etodolac has been researched along with Polyarthritis in 20 studies
Etodolac: A non-steroidal anti-inflammatory agent and cyclooxygenase-2 (COX-2) inhibitor with potent analgesic and anti-arthritic properties. It has been shown to be effective in the treatment of OSTEOARTHRITIS; RHEUMATOID ARTHRITIS; ANKYLOSING SPONDYLITIS; and in the alleviation of postoperative pain (PAIN, POSTOPERATIVE).
etodolac : A monocarboxylic acid that is acetic acid in which one of the methyl hydrogens is substituted by a 1,8-diethyl-1,3,4,9-tetrahydropyrano[3,4-b]indol-1-yl moiety. A preferential inhibitor of cyclo-oxygenase 2 and non-steroidal anti-inflammatory, it is used for the treatment of rheumatoid arthritis and osteoarthritis, and for the alleviation of postoperative pain. Administered as the racemate, only the (S)-enantiomer is active.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We describe two patients in whom acute colitis developed during etodolac treatment." | 7.69 | Acute colitis associated with etodolac. ( Porensky, RS; Wilcox, GM, 1997) |
| "The effect of treatment with the new anti-inflammatory drug etodolac on the articular and bone pathology associated with adjuvant arthritis in rats has been compared to the effects produced by aspirin and naproxen." | 7.67 | Effect of etodolac on articular and bone pathology associated with adjuvant arthritis in rats: a comparison with aspirin and naproxen. ( Klicius, J; Martel, RR; Metcalf, G, 1984) |
| "The effect of prolonged treatment with etodolac (8 mg/kg) on the articular and bone pathology at the tibiotarsal joint associated with adjuvant arthritis in the rat has been studied and compared to the effects produced by treatment with naproxen (8 mg/kg) and ibuprofen (50 mg/kg)." | 7.67 | Comparative effects of long term treatment with etodolac, naproxen and ibuprofen on articular and bone changes associated with adjuvant arthritis in rats. ( Klicius, J; Martel, RR; Metcalf, G; Rona, GA, 1984) |
| "Safer treatment for arthritis can be achieved by combining misoprostol with traditional NSAIDs or by using one of two new agents, nabumetone or etodolac." | 4.80 | Newer, safer nonsteroidal anti-inflammatory drugs. Rational NSAID selection for arthritis. ( Bensen, W; Zizzo, A, 1998) |
| "We describe two patients in whom acute colitis developed during etodolac treatment." | 3.69 | Acute colitis associated with etodolac. ( Porensky, RS; Wilcox, GM, 1997) |
| "The effect of treatment with the new anti-inflammatory drug etodolac on the articular and bone pathology associated with adjuvant arthritis in rats has been compared to the effects produced by aspirin and naproxen." | 3.67 | Effect of etodolac on articular and bone pathology associated with adjuvant arthritis in rats: a comparison with aspirin and naproxen. ( Klicius, J; Martel, RR; Metcalf, G, 1984) |
| "The effect of prolonged treatment with etodolac (8 mg/kg) on the articular and bone pathology at the tibiotarsal joint associated with adjuvant arthritis in the rat has been studied and compared to the effects produced by treatment with naproxen (8 mg/kg) and ibuprofen (50 mg/kg)." | 3.67 | Comparative effects of long term treatment with etodolac, naproxen and ibuprofen on articular and bone changes associated with adjuvant arthritis in rats. ( Klicius, J; Martel, RR; Metcalf, G; Rona, GA, 1984) |
| " Case studies of hindlimbs from normal, adjuvant arthritic, and etodolac-treated arthritic rats demonstrated the association of disease severity with inflammation, chondromalacia, replacement of adipose bone marrow with a fibroid marrow, osteoclastic bone resorption, synovial cysts, and pannus formation within the joints." | 3.67 | Prostaglandins in inflammatory bone pathology: mechanism and therapeutic benefit of etodolac. ( Hayward, MA; Howard, GA; Neuman, RG; Van Sickle, DC; Weichman, BM; Wood, DD, 1989) |
| "Using the curative model of adjuvant arthritis, adult male Sprague-Dawley rats were treated with vehicle or etodolac (1, 3, and 8 mg/kg/day, po) for 9 days." | 3.67 | Temporal relationships of the anti-inflammatory effect of etodolac in the adjuvant arthritic rat. ( Chau, TT; Lee, DK; Weichman, BM; Wooley, PH, 1988) |
| "Etodolac is a new nonsteroidal anti-inflammatory drug (NSAID) with potent analgesic and antiarthritic properties." | 2.67 | An overview of the efficacy of etodolac in arthritic disorders. ( Bacon, PA, 1990) |
| "Etodolac exhibits linear pharmacokinetics, good oral bioavailability, greater than 99% protein binding, a low oral clearance (almost exclusively non-renal), a relatively small volume of distribution and a half-life that averages 7." | 2.38 | Pharmacokinetics of sustained-release etodolac. ( Benet, LZ, 1993) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (40.00) | 18.7374 |
| 1990's | 10 (50.00) | 18.2507 |
| 2000's | 1 (5.00) | 29.6817 |
| 2010's | 1 (5.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Rozin, AP | 1 |
| Kagna, O | 1 |
| Shiller, Y | 1 |
| Tachibana, M | 1 |
| Inoue, N | 1 |
| Yoshida, E | 1 |
| Matsui, M | 1 |
| Ukai, Y | 1 |
| Yano, J | 1 |
| Martel, RR | 2 |
| Klicius, J | 2 |
| Metcalf, G | 2 |
| Rona, GA | 1 |
| Ferdinandi, ES | 1 |
| Cayen, MN | 1 |
| Pace-Asciak, C | 1 |
| Benet, LZ | 1 |
| Wilcox, GM | 1 |
| Porensky, RS | 1 |
| Bensen, W | 1 |
| Zizzo, A | 1 |
| Gopal, DV | 1 |
| Katon, RM | 1 |
| Brocks, DR | 1 |
| Jamali, F | 2 |
| Russell, AS | 2 |
| Yoshida-Suzuka, H | 1 |
| Nakamura, Y | 1 |
| Shibata, Y | 1 |
| Kimura, K | 1 |
| Scott, DL | 1 |
| Bacon, PA | 1 |
| Brater, DC | 1 |
| Hayward, MA | 1 |
| Howard, GA | 1 |
| Neuman, RG | 2 |
| Wood, DD | 2 |
| Weichman, BM | 4 |
| Van Sickle, DC | 1 |
| Singh, NN | 1 |
| Pasutto, FM | 1 |
| Coutts, RT | 1 |
| Chau, TT | 2 |
| Rona, G | 1 |
| Wilson, BD | 1 |
| Barkley, M | 1 |
| Kimball, ES | 1 |
| Lee, DK | 1 |
| Wooley, PH | 1 |
3 reviews available for etodolac and Polyarthritis
| Article | Year |
|---|---|
Pharmacokinetics of sustained-release etodolac.
Topics: Administration, Oral; Arthritis; Biological Availability; Delayed-Action Preparations; Dose-Response | 1993 |
Newer, safer nonsteroidal anti-inflammatory drugs. Rational NSAID selection for arthritis.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Arthritis; Butanones; Drug Therapy, Comb | 1998 |
Endoscopic balloon dilation of multiple NSAID-induced colonic strictures: case report and review of literature on NSAID-related colopathy.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Catheterization; Colonic Diseases; Endosco | 1999 |
1 trial available for etodolac and Polyarthritis
| Article | Year |
|---|---|
An overview of the efficacy of etodolac in arthritic disorders.
Topics: Adolescent; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Arthritis, Rheumatoid; | 1990 |
16 other studies available for etodolac and Polyarthritis
| Article | Year |
|---|---|
Sacroiliitis and severe disability due to isotretinoin therapy.
Topics: Acne Vulgaris; Adrenocorticotropic Hormone; Adult; Anti-Inflammatory Agents, Non-Steroidal; Arthralg | 2010 |
Anti-inflammatory effect and low ulcerogenic activity of etodolac, a cyclooxygenase-2 selective non-steroidal anti-inflammatory drug, on adjuvant-induced arthritis in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Cyclooxygenase Inhibitors; Diclofenac; | 2003 |
Effect of etodolac on articular and bone pathology associated with adjuvant arthritis in rats: a comparison with aspirin and naproxen.
Topics: Acetates; Animals; Anti-Inflammatory Agents; Arthritis; Arthritis, Experimental; Aspirin; Bone and B | 1984 |
Comparative effects of long term treatment with etodolac, naproxen and ibuprofen on articular and bone changes associated with adjuvant arthritis in rats.
Topics: Acetates; Animals; Anti-Inflammatory Agents; Arthritis; Arthritis, Experimental; Body Weight; Bone a | 1984 |
Disposition of etodolac, other anti-inflammatory pyranoindole-1-acetic acids and furobufen in normal and adjuvant arthritic rats.
Topics: Acetates; Animals; Anti-Inflammatory Agents; Arthritis; Arthritis, Experimental; Blood Proteins; But | 1982 |
Acute colitis associated with etodolac.
Topics: Acute Disease; Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Colitis; Etodolac; Humans; | 1997 |
Stereoselective disposition of etodolac enantiomers in synovial fluid.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Blood Proteins; Etodolac; Female; Humans; | 1991 |
Effect of etodolac, a new nonsteroidal anti-inflammatory drug, in MRL/lpr mice with articular lesions.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Cartilage, Articular; Edema; Etodolac; | 1991 |
Etodolac: the role of a new NSAID in the management of arthritis and pain. Tenth Pan American Congress of Rheumatology and the Seventeenth Congress of the Mexican Society of Rheumatology. Guadalajara, Mexico, March 15, 1990.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Etodolac; Humans; Indoleacetic Acids; Pain | 1990 |
Etodolac and the treatment of arthritis.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Cartilage; Collagen; Etodolac; Gastrointestinal | 1990 |
Evaluation of etodolac in subjects with renal impairment.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Blood Urea Nitrogen; Creatinine; Etodolac; | 1990 |
Prostaglandins in inflammatory bone pathology: mechanism and therapeutic benefit of etodolac.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Arthritis, Experimental; Bone and Bones | 1989 |
Stereoselective gas chromatographic analysis of etodolac enantiomers in human plasma and urine.
Topics: Acetates; Adult; Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Chromatography, Gas; Chromatogr | 1986 |
Histopathologic evaluation of the effects of etodolac in established adjuvant arthritis in rats: evidence for reversal of joint damage.
Topics: Acetates; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Arthritis, Experimental; Bone | 1987 |
Inhibition of prostaglandin biosynthesis by etodolac. I. Selective activities in arthritis.
Topics: Acetates; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Cartilage; Cattle; Cells, Cul | 1987 |
Temporal relationships of the anti-inflammatory effect of etodolac in the adjuvant arthritic rat.
Topics: Acetates; Acetylglucosaminidase; Animals; Anti-Inflammatory Agents; Arthritis; Arthritis, Experiment | 1988 |