etodolac has been researched along with Cancer of Colon in 11 studies
Etodolac: A non-steroidal anti-inflammatory agent and cyclooxygenase-2 (COX-2) inhibitor with potent analgesic and anti-arthritic properties. It has been shown to be effective in the treatment of OSTEOARTHRITIS; RHEUMATOID ARTHRITIS; ANKYLOSING SPONDYLITIS; and in the alleviation of postoperative pain (PAIN, POSTOPERATIVE).
etodolac : A monocarboxylic acid that is acetic acid in which one of the methyl hydrogens is substituted by a 1,8-diethyl-1,3,4,9-tetrahydropyrano[3,4-b]indol-1-yl moiety. A preferential inhibitor of cyclo-oxygenase 2 and non-steroidal anti-inflammatory, it is used for the treatment of rheumatoid arthritis and osteoarthritis, and for the alleviation of postoperative pain. Administered as the racemate, only the (S)-enantiomer is active.
| Excerpt | Relevance | Reference |
|---|---|---|
| "iii) Treatment with etodolac alone." | 5.35 | Inhibitory effects of the cyclooxygenase-2 inhibitor, etodolac, on colitis-associated tumorigenesis in p53-deficient mice treated with dextran sulfate sodium. ( Abe, A; Fujii, S; Fujimori, T; Fukui, H; Hiraishi, H; Ichikawa, K; Imura, J; Kono, T; Mukawa, K; Ono, Y; Sekikawa, A; Shinoda, M; Tominaga, K; Tomita, S; Yoshitake, N, 2008) |
| "iii) Treatment with etodolac alone." | 1.35 | Inhibitory effects of the cyclooxygenase-2 inhibitor, etodolac, on colitis-associated tumorigenesis in p53-deficient mice treated with dextran sulfate sodium. ( Abe, A; Fujii, S; Fujimori, T; Fukui, H; Hiraishi, H; Ichikawa, K; Imura, J; Kono, T; Mukawa, K; Ono, Y; Sekikawa, A; Shinoda, M; Tominaga, K; Tomita, S; Yoshitake, N, 2008) |
| "Etodolac did not increase the inhibitory effect of 5-FU on cell proliferation." | 1.32 | Combined treatment with selective cyclooxygenase-2 inhibitor and fluorinated pyrimidines for liver metastasis of colon cancer. ( Hirakawa, K; Matsunaga, N; Nishiguchi, Y; Nishino, H; Ohira, M; Seki, S; Tachimori, A; Yamada, N, 2004) |
| "Three different colon cancer cell lines, SW620, Lovo, HT-29 and a metastatic variant of HT-29, HT-29/Inv3, were employed to evaluate COX-2 expression and prostaglandin E(2) (PGE2) production in relation to their invasive abilities in vitro." | 1.31 | Tumor invasiveness and liver metastasis of colon cancer cells correlated with cyclooxygenase-2 (COX-2) expression and inhibited by a COX-2-selective inhibitor, etodolac. ( Chen, WS; Hsiao, M; Kou-Lin, J; Liu, JM; Wei, SJ; Yang, WK, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 9 (81.82) | 29.6817 |
| 2010's | 2 (18.18) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Sorski, L | 1 |
| Melamed, R | 1 |
| Matzner, P | 1 |
| Lavon, H | 1 |
| Shaashua, L | 1 |
| Rosenne, E | 1 |
| Ben-Eliyahu, S | 1 |
| Inoue, T | 1 |
| Murano, M | 1 |
| Yoda, Y | 1 |
| Kuramoto, T | 1 |
| Kakimoto, K | 1 |
| Ishida, K | 1 |
| Kawakami, K | 1 |
| Abe, Y | 1 |
| Morita, E | 1 |
| Murano, N | 1 |
| Tokioka, S | 1 |
| Maemura, K | 1 |
| Umegaki, E | 1 |
| Higuchi, K | 1 |
| Chen, WS | 3 |
| Liu, JH | 2 |
| Wei, SJ | 2 |
| Liu, JM | 3 |
| Hong, CY | 1 |
| Yang, WK | 2 |
| Sano, Y | 2 |
| Kuga, R | 1 |
| Fu, KI | 2 |
| Yoshino, T | 1 |
| Yoshida, S | 2 |
| Ochiai, A | 2 |
| Fujii, T | 1 |
| Matsunaga, N | 2 |
| Yamada, N | 2 |
| Hirakawa, K | 2 |
| Ohira, M | 1 |
| Tachimori, A | 1 |
| Nishiguchi, Y | 1 |
| Nishino, H | 1 |
| Seki, S | 1 |
| Lin, JK | 1 |
| Takeda, J | 1 |
| Kitajima, K | 1 |
| Fujii, S | 2 |
| Horiuchi, H | 1 |
| Hori, H | 1 |
| Chibana, Y | 1 |
| Okuyama, T | 1 |
| Tominaga, K | 2 |
| Ichikawa, K | 2 |
| Ono, Y | 2 |
| Teramoto, T | 1 |
| Ohkura, Y | 1 |
| Imura, J | 2 |
| Shinoda, M | 2 |
| Chiba, T | 1 |
| Sakamoto, C | 1 |
| Kawamata, H | 1 |
| Fujimori, T | 3 |
| Kaihara, T | 1 |
| Yamashita, K | 1 |
| Mukawa, K | 1 |
| Yoshitake, N | 1 |
| Abe, A | 1 |
| Kono, T | 1 |
| Sekikawa, A | 1 |
| Fukui, H | 1 |
| Tomita, S | 1 |
| Hiraishi, H | 1 |
| Hsiao, M | 1 |
| Kou-Lin, J | 1 |
11 other studies available for etodolac and Cancer of Colon
| Article | Year |
|---|---|
Reducing liver metastases of colon cancer in the context of extensive and minor surgeries through β-adrenoceptors blockade and COX2 inhibition.
Topics: Adrenergic beta-Agonists; Animals; Antineoplastic Agents; Cell Line, Tumor; Colonic Neoplasms; Cyclo | 2016 |
R-etodolac induces E-cadherin and suppresses colitis-related mouse colon tumorigenesis.
Topics: Animals; Antineoplastic Agents; Cadherins; Carcinoma; Colitis; Colonic Neoplasms; Cyclooxygenase 2; | 2010 |
Colon cancer cells with high invasive potential are susceptible to induction of apoptosis by a selective COX-2 inhibitor.
Topics: Animals; Apoptosis; Cell Survival; Colonic Neoplasms; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; | 2003 |
Superficially elevated colonic adenoma changed to undetectable configuration on ordinary endoscopy during treatment with preferential cyclooxygenase-2 inhibitor.
Topics: Adenoma; Colonic Neoplasms; Colonoscopy; Cyclooxygenase Inhibitors; Etodolac; Humans | 2003 |
[Combined treatment with fluorinated pyrimidines and selective cyclooxygenase-2 inhibitors for liver metastasis of colon cancer].
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Division; Colonic Neoplasms; Cyclooxyg | 2003 |
Combined treatment with selective cyclooxygenase-2 inhibitor and fluorinated pyrimidines for liver metastasis of colon cancer.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Division; Cell Line, Tumor; Cell Movem | 2004 |
Sequence-dependent effect of a cyclooxygenase-2 inhibitor on topoisomerase I inhibitor and 5-fluorouracil-induced cytotoxicity of colon cancer cells.
Topics: Apoptosis; Cell Line, Tumor; Colonic Neoplasms; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclo | 2004 |
Inhibitory effects of etodolac, a selective COX-2 inhibitor, on the occurrence of tumors in colitis-induced tumorigenesis model in rats.
Topics: Animals; Colitis; Colonic Neoplasms; Cyclooxygenase Inhibitors; Disease Models, Animal; Etodolac; In | 2004 |
Depressed-type early invasive colon cancer in a patient treated with cyclooxygenase-2 inhibitor.
Topics: Adenocarcinoma; Anti-Inflammatory Agents, Non-Steroidal; Colonic Neoplasms; Colonic Polyps; Cyclooxy | 2006 |
Inhibitory effects of the cyclooxygenase-2 inhibitor, etodolac, on colitis-associated tumorigenesis in p53-deficient mice treated with dextran sulfate sodium.
Topics: Animals; Cell Transformation, Neoplastic; Chemoprevention; Colitis; Colonic Neoplasms; Cyclooxygenas | 2008 |
Tumor invasiveness and liver metastasis of colon cancer cells correlated with cyclooxygenase-2 (COX-2) expression and inhibited by a COX-2-selective inhibitor, etodolac.
Topics: Aged; Aged, 80 and over; Cell Division; Cell Survival; Colonic Neoplasms; Cyclooxygenase 2; Cyclooxy | 2001 |