etodolac has been researched along with Gastrointestinal Hemorrhage in 10 studies
Etodolac: A non-steroidal anti-inflammatory agent and cyclooxygenase-2 (COX-2) inhibitor with potent analgesic and anti-arthritic properties. It has been shown to be effective in the treatment of OSTEOARTHRITIS; RHEUMATOID ARTHRITIS; ANKYLOSING SPONDYLITIS; and in the alleviation of postoperative pain (PAIN, POSTOPERATIVE).
etodolac : A monocarboxylic acid that is acetic acid in which one of the methyl hydrogens is substituted by a 1,8-diethyl-1,3,4,9-tetrahydropyrano[3,4-b]indol-1-yl moiety. A preferential inhibitor of cyclo-oxygenase 2 and non-steroidal anti-inflammatory, it is used for the treatment of rheumatoid arthritis and osteoarthritis, and for the alleviation of postoperative pain. Administered as the racemate, only the (S)-enantiomer is active.
Gastrointestinal Hemorrhage: Bleeding in any segment of the GASTROINTESTINAL TRACT from ESOPHAGUS to RECTUM.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A multi-centre, double-blind, randomised parallel-group study was conducted to compare the efficacy and safety between etodolac SR and diclofenac in treating patients with osteoarthritis of the knee." | 9.10 | Double-blind, randomised, comparative trial of etodolac SR versus diclofenac in the treatment of osteoarthritis of the knee. ( Hsu, PN; Liang, TH, 2003) |
| " The aims of the present study were to determine, in rats, the role of neutrophils in the pathogenesis of etodolac- and indomethacin-induced gastrointestinal ulceration and blood loss." | 7.69 | Neutropenia does not prevent etodolac- or indomethacin-induced gastrointestinal damage in the rat. ( Fuller, J; Gentry, C; Melarange, R; Smith, PH; Toseland, CD, 1995) |
| "A multi-centre, double-blind, randomised parallel-group study was conducted to compare the efficacy and safety between etodolac SR and diclofenac in treating patients with osteoarthritis of the knee." | 5.10 | Double-blind, randomised, comparative trial of etodolac SR versus diclofenac in the treatment of osteoarthritis of the knee. ( Hsu, PN; Liang, TH, 2003) |
| " In this study, the effect on gastrointestinal blood loss of high-dose etodolac, 300 and 500 mg bid, versus piroxicam at its normal therapeutic dose of 20 mg qd, was investigated by the 51Cr method in 23 men with osteo- or rheumatoid arthritis." | 5.06 | Gastrointestinal blood loss in arthritic patients receiving chronic dosing with etodolac and piroxicam. ( Garg, DC; Jallad, NS; Mullane, JF; Perdomo, CS; Salom, IL; Sanda, M; Weidler, DJ, 1986) |
| " The aim of the present study was to compare nabumetone, a nonacidic drug, with etodolac on rat gastric mucosal damage and prostanoid synthesis, while concurrently measuring prostanoid production during edema formation in a carrageenan model of paw inflammation." | 3.69 | Gastrointestinal irritancy, antiinflammatory activity, and prostanoid inhibition in the rat. Differentiation of effects between nabumetone and etodolac. ( Blower, PR; Durie, M; Gentry, C; Melarange, R; O'Connell, C, 1994) |
| " The aims of the present study were to determine, in rats, the role of neutrophils in the pathogenesis of etodolac- and indomethacin-induced gastrointestinal ulceration and blood loss." | 3.69 | Neutropenia does not prevent etodolac- or indomethacin-induced gastrointestinal damage in the rat. ( Fuller, J; Gentry, C; Melarange, R; Smith, PH; Toseland, CD, 1995) |
| "Nabumetone proved to be an effective anti-inflammatory agent that was devoid of gastrointestinal irritancy." | 1.29 | Nabumetone, an effective anti-inflammatory agent, lacks gastrointestinal irritancy in the rat when dosed orally for one month: comparison with tiaprofenic acid and etodolac. ( Blower, PR; Gentry, C; Melarange, R; Spangler, R; Toseland, CD, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (40.00) | 18.7374 |
| 1990's | 5 (50.00) | 18.2507 |
| 2000's | 1 (10.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Liang, TH | 1 |
| Hsu, PN | 1 |
| Arnold, JD | 2 |
| Mullane, JF | 2 |
| Hayden, DM | 1 |
| March, L | 1 |
| Hart, K | 1 |
| Perdomo, CA | 1 |
| Fencik, M | 1 |
| Berger, AE | 1 |
| Melarange, R | 3 |
| Gentry, C | 3 |
| Blower, PR | 2 |
| Toseland, CD | 2 |
| Spangler, R | 1 |
| Durie, M | 1 |
| O'Connell, C | 1 |
| Lanza, FL | 2 |
| Smith, PH | 1 |
| Fuller, J | 1 |
| Leese, P | 1 |
| Lanza, F | 1 |
| Panagides, J | 1 |
| Salom, IL | 2 |
| Jallad, NS | 1 |
| Sanda, M | 1 |
| Perdomo, CS | 1 |
| Garg, DC | 1 |
| Weidler, DJ | 1 |
2 reviews available for etodolac and Gastrointestinal Hemorrhage
| Article | Year |
|---|---|
Gastrointestinal toxicity of newer NSAIDs.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Butanones; Etodolac; Gastrointestinal Hemorrhage; Humans; N | 1993 |
Etodolac, a new nonsteroidal anti-inflammatory drug: gastrointestinal microbleeding and endoscopic studies.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Drug Administration Schedule; Etodolac; Gastrointestinal He | 1989 |
5 trials available for etodolac and Gastrointestinal Hemorrhage
| Article | Year |
|---|---|
Double-blind, randomised, comparative trial of etodolac SR versus diclofenac in the treatment of osteoarthritis of the knee.
Topics: Abdominal Pain; Aged; Analysis of Variance; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase | 2003 |
Etodolac, aspirin, and gastrointestinal microbleeding.
Topics: Acetates; Adult; Aspirin; Dose-Response Relationship, Drug; Drug Evaluation; Etodolac; Gastrointesti | 1984 |
Comparison of the effects of etodolac SR and naproxen on gastro-intestinal blood loss.
Topics: Adult; Chromium Radioisotopes; Delayed-Action Preparations; Etodolac; Gastrointestinal Hemorrhage; H | 1992 |
Etodolac compared with aspirin: an endoscopic study of the gastrointestinal tracts of normal volunteers.
Topics: Acetates; Adolescent; Adult; Aspirin; Dose-Response Relationship, Drug; Duodenitis; Endoscopy; Etodo | 1986 |
Gastrointestinal blood loss in arthritic patients receiving chronic dosing with etodolac and piroxicam.
Topics: Acetates; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Dose-Response | 1986 |
3 other studies available for etodolac and Gastrointestinal Hemorrhage
| Article | Year |
|---|---|
Nabumetone, an effective anti-inflammatory agent, lacks gastrointestinal irritancy in the rat when dosed orally for one month: comparison with tiaprofenic acid and etodolac.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Body Weight; Butanones; Carr | 1994 |
Gastrointestinal irritancy, antiinflammatory activity, and prostanoid inhibition in the rat. Differentiation of effects between nabumetone and etodolac.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Anti-Inflammatory Agents, Non-Steroidal; Butanones; Cecum; De | 1994 |
Neutropenia does not prevent etodolac- or indomethacin-induced gastrointestinal damage in the rat.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antilymphocyte Serum; Etodolac; Gastric Mucosa; Ga | 1995 |