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etodolac and Acute Hepatic Failure

etodolac has been researched along with Acute Hepatic Failure in 2 studies

Etodolac: A non-steroidal anti-inflammatory agent and cyclooxygenase-2 (COX-2) inhibitor with potent analgesic and anti-arthritic properties. It has been shown to be effective in the treatment of OSTEOARTHRITIS; RHEUMATOID ARTHRITIS; ANKYLOSING SPONDYLITIS; and in the alleviation of postoperative pain (PAIN, POSTOPERATIVE).
etodolac : A monocarboxylic acid that is acetic acid in which one of the methyl hydrogens is substituted by a 1,8-diethyl-1,3,4,9-tetrahydropyrano[3,4-b]indol-1-yl moiety. A preferential inhibitor of cyclo-oxygenase 2 and non-steroidal anti-inflammatory, it is used for the treatment of rheumatoid arthritis and osteoarthritis, and for the alleviation of postoperative pain. Administered as the racemate, only the (S)-enantiomer is active.

Research Excerpts

ExcerptRelevanceReference
" The plasma concentrations of the drug in bile duct-linked rats approximately agreed with the simulation curve by the model, with the peak concentration 6-7 h after dosing."1.30Pharmacokinetic analysis of enterohepatic circulation of etodolac and effect of hepatic and renal injury on the pharmacokinetics. ( Iwaki, M; Kitagawa, T; Ogiso, T; Tanino, T, 1997)

Research

Studies (2)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (50.00)18.2507
2000's0 (0.00)29.6817
2010's1 (50.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Sampaziotis, F1
Brais, RJ1
Griffiths, WJ1
Ogiso, T1
Kitagawa, T1
Iwaki, M1
Tanino, T1

Other Studies

2 other studies available for etodolac and Acute Hepatic Failure

ArticleYear
A case of acute liver failure due to etodolac.
    British journal of clinical pharmacology, 2013, Volume: 75, Issue:4

    Topics: Aged; Cyclooxygenase 2 Inhibitors; Etodolac; Female; Humans; Liver Failure, Acute

2013
Pharmacokinetic analysis of enterohepatic circulation of etodolac and effect of hepatic and renal injury on the pharmacokinetics.
    Biological & pharmaceutical bulletin, 1997, Volume: 20, Issue:4

    Topics: Acute Kidney Injury; Animals; Anti-Inflammatory Agents, Non-Steroidal; Bile; Carbon Tetrachloride; E

1997