etidronate has been researched along with Otosclerosis in 9 studies
Etidronic Acid: A diphosphonate which affects calcium metabolism. It inhibits ectopic calcification and slows down bone resorption and bone turnover.
etidronic acid : A 1,1-bis(phosphonic acid) that is (ethane-1,1-diyl)bis(phosphonic acid) having a hydroxy substituent at the 1-position. It inhibits the formation, growth, and dissolution of hydroxyapatite crystals by chemisorption to calcium phosphate surfaces.
Otosclerosis: Formation of spongy bone in the labyrinth capsule which can progress toward the STAPES (stapedial fixation) or anteriorly toward the COCHLEA leading to conductive, sensorineural, or mixed HEARING LOSS. Several genes are associated with familial otosclerosis with varied clinical signs.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A 2-year prospective double-blind study was performed to evaluate the role of etidronate disodium for the treatment of progressive hearing loss in patients with otosclerosis." | 9.07 | The effects of etidronate disodium on progressive hearing loss from otosclerosis. ( Hoffer, ME; Holliday, M; Kennedy, DW, 1993) |
| "The efficacy of etidronate, a bisphosphonate, was assessed as a treatment for the inner ear symptoms of otosclerosis in a retrospective case review of 896 patients diagnosed with otosclerosis, with primary complaints of dizziness, hearing loss, tinnitus or Meniere's syndrome." | 8.79 | Etidronate for the the neurotologic symptoms of otosclerosis: preliminary study. ( Brookler, KH; Tanyeri, H, 1997) |
| "A 2-year prospective double-blind study was performed to evaluate the role of etidronate disodium for the treatment of progressive hearing loss in patients with otosclerosis." | 5.07 | The effects of etidronate disodium on progressive hearing loss from otosclerosis. ( Hoffer, ME; Holliday, M; Kennedy, DW, 1993) |
| "The efficacy of etidronate, a bisphosphonate, was assessed as a treatment for the inner ear symptoms of otosclerosis in a retrospective case review of 896 patients diagnosed with otosclerosis, with primary complaints of dizziness, hearing loss, tinnitus or Meniere's syndrome." | 4.79 | Etidronate for the the neurotologic symptoms of otosclerosis: preliminary study. ( Brookler, KH; Tanyeri, H, 1997) |
| "Otosclerosis is a disease of abnormal bone remodeling in the otic capsule." | 1.38 | Third-generation bisphosphonates for treatment of sensorineural hearing loss in otosclerosis. ( Halpin, C; McKenna, MJ; Merchant, SN; Quesnel, AM; Seton, M, 2012) |
| "Otosclerosis is a bony dyscrasia characterized by histopathological findings of osteoclast production." | 1.35 | Medical treatment of otosclerosis: rationale for use of bisphosphonates. ( Brookler, K, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (11.11) | 18.7374 |
| 1990's | 3 (33.33) | 18.2507 |
| 2000's | 3 (33.33) | 29.6817 |
| 2010's | 1 (11.11) | 24.3611 |
| 2020's | 1 (11.11) | 2.80 |
| Authors | Studies |
|---|---|
| Patel, S | 1 |
| Walters, B | 1 |
| Eastwood, M | 1 |
| Abou-Foul, AK | 1 |
| Bhimrao, S | 1 |
| Brookler, K | 1 |
| Brookler, KH | 3 |
| Quesnel, AM | 1 |
| Seton, M | 1 |
| Merchant, SN | 1 |
| Halpin, C | 1 |
| McKenna, MJ | 1 |
| Kennedy, DW | 1 |
| Hoffer, ME | 1 |
| Holliday, M | 1 |
| Tanyeri, H | 1 |
| Yaşil, S | 1 |
| Cömlekçi, A | 1 |
| Güneri, A | 1 |
| Stutzmann, JJ | 1 |
| Petrovic, AG | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effects of Bisphosphonates on OI-Related Hearing Loss: A Pilot Study[NCT04152551] | Phase 4 | 100 participants (Anticipated) | Interventional | 2019-11-02 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for etidronate and Otosclerosis
| Article | Year |
|---|---|
A Systematic Review of the Effectiveness of Bisphosphonates for Otosclerosis.
Topics: Adult; Child; Diphosphonates; Etidronic Acid; Hearing Loss, Sensorineural; Humans; Otosclerosis; Ret | 2022 |
Etidronate for the the neurotologic symptoms of otosclerosis: preliminary study.
Topics: Adolescent; Adult; Aged; Diphosphonates; Ear, Inner; Etidronic Acid; Female; Humans; Male; Middle Ag | 1997 |
1 trial available for etidronate and Otosclerosis
| Article | Year |
|---|---|
The effects of etidronate disodium on progressive hearing loss from otosclerosis.
Topics: Adult; Aged; Auditory Threshold; Double-Blind Method; Etidronic Acid; Female; Hearing Loss, Bilatera | 1993 |
6 other studies available for etidronate and Otosclerosis
| Article | Year |
|---|---|
Medical treatment of otosclerosis: rationale for use of bisphosphonates.
Topics: Aged; Alendronate; Animals; Bone Density Conservation Agents; Bone Resorption; Cell Death; Combined | 2008 |
Monaural diplacusis with tinnitus, aural fullness, hyperacusis, and sensorineural hearing loss.
Topics: Bone Density Conservation Agents; Diabetes Mellitus, Type 2; Etidronic Acid; Hearing Loss, Sensorine | 2009 |
Third-generation bisphosphonates for treatment of sensorineural hearing loss in otosclerosis.
Topics: Adult; Aged; Audiometry, Pure-Tone; Auditory Threshold; Bone Conduction; Bone Density Conservation A | 2012 |
A case of dizziness, headache, aural fullness, and concentration difficulty following scuba diving.
Topics: Adult; Calcium; Combined Modality Therapy; Diet; Diving; Dizziness; Electronystagmography; Etidronic | 2003 |
Further hearing loss during osteoporosis treatment with etidronate.
Topics: Aged; Etidronic Acid; Female; Follow-Up Studies; Hearing Loss, Sensorineural; Humans; Osteoporosis, | 1998 |
Diphosphonates for otospongiosis.
Topics: Adult; Bone Development; Bone Resorption; Clodronic Acid; Diphosphonates; Etidronic Acid; Humans; Ma | 1985 |