etiocholanolone and Fever studies

Etiocholanolone: The 5-beta-reduced isomer of ANDROSTERONE. Etiocholanolone is a major metabolite of TESTOSTERONE and ANDROSTENEDIONE in many mammalian species including humans. It is excreted in the URINE.
3alpha-hydroxy-5beta-androstan-17-one : An androstanoid that is 5beta-androstane substituted by an alpha-hydroxy group at position 3 and an oxo group at position 17. It is a metabolite of testosterone in mammals.

Fever: An abnormal elevation of body temperature, usually as a result of a pathologic process.

Research Excerpts

Excerpt	Relevance	Reference
"The effect of fever on serum concentrations and urinary excretion of gentamicin sulfate was studied in humans and dogs."	9.04	Gentamicin sulfate pharmacokinetics: lower levels of gentamicin in blood during fever. ( Dale, DC; MacLowry, JD; Pennington, JE; Reynolds, HY, 1975)
"The plasma half-life and metabolic clearance rate of antipyrine, a drug metabolized by hepatic microsomal enzymes, were determined in 33 normal volunteers during a basal state and during fever induced with a single intramuscular injection of etiocholanolone."	7.65	Effects of etiocholanolone-induced fever on plasma antipyrine half-lives and metabolic clearance. ( Elin, RJ; Vesell, ES; Wolff, SM, 1975)
"A case of periodic fever is reported in a 28-year-old male."	5.27	A case of periodic fever--reevaluation of etiocholanolone fever as an established clinical entity. ( Watanobe, H, 1988)
"Etiocholanolone is a physiologically occurring metabolite of testosterone and androstenedione which are secreted by adrenals, testes, and ovaries."	5.26	Urticaria in association with etiocholanolone fever. ( Bedbur, M; Goerz, G; Graef, V, 1981)
"The effect of fever on serum concentrations and urinary excretion of gentamicin sulfate was studied in humans and dogs."	5.04	Gentamicin sulfate pharmacokinetics: lower levels of gentamicin in blood during fever. ( Dale, DC; MacLowry, JD; Pennington, JE; Reynolds, HY, 1975)
"The plasma half-life and metabolic clearance rate of antipyrine, a drug metabolized by hepatic microsomal enzymes, were determined in 33 normal volunteers during a basal state and during fever induced with a single intramuscular injection of etiocholanolone."	3.65	Effects of etiocholanolone-induced fever on plasma antipyrine half-lives and metabolic clearance. ( Elin, RJ; Vesell, ES; Wolff, SM, 1975)
"A case of periodic fever is reported in a 28-year-old male."	1.27	A case of periodic fever--reevaluation of etiocholanolone fever as an established clinical entity. ( Watanobe, H, 1988)
"Etiocholanolone is a physiologically occurring metabolite of testosterone and androstenedione which are secreted by adrenals, testes, and ovaries."	1.26	Urticaria in association with etiocholanolone fever. ( Bedbur, M; Goerz, G; Graef, V, 1981)

Timeframe	Studies, this research(%)	All Research%
pre-1990	60 (96.77)	18.7374
1990's	2 (3.23)	18.2507
2000's	0 (0.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80

Authors	Studies
SCHENKER, S	1
WILSON, H	1
SPICKARD, A	1
CARA, J	1
BEAS, F	1
SPACH, C	1
GARDNER, LI	1
NILSSON, SE	1
JACOBS, JC	1
BRAILLARD, CA	1
DEROSA, S	1
SHULMAN, JA	1
HERRMANN, WL	1
PETERSDORF, RG	1
MCDONOUGH, JR	1
HAMES, CG	1
GARRISON, GE	1
STULB, SC	1
LICHTMAN, MA	1
HEFELFINGER, DC	1
GEPPERT, LJ	1
BONDY, PK	1
COHN, GL	1
GREGORY, PB	1
Kimball, HR	5
Vogel, JM	2
Perry, S	2
Wolff, SM	9
Huhnstock, K	5
Kuhn, D	3
Oertel, GW	4
Kappas, A	1
Palmer, RH	1
Plewe, G	1
Beyer, J	1
Ben-Haim, S	2
Binur, N	1
Barzilai, D	1
Goerz, G	1
Bedbur, M	1
Graef, V	2
Steinetz, BG	1
Randolph, C	1
Werner, R	1
Mahoney, CJ	1
Stryckmans, P	1
DeBusscher, L	1
Gorin, NC	1
Féron, R	1
Homberg, JC	1
Najman, A	1
Duhamel, G	1
Sato, K	1
Groth, W	2
Vlaho, M	3
Gross, R	2
Elin, RJ	3
Finch, CA	1
Vesell, ES	1
Hirschmann, W	1
Eggeling, B	1
Mitrenga, D	1
Sieberth, HG	1
Pennington, JE	1
Dale, DC	1
Reynolds, HY	1
MacLowry, JD	1
Winckelmann, G	2
Watanobe, H	1
Maass, G	1
Schmidt, H	1
Löhner, J	1
Fehér, T	2
Halmy, L	2
Driesen, O	1
Voûte, PA	1
Vermeulen, A	1
Lipsett, MB	1
Odell, WD	1
Klokke, AH	1
Thijssen, JH	1
Barducci, O	1
Meschino, S	1
Di Paolo, N	1
Massari, F	1
Hellman, L	1
Bradlow, HL	1
Zumoff, B	1
Jerzykowski, T	1
Swiecki, J	1
Czownicki, Z	1
Dobrek, Z	1
Hahn, H	1
Blaschke, TF	1
Berk, PD	1
Song, CS	2
Mössner, G	1
Husmann, F	2
Marshall, JR	1
Glinoer, D	1
Ermans, AM	1
Gopinischi, G	1
Mamou, H	2
Mamou, JE	1
Gunz, FW	1
Mani, MK	1
Ravich, RB	1
Speden, J	1
Vincent, PC	1
Cone, TE	1
Brittinger, WD	1
Melmon, ML	1
Gelb, NA	1
van Garsse, LG	1
Cranston, WI	1
Rawlins, MD	1
Luff, RH	1
Duff, GW	1
Wegelius, O	1
Keyriläinen, O	1
Vihko, R	1
Adlercreutz, H	1
Dillard, GM	1
Bodel, P	1
Essers, U	1
Bleifeld, W	1
Kaiser, E	1
Schilling, F	1
Reimann, HA	1
Mühler, E	1
Janoschek, K	1

Article	Year
[CLINICAL SIGNIFICANCE OF FEVER-PRODUCING STEROIDS]. La Semana medica, 1964, Mar-12, Volume: 124 Topics: Abetalipoproteinemia; Adrenal Hyperplasia, Congenital; Adrenogenital Syndrome; Aspirin; Cortisone; E	1964
ETIOCHOLANOLONE FEVER. Medicine, 1965, Volume: 44 Topics: Blood; Etiocholanolone; Fever; Humans; Metabolic Diseases; Toxicology	1965
[Fever in endocrinological disorders]. Harefuah, 1982, Feb-01, Volume: 102, Issue:3 Topics: Endocrine System Diseases; Etiocholanolone; Fever; Humans	1982
Neutrophils collection and transfusion for the treatment of infection in neutropenic patients. European journal of cancer, 1975, Volume: 11suppl Topics: ABO Blood-Group System; Adrenal Cortex Hormones; Agglutinins; Agranulocytosis; Animals; Anti-Bacteri	1975
Recent advances in human steroid metabolism. Advances in clinical chemistry, 1970, Volume: 13 Topics: Adrenocorticotropic Hormone; Aldosterone; Carbon Isotopes; Dexamethasone; Estriol; Etiocholanolone;	1970
Periodic diseases in children. Postgraduate medicine, 1971, Volume: 50, Issue:5 Topics: Adolescent; Agranulocytosis; Angioedema; Child; Child, Preschool; Etiocholanolone; Familial Mediterr	1971

Article	Year
Effect of induced fever on serum iron and ferritin concentrations in man. Blood, 1977, Volume: 49, Issue:1 Topics: Adult; Diet; Endotoxins; Etiocholanolone; Female; Ferritins; Fever; Humans; Iron; Male; Pyrogens; Ti	1977
Gentamicin sulfate pharmacokinetics: lower levels of gentamicin in blood during fever. The Journal of infectious diseases, 1975, Volume: 132, Issue:3 Topics: Adult; Animals; Dogs; Etiocholanolone; Female; Fever; Gentamicins; Humans; Male	1975

Article	Year
Periodic fever associated with increased plasma unconjugated etiocholanolone and granulomatous liver disease: case report and studies in etiocholanolone and cortisol conjugation. The Journal of clinical endocrinology and metabolism, 1963, Volume: 23 Topics: Anatomy; Etiocholanolone; Fever; Granuloma; Humans; Hydrocortisone; Liver Diseases; Pyrogens	1963
Increased urinary and plasma etiocholanolone and related steroids in a boy with virilizing adrenal hyperplasia and periodic fever. The Journal of pediatrics, 1963, Volume: 62 Topics: 17-Ketosteroids; Adrenal Gland Diseases; Adrenal Hyperplasia, Congenital; Adrenogenital Syndrome; An	1963
[PERIODICALLY APPEARING DISEASE SYMPTOMS]. Svenska lakartidningen, 1963, Dec-04, Volume: 60 Topics: 17-Ketosteroids; Agranulocytosis; Communicable Diseases; Edema; Endocrinology; Etiocholanolone; Fami	1963
ETIOCHOLANOLONE FEVER. REPORT OF A CASE IN CHILDHOOD WITH PERIODIC PERITONITIS ASSOCIATED WITH ELEVATED SERUM ETIOCHOLANOLONE. Pediatrics, 1964, Volume: 33 Topics: 17-Ketosteroids; Adolescent; Blood Chemical Analysis; Child; Etiocholanolone; Familial Mediterranean	1964
EXPERIMENTAL ETIOCHOLANOLONE FEVER. The Journal of clinical endocrinology and metabolism, 1964, Volume: 24 Topics: Etiocholanolone; Fever; Humans; Inflammation; Leukocytosis; Leukopenia; Metabolic Diseases; Pharmaco	1964
GRAND ROUNDS AT BARNES HOSPITAL. I. PERIODIC FEVER. Journal of chronic diseases, 1965, Volume: 18 Topics: Abdomen; Abdominal Cavity; Adolescent; Diagnosis, Differential; Etiocholanolone; Familial Mediterran	1965
PEDIODIC FEVER; MY MOST UNFORGETTABLE PATIENT. Clinical pediatrics, 1965, Volume: 4 Topics: Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Arthritis; Blood Sedimentation; Child; Drug Th	1965
Quantitative aspects of pyrogenic and hematologic responses to etiocholanolone in man. The Journal of laboratory and clinical medicine, 1967, Volume: 69, Issue:3 Topics: Adolescent; Adult; Blood Sedimentation; Etiocholanolone; Female; Fever; Humans; Injections, Intramus	1967
Aetiocholanolone fever. A report of three cases. German medical monthly, 1967, Volume: 12, Issue:2 Topics: Adolescent; Adult; Diagnosis, Differential; Etiocholanolone; Familial Mediterranean Fever; Female; F	1967
Novel biological properties of steroid metabolites; fever-production in man. Journal of the Reticuloendothelial Society, 1967, Volume: 4, Issue:4 Topics: Anti-Inflammatory Agents; Chemical Phenomena; Chemistry; Etiocholanolone; Female; Fever; Humans; Mal	1967
The biological properties of etiocholanolone. Combined clinical staff conference at the National Institutes of Health. Annals of internal medicine, 1967, Volume: 67, Issue:6 Topics: Adult; Bone Marrow; Bone Marrow Cells; Bone Marrow Examination; Endotoxins; Etiocholanolone; Female;	1967
[Etiocholanolone and fever]. Deutsche medizinische Wochenschrift (1946), 1984, Apr-13, Volume: 109, Issue:15 Topics: Adrenal Hyperplasia, Congenital; Chromatography, Gas; Dose-Response Relationship, Drug; Etiocholanol	1984
Urticaria in association with etiocholanolone fever. The British journal of dermatology, 1981, Volume: 105, Issue:1 Topics: Adolescent; Contraceptives, Oral, Combined; Etiocholanolone; Exanthema; Female; Fever; Humans; Menst	1981
Pyrogenicity of etiocholanolone and interleukin-1 in New and Old World Monkeys. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1998, Volume: 217, Issue:4 Topics: Androsterone; Animals; Body Temperature; Etiocholanolone; Fever; Interleukin-1; Macaca mulatta; Male	1998
[Value of the etiocholanolone test in Hematology. Preliminary results (68 tests)]. La Nouvelle presse medicale, 1977, Apr-30, Volume: 6, Issue:18 Topics: Blood Cell Count; Bone Marrow Cells; Drug Tolerance; Etiocholanolone; Fever; Hematologic Diseases; H	1977
[Studies on etiocholanolone fever: Serum unconjugated eticholanolone concentration determined by radioimmunoassay]. Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine, 1977, Nov-10, Volume: 66, Issue:11 Topics: Adult; Aged; Etiocholanolone; Female; Fever; Humans; Male; Middle Aged; Radioimmunoassay	1977
[Effect of prednisolone on experimental etiocholanolone fever and its therapeutic use in leukapheresis]. Verhandlungen der Deutschen Gesellschaft fur Innere Medizin, 1978, Issue:84 Topics: Etiocholanolone; Fever; Humans; Leukapheresis; Male; Prednisolone	1978
[Modification of experimental etiocholanolone fever through indomethacin]. Verhandlungen der Deutschen Gesellschaft fur Innere Medizin, 1976, Volume: 82 Pt 2 Topics: Adult; Etiocholanolone; Fever; Humans; Indomethacin	1976
Effects of etiocholanolone-induced fever on plasma antipyrine half-lives and metabolic clearance. Clinical pharmacology and therapeutics, 1975, Volume: 17, Issue:4 Topics: Adolescent; Adult; Antipyrine; Etiocholanolone; Female; Fever; Half-Life; Humans; Male; Metabolic Cl	1975
[Etiocholanolone fever]. Die Medizinische Welt, 1975, Mar-07, Volume: 26, Issue:10 Topics: Adult; Diagnosis, Differential; Etiocholanolone; Female; Fever; Fever of Unknown Origin; Humans; Ind	1975
["Etiocholanolone fever"?]. Deutsche medizinische Wochenschrift (1946), 1992, Jun-12, Volume: 117, Issue:24 Topics: Diagnosis, Differential; Etiocholanolone; Familial Mediterranean Fever; Fever; Humans; Recurrence	1992
A case of periodic fever--reevaluation of etiocholanolone fever as an established clinical entity. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 1988, Volume: 20, Issue:6 Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adult; Androsterone; Etiocholanolone; Fever; Humans; Mal	1988
[Vegetative hyperthermia]. Deutsche medizinische Wochenschrift (1946), 1987, Feb-13, Volume: 112, Issue:7 Topics: Etiocholanolone; Fever; Humans	1987
Steroid excretion in aetiocholanolone fever. Lancet (London, England), 1968, Mar-09, Volume: 1, Issue:7541 Topics: Adolescent; Adult; Etiocholanolone; Female; Fever; Glucocorticoids; Humans	1968
A description of two brothers with permanently raised non-esterified aetiocholanolone blood level. Acta endocrinologica, 1968, Volume: 57, Issue:2 Topics: Child; Cortisone; Dehydroepiandrosterone; Dexamethasone; Etiocholanolone; Fever; Humans; Male; Pyrog	1968
[Etiocholanolone fever]. Endokrinologie, 1971, Volume: 57, Issue:3 Topics: Adult; Androstanes; Betamethasone; Dehydroepiandrosterone; Etiocholanolone; Fever; Half-Life; Humans	1971
Comparison of the effect of the pyrogens, etiocholanolone and bacterial endotoxin on plasma cortisol and growth hormone in man. The Journal of clinical endocrinology and metabolism, 1968, Volume: 28, Issue:3 Topics: Adrenocorticotropic Hormone; Adult; Body Temperature; Endotoxins; Etiocholanolone; Female; Fever; Gr	1968
Determination of unconjugated etiocholanolone in human plasma using gas-liquid chromatography. Clinica chimica acta; international journal of clinical chemistry, 1968, Volume: 20, Issue:1 Topics: Adrenocorticotropic Hormone; Chorionic Gonadotropin; Chromatography, Gas; Chromatography, Thin Layer	1968
The conjugating mechanism in a case of etiocholanolone fever. Acta medica Academiae Scientiarum Hungaricae, 1968, Volume: 25, Issue:1 Topics: Adolescent; Adrenocorticotropic Hormone; Androsterone; Dehydroepiandrosterone; Etiocholanolone; Fema	1968
[Adrenocorticotropic reaction to the administration of etiocholanolone]. Atti della Accademia dei fisiocritici in Siena. Sezione medico-fisica, 1967, Volume: 16, Issue:2 Topics: 17-Hydroxycorticosteroids; Adolescent; Adrenocorticotropic Hormone; Adult; Aged; Etiocholanolone; Fe	1967
[A method for the determination of free etiocholanolone in plasma]. Zeitschrift fur klinische Chemie und klinische Biochemie, 1971, Volume: 9, Issue:3 Topics: Adolescent; Adult; Aluminum; Chromatography, Thin Layer; Dansyl Compounds; Dinitrophenols; Etiochola	1971
The effect of etiocholanolone on granulocyte kinetics and thermogenic response in patients with breast carcinoma. Neoplasma, 1974, Volume: 21, Issue:3 Topics: Adult; Aged; Body Temperature; Breast Neoplasms; Etiocholanolone; Female; Fever; Granulocytes; Human	1974
[Fever (author's transl)]. Immunitat und Infektion, 1974, Volume: 2, Issue:1 Topics: Animals; Body Temperature Regulation; Endotoxins; Etiocholanolone; Fever; Humans; Hypothalamus; Leuk	1974
Effects of induced fever on sulfobromophthalein kinetics in man. Annals of internal medicine, 1973, Volume: 78, Issue:2 Topics: Adult; Computers; Endotoxins; Etiocholanolone; Female; Fever; Humans; Kinetics; Liver; Liver Functio	1973
[Recurring fever bouts]. Deutsche medizinische Wochenschrift (1946), 1973, Mar-02, Volume: 98, Issue:9 Topics: Etiocholanolone; Familial Mediterranean Fever; Fever; Humans; Indomethacin; Male; Middle Aged; Recur	1973
The effects of hydrocortisone and estrogen on experimental fever induced by etiocholanolone. The Journal of infectious diseases, 1973, Volume: 128, Issue:2 Topics: Adult; Body Temperature; Estradiol; Estrogens; Etiocholanolone; Female; Fever; Humans; Hydrocortison	1973
[Fever and endocrinopathies]. Acta clinica Belgica, 1973, Volume: 28, Issue:4 Topics: Endocrine System Diseases; Etiocholanolone; Fever; Humans; Hyperthyroidism; Thyroid Crisis; Thyroidi	1973
[Inflammatory and anti-inflammatory steroids in periodic disease]. La Nouvelle presse medicale, 1974, Jun-29, Volume: 3, Issue:26 Topics: Anti-Inflammatory Agents; Estradiol; Etiocholanolone; Familial Mediterranean Fever; Fever; Glucocort	1974
The use of etiocholanolone for the measurement of marrow granulocyte reserves. The Medical journal of Australia, 1970, Apr-11, Volume: 1, Issue:15 Topics: Acute Kidney Injury; Adolescent; Adult; Agranulocytosis; Blood Urea Nitrogen; Bone Marrow; Bone Marr	1970
[Cytologic and humoral changes in experimental etiocholanolone fever]. Verhandlungen der Deutschen Gesellschaft fur Innere Medizin, 1968, Volume: 74 Topics: Blood Proteins; Etiocholanolone; Fever; Humans; Hydrocortisone; Immunodiffusion; Leukocytes; Male; T	1968
Endotoxin-induced kinin production in man. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1972, Volume: 139, Issue:3 Topics: Adolescent; Adult; Agranulocytosis; Blood Pressure; Bradykinin; Endotoxins; Etiocholanolone; Female;	1972
The influence of pyrogen-induced fever on salicylamide metabolism in man. The Journal of clinical investigation, 1972, Volume: 51, Issue:11 Topics: Adult; Biotransformation; Endotoxins; Etiocholanolone; Female; Fever; Humans; Kidney; Liver; Male; P	1972
[Familial Mediterranean fever with high serum unconjugated etiocholanolone level]. Acta clinica Belgica, 1971, Volume: 26, Issue:1 Topics: Adult; Diagnosis, Differential; Etiocholanolone; Familial Mediterranean Fever; Fever; Humans; Male	1971
Relevance of experimental observations to pyrexia in clinical situations in: pyrogens and fever. Ciba Foundation symposium, 1971 Topics: Anesthesia; Antigen-Antibody Reactions; Bacterial Infections; Body Temperature Regulation; Endotoxin	1971
[Periodic disease and etiocholanolone]. La Presse medicale, 1970, Mar-28, Volume: 78, Issue:16 Topics: Adult; Amyloidosis; Cortisone; Diagnosis, Differential; Ethnicity; Etiocholanolone; Familial Mediter	1970
Successful treatment of periodic ("etiocholanolone") fever with metyrapone combined with a low dose of dexamethasone. Annals of clinical research, 1970, Volume: 2, Issue:3 Topics: Adult; Aged; Dexamethasone; Etiocholanolone; Fever; Humans; Male; Metyrapone; Middle Aged; Periodici	1970
Studies on steroid fever. II. Pyrogenic and anti-pyrogenic activity in vitro of some endogenous steroids of man. The Journal of clinical investigation, 1970, Volume: 49, Issue:12 Topics: Androsterone; Bile Acids and Salts; Buffers; Drug Antagonism; Estradiol; Etiocholanolone; Fever; Hum	1970
[Recurrent fever and raise of free etiocholanolone in the blood. Report on five patients]. Deutsche medizinische Wochenschrift (1946), 1971, Jan-15, Volume: 96, Issue:3 Topics: Adult; Chromatography, Thin Layer; Chronic Disease; Etiocholanolone; Female; Fever; Humans; Leukocyt	1971
[On the therapy of etiocholanolone fever]. Verhandlungen der Deutschen Gesellschaft fur Innere Medizin, 1967, Volume: 73 Topics: Adolescent; Adult; Betamethasone; Child; Etiocholanolone; Female; Fever; Humans; Indomethacin; Male;	1967
[New findings in etiocholanolone induced fever]. Klinische Wochenschrift, 1967, Sep-01, Volume: 45, Issue:17 Topics: Adrenal Cortex Hormones; Androstanes; Etiocholanolone; Fever; Humans; Pregnanetriol	1967
Etiocholanolone and fever. Annals of internal medicine, 1968, Volume: 68, Issue:2 Topics: Etiocholanolone; Familial Mediterranean Fever; Fever; Humans	1968
[Etiocholanone fever and liver diseases]. Die Medizinische Welt, 1968, Mar-23, Volume: 12 Topics: Adult; Chronic Disease; Etiocholanolone; Fever; Hepatitis; Humans; Male	1968
Experimental etiocholanolone fever: febrile reactivity in men and women. The Journal of clinical endocrinology and metabolism, 1966, Volume: 26, Issue:2 Topics: Adolescent; Adult; Body Temperature; Etiocholanolone; Female; Fever; Humans; Male; Pyrogens; Statist	1966
[Etiocholanone fever. Report on 3 cases]. Deutsche medizinische Wochenschrift (1946), 1966, Sep-16, Volume: 91, Issue:37 Topics: Adolescent; Adult; Betamethasone; Etiocholanolone; Female; Fever; Humans; Male; Middle Aged	1966

etiocholanolone and Fever

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