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etodolac and Ache

etodolac has been researched along with Ache in 23 studies

Etodolac: A non-steroidal anti-inflammatory agent and cyclooxygenase-2 (COX-2) inhibitor with potent analgesic and anti-arthritic properties. It has been shown to be effective in the treatment of OSTEOARTHRITIS; RHEUMATOID ARTHRITIS; ANKYLOSING SPONDYLITIS; and in the alleviation of postoperative pain (PAIN, POSTOPERATIVE).
etodolac : A monocarboxylic acid that is acetic acid in which one of the methyl hydrogens is substituted by a 1,8-diethyl-1,3,4,9-tetrahydropyrano[3,4-b]indol-1-yl moiety. A preferential inhibitor of cyclo-oxygenase 2 and non-steroidal anti-inflammatory, it is used for the treatment of rheumatoid arthritis and osteoarthritis, and for the alleviation of postoperative pain. Administered as the racemate, only the (S)-enantiomer is active.

Research Excerpts

ExcerptRelevanceReference
"The efficacy and tolerability of etodolac and indomethacin were compared in patients with osteoarthritis of the knee."9.07Double-blind, parallel comparison of etodolac and indomethacin in patients with osteoarthritis of the knee. ( Karbowski, A, 1991)
"A double-blind study was carried out to compare the effectiveness and tolerability of two non-steroidal anti-inflammatory drugs, etodolac and piroxicam, in patients with osteoarthritis of the knee."9.06A double-blind comparison of etodolac and piroxicam in the treatment of osteoarthritis. ( Freitas, GG, 1990)
"A meta-analysis was done with the final data from three trials that provided the first results relating to efficacy and safety of the new sustained-release (SR) formulation of etodolac versus established nonsteroidal anti-inflammatory drugs (NSAIDs) in the treatment of osteoarthritis (OA) of the knee."8.78Meta-analysis of three double-blind comparative trials with sustained-release etodolac in the treatment of osteoarthritis of the knee. ( Porzio, F, 1993)
"A meta-analysis was done with the data from two studies that provided the first efficacy and safety results for the new sustained-release (SR) formulation of etodolac versus established nonsteroidal anti-inflammatory drugs in patients with rheumatoid arthritis (RA)."8.78Meta-analysis of two double-blind comparative studies with the sustained-release form of etodolac in rheumatoid arthritis. ( Porzio, F, 1993)
"Etodolac is a nonsteroidal anti-inflammatory drug (NSAID) effective in the treatment of rheumatoid arthritis, osteoarthritis and ankylosing spondylitis, and in the alleviation of postoperative pain."8.78Etodolac. A reappraisal of its pharmacology and therapeutic use in rheumatic diseases and pain states. ( Balfour, JA; Buckley, MM, 1991)
"The effects of combined single oral treatments with non-steroidal anti-inflammatory drugs (NSAIDs) and the non-competitive N-methyl-D-aspartate (NMDA) receptor antagonist dextromethorphan (DM) on arthritic pain were examined in a rat model of adjuvant-induced arthritis."7.69Effects of the combined oral administration of NSAIDs and dextromethorphan on behavioral symptoms indicative of arthritic pain in rats. ( Caruso, FS; Frenk, H; Lu, J; Mao, J; Mayer, DJ; Price, DD, 1996)
" Adverse reactions, mostly regarding the G-I tract, were significantly more frequent in the tenoxicam group than in the etodolac group: 23."6.67Double-blind comparison of the efficacy and safety of etodolac SR 600 mg u.i.d. and of tenoxicam 20 mg u.i.d. in elderly patients with osteoarthritis of the hip and of the knee. ( Bogliolo, A; Perpignano, G; Puccetti, L, 1994)
" This results in an increase in the rate of absorption of the active compound and, consequently, in an earlier onset of analgesic action."6.38Piroxicam-beta-cyclodextrin in the treatment of acute pain of rheumatic disease. ( Franchimont, P; Reginster, JY, 1993)
"Etodolac-paracetamol was significantly superior to etodolac alone in reducing pain intensity (P<0."5.14Efficacy and safety of etodolac-paracetamol fixed dose combination in patients with knee osteoarthritis flare-up: a randomized, double-blind comparative evaluation. ( Ambade, R; Bartakke, G; Chandanwale, A; Chandurkar, N; Pareek, A, 2010)
"The objective of this double-blind, randomized, parallel-group study was to evaluate the pharmacokinetics of etodolac and the pharmacodynamic response of pain in patients following oral surgery who had received 200 or 400 mg of etodolac immediate release (IR), 400 or 1200 mg of etodolac extended release (ER), or a placebo."5.09Pharmacokinetic and pharmacodynamic action of etodolac in patients after oral surgery. ( Appel, A; Boni, J; Cooper, S; Korth-Bradley, J; McGoldrick, K, 1999)
"The efficacy and tolerability of etodolac and indomethacin were compared in patients with osteoarthritis of the knee."5.07Double-blind, parallel comparison of etodolac and indomethacin in patients with osteoarthritis of the knee. ( Karbowski, A, 1991)
"A double-blind study was carried out to compare the effectiveness and tolerability of two non-steroidal anti-inflammatory drugs, etodolac and piroxicam, in patients with osteoarthritis of the knee."5.06A double-blind comparison of etodolac and piroxicam in the treatment of osteoarthritis. ( Freitas, GG, 1990)
"A meta-analysis was done with the final data from three trials that provided the first results relating to efficacy and safety of the new sustained-release (SR) formulation of etodolac versus established nonsteroidal anti-inflammatory drugs (NSAIDs) in the treatment of osteoarthritis (OA) of the knee."4.78Meta-analysis of three double-blind comparative trials with sustained-release etodolac in the treatment of osteoarthritis of the knee. ( Porzio, F, 1993)
"A meta-analysis was done with the data from two studies that provided the first efficacy and safety results for the new sustained-release (SR) formulation of etodolac versus established nonsteroidal anti-inflammatory drugs in patients with rheumatoid arthritis (RA)."4.78Meta-analysis of two double-blind comparative studies with the sustained-release form of etodolac in rheumatoid arthritis. ( Porzio, F, 1993)
"Etodolac is a nonsteroidal anti-inflammatory drug (NSAID) effective in the treatment of rheumatoid arthritis, osteoarthritis and ankylosing spondylitis, and in the alleviation of postoperative pain."4.78Etodolac. A reappraisal of its pharmacology and therapeutic use in rheumatic diseases and pain states. ( Balfour, JA; Buckley, MM, 1991)
" We have previously reported that etodolac, a nonsteroidal anti-inflammatory drug, attenuates mechanical allodynia in a mouse model of neuropathic pain by a mechanism that is independent of cyclooxygenase inhibition."3.78Etodolac blocks the allyl isothiocyanate-induced response in mouse sensory neurons by selective TRPA1 activation. ( Inoue, N; Ito, S; Kyoi, T; Nogawa, M; Tajima, K, 2012)
" Both etodolac and bromelain inhibited the inflammatory pain in concanavalin A-treated paws of rats in a dose-dependent manner, but indomethacin did not."3.69Effect of etodolac on prostaglandin E2 biosynthesis, active oxygen generation and bradykinin formation. ( Dainaka, J; Hashii, H; Inoue, K; Kimura, K; Motonaga, A; Nishimura, T; Ueda, F; Yamate, K, 1994)
" Eto inhibited carrageenin-induced edema in rats, adjuvant-induced arthritis in rats, acetic acid-induced writhing in mice and brewer's yeast-induced hyperalgesia and fever in rats."3.69Anti-inflammatory effects of etodolac: comparison with other non-steroidal anti-inflammatory drugs. ( Fujisawa, H; Inoue, K; Inoue, Y; Kimura, K; Kyoi, T; Motonaga, A; Ueda, F, 1994)
"The effects of combined single oral treatments with non-steroidal anti-inflammatory drugs (NSAIDs) and the non-competitive N-methyl-D-aspartate (NMDA) receptor antagonist dextromethorphan (DM) on arthritic pain were examined in a rat model of adjuvant-induced arthritis."3.69Effects of the combined oral administration of NSAIDs and dextromethorphan on behavioral symptoms indicative of arthritic pain in rats. ( Caruso, FS; Frenk, H; Lu, J; Mao, J; Mayer, DJ; Price, DD, 1996)
" Adverse reactions, mostly regarding the G-I tract, were significantly more frequent in the tenoxicam group than in the etodolac group: 23."2.67Double-blind comparison of the efficacy and safety of etodolac SR 600 mg u.i.d. and of tenoxicam 20 mg u.i.d. in elderly patients with osteoarthritis of the hip and of the knee. ( Bogliolo, A; Perpignano, G; Puccetti, L, 1994)
" This results in an increase in the rate of absorption of the active compound and, consequently, in an earlier onset of analgesic action."2.38Piroxicam-beta-cyclodextrin in the treatment of acute pain of rheumatic disease. ( Franchimont, P; Reginster, JY, 1993)

Research

Studies (23)

TimeframeStudies, this research(%)All Research%
pre-19901 (4.35)18.7374
1990's15 (65.22)18.2507
2000's5 (21.74)29.6817
2010's2 (8.70)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Biava, M1
Porretta, GC1
Poce, G1
Supino, S1
Manetti, F1
Forli, S1
Botta, M1
Sautebin, L1
Rossi, A1
Pergola, C1
Ghelardini, C1
Norcini, M1
Makovec, F1
Giordani, A1
Anzellotti, P1
Cirilli, R1
Ferretti, R1
Gallinella, B1
La Torre, F1
Anzini, M1
Patrignani, P1
Inoue, N2
Ito, S2
Tajima, K2
Nogawa, M2
Takahashi, Y1
Sasagawa, T1
Nakamura, A1
Kyoi, T3
Pareek, A1
Chandurkar, N1
Ambade, R1
Chandanwale, A1
Bartakke, G1
Lowenthal, MN1
Tombak, A1
Lowenthal, A1
Abdel-Salam, OM1
Clark, TP1
Perpignano, G1
Bogliolo, A1
Puccetti, L1
Inoue, K2
Motonaga, A2
Dainaka, J1
Nishimura, T1
Hashii, H1
Yamate, K1
Ueda, F2
Kimura, K2
Fujisawa, H1
Inoue, Y1
Reginster, JY1
Franchimont, P1
Porzio, F2
Dreiser, RL1
Bacon, P1
Schumacher, HR1
Meng, Z1
Sieck, M1
Zonay, L1
Clayburne, G1
Baker, JF1
Park, J1
Baker, DG1
Price, DD1
Mao, J1
Lu, J1
Caruso, FS1
Frenk, H1
Mayer, DJ1
Boni, J1
Korth-Bradley, J1
McGoldrick, K1
Appel, A1
Cooper, S1
Balfour, JA1
Buckley, MM1
Karbowski, A1
Freitas, GG1
Russo Frattasi, CA1
Bevilacqua, R1

Reviews

5 reviews available for etodolac and Ache

ArticleYear
The clinical pharmacology of cyclooxygenase-2-selective and dual inhibitors.
    The Veterinary clinics of North America. Small animal practice, 2006, Volume: 36, Issue:5

    Topics: 4-Butyrolactone; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carbazoles; Cats; Cyclooxygenase

2006
Piroxicam-beta-cyclodextrin in the treatment of acute pain of rheumatic disease.
    European journal of rheumatology and inflammation, 1993, Volume: 12, Issue:4

    Topics: Acute Disease; Adult; beta-Cyclodextrins; Controlled Clinical Trials as Topic; Cyclodextrins; Diclof

1993
Meta-analysis of three double-blind comparative trials with sustained-release etodolac in the treatment of osteoarthritis of the knee.
    Rheumatology international, 1993, Volume: 13, Issue:2 Suppl

    Topics: Adult; Aged; Aged, 80 and over; Analysis of Variance; Anti-Inflammatory Agents, Non-Steroidal; Delay

1993
Meta-analysis of two double-blind comparative studies with the sustained-release form of etodolac in rheumatoid arthritis.
    Rheumatology international, 1993, Volume: 13, Issue:2 Suppl

    Topics: Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Arthritis, Rheumatoid; Delayed-Action Prepa

1993
Etodolac. A reappraisal of its pharmacology and therapeutic use in rheumatic diseases and pain states.
    Drugs, 1991, Volume: 42, Issue:2

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Etodolac; Humans; Indoleace

1991

Trials

9 trials available for etodolac and Ache

ArticleYear
Efficacy and safety of etodolac-paracetamol fixed dose combination in patients with knee osteoarthritis flare-up: a randomized, double-blind comparative evaluation.
    The Clinical journal of pain, 2010, Volume: 26, Issue:7

    Topics: Acetaminophen; Adult; Aged; Analgesics, Non-Narcotic; Cyclooxygenase Inhibitors; Double-Blind Method

2010
Double-blind comparison of the efficacy and safety of etodolac SR 600 mg u.i.d. and of tenoxicam 20 mg u.i.d. in elderly patients with osteoarthritis of the hip and of the knee.
    International journal of clinical pharmacology research, 1994, Volume: 14, Issue:5-6

    Topics: Aged; Analysis of Variance; Anti-Inflammatory Agents, Non-Steroidal; Delayed-Action Preparations; Di

1994
A comparison of the efficacy of etodolac SR (Lodine SR) and etodolac (Lodine) in patients with rheumatoid arthritis or osteoarthritis.
    Rheumatology international, 1993, Volume: 13, Issue:2 Suppl

    Topics: Adult; Aged; Arthritis, Rheumatoid; Delayed-Action Preparations; Dose-Response Relationship, Drug; D

1993
Worldwide experience with etodolac (Lodine) 300 mg b.i.d. in the treatment of osteoarthritis.
    Rheumatology international, 1993, Volume: 13, Issue:2 Suppl

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Delayed-Action Preparations; Diclofenac; Double-Blind Me

1993
Effect of a nonsteroidal antiinflammatory drug on synovial fluid in osteoarthritis.
    The Journal of rheumatology, 1996, Volume: 23, Issue:10

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Dinoprostone; Etodolac; Humans; Interleukin-6; Knee Joint;

1996
Pharmacokinetic and pharmacodynamic action of etodolac in patients after oral surgery.
    Journal of clinical pharmacology, 1999, Volume: 39, Issue:7

    Topics: Adolescent; Adult; Anti-Inflammatory Agents, Non-Steroidal; Dose-Response Relationship, Drug; Double

1999
Double-blind, parallel comparison of etodolac and indomethacin in patients with osteoarthritis of the knee.
    Current medical research and opinion, 1991, Volume: 12, Issue:5

    Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Double-Blind Method; Etodolac; Female; Humans;

1991
A double-blind comparison of etodolac and piroxicam in the treatment of osteoarthritis.
    Current medical research and opinion, 1990, Volume: 12, Issue:4

    Topics: Adult; Aged; Anti-Inflammatory Agents, Non-Steroidal; Double-Blind Method; Etodolac; Female; Humans;

1990
[Open evaluation of a new anti-inflammatory analgesic drug: etodolac. Report of a clinical trial].
    La Clinica terapeutica, 1989, May-31, Volume: 129, Issue:4

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Clinical Trials

1989

Other Studies

9 other studies available for etodolac and Ache

ArticleYear
Synthesis, in vitro, and in vivo biological evaluation and molecular docking simulations of chiral alcohol and ether derivatives of the 1,5-diarylpyrrole scaffold as novel anti-inflammatory and analgesic agents.
    Bioorganic & medicinal chemistry, 2008, Sep-01, Volume: 16, Issue:17

    Topics: Acetic Acid; Alcohols; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Binding Sites;

2008
Etodolac attenuates mechanical allodynia in a mouse model of neuropathic pain.
    Journal of pharmacological sciences, 2009, Volume: 109, Issue:4

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Celecoxib; Cyclooxygenase 2 Inhibitor

2009
Etodolac blocks the allyl isothiocyanate-induced response in mouse sensory neurons by selective TRPA1 activation.
    Pharmacology, 2012, Volume: 90, Issue:1-2

    Topics: Analgesics, Non-Narcotic; Animals; Behavior, Animal; Calcium; Cells, Cultured; CHO Cells; Cricetinae

2012
Secondary hypertrophic osteoarthropathy (HOA) mimicking primary HOA (pachydermoperiostitis or Touraine-Solente-Golé) syndrome.
    The Israel Medical Association journal : IMAJ, 2004, Volume: 6, Issue:1

    Topics: Analgesics, Opioid; Carcinoma, Non-Small-Cell Lung; Cyclooxygenase Inhibitors; Diagnosis, Differenti

2004
Anti-inflammatory, antinociceptive, and gastric effects of Hypericum perforatum in rats.
    TheScientificWorldJournal, 2005, Aug-08, Volume: 5

    Topics: Acetic Acid; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Capsaicin;

2005
Effect of etodolac on prostaglandin E2 biosynthesis, active oxygen generation and bradykinin formation.
    Prostaglandins, leukotrienes, and essential fatty acids, 1994, Volume: 51, Issue:6

    Topics: Animals; Aspirin; Bradykinin; Bromelains; Cartilage, Articular; Cell Line; Concanavalin A; Depressio

1994
Anti-inflammatory effects of etodolac: comparison with other non-steroidal anti-inflammatory drugs.
    Biological & pharmaceutical bulletin, 1994, Volume: 17, Issue:12

    Topics: Acetates; Acetic Acid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Ca

1994
Effects of the combined oral administration of NSAIDs and dextromethorphan on behavioral symptoms indicative of arthritic pain in rats.
    Pain, 1996, Volume: 68, Issue:1

    Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Beh

1996
Etodolac: the role of a new NSAID in the management of arthritis and pain. Tenth Pan American Congress of Rheumatology and the Seventeenth Congress of the Mexican Society of Rheumatology. Guadalajara, Mexico, March 15, 1990.
    Rheumatology international, 1990, Volume: 10 Suppl

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Etodolac; Humans; Indoleacetic Acids; Pain

1990