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etodolac and Polyarthritis

etodolac has been researched along with Polyarthritis in 20 studies

Etodolac: A non-steroidal anti-inflammatory agent and cyclooxygenase-2 (COX-2) inhibitor with potent analgesic and anti-arthritic properties. It has been shown to be effective in the treatment of OSTEOARTHRITIS; RHEUMATOID ARTHRITIS; ANKYLOSING SPONDYLITIS; and in the alleviation of postoperative pain (PAIN, POSTOPERATIVE).
etodolac : A monocarboxylic acid that is acetic acid in which one of the methyl hydrogens is substituted by a 1,8-diethyl-1,3,4,9-tetrahydropyrano[3,4-b]indol-1-yl moiety. A preferential inhibitor of cyclo-oxygenase 2 and non-steroidal anti-inflammatory, it is used for the treatment of rheumatoid arthritis and osteoarthritis, and for the alleviation of postoperative pain. Administered as the racemate, only the (S)-enantiomer is active.

Research Excerpts

ExcerptRelevanceReference
"We describe two patients in whom acute colitis developed during etodolac treatment."7.69Acute colitis associated with etodolac. ( Porensky, RS; Wilcox, GM, 1997)
"The effect of treatment with the new anti-inflammatory drug etodolac on the articular and bone pathology associated with adjuvant arthritis in rats has been compared to the effects produced by aspirin and naproxen."7.67Effect of etodolac on articular and bone pathology associated with adjuvant arthritis in rats: a comparison with aspirin and naproxen. ( Klicius, J; Martel, RR; Metcalf, G, 1984)
"The effect of prolonged treatment with etodolac (8 mg/kg) on the articular and bone pathology at the tibiotarsal joint associated with adjuvant arthritis in the rat has been studied and compared to the effects produced by treatment with naproxen (8 mg/kg) and ibuprofen (50 mg/kg)."7.67Comparative effects of long term treatment with etodolac, naproxen and ibuprofen on articular and bone changes associated with adjuvant arthritis in rats. ( Klicius, J; Martel, RR; Metcalf, G; Rona, GA, 1984)
"Safer treatment for arthritis can be achieved by combining misoprostol with traditional NSAIDs or by using one of two new agents, nabumetone or etodolac."4.80Newer, safer nonsteroidal anti-inflammatory drugs. Rational NSAID selection for arthritis. ( Bensen, W; Zizzo, A, 1998)
"We describe two patients in whom acute colitis developed during etodolac treatment."3.69Acute colitis associated with etodolac. ( Porensky, RS; Wilcox, GM, 1997)
"The effect of treatment with the new anti-inflammatory drug etodolac on the articular and bone pathology associated with adjuvant arthritis in rats has been compared to the effects produced by aspirin and naproxen."3.67Effect of etodolac on articular and bone pathology associated with adjuvant arthritis in rats: a comparison with aspirin and naproxen. ( Klicius, J; Martel, RR; Metcalf, G, 1984)
"The effect of prolonged treatment with etodolac (8 mg/kg) on the articular and bone pathology at the tibiotarsal joint associated with adjuvant arthritis in the rat has been studied and compared to the effects produced by treatment with naproxen (8 mg/kg) and ibuprofen (50 mg/kg)."3.67Comparative effects of long term treatment with etodolac, naproxen and ibuprofen on articular and bone changes associated with adjuvant arthritis in rats. ( Klicius, J; Martel, RR; Metcalf, G; Rona, GA, 1984)
" Case studies of hindlimbs from normal, adjuvant arthritic, and etodolac-treated arthritic rats demonstrated the association of disease severity with inflammation, chondromalacia, replacement of adipose bone marrow with a fibroid marrow, osteoclastic bone resorption, synovial cysts, and pannus formation within the joints."3.67Prostaglandins in inflammatory bone pathology: mechanism and therapeutic benefit of etodolac. ( Hayward, MA; Howard, GA; Neuman, RG; Van Sickle, DC; Weichman, BM; Wood, DD, 1989)
"Using the curative model of adjuvant arthritis, adult male Sprague-Dawley rats were treated with vehicle or etodolac (1, 3, and 8 mg/kg/day, po) for 9 days."3.67Temporal relationships of the anti-inflammatory effect of etodolac in the adjuvant arthritic rat. ( Chau, TT; Lee, DK; Weichman, BM; Wooley, PH, 1988)
"Etodolac is a new nonsteroidal anti-inflammatory drug (NSAID) with potent analgesic and antiarthritic properties."2.67An overview of the efficacy of etodolac in arthritic disorders. ( Bacon, PA, 1990)
"Etodolac exhibits linear pharmacokinetics, good oral bioavailability, greater than 99% protein binding, a low oral clearance (almost exclusively non-renal), a relatively small volume of distribution and a half-life that averages 7."2.38Pharmacokinetics of sustained-release etodolac. ( Benet, LZ, 1993)

Research

Studies (20)

TimeframeStudies, this research(%)All Research%
pre-19908 (40.00)18.7374
1990's10 (50.00)18.2507
2000's1 (5.00)29.6817
2010's1 (5.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Rozin, AP1
Kagna, O1
Shiller, Y1
Tachibana, M1
Inoue, N1
Yoshida, E1
Matsui, M1
Ukai, Y1
Yano, J1
Martel, RR2
Klicius, J2
Metcalf, G2
Rona, GA1
Ferdinandi, ES1
Cayen, MN1
Pace-Asciak, C1
Benet, LZ1
Wilcox, GM1
Porensky, RS1
Bensen, W1
Zizzo, A1
Gopal, DV1
Katon, RM1
Brocks, DR1
Jamali, F2
Russell, AS2
Yoshida-Suzuka, H1
Nakamura, Y1
Shibata, Y1
Kimura, K1
Scott, DL1
Bacon, PA1
Brater, DC1
Hayward, MA1
Howard, GA1
Neuman, RG2
Wood, DD2
Weichman, BM4
Van Sickle, DC1
Singh, NN1
Pasutto, FM1
Coutts, RT1
Chau, TT2
Rona, G1
Wilson, BD1
Barkley, M1
Kimball, ES1
Lee, DK1
Wooley, PH1

Reviews

3 reviews available for etodolac and Polyarthritis

ArticleYear
Pharmacokinetics of sustained-release etodolac.
    Rheumatology international, 1993, Volume: 13, Issue:2 Suppl

    Topics: Administration, Oral; Arthritis; Biological Availability; Delayed-Action Preparations; Dose-Response

1993
Newer, safer nonsteroidal anti-inflammatory drugs. Rational NSAID selection for arthritis.
    Canadian family physician Medecin de famille canadien, 1998, Volume: 44

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Arthritis; Butanones; Drug Therapy, Comb

1998
Endoscopic balloon dilation of multiple NSAID-induced colonic strictures: case report and review of literature on NSAID-related colopathy.
    Gastrointestinal endoscopy, 1999, Volume: 50, Issue:1

    Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Catheterization; Colonic Diseases; Endosco

1999

Trials

1 trial available for etodolac and Polyarthritis

ArticleYear
An overview of the efficacy of etodolac in arthritic disorders.
    European journal of rheumatology and inflammation, 1990, Volume: 10, Issue:1

    Topics: Adolescent; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Arthritis, Rheumatoid;

1990

Other Studies

16 other studies available for etodolac and Polyarthritis

ArticleYear
Sacroiliitis and severe disability due to isotretinoin therapy.
    Rheumatology international, 2010, Volume: 30, Issue:7

    Topics: Acne Vulgaris; Adrenocorticotropic Hormone; Adult; Anti-Inflammatory Agents, Non-Steroidal; Arthralg

2010
Anti-inflammatory effect and low ulcerogenic activity of etodolac, a cyclooxygenase-2 selective non-steroidal anti-inflammatory drug, on adjuvant-induced arthritis in rats.
    Pharmacology, 2003, Volume: 68, Issue:2

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Cyclooxygenase Inhibitors; Diclofenac;

2003
Effect of etodolac on articular and bone pathology associated with adjuvant arthritis in rats: a comparison with aspirin and naproxen.
    Agents and actions, 1984, Volume: 14, Issue:2

    Topics: Acetates; Animals; Anti-Inflammatory Agents; Arthritis; Arthritis, Experimental; Aspirin; Bone and B

1984
Comparative effects of long term treatment with etodolac, naproxen and ibuprofen on articular and bone changes associated with adjuvant arthritis in rats.
    Agents and actions, 1984, Volume: 15, Issue:3-4

    Topics: Acetates; Animals; Anti-Inflammatory Agents; Arthritis; Arthritis, Experimental; Body Weight; Bone a

1984
Disposition of etodolac, other anti-inflammatory pyranoindole-1-acetic acids and furobufen in normal and adjuvant arthritic rats.
    The Journal of pharmacology and experimental therapeutics, 1982, Volume: 220, Issue:2

    Topics: Acetates; Animals; Anti-Inflammatory Agents; Arthritis; Arthritis, Experimental; Blood Proteins; But

1982
Acute colitis associated with etodolac.
    Journal of clinical gastroenterology, 1997, Volume: 25, Issue:1

    Topics: Acute Disease; Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Colitis; Etodolac; Humans;

1997
Stereoselective disposition of etodolac enantiomers in synovial fluid.
    Journal of clinical pharmacology, 1991, Volume: 31, Issue:8

    Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Blood Proteins; Etodolac; Female; Humans;

1991
Effect of etodolac, a new nonsteroidal anti-inflammatory drug, in MRL/lpr mice with articular lesions.
    Agents and actions, 1991, Volume: 33, Issue:3-4

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Cartilage, Articular; Edema; Etodolac;

1991
Etodolac: the role of a new NSAID in the management of arthritis and pain. Tenth Pan American Congress of Rheumatology and the Seventeenth Congress of the Mexican Society of Rheumatology. Guadalajara, Mexico, March 15, 1990.
    Rheumatology international, 1990, Volume: 10 Suppl

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Etodolac; Humans; Indoleacetic Acids; Pain

1990
Etodolac and the treatment of arthritis.
    European journal of rheumatology and inflammation, 1990, Volume: 10, Issue:1

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Cartilage; Collagen; Etodolac; Gastrointestinal

1990
Evaluation of etodolac in subjects with renal impairment.
    European journal of rheumatology and inflammation, 1990, Volume: 10, Issue:1

    Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Blood Urea Nitrogen; Creatinine; Etodolac;

1990
Prostaglandins in inflammatory bone pathology: mechanism and therapeutic benefit of etodolac.
    Agents and actions, 1989, Volume: 26, Issue:3-4

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Arthritis, Experimental; Bone and Bones

1989
Stereoselective gas chromatographic analysis of etodolac enantiomers in human plasma and urine.
    Journal of chromatography, 1986, Oct-31, Volume: 382

    Topics: Acetates; Adult; Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Chromatography, Gas; Chromatogr

1986
Histopathologic evaluation of the effects of etodolac in established adjuvant arthritis in rats: evidence for reversal of joint damage.
    Arthritis and rheumatism, 1987, Volume: 30, Issue:4

    Topics: Acetates; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Arthritis, Experimental; Bone

1987
Inhibition of prostaglandin biosynthesis by etodolac. I. Selective activities in arthritis.
    Agents and actions, 1987, Volume: 21, Issue:1-2

    Topics: Acetates; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Cartilage; Cattle; Cells, Cul

1987
Temporal relationships of the anti-inflammatory effect of etodolac in the adjuvant arthritic rat.
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1988, Volume: 187, Issue:3

    Topics: Acetates; Acetylglucosaminidase; Animals; Anti-Inflammatory Agents; Arthritis; Arthritis, Experiment

1988