etodolac has been researched along with Gastric Ulcer in 10 studies
Etodolac: A non-steroidal anti-inflammatory agent and cyclooxygenase-2 (COX-2) inhibitor with potent analgesic and anti-arthritic properties. It has been shown to be effective in the treatment of OSTEOARTHRITIS; RHEUMATOID ARTHRITIS; ANKYLOSING SPONDYLITIS; and in the alleviation of postoperative pain (PAIN, POSTOPERATIVE).
etodolac : A monocarboxylic acid that is acetic acid in which one of the methyl hydrogens is substituted by a 1,8-diethyl-1,3,4,9-tetrahydropyrano[3,4-b]indol-1-yl moiety. A preferential inhibitor of cyclo-oxygenase 2 and non-steroidal anti-inflammatory, it is used for the treatment of rheumatoid arthritis and osteoarthritis, and for the alleviation of postoperative pain. Administered as the racemate, only the (S)-enantiomer is active.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The aims of the present study were to determine, in rats, the role of neutrophils in the pathogenesis of etodolac- and indomethacin-induced gastrointestinal ulceration and blood loss." | 7.69 | Neutropenia does not prevent etodolac- or indomethacin-induced gastrointestinal damage in the rat. ( Fuller, J; Gentry, C; Melarange, R; Smith, PH; Toseland, CD, 1995) |
| "At week 1 the mean number and area of gastric ulcers per subject were greater with naproxen than placebo or etodolac (area: naproxen, 7." | 5.08 | A randomized double-blind comparison of placebo, etodolac, and naproxen on gastrointestinal injury and prostaglandin production. ( Cominelli, F; Ferretti, M; Laine, L; Sloane, R, 1995) |
| " Eto inhibited carrageenin-induced edema in rats, adjuvant-induced arthritis in rats, acetic acid-induced writhing in mice and brewer's yeast-induced hyperalgesia and fever in rats." | 3.69 | Anti-inflammatory effects of etodolac: comparison with other non-steroidal anti-inflammatory drugs. ( Fujisawa, H; Inoue, K; Inoue, Y; Kimura, K; Kyoi, T; Motonaga, A; Ueda, F, 1994) |
| " The aims of the present study were to determine, in rats, the role of neutrophils in the pathogenesis of etodolac- and indomethacin-induced gastrointestinal ulceration and blood loss." | 3.69 | Neutropenia does not prevent etodolac- or indomethacin-induced gastrointestinal damage in the rat. ( Fuller, J; Gentry, C; Melarange, R; Smith, PH; Toseland, CD, 1995) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (20.00) | 18.7374 |
| 1990's | 4 (40.00) | 18.2507 |
| 2000's | 2 (20.00) | 29.6817 |
| 2010's | 2 (20.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Asselin, AA | 1 |
| Humber, LG | 2 |
| Dobson, TA | 1 |
| Komlossy, J | 1 |
| Martel, RR | 1 |
| Demerson, CA | 1 |
| Philipp, AH | 1 |
| Hassib, ST | 1 |
| Hassan, GS | 1 |
| El-Zaher, AA | 1 |
| Fouad, MA | 1 |
| Abd El-Ghafar, OA | 1 |
| Taha, EA | 1 |
| Kanbayashi, Y | 1 |
| Konishi, H | 1 |
| Abdel-Salam, OM | 1 |
| Laine, L | 2 |
| Cominelli, F | 2 |
| Sloane, R | 2 |
| Casini-Raggi, V | 1 |
| Marin-Sorensen, M | 1 |
| Weinstein, WM | 1 |
| Inoue, K | 1 |
| Fujisawa, H | 1 |
| Motonaga, A | 1 |
| Inoue, Y | 1 |
| Kyoi, T | 1 |
| Ueda, F | 1 |
| Kimura, K | 1 |
| Melarange, R | 1 |
| Gentry, C | 1 |
| Toseland, CD | 1 |
| Smith, PH | 1 |
| Fuller, J | 1 |
| Ferretti, M | 1 |
| Levy, DJ | 1 |
2 trials available for etodolac and Gastric Ulcer
| Article | Year |
|---|---|
Interaction of NSAIDs and Helicobacter pylori on gastrointestinal injury and prostaglandin production: a controlled double-blind trial.
Topics: Adolescent; Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Double-Blind Method; Etodolac; Gas | 1995 |
A randomized double-blind comparison of placebo, etodolac, and naproxen on gastrointestinal injury and prostaglandin production.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Biopsy; Dinoprostone; Double-Blind Method; Drug Admi | 1995 |
8 other studies available for etodolac and Gastric Ulcer
| Article | Year |
|---|---|
Cycloalkanoindoles. 1. Syntheses and antiinflammatory actions of some acidic tetrahydrocarbazoles, cyclopentindoles, and cycloheptindoles.
Topics: Animals; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Carbazoles; Cycloheptanes; Cyclopentanes; | 1976 |
Etodolic acid and related compounds. Chemistry and antiinflammatory actions of some potent di- and trisubstituted 1, 3, 4, 9-tetrahydropyrano[3, 4-b]indole-1-acetic acids.
Topics: Animals; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Carrageenan; Freund's Adjuvant; Indoleacet | 1976 |
Synthesis and biological evaluation of new prodrugs of etodolac and tolfenamic acid with reduced ulcerogenic potential.
Topics: Animals; Anti-Inflammatory Agents; Drug Design; Drug Stability; Edema; Etodolac; Female; Humans; Hyd | 2019 |
Predictive Factors for NSAIDs-related Gastrointestinal Toxicity: Can COX-2 Selective Inhibtor Prevent it?.
Topics: Adrenal Cortex Hormones; Aged; Anti-Inflammatory Agents, Non-Steroidal; Anticoagulants; Antineoplast | 2015 |
Anti-inflammatory, antinociceptive, and gastric effects of Hypericum perforatum in rats.
Topics: Acetic Acid; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Capsaicin; | 2005 |
Anti-inflammatory effects of etodolac: comparison with other non-steroidal anti-inflammatory drugs.
Topics: Acetates; Acetic Acid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Ca | 1994 |
Neutropenia does not prevent etodolac- or indomethacin-induced gastrointestinal damage in the rat.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antilymphocyte Serum; Etodolac; Gastric Mucosa; Ga | 1995 |
Images in clinical medicine. An aspirin tablet and a gastric ulcer.
Topics: Aged; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Etodolac; Female; Foreign Bodies; Gastroscop | 2000 |