etoposide has been researched along with Leukemia L 1210 in 86 studies
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 46 (53.49) | 18.7374 |
1990's | 32 (37.21) | 18.2507 |
2000's | 8 (9.30) | 29.6817 |
2010's | 0 (0.00) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors | Studies |
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Hansch, C; Khwaja, TA; Selassie, CD | 1 |
Jurd, L; Narayanan, VL; Paull, KD | 1 |
Amarnath, V; Hall, IH; Lee, KH; Rice, GK | 1 |
Jardine, I; Kozlowski, J; Strife, RJ | 1 |
Bisagni, E; Croisy, A; Janin, YL; Riou, JF | 1 |
Fujimoto, K; Kobunai, T; Nomura, M; Shibata, J; Sugimoto, Y; Terada, T; Wierzba, K; Yamada, Y; Yamashita, J; Yamazaki, R | 1 |
Daley, L; Demerseman, P; Etiévant, C; Guminski, Y; Hill, BT; Imbert, T; Kruczynski, A; Monneret, C | 1 |
Annereau, JP; Bailly, C; Barret, JM; Brel, V; Delcros, JG; Guilbaud, N; Guminski, Y; Imbert, T; Kruczynski, A; Lansiaux, A; Vispé, S | 1 |
Ooi, K | 1 |
Monneret, C; Schmidt, F | 1 |
Arimondo, PB; Dauzonne, D; Duca, M; Léonce, S; Monneret, C; Pfeiffer, B; Pierré, A | 1 |
Glisson, B; Liu, L; Ross, W; Rowe, T; Yalowich, J | 1 |
Glisson, BS; Hande, KR; Ross, WE; Wozniak, AJ | 1 |
Glisson, BS; Ross, WE; Smallwood, SE | 1 |
Ross, WE; Yalowich, JC | 2 |
Ross, WE; Wozniak, AJ | 1 |
Hilliard, S; Karas, JG; Peck, C; Roberts, D | 1 |
Kikuchi, H; Kondo, S; Morimura, T; Oda, Y; Takeuchi, J; Yin, D | 1 |
Lowis, SP; Newell, DR; Pearson, AD | 1 |
Osann, K; Slater, L; Stupecky, M; Sweet, P; Wetzel, M | 1 |
Reynolds, JT; Slater, LM; Stupecky, M; Sweet, P | 1 |
Chen, XH; Ma, WY; Wang, TD; Wang, ZG; Yin, SF; Zhang, CN | 1 |
Chen, XH; Ma, WY; Wang, TD; Wang, ZG; Yin, SF; Zhang, CN; Zhuang, W | 1 |
Oka, H; Okada, H; Okura, A; Suda, H; Uemura, D; Yamada, A; Yoshinari, T | 1 |
Ford, J; Ganapathi, R; Grabowski, D; Kamath, N | 1 |
Tritton, TR; Vichi, PJ | 1 |
Lorico, A; Rappa, G; Sartorelli, AC | 1 |
Demant, EJ; Grue, P; Hansen, HH; Jensen, PB; Sehested, M; Sørensen, BS | 1 |
Higashigawa, M; Inagaki, S; Kagawa, Y; Kakitoh, H; Kawasaki, H; Kuwabara, H; Ohkubo, T; Ooi, K; Sakurai, M; Sumida, K | 1 |
Arakawa, H; Iguchi, T; Kurama, M; Mano, E; Nakagawa, S; Okura, A; Tanaka, N; Yoshinari, T | 1 |
Holm, B; Jensen, PB; Sehested, M | 1 |
Higashigawa, M; Kawasaki, H; Ohkubo, T; Ooi, K; Sakurai, M | 1 |
Ganapathi, R; Grabowski, D | 1 |
Osann, K; Slater, LM; Stupecky, M; Sweet, P | 1 |
Barret, JM; Etiévant, C; Guminski, Y; Hill, BT; Kruczynski, A; Perrin, D; van Hille, B | 1 |
Bowman, KJ; Calvert, AH; Curtin, NJ; Newell, DR | 1 |
Arimondo, P; Bailly, C; Boukarim, C; Dauzonne, D; Monneret, C | 1 |
Osann, KE; Slater, LM; Stupecky, M; Sweet, P | 1 |
Carter, SK; Slavik, M | 1 |
Adamson, RH; Mead, JA; Sieber, SM | 1 |
Allen, LM | 1 |
Coulter, D; Kalish, R; Valeriote, FA; Vietti, TJ | 1 |
Allen, L | 1 |
Dombernowsky, P; Nissen, NI | 1 |
Stähelin, H | 1 |
Avery, T; Rivera, G; Roberts, DW | 1 |
Kohn, KW; Orr, A; Pommier, Y; Riou, JF | 1 |
Cho, J; Slater, LM; Wetzel, M | 1 |
Araya, S; Liu, YP; Nakamura, T | 1 |
Baguley, BC; Finlay, GJ | 1 |
Feng, MR; Grossman, HB; Liebert, M; Mancini, WR; Wagner, JG; Wedemeyer, G; Williams, M | 1 |
Cho, J; Slater, LM; Sweet, P; Wetzel, M | 1 |
Drake, F; Ford, J; Ganapathi, R; Grabowski, D; Kamath, N; Kerrigan, D; Pommier, Y | 1 |
Pratesi, G; Soranzo, C; Zunino, F | 1 |
Fry, DW | 1 |
Kawasaki, H; Ohkubo, T; Ooi, K; Sakurai, M | 2 |
Basler, GA; Casazza, AM; Crosswell, AR; Rose, WC; Saulnier, M; Trail, PA | 1 |
Gorin, NC | 1 |
Gorycki, P; King, CK; Latham, MD; Macdonald, TL; Ross, WE | 1 |
Ellis, AL; Gewirtz, DA; Povirk, LF; Randolph, JK; Swerdlow, PS; Yalowich, JC; Yanovich, S | 1 |
Ford, J; Ganapathi, R; Grabowski, D; Heiss, C; Kerrigan, D; Pommier, Y | 1 |
Braun, ID; Kennedy, KA; Lazo, JS; Meandzija, B; Pham, ET; Smaldone, LF | 1 |
Higashigawa, M; Hori, H; Kagawa, Y; Kakito, E; Kamiya, H; Kawasaki, H; Ohkubo, T; Ooi, K; Sakurai, M; Sumida, K | 1 |
Chow, KC; Glisson, BS; Ross, WE; Sullivan, DM | 1 |
Bakic, M; Chan, D; Freireich, EJ; Marton, LJ; Zwelling, LA | 1 |
Beerman, TA; Sigmund, RD; Woynarowski, JM | 1 |
Kupfer, G; Ross, W; Rowe, T | 1 |
Glisson, BS; Hodges, PK; Ross, WE; Smallwood-Kentro, S; Sullivan, DM | 1 |
Dorr, RT; Gerner, EW; Liddil, JD | 1 |
Esnault, C; Kohn, KW; Le Pecq, JB; Markovits, J; Mattern, MR; Pommier, Y; Roques, BP | 1 |
Glatte, P; Osieka, R; Pannenbäcker, R; Schmidt, CG; Seeber, S; Soll, D | 1 |
Covey, JM; Kerrigan, D; Kohn, KW; Markovits, J; Pommier, Y; Tilchen, EJ | 1 |
Latham, MD; Ross, WE; Sullivan, DM | 1 |
Kerrigan, D; Kohn, KW; Pommier, Y | 1 |
Hayakawa, M; Morise, K; Oka, Y; Saito, H | 1 |
Higashigawa, M; Kagawa, Y; Kakito, E; Kamiya, H; Kawasaki, H; Ohkubo, T; Ooi, K; Sakurai, M; Sumida, K | 1 |
Ratain, MJ; Schilsky, RL; Senekjian, EK; Simon, T; Vogelzang, NJ; Wojack, BR | 1 |
Murray, SL; Slater, LM; Stupecky, M; Sweet, P; Wetzel, MW | 1 |
Aherene, GW; Henneberry, HP; Marks, V | 1 |
Bresson, ML; Cattan, A | 1 |
Kondo, S; Nishimura, Y; Saito, H; Takeuchi, T; Umezawa, H; Yoshikawa, H | 2 |
Kuramochi, H; Nagamine, S; Nishikawa, K; Okamoto, K; Takahashi, K | 1 |
Herrmann, R; Osswald, H; Youssef, M | 1 |
3 review(s) available for etoposide and Leukemia L 1210
Article | Year |
---|---|
[The mechanism of synergistic interaction between etoposide and cytarabine].
Topics: Animals; Cell Cycle; Cytarabine; Deoxycytidine Kinase; DNA, Neoplasm; Drug Administration Schedule; Drug Synergism; Drug Therapy, Combination; Etoposide; Humans; Injections, Intraperitoneal; Leukemia L1210; Mice; Mice, Inbred Strains; Stimulation, Chemical; Time Factors | 2002 |
Investigational drugs under study by the United States National Cancer Institute.
Topics: Acrylates; Alkylating Agents; Ancitabine; Animals; Antibiotics, Antineoplastic; Antimetabolites, Antineoplastic; Antineoplastic Agents; Azacitidine; Chemical Phenomena; Chemistry; Chromomycins; Cisplatin; DNA, Neoplasm; Drug Evaluation, Preclinical; Etoposide; Humans; Ifosfamide; Leukemia L1210; Mice; Mitosis; National Institutes of Health (U.S.); Neoplasms; Neoplasms, Experimental; Razoxane; Tegafur; Teniposide; United States | 1976 |
Pharmacology of antitumor agents from higher plants.
Topics: Animals; Antineoplastic Agents, Phytogenic; Aporphines; Camptothecin; Carcinoma, Squamous Cell; Chemical Phenomena; Chemistry; Etoposide; Humans; Leukemia L1210; Leukemia, Experimental; Leukemia, Lymphoid; Maytansine; Melanoma; Naphthoquinones; Nasopharyngeal Neoplasms; Neoplasms; Neoplasms, Experimental; Phenanthrenes; Structure-Activity Relationship; Teniposide; Vinblastine; Vincristine | 1976 |
1 trial(s) available for etoposide and Leukemia L 1210
Article | Year |
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Hydroxyurea and etoposide: in vitro synergy and phase I clinical trial.
Topics: Adult; Aged; Animals; Antineoplastic Combined Chemotherapy Protocols; Drug Evaluation; Drug Synergism; Etoposide; Female; Humans; Hydroxyurea; Leukemia L1210; Male; Mice; Middle Aged; Neoplasms; Tumor Cells, Cultured | 1988 |
82 other study(ies) available for etoposide and Leukemia L 1210
Article | Year |
---|---|
Structure-activity relationships of antineoplastic agents in multidrug resistance.
Topics: Animals; Antineoplastic Agents; Cell Line; Cell Survival; Cricetinae; Dactinomycin; Drug Resistance; Leukemia L1210; Mice; Regression Analysis; Structure-Activity Relationship; Tumor Cells, Cultured | 1990 |
In vivo antitumor activity of 6-benzyl-1,3-benzodioxole derivatives against the P388, L1210, B16, and M5076 murine models.
Topics: Animals; Antineoplastic Agents; Astrocytoma; Bucladesine; Cell Differentiation; Dioxoles; DNA Topoisomerases, Type I; Leukemia L1210; Leukemia P388; Leukemia, Experimental; Mice; Tubulin | 1987 |
Antitumor agents. 86. Synthesis and cytotoxicity of alpha-methylene-gamma-lactone-bearing purines.
Topics: Adenine; Animals; Antineoplastic Agents; Cell Survival; Guanine; Humans; Hypoxanthines; Indicators and Reagents; KB Cells; Lactones; Leukemia L1210; Leukemia P388; Mice; Structure-Activity Relationship | 1987 |
Synthesis, 470-MHz 1H NMR spectra, and activity of delactonized derivatives of the anticancer drug etoposide.
Topics: Animals; Antineoplastic Agents; Chemical Phenomena; Chemistry; Etoposide; Leukemia L1210; Magnetic Resonance Spectroscopy; Mice; Podophyllotoxin | 1982 |
Synthesis and evaluation of new 6-amino-substituted benzo[c]phenanthridine derivatives.
Topics: Adenocarcinoma; Alkaloids; Animals; Antineoplastic Agents; Benzophenanthridines; Breast Neoplasms; Humans; Leukemia L1210; Leukemia P388; Mice; Molecular Structure; Phenanthridines; Structure-Activity Relationship; Topoisomerase I Inhibitors; Topoisomerase II Inhibitors; Tumor Cells, Cultured | 1993 |
Antitumor agents. 3. Synthesis and biological activity of 4 beta-alkyl derivatives containing hydroxy, amino, and amido groups of 4'-O-demethyl-4-desoxypodophyllotoxin as antitumor agents.
Topics: Animals; Antineoplastic Agents; Etoposide; Humans; Leukemia L1210; Leukemia P388; Lung Neoplasms; Molecular Structure; Podophyllotoxin; Structure-Activity Relationship; Topoisomerase II Inhibitors; Tubulin Modulators; Tumor Cells, Cultured | 1993 |
Synthesis and antitumor activity of new glycosides of epipodophyllotoxin, analogues of etoposide, and NK 611.
Topics: Animals; Antineoplastic Agents; Biopolymers; Drug Screening Assays, Antitumor; Female; Glycosides; Glycosylation; Humans; Inhibitory Concentration 50; Leukemia L1210; Leukemia P388; Mice; Mice, Inbred DBA; Podophyllotoxin; Stereoisomerism; Structure-Activity Relationship; Topoisomerase I Inhibitors; Topoisomerase II Inhibitors; Transplantation, Heterologous; Tubulin; Tumor Cells, Cultured | 1998 |
F14512, a potent antitumor agent targeting topoisomerase II vectored into cancer cells via the polyamine transport system.
Topics: Animals; Binding, Competitive; Biogenic Polyamines; Breast Neoplasms; Cell Line, Tumor; CHO Cells; Cricetinae; Cricetulus; DNA Damage; DNA Topoisomerases, Type II; DNA, Neoplasm; Drug Delivery Systems; Etoposide; Female; Humans; Leukemia L1210; Lung Neoplasms; Mice; Mice, Nude; Neoplasms; Podophyllotoxin; Topoisomerase II Inhibitors; Xenograft Model Antitumor Assays | 2008 |
Prodrug Mono Therapy: synthesis and biological evaluation of an etoposide glucuronide-prodrug.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Survival; Drug Stability; Etoposide; Glucuronidase; Leukemia L1210; Magnetic Resonance Spectroscopy; Mice; Molecular Structure; Prodrugs; Solubility | 2003 |
Novel carbamate derivatives of 4-beta-amino-4'-O-demethyl-4-desoxypodophyllotoxin as inhibitors of topoisomerase II: synthesis and biological evaluation.
Topics: Animals; Antineoplastic Agents; Carbamates; Cell Division; DNA; DNA Damage; Enzyme Inhibitors; Etoposide; G2 Phase; Leukemia L1210; Mice; Molecular Structure; Podophyllotoxin; Structure-Activity Relationship; Topoisomerase II Inhibitors | 2005 |
Role of topoisomerase II in mediating epipodophyllotoxin-induced DNA cleavage.
Topics: Animals; Cattle; Cell Nucleus; Cell Survival; DNA Topoisomerases, Type II; DNA, Neoplasm; Etoposide; Leukemia L1210; Mice; Podophyllotoxin; Structure-Activity Relationship; Teniposide; Thymus Gland | 1984 |
Inhibition of etoposide-induced DNA damage and cytotoxicity in L1210 cells by dehydrogenase inhibitors and other agents.
Topics: Aldehyde Dehydrogenase; Aldehyde Oxidoreductases; Animals; Benzoates; Benzoic Acid; Cell Survival; Disulfiram; Ditiocarb; DNA; Etoposide; Leukemia L1210; Mice; NADP; Podophyllotoxin; Thiocarbamates | 1984 |
Characterization of VP-16-induced DNA damage in isolated nuclei from L1210 cells.
Topics: Adenosine Triphosphate; Adenylyl Imidodiphosphate; Animals; DNA; Etoposide; Hydrogen-Ion Concentration; Leukemia L1210; Magnesium; Mice; Nucleotides; Podophyllotoxin; Temperature | 1984 |
Potentiation of etoposide-induced DNA damage by calcium antagonists in L1210 cells in vitro.
Topics: Animals; Cell Division; Cell Nucleus; Cell Survival; DNA Replication; DNA, Neoplasm; Drug Synergism; Etoposide; Gallopamil; Kinetics; Leukemia L1210; Mice; Podophyllotoxin; Verapamil | 1984 |
DNA damage as a basis for 4'-demethylepipodophyllotoxin-9-(4,6-O-ethylidene-beta-D-glucopyranoside) (etoposide) cytotoxicity.
Topics: Animals; Chemical Phenomena; Chemistry; Colony-Forming Units Assay; DNA; DNA, Single-Stranded; Dose-Response Relationship, Drug; Etoposide; Leukemia L1210; Mice; Podophyllotoxin | 1983 |
Response of L1210 leukemia to treatment with 1,3-bis(2-chloroethyl)-1-nitrosourea plus 4'-demethylepipodophyllotoxin-9-(4,6-O-2-thenylidene-beta-D-glucopyranoside).
Topics: Animals; Carmustine; Dose-Response Relationship, Drug; Drug Synergism; Drug Therapy, Combination; Etoposide; Female; Leukemia L1210; Mice; Mice, Inbred Strains; Podophyllotoxin; Prognosis | 1981 |
Transfection with a bcl-2 expression vector protects transplanted bone marrow from chemotherapy-induced myelosuppression.
Topics: Animals; Antineoplastic Agents; Bone Marrow; Cell Division; Cell Survival; Doxorubicin; Drug Interactions; Etoposide; Granulocyte Colony-Stimulating Factor; Leukemia L1210; Leukocyte Count; Mice; Neutrophils; Proto-Oncogenes; Recombinant Proteins; Transfection | 1994 |
Exposure and schedule dependency of etoposide in neuroblastoma and leukaemia cells in vitro.
Topics: Animals; Antineoplastic Agents, Phytogenic; Cell Survival; Culture Media; Dose-Response Relationship, Drug; Drug Stability; Etoposide; Humans; Leukemia L1210; Neuroblastoma; Tumor Cells, Cultured; Tumor Stem Cell Assay | 1995 |
Comparison of cyclosporin A, verapamil, PSC-833 and cremophor EL as enhancing agents of VP-16 in murine lymphoid leukemias.
Topics: Animals; Cell Survival; Cyclosporine; Cyclosporins; Drug Synergism; Etoposide; Glycerol; Leukemia L1210; Leukemia P388; Mice; Survival Analysis; Tumor Cells, Cultured; Verapamil | 1995 |
Cyclosporin A/VP-16 produced immunity to L1210 leukemia: the participation of cytotoxic CD8 T-lymphocytes.
Topics: Animals; CD8-Positive T-Lymphocytes; Cyclosporine; Cytotoxicity, Immunologic; Etoposide; Immunity, Cellular; Immunization, Passive; Leukemia L1210; Lymphocyte Depletion; Mice; Spleen; T-Lymphocytes, Cytotoxic | 1995 |
[Synthesis and antitumor activity of 4-O-(halogenated) acyl-4'-demethylepipodophyllotoxin analogues].
Topics: Animals; Etoposide; Humans; KB Cells; Leukemia L1210; Mice; Podophyllotoxin; Tumor Cells, Cultured | 1993 |
[Synthesis and antitumor activity of 4-S-(5-amido-1,3,4-thiodiazol-2-yl)4-deoxy-4'-demethylepipodophyllotoxi n analogues].
Topics: Animals; Etoposide; Humans; KB Cells; Leukemia L1210; Podophyllotoxin; Tumor Cells, Cultured | 1993 |
Inhibition of topoisomerase II by a novel antitumor cyclic depsipeptide, BE-22179.
Topics: Animals; Anti-Bacterial Agents; Antineoplastic Agents; DNA Topoisomerases, Type I; Echinomycin; Etoposide; Leukemia L1210; Nucleic Acid Conformation; Peptides; Topoisomerase II Inhibitors; Tumor Cells, Cultured | 1994 |
Calmodulin inhibitor trifluoperazine in combination with doxorubicin induces the selection of tumour cells with the multidrug resistant phenotype.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; ATP Binding Cassette Transporter, Subfamily B, Member 1; Calmodulin; Carrier Proteins; Cell Division; DNA Damage; DNA Topoisomerases, Type II; DNA, Neoplasm; Doxorubicin; Drug Resistance; Drug Screening Assays, Antitumor; Etoposide; Leukemia L1210; Membrane Glycoproteins; Mice; Phenotype; Trifluoperazine; Tumor Cells, Cultured | 1993 |
Protection from adriamycin cytotoxicity in L1210 cells by brefeldin A.
Topics: Amsacrine; Animals; Biological Transport; Brefeldin A; Cell Survival; Cyclopentanes; DNA Damage; DNA Repair; Doxorubicin; Drug Synergism; Endoplasmic Reticulum; Etoposide; Golgi Apparatus; Kinetics; Leukemia L1210; Mice; Microtubules; Nocodazole; Paclitaxel; Temperature; Tumor Cells, Cultured; Tumor Stem Cell Assay | 1993 |
Reversal of etoposide resistance in non-P-glycoprotein expressing multidrug resistant tumor cell lines by novobiocin.
Topics: Adenocarcinoma; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Carrier Proteins; Colonic Neoplasms; DNA Topoisomerases, Type II; DNA, Neoplasm; Drug Resistance; Etoposide; Flow Cytometry; Humans; Leukemia L1210; Lung Neoplasms; Membrane Glycoproteins; Mice; Novobiocin; Tumor Cells, Cultured | 1993 |
Targeting the cytotoxicity of topoisomerase II-directed epipodophyllotoxins to tumor cells in acidic environments.
Topics: Amsacrine; Animals; Carcinoma, Small Cell; Chloroquine; DNA Damage; DNA Topoisomerases, Type II; DNA, Neoplasm; Drug Screening Assays, Antitumor; Drug Synergism; Etoposide; Humans; Hydrogen-Ion Concentration; Leukemia L1210; Lung Neoplasms; Mice; Tumor Cells, Cultured | 1994 |
Enhanced incorporation of 1-beta-D-arabinofuranosylcytosine by pretreatment with etoposide.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cytarabine; DNA, Neoplasm; Dose-Response Relationship, Drug; Drug Administration Schedule; Etoposide; Leukemia L1210; Male; Mice; Mice, Inbred Strains | 1993 |
Stereo (C7)-dependent topoisomerase II inhibition and tumor growth suppression by a new quinolone, BO-2367.
Topics: Animals; Anti-Infective Agents; Carcinoma; Colonic Neoplasms; DNA Topoisomerases, Type II; DNA, Neoplasm; DNA, Superhelical; Drug Screening Assays, Antitumor; Enzyme Induction; Etoposide; Female; Fluoroquinolones; Leukemia L1210; Leukemia P388; Mice; Mice, Inbred Strains; Quinolones; Stereoisomerism; Topoisomerase II Inhibitors | 1993 |
ICRF-187 rescue in etoposide treatment in vivo. A model targeting high-dose topoisomerase II poisons to CNS tumors.
Topics: Amsacrine; Animals; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Blood-Brain Barrier; Brain Neoplasms; Carcinoma, Ehrlich Tumor; Central Nervous System Neoplasms; DNA Topoisomerases, Type II; Etoposide; Female; Injections, Intraperitoneal; Lethal Dose 50; Leukemia L1210; Male; Mice; Mice, Inbred DBA; Paclitaxel; Razoxane; Structure-Activity Relationship | 1996 |
Increased deoxycytidine kinase activity by etoposide in L1210 murine leukemic cells.
Topics: Animals; Cytarabine; Deoxycytidine Kinase; Etoposide; Leukemia L1210; Methotrexate; Mice; Phosphorylation | 1996 |
Cytotoxic efficacy with combinations of topoisomerase I and topoisomerase II inhibitors in sensitive and multidrug-resistant L1210 mouse leukemia cells.
Topics: Amsacrine; Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Drug Resistance, Multiple; Drug Synergism; Enzyme Inhibitors; Etoposide; Leukemia L1210; Mice; Mitoxantrone; Topoisomerase I Inhibitors; Topotecan | 1996 |
Superiority of cyclosporin A over PSC-833 in enhancement of VP-16 efficacy in murine tumors in vivo.
Topics: Animals; Antineoplastic Agents, Phytogenic; Cyclosporine; Cyclosporins; Drug Synergism; Etoposide; Female; Immunosuppressive Agents; Leukemia L1210; Lung Neoplasms; Mice; Mice, Inbred C57BL; Mice, Inbred Strains; Survival Rate; Time Factors | 1997 |
F 11782, a dual inhibitor of topoisomerases I and II with an original mechanism of action in vitro, and markedly superior in vivo antitumour activity, relative to three other dual topoisomerase inhibitors, intoplicin, aclarubicin and TAS-103.
Topics: Aclarubicin; Aminoquinolines; Animals; Antineoplastic Agents; Cell Division; Enzyme Inhibitors; Etoposide; Humans; Indenes; Indoles; Leukemia L1210; Leukemia P388; Melanoma, Experimental; Mice; Mice, Inbred C57BL; Naphthalenes; Pyrans; Pyridines; Topoisomerase I Inhibitors; Topoisomerase II Inhibitors; Tumor Cells, Cultured; Urinary Bladder Neoplasms | 2000 |
Differential effects of the poly (ADP-ribose) polymerase (PARP) inhibitor NU1025 on topoisomerase I and II inhibitor cytotoxicity in L1210 cells in vitro.
Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Camptothecin; DNA Damage; DNA, Neoplasm; Drug Screening Assays, Antitumor; Drug Synergism; Enzyme Inhibitors; Etoposide; Leukemia L1210; Nucleic Acid Synthesis Inhibitors; Proteins; Quinazolines; Topoisomerase I Inhibitors; Topoisomerase II Inhibitors | 2001 |
Design of two etoposide-amsacrine conjugates: topoisomerase II and tubuline polymerization inhibition and relation to cytotoxicity.
Topics: Amsacrine; Animals; Base Sequence; Biopolymers; DNA Topoisomerases, Type II; DNA, Neoplasm; Etoposide; Leukemia L1210; Magnetic Resonance Spectroscopy; Molecular Sequence Data; Topoisomerase II Inhibitors; Tubulin; Tubulin Modulators; Tumor Cells, Cultured | 2000 |
Enhancement of leukemia rejection by mice successfully treated for L1210 leukemia due to low dose compared to high dose VP-16.
Topics: Animals; Antineoplastic Agents, Phytogenic; Concanavalin A; Cyclosporine; Cyclosporins; Drug Screening Assays, Antitumor; Etoposide; Graft Rejection; Immunosuppressive Agents; Leukemia L1210; Lymphocyte Activation; Mice; Mice, Inbred DBA; Neoplasm Transplantation; Phytohemagglutinins | 2002 |
Comparison of uptake and binding of two epipodophyllotoxin glucopyranosides, 4'-demethyl epipodophyllotoxin thenylidene-beta-D-glucoside and 4'-demethyl epipodophyllotoxin ethylidene-beta-D-glucoside, in the L1210 leukemia cell.
Topics: Animals; Binding Sites; Biological Transport; Cell Nucleus; Etoposide; Kinetics; Leukemia L1210; Mice; Mice, Inbred DBA; Podophyllotoxin; Teniposide; Thermodynamics; Vinblastine | 1978 |
Kinetics of cytotoxicity of VM-26 and VP-16-213 on L1210 leukemia and hematopoietic stem cells.
Topics: Animals; Cell Survival; Colony-Forming Units Assay; Dose-Response Relationship, Drug; Etoposide; Hematopoietic Stem Cells; Leukemia L1210; Podophyllotoxin; Rats; Teniposide; Time Factors | 1978 |
The role of drug disposition kinetics on cellular transport of the antineoplastic agent VM-26.
Topics: Animals; Biological Transport, Active; Chemical Phenomena; Chemistry; Diffusion; Etoposide; Kinetics; Leukemia L1210; Mice; Models, Biological; Podophyllotoxin; Protein Binding; Serum Albumin; Teniposide | 1978 |
Combination chemotherapy with 4'Demethylepipodophyllotoxin 9-(4,6-0-ethylidene-beta-D-glucopyranoside), VP 16-213 (NSC 141540) in L1210 leukemia.
Topics: Animals; Antineoplastic Agents; Carmustine; Cyclophosphamide; Cytarabine; Dactinomycin; Daunorubicin; Drug Therapy, Combination; Etoposide; Female; Fluorouracil; Leukemia L1210; Male; Mercaptopurine; Methotrexate; Mice; Mice, Inbred DBA; Podophyllotoxin; Vincristine | 1976 |
Delayed toxicity of epipodophyllotoxin derivatives (VM 26 and VP 16-213), due to a local effect.
Topics: Animals; Dose-Response Relationship, Drug; Etoposide; Female; Injections, Intraperitoneal; Injections, Intravenous; Leukemia L1210; Liver; Lung; Male; Mice; Organ Size; Podophyllotoxin; Rats; Teniposide; Time Factors | 1976 |
Response of L1210 to combinations of cytosine arabinoside and VM-26 or VP16-213.
Topics: Animals; Cytarabine; Drug Therapy, Combination; Etoposide; Female; Leukemia L1210; Leukemia, Experimental; Mice; Podophyllotoxin; Pyrans; Teniposide | 1975 |
Differential effects of amsacrine and epipodophyllotoxins on topoisomerase II cleavage in the human c-myc protooncogene.
Topics: Amsacrine; Animals; Base Sequence; Binding Sites; Carcinoma, Small Cell; Cell Line; DNA Damage; DNA Topoisomerases, Type II; DNA, Neoplasm; Etoposide; Genes, myc; Humans; Leukemia L1210; Lung Neoplasms; Mice; Molecular Sequence Data; Promoter Regions, Genetic; Restriction Mapping; Substrate Specificity; Teniposide | 1992 |
Cyclosporin A potentiation of VP-16: production of long-term survival in murine acute lymphatic leukemia.
Topics: Animals; Cyclosporine; Drug Synergism; Etoposide; Female; Leukemia L1210; Leukemia P388; Mice; Mice, Inbred Strains; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Survival Rate; Time Factors | 1992 |
Arrest in late G2 or prophase of cell cycle induced by 4,4-(1,2-ethanediyl) bis (1-isobutoxycarbonyloxymethyl 2, 6-piperazinedione) (MST-16) in cultured L1210 cells.
Topics: Animals; Antineoplastic Agents; Cell Division; DNA; Drug Interactions; Etoposide; Flow Cytometry; G2 Phase; Leukemia L1210; Mice; Piperazines; Prophase; Tumor Cells, Cultured; Vincristine | 1992 |
Potentiation by phenylbisbenzimidazoles of cytotoxicity of anticancer drugs directed against topoisomerase II.
Topics: Acridines; Amsacrine; Animals; Antineoplastic Agents; Benzimidazoles; Bisbenzimidazole; Colonic Neoplasms; Doxorubicin; Drug Synergism; Etoposide; Fluorescent Dyes; Leukemia L1210; Lung Neoplasms; Melanoma; Mice; Topoisomerase II Inhibitors; Tumor Cells, Cultured; Tumor Stem Cell Assay | 1990 |
Effect of verapamil on the uptake and efflux of etoposide (VP16) in both sensitive and resistant cancer cells.
Topics: Animals; Carcinoma, Transitional Cell; Culture Media; Drug Resistance; Etoposide; Glucose; Humans; Kinetics; Leukemia L1210; Mice; Tumor Cells, Cultured; Urinary Bladder Neoplasms; Verapamil | 1991 |
Development of cyclosporin A mediated immunity in L1210 leukaemia.
Topics: Animals; Cyclosporine; Drug Synergism; Etoposide; Immunity; Immunization, Passive; Leukemia L1210; Mice; Spleen; Survival Analysis | 1991 |
Trifluoperazine modulation of resistance to the topoisomerase II inhibitor etoposide in doxorubicin resistant L1210 murine leukemia cells.
Topics: Animals; Blotting, Western; Cell Survival; DNA; DNA Damage; DNA-Binding Proteins; Dose-Response Relationship, Drug; Doxorubicin; Drug Resistance; Drug Synergism; Etoposide; In Vitro Techniques; Leukemia L1210; Mice; Trifluoperazine; Tumor Cells, Cultured | 1991 |
Different interaction of cisplatin and etoposide on in vivo and in vitro tumor systems.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Dose-Response Relationship, Drug; Drug Interactions; Etoposide; Humans; Leukemia L1210; Leukemia P388; Mice; Mice, Inbred DBA; Mice, Nude; Neoplasm Transplantation; Tumor Cells, Cultured | 1990 |
Cytotoxic synergism between trimetrexate and etoposide. Evidence that trimetrexate potentiates etoposide-induced protein-associated DNA strand breaks in L1210 leukemia cells through alterations in intracellular ATP concentrations.
Topics: Adenosine Triphosphate; Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Survival; DNA Damage; DNA, Neoplasm; Etoposide; Leukemia L1210; Mice; Quinazolines; Trimetrexate; Tumor Cells, Cultured | 1990 |
[Etoposide-induced deoxyribonucleic acid (DNA) damage and its effects on nucleotide pools in murine leukemia L1210 cells].
Topics: Animals; DNA Damage; DNA Repair; Etoposide; Injections, Intraperitoneal; Leukemia L1210; Mice; Nucleotides | 1990 |
Preclinical antitumor activity of a soluble etoposide analog, BMY-40481-30.
Topics: Animals; Antineoplastic Agents; Colonic Neoplasms; Drug Screening Assays, Antitumor; Etoposide; Humans; Leukemia L1210; Leukemia P388; Lung Neoplasms; Melanoma, Experimental; Mice; Mice, Inbred BALB C; Mice, Inbred Strains; Neoplasm Transplantation; Organophosphorus Compounds; Tumor Cells, Cultured | 1990 |
Pharmacological purging of bone marrow with drugs other than cyclophosphamide derivatives.
Topics: Animals; Antineoplastic Agents; Bleomycin; Bone Marrow; Cell Line; Cell Separation; Etoposide; Hematopoietic Stem Cells; Leukemia L1210; Leukemia, Experimental; Mice; Mice, Inbred C57BL; Podophyllotoxin | 1985 |
Inhibition of topoisomerases by fredericamycin A.
Topics: Animals; Antibiotics, Antineoplastic; DNA Damage; DNA Polymerase II; DNA, Neoplasm; Dose-Response Relationship, Drug; Etoposide; Isoquinolines; Leukemia L1210; Mice; Spiro Compounds; Time Factors; Topoisomerase I Inhibitors; Tumor Cells, Cultured | 1989 |
Expression of protein-associated DNA damage in the alkaline elution assay in the absence of enzymatic deproteinization.
Topics: Animals; Cell Line; DNA Damage; DNA Replication; DNA Topoisomerases, Type II; DNA, Neoplasm; Endopeptidase K; Etoposide; Humans; Hydrogen-Ion Concentration; Leukemia L1210; Liver Neoplasms, Experimental; Mice; Mitoxantrone; Podophyllotoxin; Protein Binding; Rats; Serine Endopeptidases; Teniposide; Tumor Cells, Cultured | 1989 |
Progressive resistance to doxorubicin in mouse leukemia L1210 cells with multidrug resistance phenotype: reductions in drug-induced topoisomerase II-mediated DNA cleavage.
Topics: Amsacrine; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Nucleus; Cell Survival; DNA Topoisomerases, Type II; DNA, Viral; Doxorubicin; Drug Resistance; Etoposide; Leukemia L1210; Membrane Glycoproteins; Mice; Neoplasm Proteins; Phenotype; Simian virus 40; Tumor Cells, Cultured | 1989 |
Lidocaine potentiation of bleomycin A2 cytotoxicity and DNA strand breakage in L1210 and human A-253 cells.
Topics: Animals; Bleomycin; Calmodulin; Carcinoma, Squamous Cell; Cell Survival; Cells, Cultured; DNA Repair; Drug Synergism; Etoposide; Head and Neck Neoplasms; Humans; Leukemia L1210; Lidocaine; Mice | 1985 |
Synergistic interaction between etoposide and 1-beta-D-arabinofuranosylcytosine.
Topics: Animals; Cytarabine; DNA Damage; DNA, Neoplasm; Drug Administration Schedule; Drug Synergism; Etoposide; Leukemia L1210; Male; Mice; Time Factors | 1989 |
[Studies on the relationship between therapeutic schedule and antitumor effect of etoposide and cytosine arabinoside in murine L1210 leukemia].
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cytarabine; Drug Administration Schedule; Drug Synergism; Etoposide; Leukemia L1210; Mice; Mice, Inbred Strains; Remission Induction; Survival Rate | 1989 |
Role of proliferation in determining sensitivity to topoisomerase II-active chemotherapy agents.
Topics: Animals; Cell Cycle; Cell Division; Cell Line; Cells, Cultured; DNA Topoisomerases, Type II; DNA, Single-Stranded; Etoposide; Flow Cytometry; Humans; Kinetics; Leukemia L1210; Leukemia, Lymphoid; Mice | 1987 |
Effect of polyamine depletion by alpha-difluoromethylornithine or (2R,5R)-6-heptyne-2,5-diamine on drug-induced topoisomerase II-mediated DNA cleavage and cytotoxicity in human and murine leukemia cells.
Topics: Alkynes; Amsacrine; Animals; Antineoplastic Agents; Cell Line; Cell Survival; Diamines; DNA; DNA Damage; DNA Topoisomerases, Type II; Eflornithine; Etoposide; Humans; Leukemia L1210; Leukemia, Myeloid, Acute; Mice; Ornithine Decarboxylase Inhibitors; Polyamines; Tumor Cells, Cultured | 1987 |
Topoisomerase-II-mediated lesions in nascent DNA: comparison of the effects of epipodophyllotoxin derivatives, VM-26 and VP-16, and 9-anilinoacridine derivatives, m-AMSA and o-AMSA.
Topics: Adenosine Triphosphate; Amsacrine; Animals; Cross-Linking Reagents; DNA; DNA Damage; DNA Replication; DNA Topoisomerases, Type II; DNA, Neoplasm; Etoposide; Leukemia L1210; Mice; Novobiocin; Podophyllotoxin; Teniposide; Topoisomerase II Inhibitors | 1988 |
Inhibition of epipodophyllotoxin cytotoxicity by interference with topoisomerase-mediated DNA cleavage.
Topics: Animals; Cell Survival; DNA; DNA Topoisomerases, Type I; Dose-Response Relationship, Drug; Ethidium; Etoposide; Leukemia L1210; Mice; Podophyllotoxin | 1985 |
Proliferation dependence of topoisomerase II mediated drug action.
Topics: Aminoacridines; Amsacrine; Animals; Cell Line; Cricetinae; Cricetulus; DNA Replication; DNA Topoisomerases, Type II; Etoposide; Female; HeLa Cells; Humans; Intercalating Agents; Kinetics; Leukemia L1210; Mice; Ovary; Plasmids; Podophyllotoxin | 1986 |
Modulation of etoposide cytotoxicity and DNA strand scission in L1210 and 8226 cells by polyamines.
Topics: Animals; Cell Survival; DNA Topoisomerases, Type II; DNA, Neoplasm; DNA, Single-Stranded; Eflornithine; Etoposide; Humans; Leukemia L1210; Mice; Multiple Myeloma; Nucleic Acid Conformation; Ornithine; Podophyllotoxin; Polyamines; Putrescine | 1986 |
Effects of the bifunctional antitumor intercalator ditercalinium on DNA in mouse leukemia L1210 cells and DNA topoisomerase II.
Topics: Amsacrine; Animals; Carbazoles; Cross-Linking Reagents; DNA Damage; DNA, Neoplasm; Etoposide; Intercalating Agents; Leukemia L1210; Mice; Nucleic Acid Conformation; Structure-Activity Relationship; Topoisomerase II Inhibitors | 1986 |
Enhancement of etoposide-induced cytotoxicity by cyclosporin A.
Topics: Animals; Cells, Cultured; Cisplatin; Cyclosporins; Doxorubicin; Drug Interactions; Etoposide; Humans; Lethal Dose 50; Leukemia L1210; Leukemia, Myeloid, Acute; Lymphoma, Non-Hodgkin; Male; Mice; Neoplasm Transplantation; Neoplasms, Germ Cell and Embryonal; Radiation, Ionizing | 1986 |
Topoisomerase II-mediated DNA breaks and cytotoxicity in relation to cell proliferation and the cell cycle in NIH 3T3 fibroblasts and L1210 leukemia cells.
Topics: Amsacrine; Animals; Cell Cycle; Cell Division; Cell Line; Cell Survival; DNA Damage; DNA Topoisomerases, Type I; Etoposide; Fibroblasts; Leukemia L1210; Mice; Proteins | 1987 |
Proliferation-dependent topoisomerase II content as a determinant of antineoplastic drug action in human, mouse, and Chinese hamster ovary cells.
Topics: Animals; Antineoplastic Agents; Cell Cycle; Cell Division; Cell Line; Cricetinae; Cricetulus; DNA Damage; DNA Topoisomerases, Type II; DNA, Neoplasm; Drug Resistance; Enzyme Induction; Etoposide; Female; Fibroblasts; Hematopoietic Stem Cells; Humans; Leukemia L1210; Mice; Neoplasm Proteins; Ovary | 1987 |
Protein-linked DNA strand breaks produced by etoposide and teniposide in mouse L1210 and human VA-13 and HT-29 cell lines: relationship to cytotoxicity.
Topics: Animals; Cell Line; Cell Survival; DNA Topoisomerases, Type II; DNA, Neoplasm; Etoposide; Humans; Kinetics; Leukemia L1210; Podophyllotoxin; Teniposide | 1987 |
[Combination chemotherapy of UFT, etoposide and CDDP in advanced gastric cancer].
Topics: Adult; Aged; Aged, 80 and over; Animals; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Drug Administration Schedule; Etoposide; Female; Humans; Leukemia L1210; Male; Mice; Middle Aged; Radiography; Stomach Neoplasms; Tegafur; Uracil | 1987 |
Sequence-dependent antitumor effect of VP-16 and 1-beta-D-arabinofuranosylcytosine in L1210 ascites tumor.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cytarabine; Dose-Response Relationship, Drug; Etoposide; Leukemia L1210; Male; Mice; Mice, Inbred Strains | 1988 |
Verapamil potentiation of VP-16-213 in acute lymphatic leukemia and reversal of pleiotropic drug resistance.
Topics: Animals; Antineoplastic Agents; Cell Survival; Cells, Cultured; Daunorubicin; Dose-Response Relationship, Drug; Drug Resistance; Drug Synergism; Etoposide; Humans; Leukemia L1210; Leukemia P388; Leukemia, Experimental; Leukemia, Lymphoid; Mice; Podophyllotoxin; Verapamil; Vincristine | 1986 |
Immunocytochemical localisation of VP16-213 in normal and malignant tissues.
Topics: Animals; Etoposide; Histocytochemistry; Leukemia L1210; Mice; Neoplasms, Experimental; Tissue Distribution | 1987 |
Vitamin A: failure to demonstrate in mice an anti-tumour effect, whether combined with cytotoxic drugs or not.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Carmustine; Cisplatin; Cyclophosphamide; Etoposide; Female; Leukemia L1210; Leukemia, Experimental; Lung Neoplasms; Male; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Neoplasm Transplantation; Neoplasms, Experimental; Teniposide; Vitamin A | 1986 |
Studies on lignan lactone antitumor agents. I. Synthesis of aminoglycosidic lignan variants related to podophyllotoxin.
Topics: Animals; Antineoplastic Agents, Phytogenic; Etoposide; Leukemia L1210; Mice; Podophyllotoxin | 1986 |
Studies on lignan lactone antitumor agents. II. Synthesis of N-alkylamino- and 2,6-dideoxy-2-aminoglycoside lignan variants related to podophyllotoxin.
Topics: Aminoglycosides; Animals; Antineoplastic Agents, Phytogenic; Etoposide; Leukemia L1210; Mice; Podophyllotoxin | 1986 |
Verapamil-induced augmentation of etoposide accumulation in L1210 cells in vitro.
Topics: Animals; Cells, Cultured; DNA Repair; Drug Synergism; Etoposide; Leukemia L1210; Mice; Podophyllotoxin; Tritium; Verapamil | 1985 |
[Antitumor effect of etoposide and its analogs].
Topics: Animals; Cell Division; Dogs; Etoposide; HeLa Cells; Humans; Leukemia L1210; Male; Mice; Podophyllotoxin; Structure-Activity Relationship | 1985 |
Timing- and sequence-dependent synergism between etoposide and methotrexate or etoposide, methotrexate and 5-fluorouracil in advanced leukemia L1210.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Drug Synergism; Etoposide; Female; Fluorouracil; Leukemia L1210; Methotrexate; Mice; Mice, Inbred Strains; Podophyllotoxin; Time Factors | 1985 |