Page last updated: 2024-10-26

etidronate and Periodontitis

etidronate has been researched along with Periodontitis in 7 studies

Etidronic Acid: A diphosphonate which affects calcium metabolism. It inhibits ectopic calcification and slows down bone resorption and bone turnover.
etidronic acid : A 1,1-bis(phosphonic acid) that is (ethane-1,1-diyl)bis(phosphonic acid) having a hydroxy substituent at the 1-position. It inhibits the formation, growth, and dissolution of hydroxyapatite crystals by chemisorption to calcium phosphate surfaces.

Periodontitis: Inflammation and loss of connective tissues supporting or surrounding the teeth. This may involve any part of the PERIODONTIUM. Periodontitis is currently classified by disease progression (CHRONIC PERIODONTITIS; AGGRESSIVE PERIODONTITIS) instead of age of onset. (From 1999 International Workshop for a Classification of Periodontal Diseases and Conditions, American Academy of Periodontology)

Research Excerpts

ExcerptRelevanceReference
"The present study was designed to evaluate the effects of risedronate, one of the most potent bisphosphonates, on alveolar bone resorption and angiogenesis in rats with experimental periodontitis to identify dose-response curves and treatment durations that can be therapeutic for periodontal therapy versus those associated with osteonecrosis of the jaws."1.35Effects of risedronate on alveolar bone loss and angiogenesis: a stereologic study in rats. ( Ayas, B; Cetinkaya, BO; Gurgor, P; Keles, GC, 2008)

Research

Studies (7)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (14.29)18.2507
2000's5 (71.43)29.6817
2010's1 (14.29)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Cetinkaya, BO1
Keles, GC1
Ayas, B1
Gurgor, P1
Hasegawa, T1
Ri, S1
Umeda, M1
Komatsubara, H1
Kobayashi, M1
Shigeta, T1
Yoshitomi, I1
Ikeda, H1
Shibuya, Y1
Asahina, I1
Komori, T1
Tenenbaum, HC1
Shelemay, A1
Girard, B1
Zohar, R1
Fritz, PC1
Lane, N1
Armitage, GC1
Loomer, P1
Hsieh, S1
Majumdar, S1
Wang, HY1
Jeffcoat, M1
Munoz, T1
Kolobkova, LN2
Nikolaev, IV1
Stepanova, EV1
Landesman, EO1
Koroleva, OV1
Shoji, K1
Horiuchi, H1
Shinoda, H1
Seleznev, AN1
Petrovich, IuA1
Kozlov, SA1
Kachkaeva, SS1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Investigation of the Effects of Bisphosphonate on the Gingival Crevicular Fluid Levels of Sclerostin and the DKK-1 in Individuals With Postmenopausal Osteoporosis With Periodontal Changes[NCT04149405]Phase 443 participants (Actual)Interventional2016-06-30Completed
Effect of Periodontal Therapy and Bisphosphonates on Gingival Crevicular Fluid Levels of Nuclear Factor- κb Ligand (RANKL) and Osteoprotegerin in Postmenopausal Osteoporosis: Results of a 12-Month Study[NCT02808988]Phase 447 participants (Actual)Interventional2013-10-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Dkk-1 Values for 12th Month

levels of dickkopf-related protein-1 in 12th month (NCT04149405)
Timeframe: 12 months

Interventionng/ml (Mean)
Group A3440.67
Group B3203.802
Group C2490.553
Group D4269.39

Dkk-1 Values for 6th Month

levels of dickkopf-related protein-1 in 6th month (NCT04149405)
Timeframe: 6 months

Interventionng/ml (Mean)
Group A3358.265
Group B1963.185
Group C3263.665
Group D4269.39

Sost Values for 12th Month

levels of sclerostin in 12th month (NCT04149405)
Timeframe: 12 month

Interventionng/ml (Mean)
Group A1702.265
Group B1347.330
Group C1114.988
Group D2131.87

Sost Values for 6th Month

levels of sclerostin in 6th month (NCT04149405)
Timeframe: 6 months

Interventionng/ml (Mean)
Group A1389.177
Group B1085.405
Group C1596.585
Group D2131.87

Reviews

1 review available for etidronate and Periodontitis

ArticleYear
Bisphosphonates and periodontics: potential applications for regulation of bone mass in the periodontium and other therapeutic/diagnostic uses.
    Journal of periodontology, 2002, Volume: 73, Issue:7

    Topics: Alendronate; Alveolar Bone Loss; Animals; Bone Density; Bone Regeneration; Diphosphonates; Etidronic

2002

Trials

2 trials available for etidronate and Periodontitis

ArticleYear
Bisphosphonate therapy improves the outcome of conventional periodontal treatment: results of a 12-month, randomized, placebo-controlled study.
    Journal of periodontology, 2005, Volume: 76, Issue:7

    Topics: Alendronate; Alveolar Bone Loss; Analysis of Variance; Chemotherapy, Adjuvant; Dental Scaling; Dipho

2005
Bisphosphonate therapy improves the outcome of conventional periodontal treatment: results of a 12-month, randomized, placebo-controlled study.
    Journal of periodontology, 2005, Volume: 76, Issue:7

    Topics: Alendronate; Alveolar Bone Loss; Analysis of Variance; Chemotherapy, Adjuvant; Dental Scaling; Dipho

2005
Bisphosphonate therapy improves the outcome of conventional periodontal treatment: results of a 12-month, randomized, placebo-controlled study.
    Journal of periodontology, 2005, Volume: 76, Issue:7

    Topics: Alendronate; Alveolar Bone Loss; Analysis of Variance; Chemotherapy, Adjuvant; Dental Scaling; Dipho

2005
Bisphosphonate therapy improves the outcome of conventional periodontal treatment: results of a 12-month, randomized, placebo-controlled study.
    Journal of periodontology, 2005, Volume: 76, Issue:7

    Topics: Alendronate; Alveolar Bone Loss; Analysis of Variance; Chemotherapy, Adjuvant; Dental Scaling; Dipho

2005
[Application of xidiphone in complex of measures for inflammatory periodontal disease prevention].
    Stomatologiia, 2007, Volume: 86, Issue:2

    Topics: Adult; Bone Density Conservation Agents; Calcium; Etidronic Acid; Female; Humans; Hydrogen-Ion Conce

2007

Other Studies

4 other studies available for etidronate and Periodontitis

ArticleYear
Effects of risedronate on alveolar bone loss and angiogenesis: a stereologic study in rats.
    Journal of periodontology, 2008, Volume: 79, Issue:10

    Topics: Alveolar Bone Loss; Alveolar Process; Animals; Blood Vessels; Bone Density; Bone Density Conservatio

2008
The observational study of delayed wound healing after tooth extraction in patients receiving oral bisphosphonate therapy.
    Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery, 2013, Volume: 41, Issue:7

    Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Alendronate; Antibiotic Prophylaxis; Bisphosph

2013
Inhibitory effects of a bisphosphonate (risedronate) on experimental periodontitis in rats.
    Journal of periodontal research, 1995, Volume: 30, Issue:4

    Topics: Alveolar Bone Loss; Analysis of Variance; Animals; Bone Density; Calcium Channel Blockers; Cell Coun

1995
[Pathogenetic validation of xidiphone use in combined therapy for periodontal diseases].
    Stomatologiia, 2002, Volume: 81, Issue:2

    Topics: Acute Disease; Adolescent; Adult; Calcium; Clinical Protocols; Drug Therapy, Combination; Etidronic

2002