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etodolac and Gastric Ulcer

etodolac has been researched along with Gastric Ulcer in 10 studies

Etodolac: A non-steroidal anti-inflammatory agent and cyclooxygenase-2 (COX-2) inhibitor with potent analgesic and anti-arthritic properties. It has been shown to be effective in the treatment of OSTEOARTHRITIS; RHEUMATOID ARTHRITIS; ANKYLOSING SPONDYLITIS; and in the alleviation of postoperative pain (PAIN, POSTOPERATIVE).
etodolac : A monocarboxylic acid that is acetic acid in which one of the methyl hydrogens is substituted by a 1,8-diethyl-1,3,4,9-tetrahydropyrano[3,4-b]indol-1-yl moiety. A preferential inhibitor of cyclo-oxygenase 2 and non-steroidal anti-inflammatory, it is used for the treatment of rheumatoid arthritis and osteoarthritis, and for the alleviation of postoperative pain. Administered as the racemate, only the (S)-enantiomer is active.

Research Excerpts

ExcerptRelevanceReference
" The aims of the present study were to determine, in rats, the role of neutrophils in the pathogenesis of etodolac- and indomethacin-induced gastrointestinal ulceration and blood loss."7.69Neutropenia does not prevent etodolac- or indomethacin-induced gastrointestinal damage in the rat. ( Fuller, J; Gentry, C; Melarange, R; Smith, PH; Toseland, CD, 1995)
"At week 1 the mean number and area of gastric ulcers per subject were greater with naproxen than placebo or etodolac (area: naproxen, 7."5.08A randomized double-blind comparison of placebo, etodolac, and naproxen on gastrointestinal injury and prostaglandin production. ( Cominelli, F; Ferretti, M; Laine, L; Sloane, R, 1995)
" Eto inhibited carrageenin-induced edema in rats, adjuvant-induced arthritis in rats, acetic acid-induced writhing in mice and brewer's yeast-induced hyperalgesia and fever in rats."3.69Anti-inflammatory effects of etodolac: comparison with other non-steroidal anti-inflammatory drugs. ( Fujisawa, H; Inoue, K; Inoue, Y; Kimura, K; Kyoi, T; Motonaga, A; Ueda, F, 1994)
" The aims of the present study were to determine, in rats, the role of neutrophils in the pathogenesis of etodolac- and indomethacin-induced gastrointestinal ulceration and blood loss."3.69Neutropenia does not prevent etodolac- or indomethacin-induced gastrointestinal damage in the rat. ( Fuller, J; Gentry, C; Melarange, R; Smith, PH; Toseland, CD, 1995)

Research

Studies (10)

TimeframeStudies, this research(%)All Research%
pre-19902 (20.00)18.7374
1990's4 (40.00)18.2507
2000's2 (20.00)29.6817
2010's2 (20.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Asselin, AA1
Humber, LG2
Dobson, TA1
Komlossy, J1
Martel, RR1
Demerson, CA1
Philipp, AH1
Hassib, ST1
Hassan, GS1
El-Zaher, AA1
Fouad, MA1
Abd El-Ghafar, OA1
Taha, EA1
Kanbayashi, Y1
Konishi, H1
Abdel-Salam, OM1
Laine, L2
Cominelli, F2
Sloane, R2
Casini-Raggi, V1
Marin-Sorensen, M1
Weinstein, WM1
Inoue, K1
Fujisawa, H1
Motonaga, A1
Inoue, Y1
Kyoi, T1
Ueda, F1
Kimura, K1
Melarange, R1
Gentry, C1
Toseland, CD1
Smith, PH1
Fuller, J1
Ferretti, M1
Levy, DJ1

Trials

2 trials available for etodolac and Gastric Ulcer

ArticleYear
Interaction of NSAIDs and Helicobacter pylori on gastrointestinal injury and prostaglandin production: a controlled double-blind trial.
    Alimentary pharmacology & therapeutics, 1995, Volume: 9, Issue:2

    Topics: Adolescent; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Double-Blind Method; Etodolac; Gas

1995
A randomized double-blind comparison of placebo, etodolac, and naproxen on gastrointestinal injury and prostaglandin production.
    Gastrointestinal endoscopy, 1995, Volume: 42, Issue:5

    Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Biopsy; Dinoprostone; Double-Blind Method; Drug Admi

1995

Other Studies

8 other studies available for etodolac and Gastric Ulcer

ArticleYear
Cycloalkanoindoles. 1. Syntheses and antiinflammatory actions of some acidic tetrahydrocarbazoles, cyclopentindoles, and cycloheptindoles.
    Journal of medicinal chemistry, 1976, Volume: 19, Issue:6

    Topics: Animals; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Carbazoles; Cycloheptanes; Cyclopentanes;

1976
Etodolic acid and related compounds. Chemistry and antiinflammatory actions of some potent di- and trisubstituted 1, 3, 4, 9-tetrahydropyrano[3, 4-b]indole-1-acetic acids.
    Journal of medicinal chemistry, 1976, Volume: 19, Issue:3

    Topics: Animals; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Carrageenan; Freund's Adjuvant; Indoleacet

1976
Synthesis and biological evaluation of new prodrugs of etodolac and tolfenamic acid with reduced ulcerogenic potential.
    European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 2019, Dec-01, Volume: 140

    Topics: Animals; Anti-Inflammatory Agents; Drug Design; Drug Stability; Edema; Etodolac; Female; Humans; Hyd

2019
Predictive Factors for NSAIDs-related Gastrointestinal Toxicity: Can COX-2 Selective Inhibtor Prevent it?.
    Hepato-gastroenterology, 2015, Volume: 62, Issue:140

    Topics: Adrenal Cortex Hormones; Aged; Anti-Inflammatory Agents, Non-Steroidal; Anticoagulants; Antineoplast

2015
Anti-inflammatory, antinociceptive, and gastric effects of Hypericum perforatum in rats.
    TheScientificWorldJournal, 2005, Aug-08, Volume: 5

    Topics: Acetic Acid; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Capsaicin;

2005
Anti-inflammatory effects of etodolac: comparison with other non-steroidal anti-inflammatory drugs.
    Biological & pharmaceutical bulletin, 1994, Volume: 17, Issue:12

    Topics: Acetates; Acetic Acid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Ca

1994
Neutropenia does not prevent etodolac- or indomethacin-induced gastrointestinal damage in the rat.
    Digestive diseases and sciences, 1995, Volume: 40, Issue:12

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antilymphocyte Serum; Etodolac; Gastric Mucosa; Ga

1995
Images in clinical medicine. An aspirin tablet and a gastric ulcer.
    The New England journal of medicine, 2000, Sep-21, Volume: 343, Issue:12

    Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Etodolac; Female; Foreign Bodies; Gastroscop

2000