etodolac has been researched along with Cancer of Liver in 8 studies
Etodolac: A non-steroidal anti-inflammatory agent and cyclooxygenase-2 (COX-2) inhibitor with potent analgesic and anti-arthritic properties. It has been shown to be effective in the treatment of OSTEOARTHRITIS; RHEUMATOID ARTHRITIS; ANKYLOSING SPONDYLITIS; and in the alleviation of postoperative pain (PAIN, POSTOPERATIVE).
etodolac : A monocarboxylic acid that is acetic acid in which one of the methyl hydrogens is substituted by a 1,8-diethyl-1,3,4,9-tetrahydropyrano[3,4-b]indol-1-yl moiety. A preferential inhibitor of cyclo-oxygenase 2 and non-steroidal anti-inflammatory, it is used for the treatment of rheumatoid arthritis and osteoarthritis, and for the alleviation of postoperative pain. Administered as the racemate, only the (S)-enantiomer is active.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We injected colon 26, a colorectal cancer cell line, in CDF1 mouse spleen and, from the following day, two kinds of COX-2 inhibitor (etodolac and nimesulide) were administered orally." | 5.33 | Etodolac, a selective cyclooxygenase-2 inhibitor, inhibits liver metastasis of colorectal cancer cells via the suppression of MMP-9 activity. ( Aoki, T; Hisada, M; Ishizaki, T; Katsumata, K; Kawakita, H; Mori, Y; Tsuchida, A; Wada, T, 2006) |
| "Etodolac was without influence at concentrations up to 100 μM." | 1.39 | Pharmacological inhibition of beta-catenin in hepatoblastoma cells. ( Armeanu-Ebinger, S; Ellerkamp, V; Fuchs, J; Lieber, J; Nagel, C; Warmann, SW; Wenz, J, 2013) |
| "Inhibition of hepatoma cells by cyclooxygenase (COX)-2-dependent and -independent mechanisms has been shown previously." | 1.34 | R-Etodolac decreases beta-catenin levels along with survival and proliferation of hepatoma cells. ( Behari, J; Leoni, L; Micsenyi, A; Monga, SP; Muller, P; Otruba, W; Sekhon, SS; Thompson, MD; Zeng, G, 2007) |
| "We injected colon 26, a colorectal cancer cell line, in CDF1 mouse spleen and, from the following day, two kinds of COX-2 inhibitor (etodolac and nimesulide) were administered orally." | 1.33 | Etodolac, a selective cyclooxygenase-2 inhibitor, inhibits liver metastasis of colorectal cancer cells via the suppression of MMP-9 activity. ( Aoki, T; Hisada, M; Ishizaki, T; Katsumata, K; Kawakita, H; Mori, Y; Tsuchida, A; Wada, T, 2006) |
| "Etodolac did not increase the inhibitory effect of 5-FU on cell proliferation." | 1.32 | Combined treatment with selective cyclooxygenase-2 inhibitor and fluorinated pyrimidines for liver metastasis of colon cancer. ( Hirakawa, K; Matsunaga, N; Nishiguchi, Y; Nishino, H; Ohira, M; Seki, S; Tachimori, A; Yamada, N, 2004) |
| "Three different colon cancer cell lines, SW620, Lovo, HT-29 and a metastatic variant of HT-29, HT-29/Inv3, were employed to evaluate COX-2 expression and prostaglandin E(2) (PGE2) production in relation to their invasive abilities in vitro." | 1.31 | Tumor invasiveness and liver metastasis of colon cancer cells correlated with cyclooxygenase-2 (COX-2) expression and inhibited by a COX-2-selective inhibitor, etodolac. ( Chen, WS; Hsiao, M; Kou-Lin, J; Liu, JM; Wei, SJ; Yang, WK, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 6 (75.00) | 29.6817 |
| 2010's | 2 (25.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Sorski, L | 1 |
| Melamed, R | 1 |
| Matzner, P | 1 |
| Lavon, H | 1 |
| Shaashua, L | 1 |
| Rosenne, E | 1 |
| Ben-Eliyahu, S | 1 |
| Ellerkamp, V | 1 |
| Lieber, J | 1 |
| Nagel, C | 1 |
| Wenz, J | 1 |
| Warmann, SW | 1 |
| Fuchs, J | 1 |
| Armeanu-Ebinger, S | 1 |
| Matsunaga, N | 2 |
| Yamada, N | 2 |
| Hirakawa, K | 2 |
| Ohira, M | 1 |
| Tachimori, A | 1 |
| Nishiguchi, Y | 1 |
| Nishino, H | 1 |
| Seki, S | 1 |
| Cheng, J | 1 |
| Imanishi, H | 1 |
| Liu, W | 1 |
| Nakamura, H | 1 |
| Morisaki, T | 1 |
| Higashino, K | 1 |
| Hada, T | 1 |
| Ishizaki, T | 1 |
| Katsumata, K | 1 |
| Tsuchida, A | 1 |
| Wada, T | 1 |
| Mori, Y | 1 |
| Hisada, M | 1 |
| Kawakita, H | 1 |
| Aoki, T | 1 |
| Behari, J | 1 |
| Zeng, G | 1 |
| Otruba, W | 1 |
| Thompson, MD | 1 |
| Muller, P | 1 |
| Micsenyi, A | 1 |
| Sekhon, SS | 1 |
| Leoni, L | 1 |
| Monga, SP | 1 |
| Chen, WS | 1 |
| Wei, SJ | 1 |
| Liu, JM | 1 |
| Hsiao, M | 1 |
| Kou-Lin, J | 1 |
| Yang, WK | 1 |
8 other studies available for etodolac and Cancer of Liver
| Article | Year |
|---|---|
Reducing liver metastases of colon cancer in the context of extensive and minor surgeries through β-adrenoceptors blockade and COX2 inhibition.
Topics: Adrenergic beta-Agonists; Animals; Antineoplastic Agents; Cell Line, Tumor; Colonic Neoplasms; Cyclo | 2016 |
Pharmacological inhibition of beta-catenin in hepatoblastoma cells.
Topics: Antineoplastic Agents; beta Catenin; Bridged Bicyclo Compounds, Heterocyclic; Celecoxib; Cell Line, | 2013 |
[Combined treatment with fluorinated pyrimidines and selective cyclooxygenase-2 inhibitors for liver metastasis of colon cancer].
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Division; Colonic Neoplasms; Cyclooxyg | 2003 |
Combined treatment with selective cyclooxygenase-2 inhibitor and fluorinated pyrimidines for liver metastasis of colon cancer.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Division; Cell Line, Tumor; Cell Movem | 2004 |
Involvement of cell cycle regulatory proteins and MAP kinase signaling pathway in growth inhibition and cell cycle arrest by a selective cyclooxygenase 2 inhibitor, etodolac, in human hepatocellular carcinoma cell lines.
Topics: Carcinoma, Hepatocellular; Cell Cycle; Cell Cycle Proteins; Cell Division; Cyclin-Dependent Kinases; | 2004 |
Etodolac, a selective cyclooxygenase-2 inhibitor, inhibits liver metastasis of colorectal cancer cells via the suppression of MMP-9 activity.
Topics: Animals; Cell Line, Tumor; Colorectal Neoplasms; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Etodol | 2006 |
R-Etodolac decreases beta-catenin levels along with survival and proliferation of hepatoma cells.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; beta Catenin; Cadherins; Carcinoma, | 2007 |
Tumor invasiveness and liver metastasis of colon cancer cells correlated with cyclooxygenase-2 (COX-2) expression and inhibited by a COX-2-selective inhibitor, etodolac.
Topics: Aged; Aged, 80 and over; Cell Division; Cell Survival; Colonic Neoplasms; Cyclooxygenase 2; Cyclooxy | 2001 |