, Northern; DNA Topoisomerases, Type I; DNA Topoisomerases, Type II; DNA-Binding Proteins; Drug Resistance, Neoplasm; Etoposide; Humans; Isoenzymes; Neoplasms; RNA, Messenger; Tumor Cells, Cultured | 1997 |
Population pharmacokinetics of total and unbound etoposide.
Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Phytogenic; Biological Availability; Blood Proteins; Chemistry, Pharmaceutical; Etoposide; Female; Humans; Infusions, Intravenous; Male; Metabolic Clearance Rate; Middle Aged; Neoplasms; Protein Binding; Retrospective Studies | 1998 |
A risk-benefit assessment of irinotecan in solid tumours.
Topics: Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Camptothecin; Cisplatin; Colorectal Neoplasms; Diarrhea; Drug Therapy, Combination; Etoposide; Fluorouracil; Humans; Irinotecan; Lung Neoplasms; Neoplasms; Risk Assessment | 1998 |
[Incidence of mutation and deletion in topoisomerase II mRNA of etoposide and m-AMSA resistant cell lines].
Topics: Amsacrine; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; DNA Topoisomerases, Type II; Drug Resistance, Neoplasm; Etoposide; Gene Deletion; Humans; Mutation; Neoplasms; RNA, Messenger; Tumor Cells, Cultured | 1998 |
Paclitaxel, cisplatin and etoposide combination chemotherapy: a comparison of dose intensity in two multifractionated dose schemas.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Dose Fractionation, Radiation; Dose-Response Relationship, Drug; Drug Administration Schedule; Etoposide; Female; Humans; Male; Middle Aged; Neoplasms; Paclitaxel | 1998 |
IAP-family protein survivin inhibits caspase activity and apoptosis induced by Fas (CD95), Bax, caspases, and anticancer drugs.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; Base Sequence; bcl-2-Associated X Protein; Caspase Inhibitors; Caspases; Cytochrome c Group; Drug Screening Assays, Antitumor; Etoposide; fas Receptor; Humans; Inhibitor of Apoptosis Proteins; Isoenzymes; Microtubule-Associated Proteins; Molecular Sequence Data; Neoplasm Proteins; Neoplasms; Proteins; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Survivin; Tumor Cells, Cultured; X-Linked Inhibitor of Apoptosis Protein | 1998 |
Anti-apoptotic oncogenes prevent caspase-dependent and independent commitment for cell death.
Topics: Amino Acid Chloromethyl Ketones; Antibodies, Monoclonal; Apoptosis; Caspase Inhibitors; Caspases; Cysteine Proteinase Inhibitors; Dactinomycin; Enzyme Activation; Etoposide; fas Receptor; HL-60 Cells; Humans; Jurkat Cells; Neoplasms; Oncogenes; Staurosporine | 1998 |
Activity of SCH 66336, a tricyclic farnesyltransferase inhibitor, against human tumor colony-forming units.
Topics: Alkyl and Aryl Transferases; Cell Survival; Cisplatin; Clone Cells; Dose-Response Relationship, Drug; Doxorubicin; Drug Resistance, Neoplasm; Etoposide; Farnesyltranstransferase; Humans; Neoplasms; Neoplastic Stem Cells; Paclitaxel; Piperidines; Pyridines; Sensitivity and Specificity; Tumor Cells, Cultured; Tumor Stem Cell Assay | 1999 |
A novel podophyllotoxin-derived compound GL331 is more potent than its congener VP-16 in killing refractory cancer cells.
Topics: Antineoplastic Agents, Phytogenic; Apoptosis; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Death; Drug Resistance, Multiple; Drug Screening Assays, Antitumor; Etoposide; Humans; Neoplasms; Podophyllotoxin; Tumor Cells, Cultured | 1999 |
Clonogenic potential and phenotypic analysis of CD34+ cells mobilized by different chemotherapy regimens.
Topics: Antineoplastic Combined Chemotherapy Protocols; Colony-Forming Units Assay; Cyclophosphamide; Drug Synergism; Epirubicin; Etoposide; Female; Granulocyte Colony-Stimulating Factor; Hematopoietic Stem Cell Mobilization; Hematopoietic Stem Cell Transplantation; Hematopoietic Stem Cells; Humans; Ifosfamide; Immunophenotyping; Leukapheresis; Leukocyte Count; Male; Neoplasms | 1999 |
Oral cancer chemotherapy: the promise and the pitfalls.
Topics: Administration, Oral; Antineoplastic Agents; Etoposide; Humans; Neoplasms; Patient Compliance | 1999 |
Testicular cancer seen as "stalking horse" for other cancers.
Topics: alpha-Fetoproteins; Antineoplastic Agents; Antineoplastic Agents, Alkylating; Antineoplastic Agents, Phytogenic; Biomarkers, Tumor; Chorionic Gonadotropin; Chromosomes, Human, Pair 12; Cisplatin; Combined Modality Therapy; Cyclophosphamide; Drug Resistance, Neoplasm; Etoposide; Evidence-Based Medicine; Humans; L-Lactate Dehydrogenase; Male; Neoplasms; Testicular Neoplasms | 1999 |
Highly sensitive liquid chromatography-electrospray mass spectrometry (LC-MS) method for the determination of etoposide levels in human serum and plasma.
Topics: Antineoplastic Agents, Phytogenic; Calibration; Chromatography, Liquid; Etoposide; Humans; Mass Spectrometry; Neoplasms; Quality Control; Sensitivity and Specificity | 2000 |
Cyclophosphamide and etoposide for pediatric solid tumors.
Topics: Antineoplastic Combined Chemotherapy Protocols; Child; Clinical Trials, Phase II as Topic; Cyclophosphamide; Etoposide; Humans; Neoplasms; Research Design | 2000 |
Resistance of tumor cells to chemo- and radiotherapy modulated by the three-dimensional architecture of solid tumors and spheroids.
Topics: Antineoplastic Agents; Benzimidazoles; Cell Communication; Cell Separation; Cell Size; Chromatin; DNA, Neoplasm; Drug Resistance, Neoplasm; Etoposide; Flow Cytometry; Fluorescent Dyes; Gene Expression Regulation, Neoplastic; Neoplasms; Spheroids, Cellular; Tumor Cells, Cultured | 2001 |
Telomere dysfunction alters the chemotherapeutic profile of transformed cells.
Topics: Animals; Antineoplastic Agents; Cell Line, Transformed; Cisplatin; Cyclin-Dependent Kinase Inhibitor p16; Doxorubicin; Etoposide; Fluorouracil; Mice; Neoplasms; Proto-Oncogene Proteins c-myc; ras Proteins; RNA; Telomerase; Telomere; Tumor Suppressor Protein p53 | 2001 |
Simulation tool for schedule-dependent etoposide exposure based on pharmacokinetic findings published in the literature.
Topics: Adolescent; Antineoplastic Agents, Phytogenic; Area Under Curve; Biological Availability; Child; Child, Preschool; Computer Simulation; Dose-Response Relationship, Drug; Drug Administration Schedule; Etoposide; Humans; Infant; Infusions, Intravenous; Neoplasms; Predictive Value of Tests; Regression Analysis; Time Factors | 2001 |
Quality of life in cancer patients treated by chemotherapy.
Topics: Adult; Aged; Antibiotics, Antineoplastic; Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Cisplatin; Colorectal Neoplasms; Epirubicin; Etoposide; Female; Fluorouracil; Humans; Leucovorin; Lung Neoplasms; Male; Middle Aged; Neoplasms; Quality of Life; Stomach Neoplasms; Surveys and Questionnaires | 2000 |
Staurosporine and conventional anticancer drugs induce overlapping, yet distinct pathways of apoptosis and caspase activation.
Topics: Antineoplastic Agents; Apoptosis; Caspases; Enzyme Activation; Etoposide; fas Receptor; HeLa Cells; Humans; Immunoblotting; Jurkat Cells; Mitochondria; Mitomycin; Neoplasms; Signal Transduction; Staurosporine; Transfection; Tumor Cells, Cultured | 2001 |
PTEN protects p53 from Mdm2 and sensitizes cancer cells to chemotherapy.
Topics: Blotting, Western; Cell Cycle; Cell Line; Cell Nucleus; Cloning, Molecular; Coloring Agents; Cytoplasm; DNA Damage; Dose-Response Relationship, Drug; Down-Regulation; Etoposide; Genes, Reporter; Glioblastoma; Humans; Microscopy, Confocal; Mutation; Neoplasms; Nuclear Proteins; Phosphoric Monoester Hydrolases; Precipitin Tests; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-mdm2; PTEN Phosphohydrolase; Retroviridae; Signal Transduction; Tetrazolium Salts; Thiazoles; Transcription, Genetic; Transduction, Genetic; Tumor Cells, Cultured; Tumor Suppressor Protein p53; Tumor Suppressor Proteins | 2002 |
The Egr-1 transcription factor directly activates PTEN during irradiation-induced signalling.
Topics: Animals; Apoptosis; Cells, Cultured; Dermis; DNA-Binding Proteins; Early Growth Response Protein 1; Etoposide; Fibroblasts; Gamma Rays; Gene Expression Regulation, Neoplastic; Humans; Immediate-Early Proteins; Mammary Glands, Animal; Mice; Mice, Knockout; Neoplasms; Nucleic Acid Synthesis Inhibitors; Phosphoric Monoester Hydrolases; Promoter Regions, Genetic; PTEN Phosphohydrolase; RNA, Messenger; Signal Transduction; Transcription Factors; Tumor Suppressor Proteins; Ultraviolet Rays | 2001 |
[Globalization of anti-cancer therapies].
Topics: Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Camptothecin; Carboplatin; Cisplatin; Colorectal Neoplasms; Etoposide; Female; Humans; Irinotecan; Lung Neoplasms; Male; Neoplasms; Ovarian Neoplasms; Paclitaxel; Prostatic Neoplasms; Stomach Neoplasms | 2002 |
The effect of heat shock, cisplatin, etoposide and quercetin on Hsp27 expression in human normal and tumour cells.
Topics: Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Cell Culture Techniques; Cell Transformation, Neoplastic; Cisplatin; Drug Resistance, Neoplasm; Etoposide; Eukaryotic Cells; Fibroblasts; Heat-Shock Proteins; HeLa Cells; Hot Temperature; HSP27 Heat-Shock Proteins; Humans; Models, Biological; Molecular Chaperones; Neoplasm Proteins; Neoplasms; Quercetin; Stress, Physiological | 2002 |
Population pharmacokinetics of high-dose etoposide in children receiving different conditioning regimens.
Topics: Adolescent; Adult; Antineoplastic Agents, Phytogenic; Bone Marrow Transplantation; Child; Child, Preschool; Etoposide; Female; Half-Life; Humans; Infant; Male; Neoplasms; Protein Binding; Transplantation Conditioning | 2002 |
Autologous peripheral blood progenitor cell transplantation with <2 x 10(6) CD34(+)/kg: an analysis of variables concerning mobilisation and engraftment.
Topics: Adolescent; Adult; Aged; Antigens, CD34; Antineoplastic Combined Chemotherapy Protocols; Blood Cell Count; Caspase 14; Caspases; Cerebral Hemorrhage; Cohort Studies; Combined Modality Therapy; Cyclophosphamide; Cytarabine; Erythropoietin; Etoposide; Female; Graft Survival; Granulocyte Colony-Stimulating Factor; Hematologic Neoplasms; Hematopoietic Stem Cell Mobilization; Hematopoietic Stem Cell Transplantation; Humans; Hydroxyurea; Infections; Leukapheresis; Life Tables; Male; Middle Aged; Neoplasms; Proportional Hazards Models; Transplantation Conditioning; Transplantation, Autologous | 2000 |
Overview of early and investigational chemotherapeutic agents in solid tumors.
Topics: Alkylating Agents; Antibiotics, Antineoplastic; Antimetabolites, Antineoplastic; Aziridines; Azo Compounds; Camptothecin; Cycloleucine; Etoposide; Floxuridine; Humans; Neoplasms; Nitrogen Mustard Compounds; Picolinic Acids; Platinum; Porfiromycin; Streptonigrin; Teniposide; Thiotepa; Tubercidin | 1976 |
[Therapeutic experiences using the new podophyllotoxin derivative VP 16-213 in malignant human tumors].
Topics: Adenocarcinoma; Bronchial Neoplasms; Carcinoma; Carcinoma, Small Cell; Etoposide; Female; Humans; Leukemia, Myeloid, Acute; Lung Neoplasms; Male; Middle Aged; Neoplasms; Ovarian Neoplasms; Podophyllotoxin; Prostatic Neoplasms; Remission, Spontaneous | 1975 |
Total-body hyperthermia with and without chemotherapy for advanced human neoplasms.
Topics: Adult; Antineoplastic Agents; Bone Marrow; Burns; Creatine Kinase; Electroencephalography; Etoposide; Female; Humans; Hyperthermia, Induced; L-Lactate Dehydrogenase; Male; Melanoma; Melphalan; Middle Aged; Neoplasm Metastasis; Neoplasms; Peripheral Nervous System Diseases; Remission, Spontaneous; Tachycardia | 1979 |
Lack of severe hypotension with VP-16-213 administered directly lv.
Topics: Adult; Aged; Blood Pressure; Etoposide; Humans; Infusions, Parenteral; Middle Aged; Neoplasms; Podophyllotoxin | 1977 |
Comparison of the human pharmacokinetics of VM-26 and VP-16, two antineoplastic epipodophyllotixin glucopyranoside derivatives.
Topics: Body Water; Etoposide; Humans; Metabolic Clearance Rate; Models, Biological; Neoplasms; Podophyllotoxin; Teniposide | 1975 |
Use of GM-CSF in children after high-dose chemotherapy.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Blood Transfusion; Child; Child, Preschool; Cisplatin; Drug Administration Schedule; Etoposide; Female; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Infant; Leukocyte Count; Male; Neoplasms; Neutropenia; Platelet Transfusion; Recombinant Proteins; Remission Induction | 1992 |
Clinical experiences with platinum and etoposide therapy in lung cancer.
Topics: Etoposide; Humans; Neoplasms; Platinum | 1992 |
Novel Approaches to the Use of Etoposide. Proceedings of a workshop. December 5-7, 1991.
Topics: Etoposide; Humans; Neoplasms | 1992 |
Mobilization of peripheral blood progenitor cells by sequential administration of interleukin-3 and granulocyte-macrophage colony-stimulating factor following polychemotherapy with etoposide, ifosfamide, and cisplatin.
Topics: Adult; Aged; Antigens, CD; Antigens, CD34; Antineoplastic Combined Chemotherapy Protocols; Cell Count; Cisplatin; Erythrocytes; Erythroid Precursor Cells; Etoposide; Female; Granulocyte-Macrophage Colony-Stimulating Factor; Granulocytes; Hematopoietic Stem Cells; Humans; Ifosfamide; Immunophenotyping; Interleukin-3; Male; Megakaryocytes; Middle Aged; Monocytes; Neoplasms | 1992 |
Bone marrow purging in patients with refractory cancer.
Topics: Adolescent; Adult; Bone Marrow Purging; Bone Marrow Transplantation; Breast Neoplasms; Child; Child, Preschool; Colony-Forming Units Assay; Etoposide; Female; Hematopoietic Stem Cells; Humans; In Vitro Techniques; Leukemia; Lymphoma; Male; Methylprednisolone; Middle Aged; Neoplasms; Transplantation, Autologous | 1992 |
What is the optimal dose and duration of treatment with etoposide? I. Maximum tolerated duration of daily treatment with 50, 75, and 100 mg of oral etoposide.
Topics: Administration, Oral; Adolescent; Adult; Aged; Drug Administration Schedule; Etoposide; Female; Humans; Male; Middle Aged; Neoplasms | 1992 |
What is the optimal dose and duration of treatment with etoposide? II. Comparative pharmacokinetic study of three schedules: 1 x 100 mg, 2 x 50 mg, and 4 x 25 mg of oral etoposide daily for 21 days.
Topics: Administration, Oral; Adolescent; Adult; Aged; Biological Availability; Drug Administration Schedule; Etoposide; Female; Humans; Male; Middle Aged; Neoplasms; Regression Analysis | 1992 |
Dose escalation of cisplatin (P), etoposide (E), and ifosfamide (I) with GM-CSF for advanced germ cell tumors.
Topics: Cisplatin; Drug Therapy, Combination; Etoposide; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Ifosfamide; Neoplasms | 1992 |
Influence of mobilized peripheral blood cells on the hematopoietic recovery by autologous marrow and recombinant human granulocyte-macrophage colony-stimulating factor after high-dose cyclophosphamide, etoposide, and cisplatin.
Topics: Antineoplastic Combined Chemotherapy Protocols; Blood Component Transfusion; Blood Transfusion; Bone Marrow Transplantation; Cisplatin; Combined Modality Therapy; Cyclophosphamide; Etoposide; Granulocyte-Macrophage Colony-Stimulating Factor; Hematopoiesis; Humans; Leukocyte Count; Neoplasms; Platelet Count; Recombinant Proteins; Transplantation, Autologous | 1992 |
The pharmacokinetics of high-dose carboplatin in pediatric patients with cancer.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Child; Child, Preschool; Dose-Response Relationship, Drug; Drug Administration Schedule; Etoposide; Female; Humans; Male; Neoplasms | 1992 |
In vitro and in vivo modulation of multi-drug resistance with amiodarone.
Topics: Adult; Amiodarone; Biological Transport; Carcinoma, Small Cell; Cell Line; Cell Survival; Colonic Neoplasms; DNA Damage; Doxorubicin; Drug Resistance; Drug Screening Assays, Antitumor; Etoposide; Female; Humans; Kinetics; Lung Neoplasms; Male; Neoplasms; Tumor Stem Cell Assay; Vincristine | 1991 |
Increased phosphorylation of DNA topoisomerase II in etoposide-resistant mutants of human cancer KB cells.
Topics: Carcinoma, Squamous Cell; DNA; DNA Topoisomerases, Type II; Etoposide; Humans; KB Cells; Mutation; Neoplasms; Phosphorylation; Tumor Cells, Cultured | 1991 |
Recent advances in etoposide therapy. Combined proceedings of two symposia: University of Maryland School of Medicine program, Alexandria, Virginia and a satellite symposium of the 9th International Symposium on Future Trends in Chemotherapy, Geneva, Swit
Topics: Etoposide; Humans; Neoplasms | 1991 |
Placental site trophoblastic tumor in a postmenopausal woman.
Topics: Antineoplastic Combined Chemotherapy Protocols; Chorionic Gonadotropin; Cisplatin; Combined Modality Therapy; Cyclophosphamide; Dactinomycin; Etoposide; Female; Humans; Menopause; Methotrexate; Middle Aged; Neoplasms; Placenta Diseases; Pregnancy; Trophoblastic Neoplasms | 1991 |
Ambulatory high-dose 5-day continuous-infusion ifosfamide combination chemotherapy in advanced solid tumors: a feasibility study.
Topics: Adult; Aged; Ambulatory Care; Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Drug Administration Schedule; Drug Stability; Epirubicin; Etoposide; Feasibility Studies; Female; Humans; Ifosfamide; Infusion Pumps, Implantable; Infusions, Intravenous; Male; Mesna; Middle Aged; Mitoxantrone; Neoplasms | 1991 |
High-dose chemotherapy with autologous bone marrow rescue: haematopoietic reconstitution by non-cryopreserved marrow.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Transplantation; Carboplatin; Carmustine; Cyclophosphamide; Etoposide; Humans; Middle Aged; Neoplasms; Remission Induction; Tissue Preservation; Transplantation, Autologous | 1991 |
Relation of systemic exposure to unbound etoposide and hematologic toxicity.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Etoposide; Female; Humans; Leukocyte Count; Linear Models; Male; Middle Aged; Neoplasms; Platelet Count; Protein Binding | 1991 |
Is treatment intensification by adding etoposide and carboplatin to fractionated total body irradiation and melphalan acceptable in children with solid tumors with respect to toxicity?
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Transplantation; Carboplatin; Child; Child, Preschool; Combined Modality Therapy; Etoposide; Humans; Infant; Melphalan; Neoplasms | 1991 |
In vitro data supporting interferon plus cytotoxic agent combinations.
Topics: Antineoplastic Combined Chemotherapy Protocols; Clone Cells; Doxorubicin; Drug Screening Assays, Antitumor; Drug Synergism; Etoposide; Fluorouracil; Humans; Interferon-alpha; Neoplasms | 1991 |
Drug monitoring in cancer therapy.
Topics: Antineoplastic Agents; Bone Marrow; Drug Monitoring; Etoposide; Humans; Neoplasms | 1991 |
Etoposide (VP 16-213) induced hepatitis. Report of three cases following standard-dose treatments.
Topics: Acute Disease; Aged; Antineoplastic Agents; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; Etoposide; Female; Humans; Liver; Male; Middle Aged; Necrosis; Neoplasms | 1991 |
Potentiation of etoposide and vincristine by two synthetic 1,4-dihydropyridine derivatives in multidrug-resistant and atypical multidrug-resistant human cancer cells.
Topics: Antineoplastic Agents; Cell Survival; Dihydropyridines; Dioxins; Drug Resistance; Drug Synergism; Etoposide; Humans; Intracellular Fluid; Neoplasms; Tritium; Tumor Cells, Cultured; Vincristine | 1991 |
Chronic daily administration of oral etoposide.
Topics: Adult; Aged; Aged, 80 and over; Carcinoma, Small Cell; Drug Administration Schedule; Drug Evaluation; Etoposide; Humans; Lung Neoplasms; Lymphoma, Non-Hodgkin; Middle Aged; Neoplasms; Neoplasms, Germ Cell and Embryonal | 1990 |
Clinical pharmacodynamics of continuous-infusion etoposide.
Topics: Adult; Aged; Blood Cell Count; Carcinoma, Small Cell; Chromatography, High Pressure Liquid; Drug Resistance; Etoposide; Humans; Infusions, Intravenous; Kidney Function Tests; Leukocyte Count; Liver Function Tests; Lung Neoplasms; Middle Aged; Neoplasms | 1990 |
Infusion of high doses of undiluted etoposide through central venous catheters during preparation for bone marrow transplantation.
Topics: Adenocarcinoma; Adolescent; Adult; Aged; Bone Marrow Transplantation; Carcinoma, Non-Small-Cell Lung; Catheterization, Central Venous; Colonic Neoplasms; Drug Administration Schedule; Etoposide; Humans; Leukemia, Myeloid, Acute; Lung Neoplasms; Lymphoma; Middle Aged; Neoplasms | 1990 |
A pilot study of high-dose carboplatin and pulsed etoposide in the treatment of childhood solid tumors.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Diseases; Carboplatin; Child; Child, Preschool; Drug Evaluation; Etoposide; Female; Gastrointestinal Diseases; Hearing Loss, Sensorineural; Humans; Infant; Male; Neoplasms; Pilot Projects | 1990 |
Prospective evaluation of a model for predicting etoposide plasma protein binding in cancer patients.
Topics: Adult; Aged; Aged, 80 and over; Bilirubin; Blood Proteins; Etoposide; Evaluation Studies as Topic; Female; Humans; Male; Middle Aged; Models, Biological; Neoplasms; Prospective Studies; Protein Binding; Serum Albumin | 1990 |
Phase I study of repeated cycles of high-dose cyclophosphamide, etoposide, and cisplatin administered without bone marrow transplantation.
Topics: Adolescent; Adult; Aged; Agranulocytosis; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Transplantation; Cisplatin; Cyclophosphamide; Drug Administration Schedule; Drug Evaluation; Etoposide; Female; Humans; Male; Middle Aged; Neoplasms; Remission Induction; Survival Rate; Thrombocytopenia | 1990 |
Changes in the clearance of total and unbound etoposide in patients with liver dysfunction.
Topics: Antineoplastic Combined Chemotherapy Protocols; Bilirubin; Chromatography, High Pressure Liquid; Cisplatin; Creatinine; Etoposide; Female; Humans; Liver; Liver Function Tests; Male; Neoplasms; Protein Binding; Regression Analysis | 1990 |
Clinical pharmacokinetics of etoposide during 120 hours continuous infusions in solid tumours.
Topics: Etoposide; Humans; Infusions, Parenteral; Neoplasms; Time Factors | 1990 |
Changes of stapedius reflex and hearing threshold in patients receiving high-dose cisplatin treatment.
Topics: Adult; Aged; Audiometry, Pure-Tone; Auditory Threshold; Cisplatin; Cochlear Diseases; Etoposide; Female; Hearing Disorders; Humans; Male; Middle Aged; Neoplasms; Stapedius | 1990 |
Combination high-dose etoposide and vincristine infusion.
Topics: Antineoplastic Combined Chemotherapy Protocols; Dose-Response Relationship, Drug; Etoposide; Humans; Infusions, Intravenous; Neoplasms; Vincristine | 1990 |
Is ectopic production of human chorionic gonadotrophin (hCG) or alpha fetoprotein (AFP) by tumours a marker of chemosensitivity?
Topics: alpha-Fetoproteins; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Chorionic Gonadotropin; Cisplatin; Dactinomycin; Doxorubicin; Etoposide; Hormones, Ectopic; Humans; Leucovorin; Methotrexate; Neoplasms; Vincristine | 1986 |
Progenitor cell numbers (CFU-GM, CFU-D, and CFU-Mix) and hemopoietic recovery following autologous marrow transplantation.
Topics: Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Transplantation; Carmustine; Colony-Forming Units Assay; Cyclophosphamide; Etoposide; Hematopoiesis; Hematopoietic Stem Cells; Humans; Neoplasms; Time Factors; Transplantation, Autologous; Whole-Body Irradiation | 1989 |
Clinical, analytical and pharmacokinetic aspects in cancer chemotherapy with platinum coordination compounds.
Topics: Adolescent; Antineoplastic Agents; Carboplatin; Child; Child, Preschool; Cisplatin; Etoposide; Humans; Infant; Neoplasms; Organoplatinum Compounds; Spectrum Analysis | 1989 |
Phase I study of vincristine and escalating doses of etoposide.
Topics: Antineoplastic Combined Chemotherapy Protocols; Blood Cell Count; Bone Marrow Diseases; Drug Evaluation; Etoposide; Humans; Neoplasms; Vincristine | 1989 |
Treatment strategies in relation to drug action.
Topics: Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Small Cell; DNA Topoisomerases, Type II; Etoposide; Hodgkin Disease; Humans; Leukemia; Lung Neoplasms; Lymphoma, Non-Hodgkin; Neoplasms; Podophyllotoxin; Teniposide | 1987 |
Altered protein binding of etoposide in patients with cancer.
Topics: Adult; Aged; Bilirubin; Blood Proteins; Etoposide; Female; Humans; Male; Middle Aged; Neoplasms; Protein Binding; Serum Albumin | 1989 |
Chronic daily administration of oral etoposide--a phase I trial.
Topics: Administration, Oral; Blood Cell Count; Bone Marrow; Capsules; Dose-Response Relationship, Drug; Drug Evaluation; Etoposide; Female; Hematocrit; Humans; Male; Neoplasms; Time Factors | 1989 |
Etoposide: a pharmacokinetic profile including an assessment of bioavailability.
Topics: Administration, Oral; Biological Availability; Carcinoma; Carcinoma, Small Cell; Etoposide; Female; Hodgkin Disease; Humans; Injections, Intravenous; Kinetics; Lung Neoplasms; Lymphoma; Male; Neoplasms; Podophyllotoxin | 1986 |
Evidence for capillary leakage during chemotherapy in man.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Capillary Permeability; Cyclophosphamide; Etoposide; Female; Humans; Male; Middle Aged; Neoplasms; Serum Albumin | 1986 |
High-dose cisplatin and etoposide in advanced malignancies of childhood.
Topics: Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Diseases; Child; Cisplatin; Drug Evaluation; Etoposide; Hearing Loss, Sensorineural; Humans; Neoplasms; Vomiting | 1987 |
Clinical trial of etoposide (VP-16) in children with recurrent malignant solid tumors. A phase II study from the Pediatric Oncology Group.
Topics: Adolescent; Adult; Blood Cell Count; Child; Child, Preschool; Drug Evaluation; Etoposide; Female; Humans; Infant; Male; Neoplasm Recurrence, Local; Neoplasms | 1988 |
VP-16.
Topics: Child; Etoposide; Humans; Neoplasms | 1988 |
Drug monitoring of etoposide (VP16-213). Correlation of pharmacokinetic parameters to clinical and biochemical data from patients receiving etoposide.
Topics: Adult; Aged; Chromatography, High Pressure Liquid; Etoposide; Female; Half-Life; Humans; Infusions, Intravenous; Kinetics; Male; Middle Aged; Neoplasms; Tissue Distribution | 1987 |
Influence of polysorbate 80 (Tween 80) and etoposide (VP-16-213) on the pharmacokinetics and urinary excretion of adriamycin and its metabolites in cancer patients.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Doxorubicin; Drug Interactions; Etoposide; Female; Humans; Kinetics; Male; Middle Aged; Neoplasms; Pharmaceutical Vehicles; Podophyllotoxin; Polysorbates | 1986 |
Etoposide pharmacokinetics in patients with normal and abnormal organ function.
Topics: Adult; Aged; Bile; Bilirubin; Chromatography, High Pressure Liquid; Creatinine; Etoposide; Female; Humans; Kinetics; Male; Metabolic Clearance Rate; Middle Aged; Neoplasms; Urine | 1986 |
[High dose cytotoxic agents followed by autologous bone marrow transplantation; treatment results in 25 patients with various malignancies].
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Transplantation; Combined Modality Therapy; Cyclophosphamide; Etoposide; Female; Humans; Male; Middle Aged; Neoplasms; Transplantation, Autologous | 1985 |
[Research project of cancer chemotherapy].
Topics: Altretamine; Aminoacridines; Amsacrine; Antineoplastic Agents; Cisplatin; Dacarbazine; Etoposide; Humans; International Cooperation; Japan; Neoplasms; Research; Thioguanine; United States | 1985 |
[A phase I study of VP-16-213 (VP, etoposide) by single and 5-day intravenous administration].
Topics: Adult; Aged; Drug Administration Schedule; Drug Evaluation; Etoposide; Female; Humans; Infusions, Parenteral; Kinetics; Leukopenia; Male; Middle Aged; Neoplasms; Podophyllotoxin; Thrombocytopenia | 1986 |