etodolac has been researched along with Anasarca in 21 studies
Etodolac: A non-steroidal anti-inflammatory agent and cyclooxygenase-2 (COX-2) inhibitor with potent analgesic and anti-arthritic properties. It has been shown to be effective in the treatment of OSTEOARTHRITIS; RHEUMATOID ARTHRITIS; ANKYLOSING SPONDYLITIS; and in the alleviation of postoperative pain (PAIN, POSTOPERATIVE).
etodolac : A monocarboxylic acid that is acetic acid in which one of the methyl hydrogens is substituted by a 1,8-diethyl-1,3,4,9-tetrahydropyrano[3,4-b]indol-1-yl moiety. A preferential inhibitor of cyclo-oxygenase 2 and non-steroidal anti-inflammatory, it is used for the treatment of rheumatoid arthritis and osteoarthritis, and for the alleviation of postoperative pain. Administered as the racemate, only the (S)-enantiomer is active.
| Excerpt | Relevance | Reference |
|---|---|---|
| "This study aimed to conduct a randomized prospective study about the efficacy of etodolac and ibuprofen on trismus, pain and edema regarding gender of patients submitted to impacted lower third molar teeth extraction." | 9.41 | The efficacy of etodolac and ibuprofen, regarding gender, on pain, edema and trismus after impacted lower third molar surgery: A randomized prospective clinical split-mouth study. ( Farnezi Bassi, AP; Faverani, LP; Reis, EN; Silva, LD, 2021) |
| "To compare the efficacy of ibuprofen (IBU) and etodolac (ETO) for controlling pain, edema, and trismus after extraction of lower third molars." | 9.22 | Comparative Assessment of the Effect of Ibuprofen and Etodolac on Edema, Trismus, and Pain in Lower Third Molar Surgery: A Randomized Clinical Trial. ( Bassi, AP; Grossi de Oliveira, GA; Silva de Oliveira, JC, 2016) |
| "This study aimed to conduct a randomized prospective study about the efficacy of etodolac and ibuprofen on trismus, pain and edema regarding gender of patients submitted to impacted lower third molar teeth extraction." | 5.41 | The efficacy of etodolac and ibuprofen, regarding gender, on pain, edema and trismus after impacted lower third molar surgery: A randomized prospective clinical split-mouth study. ( Farnezi Bassi, AP; Faverani, LP; Reis, EN; Silva, LD, 2021) |
| "To compare the efficacy of ibuprofen (IBU) and etodolac (ETO) for controlling pain, edema, and trismus after extraction of lower third molars." | 5.22 | Comparative Assessment of the Effect of Ibuprofen and Etodolac on Edema, Trismus, and Pain in Lower Third Molar Surgery: A Randomized Clinical Trial. ( Bassi, AP; Grossi de Oliveira, GA; Silva de Oliveira, JC, 2016) |
| " Eto inhibited carrageenin-induced edema in rats, adjuvant-induced arthritis in rats, acetic acid-induced writhing in mice and brewer's yeast-induced hyperalgesia and fever in rats." | 3.69 | Anti-inflammatory effects of etodolac: comparison with other non-steroidal anti-inflammatory drugs. ( Fujisawa, H; Inoue, K; Inoue, Y; Kimura, K; Kyoi, T; Motonaga, A; Ueda, F, 1994) |
| " The aim of the present study was to compare nabumetone, a nonacidic drug, with etodolac on rat gastric mucosal damage and prostanoid synthesis, while concurrently measuring prostanoid production during edema formation in a carrageenan model of paw inflammation." | 3.69 | Gastrointestinal irritancy, antiinflammatory activity, and prostanoid inhibition in the rat. Differentiation of effects between nabumetone and etodolac. ( Blower, PR; Durie, M; Gentry, C; Melarange, R; O'Connell, C, 1994) |
| ") suppressed concanavalin A-induced paw edema in rats." | 3.68 | Mechanism of anti-inflammatory action of etodolac. ( Fujisawa, H; Inoue, K; Kimura, K; Miki, N; Motonaga, A; Nishimura, T; Shibata, Y; Ueda, F; Yokota, M, 1991) |
| "Using the curative model of adjuvant arthritis, adult male Sprague-Dawley rats were treated with vehicle or etodolac (1, 3, and 8 mg/kg/day, po) for 9 days." | 3.67 | Temporal relationships of the anti-inflammatory effect of etodolac in the adjuvant arthritic rat. ( Chau, TT; Lee, DK; Weichman, BM; Wooley, PH, 1988) |
| "Edema was similar among all groups at all time points (P > ." | 3.01 | Combination of etodolac and dexamethasone improves preemptive analgesia in third molar surgery: a randomized study. ( Barbosa, S; Bassi, APF; de Souza Santos, AM; Faverani, LP; Momesso, GAC; Polo, TOB; Ramires, GAD; Silva, WPP, 2021) |
| "No difference was noted regarding trismus in any of the groups." | 2.79 | Comparison of the effect of naproxen, etodolac and diclofenac on postoperative sequels following third molar surgery: a randomised, double-blind, crossover study. ( Akbulut, N; Atakan, C; Çölok, G; Üstüner, E, 2014) |
| "Etodolac was loaded into the prepared gels or added during the gel formation." | 1.46 | Self-Assembling Organogels Based on Pluronic and Lecithin for Sustained Release of Etodolac: In Vitro and In Vivo Correlation. ( Faisal, W; Mohammed, AM; Osman, SK; Saleh, KI, 2017) |
| "The objective of this study was to prepare a self-emulsifying drug delivery system (SEDDS) for oral bioavailability enhancement of a poorly water-soluble drug, etodolac." | 1.36 | Enhanced oral bioavailability of etodolac by self-emulsifying systems: in-vitro and in-vivo evaluation. ( Barakat, NS, 2010) |
| "Etodolac had no effect on delayed hypersensitivity reactions and was much less ulcerogenic than indometacin." | 1.28 | Pharmacological properties of the new non-steroidal anti-inflammatory agent etodolac. ( Fujisawa, H; Inoue, K; Inoue, Y; Masuda, T; Nishimura, I; Nishimura, T; Sasaki, Y; Shibata, Y; Ueda, F; Yokota, M, 1991) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (19.05) | 18.7374 |
| 1990's | 5 (23.81) | 18.2507 |
| 2000's | 4 (19.05) | 29.6817 |
| 2010's | 6 (28.57) | 24.3611 |
| 2020's | 2 (9.52) | 2.80 |
| Authors | Studies |
|---|---|
| Asselin, AA | 1 |
| Humber, LG | 3 |
| Dobson, TA | 1 |
| Komlossy, J | 1 |
| Ferdinandi, E | 1 |
| Demerson, CA | 2 |
| Ahmed, S | 1 |
| Shah, U | 2 |
| Mobilio, D | 2 |
| Sabatucci, J | 1 |
| De Lange, B | 1 |
| Labbadia, F | 2 |
| Hughes, P | 2 |
| Katz, AH | 1 |
| Brigance, R | 1 |
| Conway, K | 1 |
| Williams, G | 1 |
| Biava, M | 1 |
| Porretta, GC | 1 |
| Poce, G | 1 |
| Supino, S | 1 |
| Manetti, F | 1 |
| Forli, S | 1 |
| Botta, M | 1 |
| Sautebin, L | 1 |
| Rossi, A | 1 |
| Pergola, C | 1 |
| Ghelardini, C | 1 |
| Norcini, M | 1 |
| Makovec, F | 1 |
| Giordani, A | 1 |
| Anzellotti, P | 1 |
| Cirilli, R | 1 |
| Ferretti, R | 1 |
| Gallinella, B | 1 |
| La Torre, F | 1 |
| Anzini, M | 1 |
| Patrignani, P | 1 |
| Hassib, ST | 1 |
| Hassan, GS | 1 |
| El-Zaher, AA | 1 |
| Fouad, MA | 1 |
| Abd El-Ghafar, OA | 1 |
| Taha, EA | 1 |
| Ramires, GAD | 1 |
| de Souza Santos, AM | 1 |
| Momesso, GAC | 1 |
| Polo, TOB | 1 |
| Silva, WPP | 1 |
| Barbosa, S | 1 |
| Bassi, APF | 1 |
| Faverani, LP | 2 |
| Silva, LD | 1 |
| Reis, EN | 1 |
| Farnezi Bassi, AP | 1 |
| Akbulut, N | 1 |
| Üstüner, E | 1 |
| Atakan, C | 1 |
| Çölok, G | 1 |
| Silva de Oliveira, JC | 1 |
| Grossi de Oliveira, GA | 1 |
| Bassi, AP | 1 |
| Mohammed, AM | 1 |
| Faisal, W | 1 |
| Saleh, KI | 1 |
| Osman, SK | 1 |
| Inoue, N | 2 |
| Ito, S | 1 |
| Tajima, K | 1 |
| Nogawa, M | 1 |
| Takahashi, Y | 1 |
| Sasagawa, T | 1 |
| Nakamura, A | 1 |
| Kyoi, T | 2 |
| Rozin, AP | 1 |
| Kagna, O | 1 |
| Shiller, Y | 1 |
| Barakat, NS | 1 |
| Tachibana, M | 1 |
| Yoshida, E | 1 |
| Matsui, M | 1 |
| Ukai, Y | 1 |
| Yano, J | 1 |
| Abdel-Salam, OM | 1 |
| Inoue, K | 3 |
| Fujisawa, H | 3 |
| Motonaga, A | 2 |
| Inoue, Y | 2 |
| Ueda, F | 3 |
| Kimura, K | 3 |
| Melarange, R | 1 |
| Gentry, C | 1 |
| Durie, M | 1 |
| O'Connell, C | 1 |
| Blower, PR | 1 |
| Sasaki, Y | 1 |
| Nishimura, T | 2 |
| Nishimura, I | 1 |
| Yokota, M | 2 |
| Masuda, T | 1 |
| Shibata, Y | 3 |
| Miki, N | 1 |
| Yoshida-Suzuka, H | 1 |
| Nakamura, Y | 1 |
| Lee, DK | 1 |
| Chau, TT | 1 |
| Weichman, BM | 1 |
| Wooley, PH | 1 |
4 trials available for etodolac and Anasarca
| Article | Year |
|---|---|
Combination of etodolac and dexamethasone improves preemptive analgesia in third molar surgery: a randomized study.
Topics: Analgesia; Dexamethasone; Double-Blind Method; Edema; Etodolac; Humans; Molar, Third; Pain, Postoper | 2021 |
The efficacy of etodolac and ibuprofen, regarding gender, on pain, edema and trismus after impacted lower third molar surgery: A randomized prospective clinical split-mouth study.
Topics: Adolescent; Adult; Edema; Etodolac; Female; Humans; Ibuprofen; Male; Molar, Third; Mouth; Pain, Post | 2021 |
Comparison of the effect of naproxen, etodolac and diclofenac on postoperative sequels following third molar surgery: a randomised, double-blind, crossover study.
Topics: Adolescent; Adult; Anti-Inflammatory Agents, Non-Steroidal; Cross-Over Studies; Diclofenac; Double-B | 2014 |
Comparative Assessment of the Effect of Ibuprofen and Etodolac on Edema, Trismus, and Pain in Lower Third Molar Surgery: A Randomized Clinical Trial.
Topics: Adolescent; Cyclooxygenase 2 Inhibitors; Edema; Etodolac; Female; Humans; Ibuprofen; Male; Mandible; | 2016 |
17 other studies available for etodolac and Anasarca
| Article | Year |
|---|---|
Cycloalkanoindoles. 1. Syntheses and antiinflammatory actions of some acidic tetrahydrocarbazoles, cyclopentindoles, and cycloheptindoles.
Topics: Animals; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Carbazoles; Cycloheptanes; Cyclopentanes; | 1976 |
Etodolac, a novel antiinflammatory agent. The syntheses and biological evaluation of its metabolites.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cartilage; Cells, Cultured; Chemical Phenomena; Ch | 1988 |
Structure-activity relationships among analogues of pemedolac, cis-1-ethyl-1,3,4,9-tetrahydro-4-(phenylmethyl)pyrano[3,4-b]indo le-1-a cetic acid, a potent analgesic agent.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Edema; In Vitro Techniques; Indoleacetic Acids; Ma | 1988 |
Synthesis, in vitro, and in vivo biological evaluation and molecular docking simulations of chiral alcohol and ether derivatives of the 1,5-diarylpyrrole scaffold as novel anti-inflammatory and analgesic agents.
Topics: Acetic Acid; Alcohols; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Binding Sites; | 2008 |
Synthesis and biological evaluation of new prodrugs of etodolac and tolfenamic acid with reduced ulcerogenic potential.
Topics: Animals; Anti-Inflammatory Agents; Drug Design; Drug Stability; Edema; Etodolac; Female; Humans; Hyd | 2019 |
Self-Assembling Organogels Based on Pluronic and Lecithin for Sustained Release of Etodolac: In Vitro and In Vivo Correlation.
Topics: Administration, Cutaneous; Animals; Carrageenan; Cyclooxygenase 2 Inhibitors; Delayed-Action Prepara | 2017 |
Etodolac attenuates mechanical allodynia in a mouse model of neuropathic pain.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Celecoxib; Cyclooxygenase 2 Inhibitor | 2009 |
Sacroiliitis and severe disability due to isotretinoin therapy.
Topics: Acne Vulgaris; Adrenocorticotropic Hormone; Adult; Anti-Inflammatory Agents, Non-Steroidal; Arthralg | 2010 |
Enhanced oral bioavailability of etodolac by self-emulsifying systems: in-vitro and in-vivo evaluation.
Topics: Absorption; Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Biological Avail | 2010 |
Anti-inflammatory effect and low ulcerogenic activity of etodolac, a cyclooxygenase-2 selective non-steroidal anti-inflammatory drug, on adjuvant-induced arthritis in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Cyclooxygenase Inhibitors; Diclofenac; | 2003 |
Anti-inflammatory, antinociceptive, and gastric effects of Hypericum perforatum in rats.
Topics: Acetic Acid; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Capsaicin; | 2005 |
Anti-inflammatory effects of etodolac: comparison with other non-steroidal anti-inflammatory drugs.
Topics: Acetates; Acetic Acid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Ca | 1994 |
Gastrointestinal irritancy, antiinflammatory activity, and prostanoid inhibition in the rat. Differentiation of effects between nabumetone and etodolac.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Anti-Inflammatory Agents, Non-Steroidal; Butanones; Cecum; De | 1994 |
Pharmacological properties of the new non-steroidal anti-inflammatory agent etodolac.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Cartilage, Articular; Che | 1991 |
Mechanism of anti-inflammatory action of etodolac.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Bradykinin; Capillary Permeability; Concanavalin A | 1991 |
Effect of etodolac, a new nonsteroidal anti-inflammatory drug, in MRL/lpr mice with articular lesions.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Cartilage, Articular; Edema; Etodolac; | 1991 |
Temporal relationships of the anti-inflammatory effect of etodolac in the adjuvant arthritic rat.
Topics: Acetates; Acetylglucosaminidase; Animals; Anti-Inflammatory Agents; Arthritis; Arthritis, Experiment | 1988 |