Page last updated: 2024-10-26

etodolac and Anasarca

etodolac has been researched along with Anasarca in 21 studies

Etodolac: A non-steroidal anti-inflammatory agent and cyclooxygenase-2 (COX-2) inhibitor with potent analgesic and anti-arthritic properties. It has been shown to be effective in the treatment of OSTEOARTHRITIS; RHEUMATOID ARTHRITIS; ANKYLOSING SPONDYLITIS; and in the alleviation of postoperative pain (PAIN, POSTOPERATIVE).
etodolac : A monocarboxylic acid that is acetic acid in which one of the methyl hydrogens is substituted by a 1,8-diethyl-1,3,4,9-tetrahydropyrano[3,4-b]indol-1-yl moiety. A preferential inhibitor of cyclo-oxygenase 2 and non-steroidal anti-inflammatory, it is used for the treatment of rheumatoid arthritis and osteoarthritis, and for the alleviation of postoperative pain. Administered as the racemate, only the (S)-enantiomer is active.

Research Excerpts

ExcerptRelevanceReference
"This study aimed to conduct a randomized prospective study about the efficacy of etodolac and ibuprofen on trismus, pain and edema regarding gender of patients submitted to impacted lower third molar teeth extraction."9.41The efficacy of etodolac and ibuprofen, regarding gender, on pain, edema and trismus after impacted lower third molar surgery: A randomized prospective clinical split-mouth study. ( Farnezi Bassi, AP; Faverani, LP; Reis, EN; Silva, LD, 2021)
"To compare the efficacy of ibuprofen (IBU) and etodolac (ETO) for controlling pain, edema, and trismus after extraction of lower third molars."9.22Comparative Assessment of the Effect of Ibuprofen and Etodolac on Edema, Trismus, and Pain in Lower Third Molar Surgery: A Randomized Clinical Trial. ( Bassi, AP; Grossi de Oliveira, GA; Silva de Oliveira, JC, 2016)
"This study aimed to conduct a randomized prospective study about the efficacy of etodolac and ibuprofen on trismus, pain and edema regarding gender of patients submitted to impacted lower third molar teeth extraction."5.41The efficacy of etodolac and ibuprofen, regarding gender, on pain, edema and trismus after impacted lower third molar surgery: A randomized prospective clinical split-mouth study. ( Farnezi Bassi, AP; Faverani, LP; Reis, EN; Silva, LD, 2021)
"To compare the efficacy of ibuprofen (IBU) and etodolac (ETO) for controlling pain, edema, and trismus after extraction of lower third molars."5.22Comparative Assessment of the Effect of Ibuprofen and Etodolac on Edema, Trismus, and Pain in Lower Third Molar Surgery: A Randomized Clinical Trial. ( Bassi, AP; Grossi de Oliveira, GA; Silva de Oliveira, JC, 2016)
" Eto inhibited carrageenin-induced edema in rats, adjuvant-induced arthritis in rats, acetic acid-induced writhing in mice and brewer's yeast-induced hyperalgesia and fever in rats."3.69Anti-inflammatory effects of etodolac: comparison with other non-steroidal anti-inflammatory drugs. ( Fujisawa, H; Inoue, K; Inoue, Y; Kimura, K; Kyoi, T; Motonaga, A; Ueda, F, 1994)
" The aim of the present study was to compare nabumetone, a nonacidic drug, with etodolac on rat gastric mucosal damage and prostanoid synthesis, while concurrently measuring prostanoid production during edema formation in a carrageenan model of paw inflammation."3.69Gastrointestinal irritancy, antiinflammatory activity, and prostanoid inhibition in the rat. Differentiation of effects between nabumetone and etodolac. ( Blower, PR; Durie, M; Gentry, C; Melarange, R; O'Connell, C, 1994)
") suppressed concanavalin A-induced paw edema in rats."3.68Mechanism of anti-inflammatory action of etodolac. ( Fujisawa, H; Inoue, K; Kimura, K; Miki, N; Motonaga, A; Nishimura, T; Shibata, Y; Ueda, F; Yokota, M, 1991)
"Using the curative model of adjuvant arthritis, adult male Sprague-Dawley rats were treated with vehicle or etodolac (1, 3, and 8 mg/kg/day, po) for 9 days."3.67Temporal relationships of the anti-inflammatory effect of etodolac in the adjuvant arthritic rat. ( Chau, TT; Lee, DK; Weichman, BM; Wooley, PH, 1988)
"Edema was similar among all groups at all time points (P > ."3.01Combination of etodolac and dexamethasone improves preemptive analgesia in third molar surgery: a randomized study. ( Barbosa, S; Bassi, APF; de Souza Santos, AM; Faverani, LP; Momesso, GAC; Polo, TOB; Ramires, GAD; Silva, WPP, 2021)
"No difference was noted regarding trismus in any of the groups."2.79Comparison of the effect of naproxen, etodolac and diclofenac on postoperative sequels following third molar surgery: a randomised, double-blind, crossover study. ( Akbulut, N; Atakan, C; Çölok, G; Üstüner, E, 2014)
"Etodolac was loaded into the prepared gels or added during the gel formation."1.46Self-Assembling Organogels Based on Pluronic and Lecithin for Sustained Release of Etodolac: In Vitro and In Vivo Correlation. ( Faisal, W; Mohammed, AM; Osman, SK; Saleh, KI, 2017)
"The objective of this study was to prepare a self-emulsifying drug delivery system (SEDDS) for oral bioavailability enhancement of a poorly water-soluble drug, etodolac."1.36Enhanced oral bioavailability of etodolac by self-emulsifying systems: in-vitro and in-vivo evaluation. ( Barakat, NS, 2010)
"Etodolac had no effect on delayed hypersensitivity reactions and was much less ulcerogenic than indometacin."1.28Pharmacological properties of the new non-steroidal anti-inflammatory agent etodolac. ( Fujisawa, H; Inoue, K; Inoue, Y; Masuda, T; Nishimura, I; Nishimura, T; Sasaki, Y; Shibata, Y; Ueda, F; Yokota, M, 1991)

Research

Studies (21)

TimeframeStudies, this research(%)All Research%
pre-19904 (19.05)18.7374
1990's5 (23.81)18.2507
2000's4 (19.05)29.6817
2010's6 (28.57)24.3611
2020's2 (9.52)2.80

Authors

AuthorsStudies
Asselin, AA1
Humber, LG3
Dobson, TA1
Komlossy, J1
Ferdinandi, E1
Demerson, CA2
Ahmed, S1
Shah, U2
Mobilio, D2
Sabatucci, J1
De Lange, B1
Labbadia, F2
Hughes, P2
Katz, AH1
Brigance, R1
Conway, K1
Williams, G1
Biava, M1
Porretta, GC1
Poce, G1
Supino, S1
Manetti, F1
Forli, S1
Botta, M1
Sautebin, L1
Rossi, A1
Pergola, C1
Ghelardini, C1
Norcini, M1
Makovec, F1
Giordani, A1
Anzellotti, P1
Cirilli, R1
Ferretti, R1
Gallinella, B1
La Torre, F1
Anzini, M1
Patrignani, P1
Hassib, ST1
Hassan, GS1
El-Zaher, AA1
Fouad, MA1
Abd El-Ghafar, OA1
Taha, EA1
Ramires, GAD1
de Souza Santos, AM1
Momesso, GAC1
Polo, TOB1
Silva, WPP1
Barbosa, S1
Bassi, APF1
Faverani, LP2
Silva, LD1
Reis, EN1
Farnezi Bassi, AP1
Akbulut, N1
Üstüner, E1
Atakan, C1
Çölok, G1
Silva de Oliveira, JC1
Grossi de Oliveira, GA1
Bassi, AP1
Mohammed, AM1
Faisal, W1
Saleh, KI1
Osman, SK1
Inoue, N2
Ito, S1
Tajima, K1
Nogawa, M1
Takahashi, Y1
Sasagawa, T1
Nakamura, A1
Kyoi, T2
Rozin, AP1
Kagna, O1
Shiller, Y1
Barakat, NS1
Tachibana, M1
Yoshida, E1
Matsui, M1
Ukai, Y1
Yano, J1
Abdel-Salam, OM1
Inoue, K3
Fujisawa, H3
Motonaga, A2
Inoue, Y2
Ueda, F3
Kimura, K3
Melarange, R1
Gentry, C1
Durie, M1
O'Connell, C1
Blower, PR1
Sasaki, Y1
Nishimura, T2
Nishimura, I1
Yokota, M2
Masuda, T1
Shibata, Y3
Miki, N1
Yoshida-Suzuka, H1
Nakamura, Y1
Lee, DK1
Chau, TT1
Weichman, BM1
Wooley, PH1

Trials

4 trials available for etodolac and Anasarca

ArticleYear
Combination of etodolac and dexamethasone improves preemptive analgesia in third molar surgery: a randomized study.
    Clinical oral investigations, 2021, Volume: 25, Issue:4

    Topics: Analgesia; Dexamethasone; Double-Blind Method; Edema; Etodolac; Humans; Molar, Third; Pain, Postoper

2021
The efficacy of etodolac and ibuprofen, regarding gender, on pain, edema and trismus after impacted lower third molar surgery: A randomized prospective clinical split-mouth study.
    Medicina oral, patologia oral y cirugia bucal, 2021, Mar-01, Volume: 26, Issue:2

    Topics: Adolescent; Adult; Edema; Etodolac; Female; Humans; Ibuprofen; Male; Molar, Third; Mouth; Pain, Post

2021
Comparison of the effect of naproxen, etodolac and diclofenac on postoperative sequels following third molar surgery: a randomised, double-blind, crossover study.
    Medicina oral, patologia oral y cirugia bucal, 2014, Mar-01, Volume: 19, Issue:2

    Topics: Adolescent; Adult; Anti-Inflammatory Agents, Non-Steroidal; Cross-Over Studies; Diclofenac; Double-B

2014
Comparative Assessment of the Effect of Ibuprofen and Etodolac on Edema, Trismus, and Pain in Lower Third Molar Surgery: A Randomized Clinical Trial.
    Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons, 2016, Volume: 74, Issue:8

    Topics: Adolescent; Cyclooxygenase 2 Inhibitors; Edema; Etodolac; Female; Humans; Ibuprofen; Male; Mandible;

2016

Other Studies

17 other studies available for etodolac and Anasarca

ArticleYear
Cycloalkanoindoles. 1. Syntheses and antiinflammatory actions of some acidic tetrahydrocarbazoles, cyclopentindoles, and cycloheptindoles.
    Journal of medicinal chemistry, 1976, Volume: 19, Issue:6

    Topics: Animals; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Carbazoles; Cycloheptanes; Cyclopentanes;

1976
Etodolac, a novel antiinflammatory agent. The syntheses and biological evaluation of its metabolites.
    Journal of medicinal chemistry, 1988, Volume: 31, Issue:9

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cartilage; Cells, Cultured; Chemical Phenomena; Ch

1988
Structure-activity relationships among analogues of pemedolac, cis-1-ethyl-1,3,4,9-tetrahydro-4-(phenylmethyl)pyrano[3,4-b]indo le-1-a cetic acid, a potent analgesic agent.
    Journal of medicinal chemistry, 1988, Volume: 31, Issue:11

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Edema; In Vitro Techniques; Indoleacetic Acids; Ma

1988
Synthesis, in vitro, and in vivo biological evaluation and molecular docking simulations of chiral alcohol and ether derivatives of the 1,5-diarylpyrrole scaffold as novel anti-inflammatory and analgesic agents.
    Bioorganic & medicinal chemistry, 2008, Sep-01, Volume: 16, Issue:17

    Topics: Acetic Acid; Alcohols; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Binding Sites;

2008
Synthesis and biological evaluation of new prodrugs of etodolac and tolfenamic acid with reduced ulcerogenic potential.
    European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 2019, Dec-01, Volume: 140

    Topics: Animals; Anti-Inflammatory Agents; Drug Design; Drug Stability; Edema; Etodolac; Female; Humans; Hyd

2019
Self-Assembling Organogels Based on Pluronic and Lecithin for Sustained Release of Etodolac: In Vitro and In Vivo Correlation.
    Current drug delivery, 2017, Volume: 14, Issue:7

    Topics: Administration, Cutaneous; Animals; Carrageenan; Cyclooxygenase 2 Inhibitors; Delayed-Action Prepara

2017
Etodolac attenuates mechanical allodynia in a mouse model of neuropathic pain.
    Journal of pharmacological sciences, 2009, Volume: 109, Issue:4

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Celecoxib; Cyclooxygenase 2 Inhibitor

2009
Sacroiliitis and severe disability due to isotretinoin therapy.
    Rheumatology international, 2010, Volume: 30, Issue:7

    Topics: Acne Vulgaris; Adrenocorticotropic Hormone; Adult; Anti-Inflammatory Agents, Non-Steroidal; Arthralg

2010
Enhanced oral bioavailability of etodolac by self-emulsifying systems: in-vitro and in-vivo evaluation.
    The Journal of pharmacy and pharmacology, 2010, Volume: 62, Issue:2

    Topics: Absorption; Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Biological Avail

2010
Anti-inflammatory effect and low ulcerogenic activity of etodolac, a cyclooxygenase-2 selective non-steroidal anti-inflammatory drug, on adjuvant-induced arthritis in rats.
    Pharmacology, 2003, Volume: 68, Issue:2

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Cyclooxygenase Inhibitors; Diclofenac;

2003
Anti-inflammatory, antinociceptive, and gastric effects of Hypericum perforatum in rats.
    TheScientificWorldJournal, 2005, Aug-08, Volume: 5

    Topics: Acetic Acid; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Capsaicin;

2005
Anti-inflammatory effects of etodolac: comparison with other non-steroidal anti-inflammatory drugs.
    Biological & pharmaceutical bulletin, 1994, Volume: 17, Issue:12

    Topics: Acetates; Acetic Acid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Ca

1994
Gastrointestinal irritancy, antiinflammatory activity, and prostanoid inhibition in the rat. Differentiation of effects between nabumetone and etodolac.
    Digestive diseases and sciences, 1994, Volume: 39, Issue:3

    Topics: 6-Ketoprostaglandin F1 alpha; Animals; Anti-Inflammatory Agents, Non-Steroidal; Butanones; Cecum; De

1994
Pharmacological properties of the new non-steroidal anti-inflammatory agent etodolac.
    Arzneimittel-Forschung, 1991, Volume: 41, Issue:3

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Cartilage, Articular; Che

1991
Mechanism of anti-inflammatory action of etodolac.
    Arzneimittel-Forschung, 1991, Volume: 41, Issue:3

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Bradykinin; Capillary Permeability; Concanavalin A

1991
Effect of etodolac, a new nonsteroidal anti-inflammatory drug, in MRL/lpr mice with articular lesions.
    Agents and actions, 1991, Volume: 33, Issue:3-4

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Cartilage, Articular; Edema; Etodolac;

1991
Temporal relationships of the anti-inflammatory effect of etodolac in the adjuvant arthritic rat.
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1988, Volume: 187, Issue:3

    Topics: Acetates; Acetylglucosaminidase; Animals; Anti-Inflammatory Agents; Arthritis; Arthritis, Experiment

1988