etodolac has been researched along with Pain, Postoperative in 29 studies
Etodolac: A non-steroidal anti-inflammatory agent and cyclooxygenase-2 (COX-2) inhibitor with potent analgesic and anti-arthritic properties. It has been shown to be effective in the treatment of OSTEOARTHRITIS; RHEUMATOID ARTHRITIS; ANKYLOSING SPONDYLITIS; and in the alleviation of postoperative pain (PAIN, POSTOPERATIVE).
etodolac : A monocarboxylic acid that is acetic acid in which one of the methyl hydrogens is substituted by a 1,8-diethyl-1,3,4,9-tetrahydropyrano[3,4-b]indol-1-yl moiety. A preferential inhibitor of cyclo-oxygenase 2 and non-steroidal anti-inflammatory, it is used for the treatment of rheumatoid arthritis and osteoarthritis, and for the alleviation of postoperative pain. Administered as the racemate, only the (S)-enantiomer is active.
Pain, Postoperative: Pain during the period after surgery.
| Excerpt | Relevance | Reference |
|---|---|---|
| "This study aimed to conduct a randomized prospective study about the efficacy of etodolac and ibuprofen on trismus, pain and edema regarding gender of patients submitted to impacted lower third molar teeth extraction." | 9.41 | The efficacy of etodolac and ibuprofen, regarding gender, on pain, edema and trismus after impacted lower third molar surgery: A randomized prospective clinical split-mouth study. ( Farnezi Bassi, AP; Faverani, LP; Reis, EN; Silva, LD, 2021) |
| "To compare the efficacy of ibuprofen (IBU) and etodolac (ETO) for controlling pain, edema, and trismus after extraction of lower third molars." | 9.22 | Comparative Assessment of the Effect of Ibuprofen and Etodolac on Edema, Trismus, and Pain in Lower Third Molar Surgery: A Randomized Clinical Trial. ( Bassi, AP; Grossi de Oliveira, GA; Silva de Oliveira, JC, 2016) |
| "Etodolac is a selective cyclo-oxygenase-2 (COX-2) inhibitor, with evidence of efficacy in osteoarthritis and rheumatoid arthritis." | 6.45 | Single dose oral etodolac for acute postoperative pain in adults. ( Derry, S; McQuay, HJ; Moore, RA; Tirunagari, SK, 2009) |
| "This study aimed to conduct a randomized prospective study about the efficacy of etodolac and ibuprofen on trismus, pain and edema regarding gender of patients submitted to impacted lower third molar teeth extraction." | 5.41 | The efficacy of etodolac and ibuprofen, regarding gender, on pain, edema and trismus after impacted lower third molar surgery: A randomized prospective clinical split-mouth study. ( Farnezi Bassi, AP; Faverani, LP; Reis, EN; Silva, LD, 2021) |
| "To compare the efficacy of ibuprofen (IBU) and etodolac (ETO) for controlling pain, edema, and trismus after extraction of lower third molars." | 5.22 | Comparative Assessment of the Effect of Ibuprofen and Etodolac on Edema, Trismus, and Pain in Lower Third Molar Surgery: A Randomized Clinical Trial. ( Bassi, AP; Grossi de Oliveira, GA; Silva de Oliveira, JC, 2016) |
| "Presented are the results of four postsurgical pain studies, one study of acute gouty arthritis and nine studies of acute musculoskeletal disorders: acute low back pain, acute painful shoulder, tendinitis and bursitis, and acute sports injuries." | 3.76 | Etodolac: analgesic effects in musculoskeletal and postoperative pain. ( Pena, M, 1990) |
| "Edema was similar among all groups at all time points (P > ." | 3.01 | Combination of etodolac and dexamethasone improves preemptive analgesia in third molar surgery: a randomized study. ( Barbosa, S; Bassi, APF; de Souza Santos, AM; Faverani, LP; Momesso, GAC; Polo, TOB; Ramires, GAD; Silva, WPP, 2021) |
| "No difference was noted regarding trismus in any of the groups." | 2.79 | Comparison of the effect of naproxen, etodolac and diclofenac on postoperative sequels following third molar surgery: a randomised, double-blind, crossover study. ( Akbulut, N; Atakan, C; Çölok, G; Üstüner, E, 2014) |
| " The following medications were randomly given to the patients who declared pain in the sixth hour after the operation: naproxen sodium, meloxicam, rofecoxib, paracetamol, dipyrone, and etodolac in proper dosage to form groups of 20 for each medication." | 2.72 | [Postoperative pain management in clinics of otolaryngology]. ( Cağici, CA; Calişkan, EE; Erkan, AN; Gencay, S; Ozlüoğlu, LN; Sener, M; Yavuz, H; Yilmaz, I; Yilmazer, C, 2006) |
| "In both groups, postoperative pain was treated with buprenorphine suppository." | 2.71 | Oral etodolac, a COX-2 inhibitor, reduces postoperative pain immediately after fast-track cardiac surgery. ( Goto, F; Koizuka, S; Nishikawa, K; Obata, H; Saito, S; Saito, Y; Sasaki, M; Takahashi, K, 2004) |
| "Nitroglycerin (NTG) has been found efficacious in acute pain, but has not been tested for chronic pain with neuropathic characteristics." | 2.71 | Efficacy of transdermal nitroglycerin combined with etodolac for the treatment of chronic post-thoracotomy pain: an open-label prospective clinical trial. ( Eidelman, LA; Glantz, L; Godovic, G; Kramer, M; Lekar, M, 2004) |
| "Etodolac is a new nonsteroidal anti-inflammatory drug (NSAID)." | 2.67 | Clinical response to etodolac in the management of pain. ( Mizraji, M, 1990) |
| "Etodolac is a selective cyclo-oxygenase-2 (COX-2) inhibitor, with evidence of efficacy in osteoarthritis and rheumatoid arthritis." | 2.45 | Single dose oral etodolac for acute postoperative pain in adults. ( Derry, S; McQuay, HJ; Moore, RA; Tirunagari, SK, 2009) |
| "Etodolac is a new non-steroidal agent (NSAID) with anti-inflammatory and analgesic activity." | 2.37 | Etodolac. A preliminary review of its pharmacodynamic activity and therapeutic use. ( Brogden, RN; Lynch, S, 1986) |
| "Ketorolac was the most frequent NSAID prescribed, commonly on the first postoperative day." | 1.42 | Non-steroidal anti-inflammatory drug administration after coronary artery bypass surgery: utilization persists despite the boxed warning. ( Bateman, BT; Bykov, K; Choudhry, NK; Kulik, A, 2015) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (20.69) | 18.7374 |
| 1990's | 6 (20.69) | 18.2507 |
| 2000's | 11 (37.93) | 29.6817 |
| 2010's | 4 (13.79) | 24.3611 |
| 2020's | 2 (6.90) | 2.80 |
| Authors | Studies |
|---|---|
| Ramires, GAD | 1 |
| de Souza Santos, AM | 1 |
| Momesso, GAC | 1 |
| Polo, TOB | 1 |
| Silva, WPP | 1 |
| Barbosa, S | 1 |
| Bassi, APF | 1 |
| Faverani, LP | 2 |
| Silva, LD | 1 |
| Reis, EN | 1 |
| Farnezi Bassi, AP | 1 |
| Akbulut, N | 1 |
| Üstüner, E | 1 |
| Atakan, C | 1 |
| Çölok, G | 1 |
| Kulik, A | 1 |
| Bykov, K | 1 |
| Choudhry, NK | 1 |
| Bateman, BT | 1 |
| Silva de Oliveira, JC | 1 |
| Grossi de Oliveira, GA | 1 |
| Bassi, AP | 1 |
| Tirunagari, SK | 1 |
| Derry, S | 1 |
| Moore, RA | 1 |
| McQuay, HJ | 1 |
| Pareek, A | 1 |
| Chandurkar, N | 1 |
| Gupta, A | 1 |
| Desai, Y | 1 |
| Kumar S, H | 1 |
| Swamy, A | 1 |
| Sirsikar, A | 1 |
| Comfort, MB | 1 |
| Tse, AS | 1 |
| Tsang, AC | 1 |
| McGrath, C | 1 |
| Immer, FF | 1 |
| Immer-Bansi, AS | 1 |
| Trachsel, N | 1 |
| Berdat, PA | 1 |
| Eigenmann, V | 1 |
| Curatolo, M | 1 |
| Carrel, TP | 1 |
| Koizuka, S | 1 |
| Saito, S | 1 |
| Obata, H | 1 |
| Sasaki, M | 1 |
| Nishikawa, K | 1 |
| Takahashi, K | 1 |
| Saito, Y | 1 |
| Goto, F | 1 |
| Glantz, L | 1 |
| Godovic, G | 1 |
| Lekar, M | 1 |
| Kramer, M | 1 |
| Eidelman, LA | 1 |
| Ness, TA | 1 |
| Torres, SM | 1 |
| Kramek, EA | 1 |
| Blauvelt, MM | 1 |
| Lin, S | 1 |
| Levin, L | 1 |
| Emodi, O | 1 |
| Abu El-Naaj, I | 1 |
| Peled, M | 1 |
| Yilmaz, I | 1 |
| Sener, M | 1 |
| Yavuz, H | 1 |
| Yilmazer, C | 1 |
| Erkan, AN | 1 |
| Cağici, CA | 1 |
| Gencay, S | 1 |
| Calişkan, EE | 1 |
| Ozlüoğlu, LN | 1 |
| Versichelen, L | 1 |
| Bilsback, P | 1 |
| Rolly, G | 1 |
| Merlo, M | 1 |
| Joubert, L | 1 |
| Hutton, CE | 1 |
| Gaston, GW | 1 |
| Mallow, RD | 1 |
| Frank, JE | 1 |
| Tucker, PW | 1 |
| Smith, JR | 1 |
| Adams, DF | 1 |
| Casey, R | 1 |
| Zadra, J | 1 |
| Khonsari, H | 1 |
| Hersh, EV | 1 |
| Levin, LM | 1 |
| Cooper, SA | 1 |
| Reynolds, D | 1 |
| Gallegos, LT | 1 |
| McGoldrick, K | 1 |
| Appel, A | 1 |
| Menke, ER | 1 |
| Jackson, CR | 1 |
| Bagby, MD | 1 |
| Tracy, TS | 1 |
| Burgess, FW | 1 |
| Browning, RA | 1 |
| Mizraji, M | 1 |
| Pena, M | 1 |
| Lynch, S | 1 |
| Brogden, RN | 1 |
| Giglio, JA | 1 |
| Campbell, RL | 1 |
| Scott, R | 1 |
| Ellis, E | 1 |
| Upton, LG | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Incidence of Postoperative Pain After Using Different Types of Sealers (A Randomized Clinical Trial)[NCT05841290] | 40 participants (Anticipated) | Interventional | 2023-05-31 | Not yet recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
4 reviews available for etodolac and Pain, Postoperative
| Article | Year |
|---|---|
Single dose oral etodolac for acute postoperative pain in adults.
Topics: Acute Disease; Administration, Oral; Adult; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase | 2009 |
Evidence-based review of clinical studies on pharmacology (non-anesthetic studies).
Topics: Acetaminophen; Administration, Oral; Analgesics; Anxiety; Dental Pulp Diseases; Dexamethasone; Drug | 2009 |
Etodolac: analgesic effects in musculoskeletal and postoperative pain.
Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Gouty; Aspirin; Athletic Injuries | 1990 |
Etodolac. A preliminary review of its pharmacodynamic activity and therapeutic use.
Topics: Acetates; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Aspirin; Etodolac; Humans; | 1986 |
22 trials available for etodolac and Pain, Postoperative
| Article | Year |
|---|---|
Combination of etodolac and dexamethasone improves preemptive analgesia in third molar surgery: a randomized study.
Topics: Analgesia; Dexamethasone; Double-Blind Method; Edema; Etodolac; Humans; Molar, Third; Pain, Postoper | 2021 |
The efficacy of etodolac and ibuprofen, regarding gender, on pain, edema and trismus after impacted lower third molar surgery: A randomized prospective clinical split-mouth study.
Topics: Adolescent; Adult; Edema; Etodolac; Female; Humans; Ibuprofen; Male; Molar, Third; Mouth; Pain, Post | 2021 |
Comparison of the effect of naproxen, etodolac and diclofenac on postoperative sequels following third molar surgery: a randomised, double-blind, crossover study.
Topics: Adolescent; Adult; Anti-Inflammatory Agents, Non-Steroidal; Cross-Over Studies; Diclofenac; Double-B | 2014 |
Comparative Assessment of the Effect of Ibuprofen and Etodolac on Edema, Trismus, and Pain in Lower Third Molar Surgery: A Randomized Clinical Trial.
Topics: Adolescent; Cyclooxygenase 2 Inhibitors; Edema; Etodolac; Female; Humans; Ibuprofen; Male; Mandible; | 2016 |
Comparative evaluation of efficacy and safety of etodolac and diclofenac sodium injection in patients with postoperative orthopedic pain.
Topics: Adolescent; Adult; Aged; Cyclooxygenase Inhibitors; Diclofenac; Drug Administration Schedule; Etodol | 2011 |
A study of the comparative efficacy of three common analgesics in the control of pain after third molar surgery under local anaesthesia.
Topics: Acetaminophen; Analgesics; Analgesics, Non-Narcotic; Analgesics, Opioid; Anesthesia, Dental; Anesthe | 2002 |
Pain treatment with a COX-2 inhibitor after coronary artery bypass operation: a randomized trial.
Topics: Aged; Analgesics, Opioid; Coronary Artery Bypass; Creatinine; Cyclooxygenase 2; Cyclooxygenase 2 Inh | 2003 |
Oral etodolac, a COX-2 inhibitor, reduces postoperative pain immediately after fast-track cardiac surgery.
Topics: Administration, Oral; Aged; Analgesics, Opioid; Buprenorphine; Coronary Artery Bypass; Cyclooxygenas | 2004 |
Efficacy of transdermal nitroglycerin combined with etodolac for the treatment of chronic post-thoracotomy pain: an open-label prospective clinical trial.
Topics: Administration, Cutaneous; Aged; Anti-Inflammatory Agents, Non-Steroidal; Drug Therapy, Combination; | 2004 |
Effect of dosing and sampling time on serum thyroxine, free thyroxine, and thyrotropin concentrations in dogs following multidose etodolac administration.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Dog Diseases; Dogs; Drug Administration Schedule; | 2003 |
Etodolac versus dexamethasone effect in reduction of postoperative symptoms following surgical endodontic treatment: a double-blind study.
Topics: Adolescent; Adult; Analysis of Variance; Anti-Inflammatory Agents; Apicoectomy; Dexamethasone; Doubl | 2006 |
[Postoperative pain management in clinics of otolaryngology].
Topics: Acetaminophen; Adolescent; Adult; Aged; Analgesics; Dipyrone; Etodolac; Female; Humans; Lactones; Ma | 2006 |
Etodolac in postsurgical pain: a double-blind dose-ranging efficacy study with aspirin and placebo.
Topics: Acetates; Adolescent; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Dose-Response R | 1982 |
The efficacy of etodolac for patients with pain following oral surgery.
Topics: Acetates; Adolescent; Adult; Aged; Analgesics; Aspirin; Clinical Trials as Topic; Double-Blind Metho | 1984 |
A comparison of 2 analgesic regimens for the control of postoperative periodontal discomfort.
Topics: Acetaminophen; Administration, Oral; Adult; Alveolectomy; Analgesics, Non-Narcotic; Analgesics, Opio | 1996 |
A comparison of etodolac (Ultradol) with acetaminophen plus codeine (Tylenol #3) in controlling post-surgical pain in vasectomy patients.
Topics: Acetaminophen; Adult; Ambulatory Surgical Procedures; Analgesics, Non-Narcotic; Analgesics, Opioid; | 1997 |
Conventional and extended-release etodolac for postsurgical dental pain.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase Inhibitors; Delayed-Action Preparatio | 1999 |
The effectiveness of prophylactic etodolac on postendodontic pain.
Topics: Acute Disease; Administration, Oral; Analgesics, Non-Narcotic; Analysis of Variance; Anti-Inflammato | 2000 |
Clinical response to etodolac in the management of pain.
Topics: Acute Disease; Anti-Inflammatory Agents, Non-Steroidal; Athletic Injuries; Bursitis; Diclofenac; Eto | 1990 |
Etodolac: analgesic effects in musculoskeletal and postoperative pain.
Topics: Acetaminophen; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Gouty; Aspirin; Athletic Injuries | 1990 |
Comparison of etodolac, zomepirac, and placebo for relief of pain after oral surgery.
Topics: Acetates; Adolescent; Adult; Anti-Inflammatory Agents, Non-Steroidal; Clinical Trials as Topic; Doub | 1986 |
Double-blind evaluation of etodolac (200 mg, 400 mg) compared with zomepirac (100 mg) and placebo on third molar extraction pain.
Topics: Acetates; Adolescent; Adult; Anti-Inflammatory Agents, Non-Steroidal; Clinical Trials as Topic; Doub | 1986 |
4 other studies available for etodolac and Pain, Postoperative
| Article | Year |
|---|---|
Non-steroidal anti-inflammatory drug administration after coronary artery bypass surgery: utilization persists despite the boxed warning.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Cohort Studies; Coronary Artery Bypass; Databases, Fa | 2015 |
The effectiveness of 100 and 200 mg etodolac (Ultradol), aspirin, and placebo in patients with pain following oral surgery.
Topics: Acetates; Adolescent; Adult; Analgesics; Aspirin; Double-Blind Method; Etodolac; Female; Humans; Mal | 1983 |
Nonsteroidal anti-inflammatory drugs for perioperative pain control.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Butanones; Celecoxib; Cyclooxygenase Inhibitors; Diclofenac | 2001 |
Etodolac.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Clinical Trials as Topic; Etodolac; Humans; Indoleac | 1991 |